YJL070C_p

Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL070C / YJL070C

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:2.97|P-value:3.03E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-2.81|P-value:9.81E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.80|P-value:6.41E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:4.33|P-value:3.53E-7 ID:SGTC_180|Compound:1486-1293|FD-Score:4.19|P-value:8.04E-7 ID:SGTC_200|Compound:k038-0079|FD-Score:2.94|P-value:3.45E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:2.98|P-value:2.95E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-3.06|P-value:3.69E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.24|P-value:9.86E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-2.82|P-value:9.46E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.22|P-value:1.06E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.37|P-value:5.30E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:2.81|P-value:5.85E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.49|P-value:1.35E-7 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.23|P-value:1.74E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.38|P-value:4.98E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:2.94|P-value:3.46E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.77|P-value:6.95E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.48|P-value:1.50E-7 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.31|P-value:7.18E-5 ID:SGTC_1304|Compound:1165-0502|FD-Score:-3.57|P-value:3.82E-5 ID:SGTC_1307|Compound:1187-1599|FD-Score:2.87|P-value:4.63E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:2.81|P-value:5.92E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:2.91|P-value:3.99E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:-3.71|P-value:1.99E-5 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.75|P-value:8.40E-6 ID:SGTC_1695|Compound:st026914|FD-Score:3.29|P-value:7.70E-5 ID:SGTC_1702|Compound:st027038|FD-Score:5.18|P-value:1.67E-9 ID:SGTC_1713|Compound:st033146|FD-Score:2.81|P-value:5.94E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:4.05|P-value:1.73E-6 ID:SGTC_1862|Compound:st057513|FD-Score:-3.74|P-value:1.70E-5 ID:SGTC_1982|Compound:st072467|FD-Score:-3.29|P-value:1.36E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-2.82|P-value:9.19E-4 ID:SGTC_1991|Compound:st073000|FD-Score:-3.18|P-value:2.19E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-5.08|P-value:7.43E-9 ID:SGTC_2022|Compound:5136654|FD-Score:-4.40|P-value:4.95E-7 ID:SGTC_2033|Compound:5192550|FD-Score:2.71|P-value:8.64E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-2.97|P-value:5.20E-4 ID:SGTC_2253|Compound:7938677|FD-Score:7.61|P-value:2.35E-18 ID:SGTC_2260|Compound:7964312|FD-Score:3.36|P-value:5.65E-5 ID:SGTC_2354|Compound:9060492|FD-Score:2.80|P-value:6.08E-4 ID:SGTC_2362|Compound:9071156|FD-Score:2.72|P-value:8.45E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.15|P-value:1.44E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-2.88|P-value:7.38E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.00|P-value:4.56E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.35|P-value:5.91E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.96|P-value:7.15E-9 ID:SGTC_2459|Compound:5811157|FD-Score:-2.99|P-value:4.73E-4 ID:SGTC_2466|Compound:5983409|FD-Score:-3.06|P-value:3.63E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-5.26|P-value:2.31E-9 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.85|P-value:9.74E-6 ID:SGTC_2591|Compound:skatole|FD-Score:4.70|P-value:3.83E-8 ID:SGTC_2616|Compound:abietic acid|FD-Score:2.94|P-value:3.51E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:2.98|P-value:3.01E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:2.78|P-value:6.67E-4 ID:SGTC_2927|Compound:9011802|FD-Score:2.72|P-value:8.32E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-2.97|P-value:5.31E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-2.87|P-value:7.62E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-3.55|P-value:4.26E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-3.68|P-value:2.27E-5 ID:SGTC_3080|Compound:9117754|FD-Score:2.69|P-value:9.43E-4 ID:SGTC_3240|Compound:9133527|FD-Score:3.20|P-value:1.17E-4 ID:SGTC_3244|Compound:9134489|FD-Score:4.17|P-value:8.80E-7 ID:SGTC_44|Compound:0929-0055|FD-Score:2.97|P-value:3.03E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-2.81|P-value:9.81E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.80|P-value:6.41E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:4.33|P-value:3.53E-7 ID:SGTC_180|Compound:1486-1293|FD-Score:4.19|P-value:8.04E-7 ID:SGTC_200|Compound:k038-0079|FD-Score:2.94|P-value:3.45E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:2.98|P-value:2.95E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-3.06|P-value:3.69E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.24|P-value:9.86E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-2.82|P-value:9.46E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.22|P-value:1.06E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.37|P-value:5.30E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:2.81|P-value:5.85E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.49|P-value:1.35E-7 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.23|P-value:1.74E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.38|P-value:4.98E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:2.94|P-value:3.46E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.77|P-value:6.95E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.48|P-value:1.50E-7 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.31|P-value:7.18E-5 ID:SGTC_1304|Compound:1165-0502|FD-Score:-3.57|P-value:3.82E-5 ID:SGTC_1307|Compound:1187-1599|FD-Score:2.87|P-value:4.63E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:2.81|P-value:5.92E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:2.91|P-value:3.99E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:-3.71|P-value:1.99E-5 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.75|P-value:8.40E-6 ID:SGTC_1695|Compound:st026914|FD-Score:3.29|P-value:7.70E-5 ID:SGTC_1702|Compound:st027038|FD-Score:5.18|P-value:1.67E-9 ID:SGTC_1713|Compound:st033146|FD-Score:2.81|P-value:5.94E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:4.05|P-value:1.73E-6 ID:SGTC_1862|Compound:st057513|FD-Score:-3.74|P-value:1.70E-5 ID:SGTC_1982|Compound:st072467|FD-Score:-3.29|P-value:1.36E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-2.82|P-value:9.19E-4 ID:SGTC_1991|Compound:st073000|FD-Score:-3.18|P-value:2.19E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-5.08|P-value:7.43E-9 ID:SGTC_2022|Compound:5136654|FD-Score:-4.40|P-value:4.95E-7 ID:SGTC_2033|Compound:5192550|FD-Score:2.71|P-value:8.64E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-2.97|P-value:5.20E-4 ID:SGTC_2253|Compound:7938677|FD-Score:7.61|P-value:2.35E-18 ID:SGTC_2260|Compound:7964312|FD-Score:3.36|P-value:5.65E-5 ID:SGTC_2354|Compound:9060492|FD-Score:2.80|P-value:6.08E-4 ID:SGTC_2362|Compound:9071156|FD-Score:2.72|P-value:8.45E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.15|P-value:1.44E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-2.88|P-value:7.38E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.00|P-value:4.56E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.35|P-value:5.91E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.96|P-value:7.15E-9 ID:SGTC_2459|Compound:5811157|FD-Score:-2.99|P-value:4.73E-4 ID:SGTC_2466|Compound:5983409|FD-Score:-3.06|P-value:3.63E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-5.26|P-value:2.31E-9 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.85|P-value:9.74E-6 ID:SGTC_2591|Compound:skatole|FD-Score:4.70|P-value:3.83E-8 ID:SGTC_2616|Compound:abietic acid|FD-Score:2.94|P-value:3.51E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:2.98|P-value:3.01E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:2.78|P-value:6.67E-4 ID:SGTC_2927|Compound:9011802|FD-Score:2.72|P-value:8.32E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-2.97|P-value:5.31E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-2.87|P-value:7.62E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-3.55|P-value:4.26E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-3.68|P-value:2.27E-5 ID:SGTC_3080|Compound:9117754|FD-Score:2.69|P-value:9.43E-4 ID:SGTC_3240|Compound:9133527|FD-Score:3.20|P-value:1.17E-4 ID:SGTC_3244|Compound:9134489|FD-Score:4.17|P-value:8.80E-7

Top fitness defect scores for YJL070C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2253 7938677 7.61 135.8 µM 2.35E-18 1 1.36E-14
2 SGTC_1702 st027038 5.18 51.0 µM 1.67E-9 3 1.12E-7
3 SGTC_2454 5-benzylidenerhodanine 4.96 10.4 µM 7.15E-9 TRP & mitochondrial translation 19 3.51E-7
4 SGTC_2591 skatole 4.70 100.0 µM 3.83E-8 18 1.30E-6
5 SGTC_996 3970-0799 4.49 1.8 µM 1.35E-7 64 3.50E-6
6 SGTC_1250 0485-0349 4.48 40.2 µM 1.50E-7 20 3.79E-6
7 SGTC_158 k038-0087 4.33 26.4 µM 3.53E-7 ubiquinone biosynthesis & proteasome 117 7.39E-6
8 SGTC_180 1486-1293 4.19 102.8 µM 8.04E-7 39 1.41E-5
9 SGTC_3244 9134489 4.17 49.5 µM 8.80E-7 12 1.51E-5
10 SGTC_1823 3-hydroxy-2-naphthoic acid 4.05 106.0 µM 1.73E-6 12 2.57E-5
11 SGTC_64 000l-0018 3.80 272.1 µM 6.41E-6 ubiquinone biosynthesis & proteasome 159 7.15E-5
12 SGTC_1486 3970-0793 3.75 4.5 µM 8.40E-6 12 8.84E-5
13 SGTC_1006 4099-6547 3.38 255.0 µM 4.98E-5 44 3.56E-4
14 SGTC_704 1310-0270 3.37 142.0 µM 5.30E-5 57 3.74E-4
15 SGTC_2260 7964312 3.36 200.0 µM 5.65E-5 26 3.93E-4
16 SGTC_2408 sulbentine 3.35 18.4 µM 5.91E-5 70 4.07E-4
17 SGTC_1299 1079-1439 3.31 3.7 µM 7.18E-5 TSC3-RPN4 34 4.74E-4
18 SGTC_1695 st026914 3.29 34.5 µM 7.70E-5 43 5.01E-4
19 SGTC_462 ag-879 3.24 158.0 µM 9.86E-5 59 6.08E-4
20 SGTC_495 decylubiquinone 3.22 155.0 µM 1.06E-4 copper-dependent oxidative stress 60 6.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.167 2.11E-22 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.133 1.02E-14 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.127 1.43E-13 YMR291W TDA1 hom Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.127 1.99E-13 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.125 3.91E-13 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.120 3.48E-12 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.118 6.28E-12 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.118 7.79E-12 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.116 1.85E-11 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.113 6.33E-11 YIL059C_d YIL059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
0.108 3.50E-10 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.108 3.54E-10 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.107 4.72E-10 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.107 5.17E-10 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.107 5.72E-10 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data