YJL093C / TOK1

Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL093C / TOK1

Click on Significant Values for Screen Details ID:SGTC_149|Compound:3970-0822|FD-Score:-3.36|P-value:3.51E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.12|P-value:8.78E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:-3.66|P-value:1.11E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:-3.49|P-value:2.13E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:3.63|P-value:1.37E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:4.55|P-value:2.47E-6 ID:SGTC_967|Compound:1306-0166|FD-Score:3.85|P-value:5.78E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.66|P-value:1.22E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.28|P-value:6.00E-8 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.71|P-value:1.01E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.16|P-value:7.75E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.23|P-value:6.01E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.11|P-value:9.22E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:5.87|P-value:1.94E-9 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.49|P-value:2.39E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:4.71|P-value:1.18E-6 ID:SGTC_1523|Compound:st012844|FD-Score:3.61|P-value:1.51E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.85|P-value:5.70E-5 ID:SGTC_1729|Compound:st035615|FD-Score:4.31|P-value:7.77E-6 ID:SGTC_1792|Compound:st045773|FD-Score:4.80|P-value:7.24E-7 ID:SGTC_1892|Compound:st058411|FD-Score:3.51|P-value:2.16E-4 ID:SGTC_1910|Compound:st062352|FD-Score:10.70|P-value:1.87E-27 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.42|P-value:2.85E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.83|P-value:6.24E-7 ID:SGTC_1950|Compound:st077106|FD-Score:3.44|P-value:2.84E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.75|P-value:8.66E-5 ID:SGTC_2012|Compound:4023501|FD-Score:4.12|P-value:1.79E-5 ID:SGTC_2056|Compound:5235370|FD-Score:5.01|P-value:2.56E-7 ID:SGTC_2097|Compound:5376186|FD-Score:-3.18|P-value:6.66E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.09|P-value:9.07E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.27|P-value:5.31E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-4.08|P-value:1.93E-5 ID:SGTC_2386|Compound:9075165|FD-Score:-3.58|P-value:1.55E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.31|P-value:4.54E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.44|P-value:2.82E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.13|P-value:8.47E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.79|P-value:7.29E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-3.61|P-value:1.36E-4 ID:SGTC_2829|Compound:7992743|FD-Score:6.42|P-value:5.99E-11 ID:SGTC_2942|Compound:9052777|FD-Score:-3.63|P-value:1.24E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.24|P-value:5.93E-4 ID:SGTC_3248|Compound:9135562|FD-Score:4.13|P-value:1.75E-5 ID:SGTC_3260|Compound:9137109|FD-Score:3.18|P-value:7.18E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.20|P-value:6.65E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.15|P-value:8.09E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.36|P-value:3.51E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.12|P-value:8.78E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:-3.66|P-value:1.11E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:-3.49|P-value:2.13E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:3.63|P-value:1.37E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:4.55|P-value:2.47E-6 ID:SGTC_967|Compound:1306-0166|FD-Score:3.85|P-value:5.78E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.66|P-value:1.22E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.28|P-value:6.00E-8 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.71|P-value:1.01E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.16|P-value:7.75E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.23|P-value:6.01E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.11|P-value:9.22E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:5.87|P-value:1.94E-9 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.49|P-value:2.39E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:4.71|P-value:1.18E-6 ID:SGTC_1523|Compound:st012844|FD-Score:3.61|P-value:1.51E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.85|P-value:5.70E-5 ID:SGTC_1729|Compound:st035615|FD-Score:4.31|P-value:7.77E-6 ID:SGTC_1792|Compound:st045773|FD-Score:4.80|P-value:7.24E-7 ID:SGTC_1892|Compound:st058411|FD-Score:3.51|P-value:2.16E-4 ID:SGTC_1910|Compound:st062352|FD-Score:10.70|P-value:1.87E-27 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.42|P-value:2.85E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.83|P-value:6.24E-7 ID:SGTC_1950|Compound:st077106|FD-Score:3.44|P-value:2.84E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.75|P-value:8.66E-5 ID:SGTC_2012|Compound:4023501|FD-Score:4.12|P-value:1.79E-5 ID:SGTC_2056|Compound:5235370|FD-Score:5.01|P-value:2.56E-7 ID:SGTC_2097|Compound:5376186|FD-Score:-3.18|P-value:6.66E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.09|P-value:9.07E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.27|P-value:5.31E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-4.08|P-value:1.93E-5 ID:SGTC_2386|Compound:9075165|FD-Score:-3.58|P-value:1.55E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.31|P-value:4.54E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.44|P-value:2.82E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.13|P-value:8.47E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.79|P-value:7.29E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-3.61|P-value:1.36E-4 ID:SGTC_2829|Compound:7992743|FD-Score:6.42|P-value:5.99E-11 ID:SGTC_2942|Compound:9052777|FD-Score:-3.63|P-value:1.24E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.24|P-value:5.93E-4 ID:SGTC_3248|Compound:9135562|FD-Score:4.13|P-value:1.75E-5 ID:SGTC_3260|Compound:9137109|FD-Score:3.18|P-value:7.18E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.20|P-value:6.65E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.15|P-value:8.09E-4

Top fitness defect scores for YJL093C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1910 st062352 10.70 60.4 µM 1.87E-27 1 3.14E-27
2 SGTC_2829 7992743 6.42 58.4 µM 5.99E-11 4 7.02E-11
3 SGTC_1261 0712-0010 5.87 12.7 µM 1.94E-9 RNA processing & uracil transport 4 2.21E-9
4 SGTC_1026 k007-1105 5.28 30.6 µM 6.00E-8 ERAD & cell cycle 55 6.61E-8
5 SGTC_2056 5235370 5.01 200.0 µM 2.56E-7 23 2.79E-7
6 SGTC_1948 st076329 4.83 66.6 µM 6.24E-7 10 6.74E-7
7 SGTC_1792 st045773 4.80 43.6 µM 7.24E-7 14 7.81E-7
8 SGTC_1396 3511-0007 4.71 98.6 µM 1.18E-6 mitochondrial processes 6 1.27E-6
9 SGTC_726 3448-4391 4.55 34.2 µM 2.47E-6 5 2.64E-6
10 SGTC_1729 st035615 4.31 46.0 µM 7.77E-6 27 8.22E-6
11 SGTC_3248 9135562 4.13 49.5 µM 1.75E-5 5 1.84E-5
12 SGTC_2012 4023501 4.12 200.0 µM 1.79E-5 23 1.88E-5
13 SGTC_1524 corynanthine 3.85 62.1 µM 5.70E-5 19 5.94E-5
14 SGTC_967 1306-0166 3.85 352.0 µM 5.78E-5 40 6.01E-5
15 SGTC_2616 abietic acid 3.79 100.0 µM 7.29E-5 36 7.58E-5
16 SGTC_2001 4023502 3.75 57.7 µM 8.66E-5 mitochondrial processes 23 8.99E-5
17 SGTC_1076 itraconazole 3.71 331.0 nM 1.01E-4 37 1.04E-4
18 SGTC_1014 4130-3005 3.66 69.3 µM 1.22E-4 27 1.27E-4
19 SGTC_725 1497-0963 3.63 19.0 µM 1.37E-4 copper-dependent oxidative stress 27 1.42E-4
20 SGTC_1523 st012844 3.61 44.7 µM 1.51E-4 60S ribosome export 34 1.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.36E-13 YPR054W SMK1 hom Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
0.106 9.09E-10 YPR058W YMC1 hom Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC1 has a paralog, YMC2, that arose from the whole genome duplication
0.100 6.06E-9 YHR146W CRP1 hom Protein that binds to cruciform DNA structures
0.099 7.96E-9 YGR242W_d YGR242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
0.097 1.85E-8 YKL027W YKL027W hom Protein of unknown function, localized to the mitochondrial outer membrane
0.095 4.11E-8 YNL120C_d YNL120C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene
0.094 4.16E-8 YLR050C_p YLR050C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene
0.092 9.73E-8 YPL182C_d YPL182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
0.087 4.24E-7 YOR264W DSE3 hom Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.086 5.63E-7 YGR266W YGR266W hom Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress
0.085 7.34E-7 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.083 1.60E-6 YOR105W_p YOR105W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.083 1.66E-6 YLR080W EMP46 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.081 2.92E-6 YNL009W IDP3 hom Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication
0.081 2.94E-6 YJR002W MPP10 het Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p