YJL089W / SIP4

C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL089W / SIP4

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:3.26|P-value:7.70E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:4.49|P-value:6.33E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:7.59|P-value:7.12E-14 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.35|P-value:5.21E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.02|P-value:4.55E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.40|P-value:4.27E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:-3.19|P-value:8.88E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:4.00|P-value:5.03E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:-5.45|P-value:4.83E-8 ID:SGTC_529|Compound:4076-0302|FD-Score:4.52|P-value:5.55E-6 ID:SGTC_530|Compound:4358-1714|FD-Score:4.33|P-value:1.29E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:3.20|P-value:9.37E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.29|P-value:6.84E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.33|P-value:6.13E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.68|P-value:1.74E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.29|P-value:6.98E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.87|P-value:8.37E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:5.30|P-value:1.27E-7 ID:SGTC_893|Compound:0958-0369|FD-Score:3.63|P-value:2.12E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:3.55|P-value:2.80E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.19|P-value:2.29E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.28|P-value:7.21E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:-3.68|P-value:1.56E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.43|P-value:8.33E-6 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.55|P-value:2.74E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.36|P-value:5.48E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.97|P-value:5.74E-5 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.32|P-value:6.24E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.21|P-value:9.00E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:-3.56|P-value:2.44E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-4.31|P-value:1.22E-5 ID:SGTC_1760|Compound:st045453|FD-Score:-3.48|P-value:3.26E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.78|P-value:9.25E-9 ID:SGTC_1787|Compound:fluconazole|FD-Score:5.21|P-value:1.97E-7 ID:SGTC_1808|Compound:st050063|FD-Score:-3.35|P-value:5.19E-4 ID:SGTC_1812|Compound:st052057|FD-Score:4.39|P-value:9.63E-6 ID:SGTC_1813|Compound:st051246|FD-Score:4.17|P-value:2.51E-5 ID:SGTC_1819|Compound:st053448|FD-Score:-3.74|P-value:1.27E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:5.13|P-value:2.92E-7 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.92|P-value:8.43E-7 ID:SGTC_2014|Compound:4013930|FD-Score:-4.20|P-value:1.96E-5 ID:SGTC_2022|Compound:5136654|FD-Score:-4.94|P-value:6.60E-7 ID:SGTC_2063|Compound:5246145|FD-Score:3.20|P-value:9.45E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-4.06|P-value:3.50E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.74|P-value:1.38E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.44|P-value:7.84E-6 ID:SGTC_2143|Compound:5623677|FD-Score:3.43|P-value:4.32E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.46|P-value:3.84E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.65|P-value:1.94E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.39|P-value:5.00E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.18|P-value:9.02E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.99|P-value:5.28E-5 ID:SGTC_2785|Compound:7756463|FD-Score:-3.40|P-value:4.33E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-3.20|P-value:8.59E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.64|P-value:2.01E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.26|P-value:7.70E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:4.49|P-value:6.33E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:7.59|P-value:7.12E-14 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.35|P-value:5.21E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.02|P-value:4.55E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.40|P-value:4.27E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:-3.19|P-value:8.88E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:4.00|P-value:5.03E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:-5.45|P-value:4.83E-8 ID:SGTC_529|Compound:4076-0302|FD-Score:4.52|P-value:5.55E-6 ID:SGTC_530|Compound:4358-1714|FD-Score:4.33|P-value:1.29E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:3.20|P-value:9.37E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.29|P-value:6.84E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.33|P-value:6.13E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.68|P-value:1.74E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.29|P-value:6.98E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.87|P-value:8.37E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:5.30|P-value:1.27E-7 ID:SGTC_893|Compound:0958-0369|FD-Score:3.63|P-value:2.12E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:3.55|P-value:2.80E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.19|P-value:2.29E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.28|P-value:7.21E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:-3.68|P-value:1.56E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.43|P-value:8.33E-6 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.55|P-value:2.74E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.36|P-value:5.48E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.97|P-value:5.74E-5 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.32|P-value:6.24E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.21|P-value:9.00E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:-3.56|P-value:2.44E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-4.31|P-value:1.22E-5 ID:SGTC_1760|Compound:st045453|FD-Score:-3.48|P-value:3.26E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.78|P-value:9.25E-9 ID:SGTC_1787|Compound:fluconazole|FD-Score:5.21|P-value:1.97E-7 ID:SGTC_1808|Compound:st050063|FD-Score:-3.35|P-value:5.19E-4 ID:SGTC_1812|Compound:st052057|FD-Score:4.39|P-value:9.63E-6 ID:SGTC_1813|Compound:st051246|FD-Score:4.17|P-value:2.51E-5 ID:SGTC_1819|Compound:st053448|FD-Score:-3.74|P-value:1.27E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:5.13|P-value:2.92E-7 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.92|P-value:8.43E-7 ID:SGTC_2014|Compound:4013930|FD-Score:-4.20|P-value:1.96E-5 ID:SGTC_2022|Compound:5136654|FD-Score:-4.94|P-value:6.60E-7 ID:SGTC_2063|Compound:5246145|FD-Score:3.20|P-value:9.45E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-4.06|P-value:3.50E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.74|P-value:1.38E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.44|P-value:7.84E-6 ID:SGTC_2143|Compound:5623677|FD-Score:3.43|P-value:4.32E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.46|P-value:3.84E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.65|P-value:1.94E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.39|P-value:5.00E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.18|P-value:9.02E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.99|P-value:5.28E-5 ID:SGTC_2785|Compound:7756463|FD-Score:-3.40|P-value:4.33E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-3.20|P-value:8.59E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.64|P-value:2.01E-4

Top fitness defect scores for YJL089W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 7.59 9.0 µM 7.12E-14 cell wall 140 1.60E-14
2 SGTC_1785 bathophenanthroline 5.78 24.0 µM 9.25E-9 heme requiring 10 3.79E-9
3 SGTC_795 0685-0265 5.30 78.0 µM 1.27E-7 excess fatty acid 9 5.93E-8
4 SGTC_1787 fluconazole 5.21 80.0 µM 1.97E-7 iron homeostasis 7 9.42E-8
5 SGTC_1874 staurosporine 5.13 7.6 µM 2.92E-7 cell wall signaling 16 1.43E-7
6 SGTC_1951 sophoraflavanone G 4.92 9.2 µM 8.43E-7 RNA processing & uracil transport 7 4.35E-7
7 SGTC_529 4076-0302 4.52 30.3 µM 5.55E-6 mitochondrial processes 9 3.15E-6
8 SGTC_56 0957-0365 4.49 83.2 µM 6.33E-6 Golgi 34 3.61E-6
9 SGTC_2137 5261020 4.44 140.0 µM 7.84E-6 30 4.53E-6
10 SGTC_1037 k284-1091 4.43 78.7 µM 8.33E-6 8 4.82E-6
11 SGTC_1812 st052057 4.39 4.3 µM 9.63E-6 calcium & mitochondrial duress 15 5.62E-6
12 SGTC_530 4358-1714 4.33 28.0 µM 1.29E-5 35 7.62E-6
13 SGTC_967 1306-0166 4.19 352.0 µM 2.29E-5 25 1.40E-5
14 SGTC_1813 st051246 4.17 8.6 µM 2.51E-5 TSC3-RPN4 10 1.54E-5
15 SGTC_161 4065-0411 4.02 162.2 µM 4.55E-5 60 2.87E-5
16 SGTC_516 3992-2719 4.00 87.3 µM 5.03E-5 16 3.19E-5
17 SGTC_2711 st079103 3.99 59.1 µM 5.28E-5 7 3.36E-5
18 SGTC_1154 4088-0362 3.97 150.0 µM 5.74E-5 19 3.66E-5
19 SGTC_770 0389-1121 3.87 67.2 µM 8.37E-5 RPP1 & pyrimidine depletion 31 5.45E-5
20 SGTC_2115 tiliquinol 3.74 12.8 µM 1.38E-4 12 9.24E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 9.62E-22 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.153 3.79E-19 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.150 2.87E-18 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.142 1.42E-16 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.139 7.06E-16 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.136 2.21E-15 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.129 5.74E-14 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.125 3.39E-13 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.125 4.07E-13 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.124 6.85E-13 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.122 1.42E-12 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.120 2.85E-12 YLR444C_d YLR444C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.116 1.43E-11 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.114 3.65E-11 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.113 4.95E-11 YOR127W RGA1 hom GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress