YJL092W / SRS2

DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL092W / SRS2

Click on Significant Values for Screen Details ID:SGTC_60|Compound:0986-0278|FD-Score:3.81|P-value:6.84E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:4.89|P-value:4.91E-7 ID:SGTC_244|Compound:nsc-207895|FD-Score:8.73|P-value:9.62E-19 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.65|P-value:1.33E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.98|P-value:3.00E-7 ID:SGTC_251|Compound:melphalan|FD-Score:3.52|P-value:2.20E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:7.41|P-value:5.01E-14 ID:SGTC_268|Compound:camptothecin|FD-Score:5.36|P-value:3.95E-8 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.56|P-value:2.51E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.55|P-value:1.60E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.71|P-value:1.04E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.70|P-value:1.08E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.24|P-value:6.15E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.63|P-value:1.41E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.63|P-value:1.75E-6 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.22|P-value:5.45E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.50|P-value:1.89E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.69|P-value:8.98E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:3.21|P-value:6.61E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:6.06|P-value:6.09E-10 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.13|P-value:8.88E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.80|P-value:7.75E-7 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.39|P-value:2.89E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.14|P-value:8.60E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.25|P-value:5.81E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.22|P-value:6.48E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.84|P-value:6.14E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.70|P-value:1.08E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:6.30|P-value:1.28E-10 ID:SGTC_1522|Compound:st012842|FD-Score:3.73|P-value:9.49E-5 ID:SGTC_1707|Compound:st032323|FD-Score:12.10|P-value:1.79E-34 ID:SGTC_1718|Compound:roemerine|FD-Score:4.32|P-value:7.73E-6 ID:SGTC_1886|Compound:st057356|FD-Score:3.30|P-value:4.93E-4 ID:SGTC_1915|Compound:st067105|FD-Score:11.30|P-value:2.41E-30 ID:SGTC_1942|Compound:st076330|FD-Score:5.18|P-value:1.05E-7 ID:SGTC_1999|Compound:st074831|FD-Score:3.21|P-value:6.76E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.54|P-value:1.99E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.33|P-value:4.32E-4 ID:SGTC_2154|Compound:5570129|FD-Score:-3.52|P-value:1.81E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-5.52|P-value:1.16E-8 ID:SGTC_2174|Compound:5790901|FD-Score:4.23|P-value:1.15E-5 ID:SGTC_2322|Compound:7413319|FD-Score:-4.01|P-value:2.41E-5 ID:SGTC_2323|Compound:6148992|FD-Score:-4.06|P-value:1.93E-5 ID:SGTC_2365|Compound:9042475|FD-Score:4.60|P-value:2.00E-6 ID:SGTC_2424|Compound:5537928|FD-Score:3.29|P-value:5.05E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.31|P-value:4.68E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.53|P-value:2.11E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.52|P-value:2.15E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.19|P-value:7.30E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:5.03|P-value:2.35E-7 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.33|P-value:7.49E-6 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:4.17|P-value:1.50E-5 ID:SGTC_2671|Compound:danthron|FD-Score:4.20|P-value:1.29E-5 ID:SGTC_2702|Compound:st077768|FD-Score:3.26|P-value:5.66E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.21|P-value:6.70E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.25|P-value:1.03E-5 ID:SGTC_2803|Compound:7707263|FD-Score:5.00|P-value:2.76E-7 ID:SGTC_2996|Compound:9066192|FD-Score:4.94|P-value:3.84E-7 ID:SGTC_3075|Compound:9116269|FD-Score:4.92|P-value:4.19E-7 ID:SGTC_3110|Compound:9122132|FD-Score:5.75|P-value:4.12E-9 ID:SGTC_3189|Compound:9110682|FD-Score:3.86|P-value:5.61E-5 ID:SGTC_3286|Compound:9117135|FD-Score:3.10|P-value:9.94E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:3.81|P-value:6.84E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:4.89|P-value:4.91E-7 ID:SGTC_244|Compound:nsc-207895|FD-Score:8.73|P-value:9.62E-19 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.65|P-value:1.33E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.98|P-value:3.00E-7 ID:SGTC_251|Compound:melphalan|FD-Score:3.52|P-value:2.20E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:7.41|P-value:5.01E-14 ID:SGTC_268|Compound:camptothecin|FD-Score:5.36|P-value:3.95E-8 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.56|P-value:2.51E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.55|P-value:1.60E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.71|P-value:1.04E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.70|P-value:1.08E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.24|P-value:6.15E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.63|P-value:1.41E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.63|P-value:1.75E-6 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.22|P-value:5.45E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.50|P-value:1.89E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.69|P-value:8.98E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:3.21|P-value:6.61E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:6.06|P-value:6.09E-10 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.13|P-value:8.88E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.80|P-value:7.75E-7 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.39|P-value:2.89E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.14|P-value:8.60E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.25|P-value:5.81E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.22|P-value:6.48E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.84|P-value:6.14E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.70|P-value:1.08E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:6.30|P-value:1.28E-10 ID:SGTC_1522|Compound:st012842|FD-Score:3.73|P-value:9.49E-5 ID:SGTC_1707|Compound:st032323|FD-Score:12.10|P-value:1.79E-34 ID:SGTC_1718|Compound:roemerine|FD-Score:4.32|P-value:7.73E-6 ID:SGTC_1886|Compound:st057356|FD-Score:3.30|P-value:4.93E-4 ID:SGTC_1915|Compound:st067105|FD-Score:11.30|P-value:2.41E-30 ID:SGTC_1942|Compound:st076330|FD-Score:5.18|P-value:1.05E-7 ID:SGTC_1999|Compound:st074831|FD-Score:3.21|P-value:6.76E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.54|P-value:1.99E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.33|P-value:4.32E-4 ID:SGTC_2154|Compound:5570129|FD-Score:-3.52|P-value:1.81E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-5.52|P-value:1.16E-8 ID:SGTC_2174|Compound:5790901|FD-Score:4.23|P-value:1.15E-5 ID:SGTC_2322|Compound:7413319|FD-Score:-4.01|P-value:2.41E-5 ID:SGTC_2323|Compound:6148992|FD-Score:-4.06|P-value:1.93E-5 ID:SGTC_2365|Compound:9042475|FD-Score:4.60|P-value:2.00E-6 ID:SGTC_2424|Compound:5537928|FD-Score:3.29|P-value:5.05E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.31|P-value:4.68E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.53|P-value:2.11E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.52|P-value:2.15E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.19|P-value:7.30E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:5.03|P-value:2.35E-7 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.33|P-value:7.49E-6 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:4.17|P-value:1.50E-5 ID:SGTC_2671|Compound:danthron|FD-Score:4.20|P-value:1.29E-5 ID:SGTC_2702|Compound:st077768|FD-Score:3.26|P-value:5.66E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.21|P-value:6.70E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.25|P-value:1.03E-5 ID:SGTC_2803|Compound:7707263|FD-Score:5.00|P-value:2.76E-7 ID:SGTC_2996|Compound:9066192|FD-Score:4.94|P-value:3.84E-7 ID:SGTC_3075|Compound:9116269|FD-Score:4.92|P-value:4.19E-7 ID:SGTC_3110|Compound:9122132|FD-Score:5.75|P-value:4.12E-9 ID:SGTC_3189|Compound:9110682|FD-Score:3.86|P-value:5.61E-5 ID:SGTC_3286|Compound:9117135|FD-Score:3.10|P-value:9.94E-4

Top fitness defect scores for YJL092W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1707 st032323 12.10 6.3 µM 1.79E-34 DNA damage response 7 3.67E-34
2 SGTC_1915 st067105 11.30 30.6 µM 2.41E-30 RNA pol III & RNase P/MRP 2 4.42E-30
3 SGTC_244 nsc-207895 8.73 1.3 µM 9.62E-19 DNA damage response 5 1.31E-18
4 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 7.41 44.4 nM 5.01E-14 DNA damage response 16 6.08E-14
5 SGTC_1507 4075-3230 6.30 155.0 µM 1.28E-10 2 1.44E-10
6 SGTC_1079 idarubicin 6.06 2.4 µM 6.09E-10 DNA damage response 7 6.74E-10
7 SGTC_3110 9122132 5.75 49.5 µM 4.12E-9 redox potentiating 7 4.47E-9
8 SGTC_268 camptothecin 5.36 39.6 µM 3.95E-8 DNA damage response 40 4.21E-8
9 SGTC_1942 st076330 5.18 65.2 µM 1.05E-7 8 1.11E-7
10 SGTC_2617 dihydrotanshinone i 5.03 20.8 µM 2.35E-7 copper-dependent oxidative stress 14 2.46E-7
11 SGTC_2803 7707263 5.00 71.4 µM 2.76E-7 15 2.89E-7
12 SGTC_248 streptozotocin 4.98 5.2 mM 3.00E-7 DNA damage response 15 3.13E-7
13 SGTC_2996 9066192 4.94 71.4 µM 3.84E-7 10 4.01E-7
14 SGTC_3075 9116269 4.92 49.5 µM 4.19E-7 10 4.37E-7
15 SGTC_177 1327-0068 4.89 8.4 µM 4.91E-7 29 5.11E-7
16 SGTC_1082 camptothecin 4.80 424.9 nM 7.75E-7 DNA damage response 34 8.04E-7
17 SGTC_915 methyl methanesulfonate (MMS) 4.63 110.0 mM 1.75E-6 DNA damage response 23 1.81E-6
18 SGTC_2365 9042475 4.60 200.0 µM 2.00E-6 20 2.06E-6
19 SGTC_451 chloral hydrate 4.56 100.0 µM 2.51E-6 33 2.58E-6
20 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 4.33 100.0 µM 7.49E-6 19 7.63E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.455 5.32E-171 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.423 1.83E-145 YBR098W MMS4 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.422 8.15E-145 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.375 1.67E-112 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.364 2.06E-105 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.357 9.25E-102 YDR076W RAD55 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
0.329 1.17E-85 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.322 7.15E-82 YDR004W RAD57 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
0.218 1.92E-37 YER095W RAD51 hom Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
0.214 5.15E-36 YMR048W CSM3 hom Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress
0.196 1.91E-30 YDR075W PPH3 hom Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes
0.195 5.84E-30 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.184 4.70E-27 YER162C RAD4 hom Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins
0.181 4.35E-26 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
0.177 3.87E-25 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein