YJL069C / UTP18

Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL069C / UTP18

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:3.19|P-value:1.71E-4 ID:SGTC_57|Compound:miconazole|FD-Score:2.91|P-value:5.29E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.04|P-value:6.04E-12 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.84|P-value:9.00E-6 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.40|P-value:7.40E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:2.77|P-value:9.37E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.15|P-value:1.97E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:-2.99|P-value:4.14E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.02|P-value:3.52E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-2.86|P-value:6.95E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:-2.89|P-value:6.17E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.56|P-value:3.21E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:5.27|P-value:1.67E-9 ID:SGTC_617|Compound:3770-0098|FD-Score:4.18|P-value:1.35E-6 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.33|P-value:1.01E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.00|P-value:9.71E-9 ID:SGTC_673|Compound:1082-0474|FD-Score:3.93|P-value:5.14E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.13|P-value:2.22E-4 ID:SGTC_698|Compound:k064-0052|FD-Score:-2.81|P-value:8.51E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:-3.90|P-value:6.66E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:3.60|P-value:2.63E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:8.38|P-value:2.68E-21 ID:SGTC_832|Compound:4083-0019|FD-Score:3.19|P-value:1.71E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:5.30|P-value:1.34E-9 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.21|P-value:1.65E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:4.14|P-value:1.69E-6 ID:SGTC_1120|Compound:ficusin|FD-Score:2.86|P-value:6.45E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.19|P-value:1.81E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.01|P-value:3.31E-6 ID:SGTC_1141|Compound:3253-0389|FD-Score:2.87|P-value:6.35E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:-2.89|P-value:6.30E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.08|P-value:2.71E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.49|P-value:4.86E-5 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.36|P-value:8.66E-5 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.02|P-value:3.75E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-2.80|P-value:8.99E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.05|P-value:3.31E-4 ID:SGTC_1663|Compound:st014140|FD-Score:-3.17|P-value:1.99E-4 ID:SGTC_1664|Compound:st014217|FD-Score:-5.18|P-value:3.40E-9 ID:SGTC_1786|Compound:berberine|FD-Score:-4.31|P-value:7.13E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.43|P-value:3.35E-7 ID:SGTC_1915|Compound:st067105|FD-Score:2.86|P-value:6.51E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.50|P-value:4.60E-5 ID:SGTC_1939|Compound:st074455|FD-Score:4.18|P-value:1.33E-6 ID:SGTC_1987|Compound:st072290|FD-Score:2.83|P-value:7.37E-4 ID:SGTC_2089|Compound:5281248|FD-Score:-2.90|P-value:6.01E-4 ID:SGTC_2100|Compound:5377183|FD-Score:-3.43|P-value:6.38E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.56|P-value:3.12E-5 ID:SGTC_2198|Compound:6589944|FD-Score:3.00|P-value:3.75E-4 ID:SGTC_2218|Compound:6965428|FD-Score:3.18|P-value:1.77E-4 ID:SGTC_2309|Compound:7664088|FD-Score:2.82|P-value:7.70E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.15|P-value:2.03E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.37|P-value:7.53E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.87|P-value:2.32E-8 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.06|P-value:2.56E-6 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.16|P-value:2.12E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.33|P-value:5.94E-7 ID:SGTC_3069|Compound:9117009|FD-Score:2.80|P-value:8.09E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-2.92|P-value:5.62E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-2.83|P-value:7.93E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.50|P-value:4.50E-5 ID:SGTC_3222|Compound:9128301|FD-Score:-4.72|P-value:6.57E-8 ID:SGTC_3249|Compound:9135183|FD-Score:-2.80|P-value:8.95E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.52|P-value:4.11E-5 ID:SGTC_3346|Compound:9158254|FD-Score:2.98|P-value:4.01E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.19|P-value:1.71E-4 ID:SGTC_57|Compound:miconazole|FD-Score:2.91|P-value:5.29E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.04|P-value:6.04E-12 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.84|P-value:9.00E-6 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.40|P-value:7.40E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:2.77|P-value:9.37E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.15|P-value:1.97E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:-2.99|P-value:4.14E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.02|P-value:3.52E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-2.86|P-value:6.95E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:-2.89|P-value:6.17E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.56|P-value:3.21E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:5.27|P-value:1.67E-9 ID:SGTC_617|Compound:3770-0098|FD-Score:4.18|P-value:1.35E-6 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.33|P-value:1.01E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.00|P-value:9.71E-9 ID:SGTC_673|Compound:1082-0474|FD-Score:3.93|P-value:5.14E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.13|P-value:2.22E-4 ID:SGTC_698|Compound:k064-0052|FD-Score:-2.81|P-value:8.51E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:-3.90|P-value:6.66E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:3.60|P-value:2.63E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:8.38|P-value:2.68E-21 ID:SGTC_832|Compound:4083-0019|FD-Score:3.19|P-value:1.71E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:5.30|P-value:1.34E-9 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.21|P-value:1.65E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:4.14|P-value:1.69E-6 ID:SGTC_1120|Compound:ficusin|FD-Score:2.86|P-value:6.45E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.19|P-value:1.81E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.01|P-value:3.31E-6 ID:SGTC_1141|Compound:3253-0389|FD-Score:2.87|P-value:6.35E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:-2.89|P-value:6.30E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.08|P-value:2.71E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.49|P-value:4.86E-5 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.36|P-value:8.66E-5 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.02|P-value:3.75E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-2.80|P-value:8.99E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.05|P-value:3.31E-4 ID:SGTC_1663|Compound:st014140|FD-Score:-3.17|P-value:1.99E-4 ID:SGTC_1664|Compound:st014217|FD-Score:-5.18|P-value:3.40E-9 ID:SGTC_1786|Compound:berberine|FD-Score:-4.31|P-value:7.13E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.43|P-value:3.35E-7 ID:SGTC_1915|Compound:st067105|FD-Score:2.86|P-value:6.51E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.50|P-value:4.60E-5 ID:SGTC_1939|Compound:st074455|FD-Score:4.18|P-value:1.33E-6 ID:SGTC_1987|Compound:st072290|FD-Score:2.83|P-value:7.37E-4 ID:SGTC_2089|Compound:5281248|FD-Score:-2.90|P-value:6.01E-4 ID:SGTC_2100|Compound:5377183|FD-Score:-3.43|P-value:6.38E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.56|P-value:3.12E-5 ID:SGTC_2198|Compound:6589944|FD-Score:3.00|P-value:3.75E-4 ID:SGTC_2218|Compound:6965428|FD-Score:3.18|P-value:1.77E-4 ID:SGTC_2309|Compound:7664088|FD-Score:2.82|P-value:7.70E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.15|P-value:2.03E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.37|P-value:7.53E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.87|P-value:2.32E-8 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.06|P-value:2.56E-6 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.16|P-value:2.12E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.33|P-value:5.94E-7 ID:SGTC_3069|Compound:9117009|FD-Score:2.80|P-value:8.09E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-2.92|P-value:5.62E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-2.83|P-value:7.93E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.50|P-value:4.50E-5 ID:SGTC_3222|Compound:9128301|FD-Score:-4.72|P-value:6.57E-8 ID:SGTC_3249|Compound:9135183|FD-Score:-2.80|P-value:8.95E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.52|P-value:4.11E-5 ID:SGTC_3346|Compound:9158254|FD-Score:2.98|P-value:4.01E-4

Top fitness defect scores for YJL069C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_800 3448-7362 8.38 155.0 µM 2.68E-21 translation 7 2.59E-17 0.07
2 SGTC_58 0957-0393 6.04 9.0 µM 6.04E-12 cell wall 28 7.63E-10 0.32
3 SGTC_839 0122-0028 5.30 230.0 µM 1.34E-9 RSC complex & mRNA processing 17 5.74E-8 0.00
4 SGTC_586 0957-0265 5.27 8.2 µM 1.67E-9 cell wall 28 6.86E-8 0.32
5 SGTC_625 k213-0058 5.00 121.0 µM 9.71E-9 translation 8 2.80E-7 0.10
6 SGTC_2768 sulfasalazine 4.87 50.2 µM 2.32E-8 5 5.62E-7 0.62
7 SGTC_1787 fluconazole 4.43 80.0 µM 3.35E-7 iron homeostasis 8 4.79E-6 0.22
8 SGTC_2777 climbazole 4.33 1.5 µM 5.94E-7 iron homeostasis 2 7.57E-6 0.13
9 SGTC_1939 st074455 4.18 53.6 µM 1.33E-6 5 1.45E-5 0.29
10 SGTC_617 3770-0098 4.18 35.0 µM 1.35E-6 exosome 23 1.46E-5 0.23
11 SGTC_935 2996-0153 4.14 430.0 µM 1.69E-6 PDR1 1 1.76E-5 0.56
12 SGTC_2770 toltrazuril 4.06 17.5 µM 2.56E-6 3 2.45E-5 0.83
13 SGTC_1133 3473-0247 4.01 50.0 µM 3.31E-6 RSC complex & mRNA processing 43 3.01E-5 0.01
14 SGTC_673 1082-0474 3.93 110.0 µM 5.14E-6 RSC complex & mRNA processing 54 4.28E-5 0.13
15 SGTC_708 3448-5400 3.60 146.0 µM 2.63E-5 24 1.59E-4 0.00
16 SGTC_2109 5483026 3.56 200.0 µM 3.12E-5 RSC complex & mRNA processing 41 1.83E-4 0.01
17 SGTC_563 tetrahydrosecaminediol 3.56 614.0 µM 3.21E-5 amide catabolism 5 1.87E-4 0.02
18 SGTC_2679 rapamycin 3.37 1.0 nM 7.53E-5 64 3.71E-4 0.10
19 SGTC_56 0957-0365 3.19 83.2 µM 1.71E-4 Golgi 11 7.19E-4 0.05
20 SGTC_832 4083-0019 3.19 164.0 µM 1.71E-4 translation 44 7.20E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.227 2.68E-40 YDR449C UTP6 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.220 4.25E-38 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.213 1.29E-35 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.207 8.22E-34 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.206 2.28E-33 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.204 5.79E-33 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.197 8.12E-31 YOR141C ARP8 hom Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity
0.197 1.19E-30 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.192 3.70E-29 YPR190C RPC82 het RNA polymerase III subunit C82
0.190 1.69E-28 YCL037C SRO9 hom Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication
0.189 1.74E-28 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.189 2.13E-28 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.179 1.04E-25 YLR222C UTP13 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.178 1.96E-25 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.177 4.10E-25 YML128C MSC1 hom Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated