YJL072C / PSF2

Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL072C / PSF2

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:3.35|P-value:7.72E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:5.19|P-value:4.74E-7 ID:SGTC_36|Compound:0335-0881|FD-Score:17.10|P-value:1.02E-58 ID:SGTC_64|Compound:000l-0018|FD-Score:11.60|P-value:5.10E-28 ID:SGTC_67|Compound:0335-0847|FD-Score:3.87|P-value:1.28E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.65|P-value:2.86E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.44|P-value:5.69E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-4.59|P-value:7.27E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:4.81|P-value:2.76E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:7.52|P-value:6.37E-13 ID:SGTC_158|Compound:k038-0087|FD-Score:7.09|P-value:1.09E-11 ID:SGTC_165|Compound:k038-0023|FD-Score:4.90|P-value:1.89E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:4.63|P-value:6.12E-6 ID:SGTC_216|Compound:k038-0035|FD-Score:5.35|P-value:2.16E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:3.32|P-value:8.53E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.75|P-value:2.02E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.77|P-value:1.86E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.79|P-value:1.70E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-4.22|P-value:3.34E-5 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.80|P-value:1.63E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:-6.36|P-value:9.45E-10 ID:SGTC_778|Compound:3456-2434|FD-Score:-9.07|P-value:5.51E-18 ID:SGTC_794|Compound:k038-0031|FD-Score:5.33|P-value:2.35E-7 ID:SGTC_821|Compound:1114-0266|FD-Score:-3.79|P-value:1.70E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.38|P-value:7.13E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.55|P-value:4.02E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:6.84|P-value:5.36E-11 ID:SGTC_1013|Compound:4112-3890|FD-Score:5.79|P-value:2.32E-8 ID:SGTC_1020|Compound:4335-0961|FD-Score:7.78|P-value:9.92E-14 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.33|P-value:8.40E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.77|P-value:1.83E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.40|P-value:6.66E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-4.90|P-value:1.89E-6 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.01|P-value:7.74E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:5.28|P-value:3.15E-7 ID:SGTC_1568|Compound:digitonin|FD-Score:-4.55|P-value:8.49E-6 ID:SGTC_1613|Compound:st002381|FD-Score:3.72|P-value:2.25E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.59|P-value:3.47E-4 ID:SGTC_1848|Compound:st056003|FD-Score:4.24|P-value:3.08E-5 ID:SGTC_1911|Compound:st060208|FD-Score:-5.25|P-value:3.49E-7 ID:SGTC_2016|Compound:5121758|FD-Score:3.52|P-value:4.49E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.09|P-value:5.54E-5 ID:SGTC_2301|Compound:7769476|FD-Score:5.10|P-value:7.35E-7 ID:SGTC_2457|Compound:5731572|FD-Score:-3.52|P-value:4.47E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.91|P-value:1.09E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.35|P-value:7.72E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:5.19|P-value:4.74E-7 ID:SGTC_36|Compound:0335-0881|FD-Score:17.10|P-value:1.02E-58 ID:SGTC_64|Compound:000l-0018|FD-Score:11.60|P-value:5.10E-28 ID:SGTC_67|Compound:0335-0847|FD-Score:3.87|P-value:1.28E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.65|P-value:2.86E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.44|P-value:5.69E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-4.59|P-value:7.27E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:4.81|P-value:2.76E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:7.52|P-value:6.37E-13 ID:SGTC_158|Compound:k038-0087|FD-Score:7.09|P-value:1.09E-11 ID:SGTC_165|Compound:k038-0023|FD-Score:4.90|P-value:1.89E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:4.63|P-value:6.12E-6 ID:SGTC_216|Compound:k038-0035|FD-Score:5.35|P-value:2.16E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:3.32|P-value:8.53E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.75|P-value:2.02E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.77|P-value:1.86E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.79|P-value:1.70E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-4.22|P-value:3.34E-5 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.80|P-value:1.63E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:-6.36|P-value:9.45E-10 ID:SGTC_778|Compound:3456-2434|FD-Score:-9.07|P-value:5.51E-18 ID:SGTC_794|Compound:k038-0031|FD-Score:5.33|P-value:2.35E-7 ID:SGTC_821|Compound:1114-0266|FD-Score:-3.79|P-value:1.70E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.38|P-value:7.13E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.55|P-value:4.02E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:6.84|P-value:5.36E-11 ID:SGTC_1013|Compound:4112-3890|FD-Score:5.79|P-value:2.32E-8 ID:SGTC_1020|Compound:4335-0961|FD-Score:7.78|P-value:9.92E-14 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.33|P-value:8.40E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.77|P-value:1.83E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.40|P-value:6.66E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-4.90|P-value:1.89E-6 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.01|P-value:7.74E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:5.28|P-value:3.15E-7 ID:SGTC_1568|Compound:digitonin|FD-Score:-4.55|P-value:8.49E-6 ID:SGTC_1613|Compound:st002381|FD-Score:3.72|P-value:2.25E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.59|P-value:3.47E-4 ID:SGTC_1848|Compound:st056003|FD-Score:4.24|P-value:3.08E-5 ID:SGTC_1911|Compound:st060208|FD-Score:-5.25|P-value:3.49E-7 ID:SGTC_2016|Compound:5121758|FD-Score:3.52|P-value:4.49E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.09|P-value:5.54E-5 ID:SGTC_2301|Compound:7769476|FD-Score:5.10|P-value:7.35E-7 ID:SGTC_2457|Compound:5731572|FD-Score:-3.52|P-value:4.47E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.91|P-value:1.09E-4

Top fitness defect scores for YJL072C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_36 0335-0881 17.10 14.2 µM 1.02E-58 ubiquinone biosynthesis & proteasome 1 1.42E-65 4.19
2 SGTC_64 000l-0018 11.60 272.1 µM 5.10E-28 ubiquinone biosynthesis & proteasome 12 3.55E-31 2.27
3 SGTC_1020 4335-0961 7.78 93.3 µM 9.92E-14 1 3.55E-15 2.52
4 SGTC_142 0335-0849 7.52 62.7 µM 6.37E-13 ubiquinone biosynthesis & proteasome 7 2.85E-14 0.55
5 SGTC_158 k038-0087 7.09 26.4 µM 1.09E-11 ubiquinone biosynthesis & proteasome 8 6.83E-13 0.12
6 SGTC_1011 4112-3381 6.84 17.4 µM 5.36E-11 1 4.06E-12 3.17
7 SGTC_1013 4112-3890 5.79 241.0 µM 2.32E-8 TSC3-RPN4 1 3.60E-9 0.54
8 SGTC_216 k038-0035 5.35 28.4 µM 2.16E-7 ubiquinone biosynthesis & proteasome 9 4.34E-8 0.32
9 SGTC_794 k038-0031 5.33 316.0 µM 2.35E-7 ubiquinone biosynthesis & proteasome 9 4.78E-8 0.26
10 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 5.28 85.4 µM 3.15E-7 1 6.64E-8 0.91
11 SGTC_16 erodoxin 5.19 22.8 µM 4.74E-7 unfolded protein response 17 1.05E-7 0.10
12 SGTC_2301 7769476 5.10 200.0 µM 7.35E-7 5 1.71E-7 0.02
13 SGTC_165 k038-0023 4.90 64.4 µM 1.89E-6 ubiquinone biosynthesis & proteasome 15 4.90E-7 0.21
14 SGTC_137 0438-0332 4.81 85.4 µM 2.76E-6 ubiquinone biosynthesis & proteasome 30 7.47E-7 0.17
15 SGTC_200 k038-0079 4.63 37.5 µM 6.12E-6 ubiquinone biosynthesis & proteasome 8 1.82E-6 0.26
16 SGTC_1848 st056003 4.24 16.4 µM 3.08E-5 2 1.11E-5 0.32
17 SGTC_2233 sulbentine 4.09 40.4 µM 5.54E-5 36 2.12E-5 0.14
18 SGTC_1564 D-Arginine 4.01 115.0 µM 7.74E-5 9 3.08E-5 0.16
19 SGTC_2784 7567673 3.91 72.7 µM 1.09E-4 iron homeostasis 14 4.54E-5 0.12
20 SGTC_67 0335-0847 3.87 266.0 µM 1.28E-4 ubiquinone biosynthesis & proteasome 24 5.40E-5 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.496 1.51E-207 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.478 9.31E-191 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.473 1.13E-186 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.457 2.09E-172 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.454 3.29E-170 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.433 2.34E-153 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.422 3.91E-145 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.420 1.71E-143 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.419 1.47E-142 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.412 9.46E-138 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.412 1.18E-137 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.405 1.49E-132 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.401 2.66E-129 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.400 2.82E-129 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.399 3.33E-128 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data