YJL083W / TAX4

EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL083W / TAX4

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:-4.48|P-value:1.22E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:3.44|P-value:9.51E-5 ID:SGTC_446|Compound:go6976|FD-Score:4.32|P-value:1.50E-6 ID:SGTC_501|Compound:nsc-95397|FD-Score:2.89|P-value:8.49E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:2.96|P-value:6.44E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.02|P-value:5.21E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.41|P-value:1.74E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-3.16|P-value:4.62E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.42|P-value:1.05E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.50|P-value:7.47E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.43|P-value:1.02E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.23|P-value:4.23E-6 ID:SGTC_751|Compound:0833-0568|FD-Score:3.44|P-value:9.66E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:-3.45|P-value:1.49E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.15|P-value:4.88E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.00|P-value:5.64E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.03|P-value:7.69E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.61|P-value:4.55E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.57|P-value:4.11E-7 ID:SGTC_1521|Compound:st012942|FD-Score:3.17|P-value:2.87E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.04|P-value:4.84E-4 ID:SGTC_1716|Compound:st033144|FD-Score:2.91|P-value:7.74E-4 ID:SGTC_1717|Compound:st033143|FD-Score:5.28|P-value:6.20E-9 ID:SGTC_1723|Compound:st034307|FD-Score:-3.01|P-value:8.28E-4 ID:SGTC_1751|Compound:st044839|FD-Score:4.52|P-value:5.24E-7 ID:SGTC_1759|Compound:st043059|FD-Score:3.34|P-value:1.47E-4 ID:SGTC_1812|Compound:st052057|FD-Score:5.13|P-value:1.60E-8 ID:SGTC_1887|Compound:st057648|FD-Score:-3.34|P-value:2.30E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.12|P-value:3.57E-4 ID:SGTC_1977|Compound:st070720|FD-Score:4.40|P-value:1.03E-6 ID:SGTC_1992|Compound:st073643|FD-Score:-3.56|P-value:9.15E-5 ID:SGTC_1993|Compound:st073995|FD-Score:-4.46|P-value:1.32E-6 ID:SGTC_2004|Compound:4023728|FD-Score:3.00|P-value:5.56E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.88|P-value:1.38E-5 ID:SGTC_2109|Compound:5483026|FD-Score:-3.33|P-value:2.38E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.06|P-value:4.52E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.35|P-value:2.23E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.77|P-value:1.32E-7 ID:SGTC_2432|Compound:5630864|FD-Score:2.95|P-value:6.66E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.20|P-value:2.84E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.14|P-value:4.96E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.54|P-value:1.00E-4 ID:SGTC_3008|Compound:9078912|FD-Score:-3.43|P-value:1.58E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.76|P-value:3.96E-5 ID:SGTC_3344|Compound:9148862|FD-Score:3.30|P-value:1.69E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.48|P-value:1.22E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:3.44|P-value:9.51E-5 ID:SGTC_446|Compound:go6976|FD-Score:4.32|P-value:1.50E-6 ID:SGTC_501|Compound:nsc-95397|FD-Score:2.89|P-value:8.49E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:2.96|P-value:6.44E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.02|P-value:5.21E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.41|P-value:1.74E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-3.16|P-value:4.62E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.42|P-value:1.05E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.50|P-value:7.47E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.43|P-value:1.02E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.23|P-value:4.23E-6 ID:SGTC_751|Compound:0833-0568|FD-Score:3.44|P-value:9.66E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:-3.45|P-value:1.49E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.15|P-value:4.88E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.00|P-value:5.64E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.03|P-value:7.69E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.61|P-value:4.55E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.57|P-value:4.11E-7 ID:SGTC_1521|Compound:st012942|FD-Score:3.17|P-value:2.87E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.04|P-value:4.84E-4 ID:SGTC_1716|Compound:st033144|FD-Score:2.91|P-value:7.74E-4 ID:SGTC_1717|Compound:st033143|FD-Score:5.28|P-value:6.20E-9 ID:SGTC_1723|Compound:st034307|FD-Score:-3.01|P-value:8.28E-4 ID:SGTC_1751|Compound:st044839|FD-Score:4.52|P-value:5.24E-7 ID:SGTC_1759|Compound:st043059|FD-Score:3.34|P-value:1.47E-4 ID:SGTC_1812|Compound:st052057|FD-Score:5.13|P-value:1.60E-8 ID:SGTC_1887|Compound:st057648|FD-Score:-3.34|P-value:2.30E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.12|P-value:3.57E-4 ID:SGTC_1977|Compound:st070720|FD-Score:4.40|P-value:1.03E-6 ID:SGTC_1992|Compound:st073643|FD-Score:-3.56|P-value:9.15E-5 ID:SGTC_1993|Compound:st073995|FD-Score:-4.46|P-value:1.32E-6 ID:SGTC_2004|Compound:4023728|FD-Score:3.00|P-value:5.56E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.88|P-value:1.38E-5 ID:SGTC_2109|Compound:5483026|FD-Score:-3.33|P-value:2.38E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.06|P-value:4.52E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.35|P-value:2.23E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.77|P-value:1.32E-7 ID:SGTC_2432|Compound:5630864|FD-Score:2.95|P-value:6.66E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.20|P-value:2.84E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.14|P-value:4.96E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.54|P-value:1.00E-4 ID:SGTC_3008|Compound:9078912|FD-Score:-3.43|P-value:1.58E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.76|P-value:3.96E-5 ID:SGTC_3344|Compound:9148862|FD-Score:3.30|P-value:1.69E-4

Top fitness defect scores for YJL083W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1717 st033143 5.28 58.0 µM 6.20E-9 20 6.36E-8
2 SGTC_1812 st052057 5.13 4.3 µM 1.60E-8 calcium & mitochondrial duress 9 1.46E-7
3 SGTC_2407 paclitaxel 4.77 400.0 µM 1.32E-7 18 9.22E-7
4 SGTC_1445 4239-0156 4.57 97.7 µM 4.11E-7 16 2.48E-6
5 SGTC_1751 st044839 4.52 27.2 µM 5.24E-7 Golgi 7 3.06E-6
6 SGTC_1977 st070720 4.40 65.3 µM 1.03E-6 6 5.51E-6
7 SGTC_446 go6976 4.32 132.0 µM 1.50E-6 10 7.68E-6
8 SGTC_2479 5617353 4.20 43.9 µM 2.84E-6 30 1.34E-5
9 SGTC_2061 5245884 3.88 81.0 µM 1.38E-5 tubulin folding & SWR complex 25 5.32E-5
10 SGTC_1343 1487-0095 3.61 224.0 µM 4.55E-5 12 1.51E-4
11 SGTC_744 1594-0068 3.50 283.0 µM 7.47E-5 amide catabolism 43 2.33E-4
12 SGTC_116 0155-0182 3.44 31.8 µM 9.51E-5 mitochondrial response to ROS 121 2.88E-4
13 SGTC_751 0833-0568 3.44 350.0 µM 9.66E-5 40 2.92E-4
14 SGTC_746 1095-0025 3.43 46.6 µM 1.02E-4 RSC & ERG11 28 3.07E-4
15 SGTC_737 1950-0117 3.42 57.9 µM 1.05E-4 36 3.13E-4
16 SGTC_1759 st043059 3.34 70.0 µM 1.47E-4 amide catabolism 45 4.22E-4
17 SGTC_3344 9148862 3.30 3.9 µM 1.69E-4 27 4.76E-4
18 SGTC_1521 st012942 3.17 49.4 µM 2.87E-4 75 7.55E-4
19 SGTC_1923 st058458 3.12 19.1 µM 3.57E-4 77 9.14E-4
20 SGTC_2237 6667747 3.06 47.2 µM 4.52E-4 43 0.00112

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.204 7.80E-33 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.148 6.24E-18 YER065C ICL1 hom Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
0.115 2.35E-11 YER011W TIR1 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
0.115 2.61E-11 YJL125C GCD14 het Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
0.110 1.65E-10 YOR375C GDH1 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication
0.110 1.87E-10 YMR195W ICY1 hom Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
0.105 9.19E-10 YJL060W BNA3 hom Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate
0.102 2.81E-9 YDR046C BAP3 hom Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication
0.102 3.29E-9 YAL014C SYN8 hom Endosomal SNARE related to mammalian syntaxin 8
0.101 4.27E-9 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.100 7.37E-9 YHR049W FSH1 hom Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2
0.099 8.03E-9 YIL087C AIM19 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth
0.098 1.31E-8 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.096 2.41E-8 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.089 2.53E-7 YOL057W YOL057W hom Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers