YJL075C_d / APQ13

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL075C / APQ13

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.16|P-value:6.44E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.18|P-value:6.15E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.39|P-value:3.05E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.16|P-value:6.56E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.46|P-value:2.19E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.81|P-value:5.46E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:3.07|P-value:9.54E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:4.92|P-value:3.35E-7 ID:SGTC_93|Compound:0109-0045|FD-Score:3.90|P-value:4.05E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.23|P-value:5.16E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.91|P-value:3.49E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.69|P-value:8.96E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.87|P-value:4.56E-5 ID:SGTC_492|Compound:tmb-8|FD-Score:3.33|P-value:3.92E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.33|P-value:3.83E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-3.14|P-value:6.94E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.78|P-value:6.69E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:3.20|P-value:6.21E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.26|P-value:4.92E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:5.80|P-value:2.25E-9 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.29|P-value:7.19E-6 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.16|P-value:1.29E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.90|P-value:3.72E-7 ID:SGTC_1602|Compound:st001878|FD-Score:5.46|P-value:1.65E-8 ID:SGTC_1605|Compound:st000082|FD-Score:-3.95|P-value:3.04E-5 ID:SGTC_1624|Compound:st003710|FD-Score:4.38|P-value:4.81E-6 ID:SGTC_1781|Compound:st038725|FD-Score:6.54|P-value:1.87E-11 ID:SGTC_2403|Compound:6032726|FD-Score:3.23|P-value:5.56E-4 ID:SGTC_2477|Compound:5967686|FD-Score:6.79|P-value:3.33E-12 ID:SGTC_2730|Compound:imipramine|FD-Score:4.32|P-value:6.23E-6 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.39|P-value:3.12E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.38|P-value:3.15E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.71|P-value:8.93E-5 ID:SGTC_2882|Compound:9058044|FD-Score:-3.59|P-value:1.32E-4 ID:SGTC_3003|Compound:9075612|FD-Score:-4.29|P-value:6.60E-6 ID:SGTC_3011|Compound:9081274|FD-Score:3.26|P-value:4.99E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-3.82|P-value:5.21E-5 ID:SGTC_3090|Compound:9117696|FD-Score:4.56|P-value:2.00E-6 ID:SGTC_3108|Compound:9121785|FD-Score:-3.56|P-value:1.49E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.79|P-value:6.35E-7 ID:SGTC_3132|Compound:9126706|FD-Score:3.30|P-value:4.30E-4 ID:SGTC_3135|Compound:9127742|FD-Score:4.59|P-value:1.75E-6 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.16|P-value:6.44E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.18|P-value:6.15E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.39|P-value:3.05E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.16|P-value:6.56E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.46|P-value:2.19E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.81|P-value:5.46E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:3.07|P-value:9.54E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:4.92|P-value:3.35E-7 ID:SGTC_93|Compound:0109-0045|FD-Score:3.90|P-value:4.05E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.23|P-value:5.16E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.91|P-value:3.49E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.69|P-value:8.96E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.87|P-value:4.56E-5 ID:SGTC_492|Compound:tmb-8|FD-Score:3.33|P-value:3.92E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.33|P-value:3.83E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-3.14|P-value:6.94E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.78|P-value:6.69E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:3.20|P-value:6.21E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.26|P-value:4.92E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:5.80|P-value:2.25E-9 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.29|P-value:7.19E-6 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.16|P-value:1.29E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.90|P-value:3.72E-7 ID:SGTC_1602|Compound:st001878|FD-Score:5.46|P-value:1.65E-8 ID:SGTC_1605|Compound:st000082|FD-Score:-3.95|P-value:3.04E-5 ID:SGTC_1624|Compound:st003710|FD-Score:4.38|P-value:4.81E-6 ID:SGTC_1781|Compound:st038725|FD-Score:6.54|P-value:1.87E-11 ID:SGTC_2403|Compound:6032726|FD-Score:3.23|P-value:5.56E-4 ID:SGTC_2477|Compound:5967686|FD-Score:6.79|P-value:3.33E-12 ID:SGTC_2730|Compound:imipramine|FD-Score:4.32|P-value:6.23E-6 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.39|P-value:3.12E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.38|P-value:3.15E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.71|P-value:8.93E-5 ID:SGTC_2882|Compound:9058044|FD-Score:-3.59|P-value:1.32E-4 ID:SGTC_3003|Compound:9075612|FD-Score:-4.29|P-value:6.60E-6 ID:SGTC_3011|Compound:9081274|FD-Score:3.26|P-value:4.99E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-3.82|P-value:5.21E-5 ID:SGTC_3090|Compound:9117696|FD-Score:4.56|P-value:2.00E-6 ID:SGTC_3108|Compound:9121785|FD-Score:-3.56|P-value:1.49E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.79|P-value:6.35E-7 ID:SGTC_3132|Compound:9126706|FD-Score:3.30|P-value:4.30E-4 ID:SGTC_3135|Compound:9127742|FD-Score:4.59|P-value:1.75E-6

Top fitness defect scores for YJL075C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2477 5967686 6.79 25.2 µM 3.33E-12 3 5.75E-12
2 SGTC_1781 st038725 6.54 66.3 µM 1.87E-11 NEO1 48 3.11E-11
3 SGTC_833 3852-0053 5.80 558.0 µM 2.25E-9 2 3.33E-9
4 SGTC_1602 st001878 5.46 87.6 µM 1.65E-8 7 2.33E-8
5 SGTC_91 0417-1751 4.92 58.4 µM 3.35E-7 Golgi 26 4.41E-7
6 SGTC_1446 4239-0190 4.90 62.0 µM 3.72E-7 18 4.88E-7
7 SGTC_3126 9127922 4.79 49.5 µM 6.35E-7 fatty acid desaturase (OLE1) 25 8.24E-7
8 SGTC_3135 9127742 4.59 49.5 µM 1.75E-6 10 2.22E-6
9 SGTC_3090 9117696 4.56 49.5 µM 2.00E-6 11 2.53E-6
10 SGTC_1624 st003710 4.38 6.2 µM 4.81E-6 calcium & mitochondrial duress 31 5.96E-6
11 SGTC_2730 imipramine 4.32 71.3 µM 6.23E-6 14 7.67E-6
12 SGTC_1130 3454-2858 4.29 15.9 µM 7.19E-6 NEO1 68 8.83E-6
13 SGTC_1279 0874-0590 4.16 65.2 µM 1.29E-5 28 1.56E-5
14 SGTC_93 0109-0045 3.90 59.2 µM 4.05E-5 DNA damage response 49 4.79E-5
15 SGTC_471 1-acyl-paf 3.87 4.0 µM 4.56E-5 DNA intercalators 33 5.38E-5
16 SGTC_552 k242-0005 3.78 476.0 µM 6.69E-5 19 7.82E-5
17 SGTC_2870 9038528 3.71 13.0 µM 8.93E-5 23 1.04E-4
18 SGTC_47 0149-0135 3.39 24.2 µM 3.05E-4 TSC3-RPN4 39 3.45E-4
19 SGTC_2742 clothiapine 3.39 36.3 µM 3.12E-4 NEO1 32 3.52E-4
20 SGTC_2841 9004761 3.38 39.0 µM 3.15E-4 amide catabolism 57 3.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.26E-18 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.149 4.80E-18 YML036W CGI121 hom Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification
0.135 4.97E-15 YJR063W RPA12 hom RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
0.130 4.30E-14 YDR378C LSM6 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.125 4.31E-13 YCR077C PAT1 hom Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress
0.114 4.34E-11 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.113 6.38E-11 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.111 1.33E-10 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.109 2.23E-10 YGR085C RPL11B hom Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication
0.107 4.33E-10 YKR030W GMH1 hom Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
0.106 7.57E-10 YGL188C-A_p YGL188C-A_p hom Putative protein of unknown function
0.100 7.09E-9 YMR227C TAF7 het TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.099 7.94E-9 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.098 1.31E-8 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.097 1.60E-8 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis