YJL080C / SCP160

Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL080C / SCP160

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.75|P-value:6.03E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.29|P-value:3.69E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:6.03|P-value:3.62E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:11.10|P-value:4.95E-30 ID:SGTC_72|Compound:0744-0168|FD-Score:3.13|P-value:6.57E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.13|P-value:6.62E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:5.90|P-value:8.40E-10 ID:SGTC_133|Compound:0724-0033|FD-Score:3.43|P-value:2.21E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:17.10|P-value:6.11E-68 ID:SGTC_161|Compound:4065-0411|FD-Score:3.85|P-value:3.98E-5 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.40|P-value:2.46E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.90|P-value:3.21E-5 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.21|P-value:4.90E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.77|P-value:1.91E-9 ID:SGTC_487|Compound:nimodipine|FD-Score:3.03|P-value:9.29E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.29|P-value:3.72E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:4.21|P-value:8.29E-6 ID:SGTC_575|Compound:k072-0246|FD-Score:3.10|P-value:7.24E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.49|P-value:1.73E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.23|P-value:4.67E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.28|P-value:3.82E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:4.25|P-value:6.72E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.41|P-value:3.01E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:4.41|P-value:3.25E-6 ID:SGTC_839|Compound:0122-0028|FD-Score:4.63|P-value:1.11E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:5.55|P-value:7.23E-9 ID:SGTC_913|Compound:3487-1245|FD-Score:3.27|P-value:3.93E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:7.58|P-value:5.34E-15 ID:SGTC_980|Compound:1473-0395|FD-Score:3.17|P-value:5.64E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.66|P-value:9.38E-7 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.36|P-value:2.79E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.28|P-value:6.03E-6 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.37|P-value:2.78E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:-3.23|P-value:5.88E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:5.08|P-value:1.01E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.75|P-value:6.15E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.32|P-value:4.96E-6 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.58|P-value:1.37E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:5.12|P-value:8.49E-8 ID:SGTC_1340|Compound:1486-1359|FD-Score:6.33|P-value:5.11E-11 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.11|P-value:7.09E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:-3.08|P-value:9.99E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.76|P-value:5.87E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.66|P-value:1.19E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.53|P-value:1.48E-4 ID:SGTC_1603|Compound:st002045|FD-Score:-3.76|P-value:7.77E-5 ID:SGTC_1617|Compound:st002906|FD-Score:-3.81|P-value:6.46E-5 ID:SGTC_1674|Compound:st016616|FD-Score:3.15|P-value:6.17E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.16|P-value:5.83E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.00|P-value:1.59E-7 ID:SGTC_1759|Compound:st043059|FD-Score:4.20|P-value:8.44E-6 ID:SGTC_1772|Compound:st048439|FD-Score:5.26|P-value:3.77E-8 ID:SGTC_1774|Compound:st048371|FD-Score:9.66|P-value:3.86E-23 ID:SGTC_1778|Compound:st046819|FD-Score:4.18|P-value:9.32E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.15|P-value:7.75E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.16|P-value:5.80E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-3.11|P-value:9.13E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.13|P-value:6.60E-4 ID:SGTC_2351|Compound:9026858|FD-Score:4.65|P-value:9.62E-7 ID:SGTC_2543|Compound:pimpinellin|FD-Score:4.11|P-value:1.29E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.42|P-value:2.25E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.67|P-value:9.10E-7 ID:SGTC_2650|Compound:prasterone|FD-Score:3.29|P-value:3.65E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.34|P-value:2.48E-8 ID:SGTC_2807|Compound:7945238|FD-Score:3.19|P-value:5.23E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.57|P-value:1.45E-6 ID:SGTC_2985|Compound:9022375|FD-Score:3.04|P-value:8.87E-4 ID:SGTC_3260|Compound:9137109|FD-Score:3.08|P-value:7.82E-4 ID:SGTC_3261|Compound:9137475|FD-Score:3.38|P-value:2.65E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.23|P-value:4.65E-4 ID:SGTC_3267|Compound:9137951|FD-Score:-3.85|P-value:5.48E-5 ID:SGTC_7|Compound:0192-1582|FD-Score:3.75|P-value:6.03E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.29|P-value:3.69E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:6.03|P-value:3.62E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:11.10|P-value:4.95E-30 ID:SGTC_72|Compound:0744-0168|FD-Score:3.13|P-value:6.57E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.13|P-value:6.62E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:5.90|P-value:8.40E-10 ID:SGTC_133|Compound:0724-0033|FD-Score:3.43|P-value:2.21E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:17.10|P-value:6.11E-68 ID:SGTC_161|Compound:4065-0411|FD-Score:3.85|P-value:3.98E-5 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.40|P-value:2.46E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.90|P-value:3.21E-5 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.21|P-value:4.90E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.77|P-value:1.91E-9 ID:SGTC_487|Compound:nimodipine|FD-Score:3.03|P-value:9.29E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.29|P-value:3.72E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:4.21|P-value:8.29E-6 ID:SGTC_575|Compound:k072-0246|FD-Score:3.10|P-value:7.24E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.49|P-value:1.73E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.23|P-value:4.67E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.28|P-value:3.82E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:4.25|P-value:6.72E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.41|P-value:3.01E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:4.41|P-value:3.25E-6 ID:SGTC_839|Compound:0122-0028|FD-Score:4.63|P-value:1.11E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:5.55|P-value:7.23E-9 ID:SGTC_913|Compound:3487-1245|FD-Score:3.27|P-value:3.93E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:7.58|P-value:5.34E-15 ID:SGTC_980|Compound:1473-0395|FD-Score:3.17|P-value:5.64E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.66|P-value:9.38E-7 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.36|P-value:2.79E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.28|P-value:6.03E-6 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.37|P-value:2.78E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:-3.23|P-value:5.88E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:5.08|P-value:1.01E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.75|P-value:6.15E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.32|P-value:4.96E-6 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.58|P-value:1.37E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:5.12|P-value:8.49E-8 ID:SGTC_1340|Compound:1486-1359|FD-Score:6.33|P-value:5.11E-11 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.11|P-value:7.09E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:-3.08|P-value:9.99E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.76|P-value:5.87E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.66|P-value:1.19E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.53|P-value:1.48E-4 ID:SGTC_1603|Compound:st002045|FD-Score:-3.76|P-value:7.77E-5 ID:SGTC_1617|Compound:st002906|FD-Score:-3.81|P-value:6.46E-5 ID:SGTC_1674|Compound:st016616|FD-Score:3.15|P-value:6.17E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.16|P-value:5.83E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.00|P-value:1.59E-7 ID:SGTC_1759|Compound:st043059|FD-Score:4.20|P-value:8.44E-6 ID:SGTC_1772|Compound:st048439|FD-Score:5.26|P-value:3.77E-8 ID:SGTC_1774|Compound:st048371|FD-Score:9.66|P-value:3.86E-23 ID:SGTC_1778|Compound:st046819|FD-Score:4.18|P-value:9.32E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.15|P-value:7.75E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.16|P-value:5.80E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-3.11|P-value:9.13E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.13|P-value:6.60E-4 ID:SGTC_2351|Compound:9026858|FD-Score:4.65|P-value:9.62E-7 ID:SGTC_2543|Compound:pimpinellin|FD-Score:4.11|P-value:1.29E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.42|P-value:2.25E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.67|P-value:9.10E-7 ID:SGTC_2650|Compound:prasterone|FD-Score:3.29|P-value:3.65E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.34|P-value:2.48E-8 ID:SGTC_2807|Compound:7945238|FD-Score:3.19|P-value:5.23E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.57|P-value:1.45E-6 ID:SGTC_2985|Compound:9022375|FD-Score:3.04|P-value:8.87E-4 ID:SGTC_3260|Compound:9137109|FD-Score:3.08|P-value:7.82E-4 ID:SGTC_3261|Compound:9137475|FD-Score:3.38|P-value:2.65E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.23|P-value:4.65E-4 ID:SGTC_3267|Compound:9137951|FD-Score:-3.85|P-value:5.48E-5

Top fitness defect scores for YJL080C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 17.10 40.9 µM 6.11E-68 cell wall 12 1.01E-65
2 SGTC_58 0957-0393 11.10 9.0 µM 4.95E-30 cell wall 63 5.02E-29
3 SGTC_1774 st048371 9.66 48.5 µM 3.86E-23 RNA processing & uracil transport 1 2.33E-22
4 SGTC_951 1171-0579 7.58 82.7 µM 5.34E-15 cell wall 19 1.73E-14
5 SGTC_1340 1486-1359 6.33 257.0 µM 5.11E-11 2 1.21E-10
6 SGTC_18 0111-0177 6.03 500.0 nM 3.62E-10 17 8.03E-10
7 SGTC_121 0557-0495 5.90 61.3 µM 8.40E-10 calcium & mitochondrial duress 19 1.81E-9
8 SGTC_467 ro 31-8220 5.77 72.8 µM 1.91E-9 calcium & mitochondrial duress 32 4.00E-9
9 SGTC_863 0466-0191 5.55 129.0 µM 7.23E-9 cell wall 35 1.44E-8
10 SGTC_2688 kanamycin b 5.34 96.7 µM 2.48E-8 calcium & mitochondrial duress 215 4.74E-8
11 SGTC_1772 st048439 5.26 82.2 µM 3.77E-8 15 7.11E-8
12 SGTC_1205 4161-2785 5.12 76.0 µM 8.49E-8 11 1.56E-7
13 SGTC_1160 4092-0570 5.08 10.5 µM 1.01E-7 plasma membrane duress 20 1.84E-7
14 SGTC_1712 st032288 5.00 53.4 µM 1.59E-7 calcium & mitochondrial duress 118 2.85E-7
15 SGTC_2584 androsterone 4.67 48.7 µM 9.10E-7 cell wall 92 1.54E-6
16 SGTC_1069 diphenylcyclopropenone 4.66 8.5 µM 9.38E-7 18 1.58E-6
17 SGTC_2351 9026858 4.65 72.3 µM 9.62E-7 RNA processing & uracil transport 16 1.62E-6
18 SGTC_839 0122-0028 4.63 230.0 µM 1.11E-6 RSC complex & mRNA processing 22 1.86E-6
19 SGTC_1202 1988-0068 4.58 29.6 µM 1.37E-6 RNA processing & uracil transport 11 2.27E-6
20 SGTC_2814 7977482 4.57 43.0 µM 1.45E-6 33 2.40E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.394 4.98E-125 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.371 3.94E-110 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.366 7.96E-107 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.337 7.94E-90 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.335 9.80E-89 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.332 4.37E-87 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.323 1.55E-82 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.317 3.43E-79 YJL073W JEM1 hom DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
0.312 1.59E-76 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.308 1.95E-74 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.306 1.90E-73 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.304 8.74E-73 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.304 1.57E-72 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.300 1.17E-70 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.295 1.66E-68 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication