YJL074C / SMC3

Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL074C / SMC3

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:2.89|P-value:2.25E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.25|P-value:4.01E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:4.16|P-value:2.28E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:4.32|P-value:8.11E-8 ID:SGTC_149|Compound:3970-0822|FD-Score:-2.84|P-value:3.07E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:6.72|P-value:1.88E-16 ID:SGTC_161|Compound:4065-0411|FD-Score:6.88|P-value:3.62E-17 ID:SGTC_207|Compound:4185-0010|FD-Score:3.13|P-value:7.11E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:4.61|P-value:1.14E-8 ID:SGTC_286|Compound:k060-0067|FD-Score:3.58|P-value:6.99E-6 ID:SGTC_302|Compound:1094-0063|FD-Score:2.55|P-value:9.84E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:-3.28|P-value:3.80E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-2.89|P-value:2.42E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.29|P-value:3.18E-5 ID:SGTC_398|Compound:bronopol|FD-Score:4.55|P-value:1.71E-8 ID:SGTC_403|Compound:arphamenine a|FD-Score:2.98|P-value:1.45E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-2.64|P-value:7.24E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:-2.69|P-value:5.83E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:3.59|P-value:6.71E-6 ID:SGTC_757|Compound:1066-0008|FD-Score:-2.90|P-value:2.30E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:2.74|P-value:4.28E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.01|P-value:5.85E-7 ID:SGTC_968|Compound:1309-0633|FD-Score:2.99|P-value:1.42E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.18|P-value:5.68E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:3.85|P-value:1.46E-6 ID:SGTC_999|Compound:4022-0066|FD-Score:-5.11|P-value:3.21E-10 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.78|P-value:2.26E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.25|P-value:4.30E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.44|P-value:1.62E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.77|P-value:2.36E-6 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.70|P-value:5.25E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:-2.74|P-value:4.63E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:-2.67|P-value:6.48E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:-2.85|P-value:2.92E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.42|P-value:1.65E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.65|P-value:6.91E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:2.87|P-value:2.41E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:-2.95|P-value:1.86E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:2.57|P-value:9.05E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.70|P-value:5.19E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.21|P-value:4.95E-5 ID:SGTC_1652|Compound:st011932|FD-Score:3.83|P-value:1.71E-6 ID:SGTC_1654|Compound:st012436|FD-Score:2.63|P-value:7.07E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.03|P-value:5.10E-7 ID:SGTC_2055|Compound:5235184|FD-Score:3.32|P-value:2.77E-5 ID:SGTC_2127|Compound:5253358|FD-Score:3.34|P-value:2.45E-5 ID:SGTC_2353|Compound:9059630|FD-Score:2.93|P-value:1.88E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.05|P-value:1.06E-4 ID:SGTC_2355|Compound:9061122|FD-Score:2.60|P-value:7.99E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-2.72|P-value:5.15E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.18|P-value:5.64E-5 ID:SGTC_2460|Compound:5552655|FD-Score:-3.31|P-value:3.14E-5 ID:SGTC_2465|Compound:5809242|FD-Score:-3.38|P-value:2.21E-5 ID:SGTC_2467|Compound:5474540|FD-Score:-2.94|P-value:1.97E-4 ID:SGTC_2473|Compound:5854593|FD-Score:-2.85|P-value:2.88E-4 ID:SGTC_2481|Compound:5478948|FD-Score:2.70|P-value:5.11E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.83|P-value:2.94E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-2.67|P-value:6.36E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.70|P-value:3.92E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:2.80|P-value:3.43E-4 ID:SGTC_3004|Compound:9076122|FD-Score:2.96|P-value:1.65E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.30|P-value:3.02E-5 ID:SGTC_57|Compound:miconazole|FD-Score:2.89|P-value:2.25E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.25|P-value:4.01E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:4.16|P-value:2.28E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:4.32|P-value:8.11E-8 ID:SGTC_149|Compound:3970-0822|FD-Score:-2.84|P-value:3.07E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:6.72|P-value:1.88E-16 ID:SGTC_161|Compound:4065-0411|FD-Score:6.88|P-value:3.62E-17 ID:SGTC_207|Compound:4185-0010|FD-Score:3.13|P-value:7.11E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:4.61|P-value:1.14E-8 ID:SGTC_286|Compound:k060-0067|FD-Score:3.58|P-value:6.99E-6 ID:SGTC_302|Compound:1094-0063|FD-Score:2.55|P-value:9.84E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:-3.28|P-value:3.80E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-2.89|P-value:2.42E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.29|P-value:3.18E-5 ID:SGTC_398|Compound:bronopol|FD-Score:4.55|P-value:1.71E-8 ID:SGTC_403|Compound:arphamenine a|FD-Score:2.98|P-value:1.45E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-2.64|P-value:7.24E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:-2.69|P-value:5.83E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:3.59|P-value:6.71E-6 ID:SGTC_757|Compound:1066-0008|FD-Score:-2.90|P-value:2.30E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:2.74|P-value:4.28E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.01|P-value:5.85E-7 ID:SGTC_968|Compound:1309-0633|FD-Score:2.99|P-value:1.42E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.18|P-value:5.68E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:3.85|P-value:1.46E-6 ID:SGTC_999|Compound:4022-0066|FD-Score:-5.11|P-value:3.21E-10 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.78|P-value:2.26E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.25|P-value:4.30E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.44|P-value:1.62E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.77|P-value:2.36E-6 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.70|P-value:5.25E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:-2.74|P-value:4.63E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:-2.67|P-value:6.48E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:-2.85|P-value:2.92E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.42|P-value:1.65E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.65|P-value:6.91E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:2.87|P-value:2.41E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:-2.95|P-value:1.86E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:2.57|P-value:9.05E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.70|P-value:5.19E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.21|P-value:4.95E-5 ID:SGTC_1652|Compound:st011932|FD-Score:3.83|P-value:1.71E-6 ID:SGTC_1654|Compound:st012436|FD-Score:2.63|P-value:7.07E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.03|P-value:5.10E-7 ID:SGTC_2055|Compound:5235184|FD-Score:3.32|P-value:2.77E-5 ID:SGTC_2127|Compound:5253358|FD-Score:3.34|P-value:2.45E-5 ID:SGTC_2353|Compound:9059630|FD-Score:2.93|P-value:1.88E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.05|P-value:1.06E-4 ID:SGTC_2355|Compound:9061122|FD-Score:2.60|P-value:7.99E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-2.72|P-value:5.15E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.18|P-value:5.64E-5 ID:SGTC_2460|Compound:5552655|FD-Score:-3.31|P-value:3.14E-5 ID:SGTC_2465|Compound:5809242|FD-Score:-3.38|P-value:2.21E-5 ID:SGTC_2467|Compound:5474540|FD-Score:-2.94|P-value:1.97E-4 ID:SGTC_2473|Compound:5854593|FD-Score:-2.85|P-value:2.88E-4 ID:SGTC_2481|Compound:5478948|FD-Score:2.70|P-value:5.11E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.83|P-value:2.94E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-2.67|P-value:6.36E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.70|P-value:3.92E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:2.80|P-value:3.43E-4 ID:SGTC_3004|Compound:9076122|FD-Score:2.96|P-value:1.65E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.30|P-value:3.02E-5

Top fitness defect scores for YJL074C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_161 4065-0411 6.88 162.2 µM 3.62E-17 4 2.94E-12 0.77
2 SGTC_158 k038-0087 6.72 26.4 µM 1.88E-16 ubiquinone biosynthesis & proteasome 11 9.11E-12 0.08
3 SGTC_268 camptothecin 4.61 39.6 µM 1.14E-8 DNA damage response 35 2.04E-6 0.05
4 SGTC_398 bronopol 4.55 33.3 µM 1.71E-8 RNA processing & uracil transport 5 2.69E-6 0.15
5 SGTC_146 3448-8650 4.32 53.1 µM 8.11E-8 NEO1-PIK1 10 7.88E-6 0.08
6 SGTC_86 0417-1630 4.16 471.9 µM 2.28E-7 ubiquinone biosynthesis & proteasome 27 1.61E-5 0.01
7 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 4.03 70.1 µM 5.10E-7 5 2.81E-5 0.10
8 SGTC_915 methyl methanesulfonate (MMS) 4.01 110.0 mM 5.85E-7 DNA damage response 10 3.09E-5 0.42
9 SGTC_997 3996-0078 3.85 137.0 µM 1.46E-6 7 5.82E-5 0.03
10 SGTC_1652 st011932 3.83 78.0 µM 1.71E-6 RSC complex & mRNA processing 36 6.49E-5 0.39
11 SGTC_1001 4048-4355 3.78 44.4 µM 2.26E-6 copper-dependent oxidative stress 12 7.86E-5 0.04
12 SGTC_1082 camptothecin 3.77 424.9 nM 2.36E-6 DNA damage response 21 8.11E-5 0.11
13 SGTC_504 lovastatin 3.59 124.0 µM 6.71E-6 8 1.68E-4 0.30
14 SGTC_286 k060-0067 3.58 22.9 µM 6.99E-6 tubulin folding & SWR complex 11 1.72E-4 0.14
15 SGTC_1456 k015-0012 3.42 13.0 µM 1.65E-5 14 3.13E-4 0.12
16 SGTC_2127 5253358 3.34 187.9 µM 2.45E-5 9 4.12E-4 0.04
17 SGTC_2055 5235184 3.32 200.0 µM 2.77E-5 ERG2 8 4.48E-4 0.06
18 SGTC_3342 9147791 3.30 14.5 µM 3.02E-5 3 4.76E-4 0.01
19 SGTC_354 2783-3500 3.29 4.9 µM 3.18E-5 cell wall 43 4.93E-4 0.01
20 SGTC_64 000l-0018 3.25 272.1 µM 4.01E-5 ubiquinone biosynthesis & proteasome 64 5.79E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.238 2.14E-44 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.208 4.92E-34 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.199 2.13E-31 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.197 1.35E-30 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.186 1.22E-27 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.184 6.67E-27 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.183 1.44E-26 YLR135W SLX4 hom Endonuclease involved in processing DNA; acts during recombination and repair; cleaves branched structures in a complex with Slx1p; involved interstrand cross-link repair and in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress
0.181 4.42E-26 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.178 2.11E-25 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.175 1.46E-24 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.174 2.66E-24 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.171 2.27E-23 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.170 3.02E-23 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.168 1.12E-22 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.162 3.68E-21 YLR451W LEU3 hom Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation