YJL094C / KHA1

Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL094C / KHA1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.61|P-value:3.99E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:-2.95|P-value:6.27E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.83|P-value:1.49E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:18.60|P-value:4.13E-91 ID:SGTC_178|Compound:4092-0806|FD-Score:5.70|P-value:2.73E-10 ID:SGTC_263|Compound:alizarin|FD-Score:9.70|P-value:2.45E-26 ID:SGTC_308|Compound:4092-1169|FD-Score:5.07|P-value:1.81E-8 ID:SGTC_339|Compound:3091-4833|FD-Score:3.56|P-value:5.57E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:3.63|P-value:3.91E-5 ID:SGTC_394|Compound:menadione|FD-Score:3.71|P-value:2.70E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:-2.85|P-value:9.43E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.70|P-value:2.71E-5 ID:SGTC_444|Compound:curcumin|FD-Score:3.20|P-value:2.52E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:7.38|P-value:4.68E-16 ID:SGTC_699|Compound:0375-0592|FD-Score:3.36|P-value:1.29E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.18|P-value:2.56E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.30|P-value:1.56E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.55|P-value:5.76E-5 ID:SGTC_848|Compound:0368-0089|FD-Score:3.87|P-value:1.27E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:3.26|P-value:1.99E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.70|P-value:2.95E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:3.08|P-value:4.04E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:5.24|P-value:6.08E-9 ID:SGTC_1145|Compound:3546-0597|FD-Score:5.16|P-value:9.86E-9 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.03|P-value:2.64E-11 ID:SGTC_1163|Compound:k060-0048|FD-Score:5.89|P-value:7.47E-11 ID:SGTC_1230|Compound:0170-0365|FD-Score:9.05|P-value:3.30E-23 ID:SGTC_1244|Compound:0416-0015|FD-Score:2.90|P-value:8.00E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:-2.86|P-value:8.87E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.80|P-value:1.78E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:-3.12|P-value:3.25E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.65|P-value:3.46E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:2.95|P-value:6.66E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.46|P-value:8.62E-5 ID:SGTC_1652|Compound:st011932|FD-Score:3.63|P-value:3.91E-5 ID:SGTC_1658|Compound:st012944|FD-Score:6.53|P-value:6.24E-13 ID:SGTC_1660|Compound:st012960|FD-Score:3.03|P-value:5.01E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.17|P-value:2.94E-6 ID:SGTC_1712|Compound:st032288|FD-Score:5.99|P-value:3.53E-11 ID:SGTC_1754|Compound:st042065|FD-Score:-3.22|P-value:2.16E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.74|P-value:2.37E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.23|P-value:2.13E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.93|P-value:9.70E-6 ID:SGTC_2006|Compound:4011487|FD-Score:5.66|P-value:3.67E-10 ID:SGTC_2014|Compound:4013930|FD-Score:2.87|P-value:9.11E-4 ID:SGTC_2021|Compound:4019055|FD-Score:9.35|P-value:1.23E-24 ID:SGTC_2046|Compound:4110841|FD-Score:3.83|P-value:1.53E-5 ID:SGTC_2090|Compound:5301565|FD-Score:4.04|P-value:5.64E-6 ID:SGTC_2100|Compound:5377183|FD-Score:-3.71|P-value:2.52E-5 ID:SGTC_2153|Compound:5569715|FD-Score:3.56|P-value:5.57E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:8.14|P-value:4.01E-19 ID:SGTC_2257|Compound:7960413|FD-Score:3.00|P-value:5.52E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.11|P-value:3.70E-4 ID:SGTC_2275|Compound:7947463|FD-Score:10.70|P-value:1.02E-31 ID:SGTC_2291|Compound:7917025|FD-Score:3.51|P-value:6.78E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.96|P-value:8.31E-6 ID:SGTC_2381|Compound:9035592|FD-Score:-3.32|P-value:1.46E-4 ID:SGTC_2389|Compound:9091542|FD-Score:12.50|P-value:8.98E-43 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.63|P-value:3.97E-5 ID:SGTC_2551|Compound:apiole|FD-Score:3.28|P-value:1.81E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:-3.90|P-value:1.06E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.90|P-value:4.86E-8 ID:SGTC_2586|Compound:curcumin|FD-Score:10.60|P-value:4.28E-31 ID:SGTC_2591|Compound:skatole|FD-Score:-3.16|P-value:2.80E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:5.66|P-value:3.80E-10 ID:SGTC_2619|Compound:obliquin|FD-Score:6.05|P-value:2.30E-11 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.47|P-value:7.63E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-4.51|P-value:4.21E-7 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.18|P-value:2.79E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.04|P-value:5.60E-6 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.54|P-value:5.84E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:3.46|P-value:8.58E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:12.70|P-value:1.15E-43 ID:SGTC_2742|Compound:clothiapine|FD-Score:2.90|P-value:8.14E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.24|P-value:2.19E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.26|P-value:1.96E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.00|P-value:5.53E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.06|P-value:5.02E-6 ID:SGTC_3152|Compound:9099253|FD-Score:3.79|P-value:1.87E-5 ID:SGTC_3202|Compound:9113761|FD-Score:3.18|P-value:2.69E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.27|P-value:1.79E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.02|P-value:4.85E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.61|P-value:3.99E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:-2.95|P-value:6.27E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.83|P-value:1.49E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:18.60|P-value:4.13E-91 ID:SGTC_178|Compound:4092-0806|FD-Score:5.70|P-value:2.73E-10 ID:SGTC_263|Compound:alizarin|FD-Score:9.70|P-value:2.45E-26 ID:SGTC_308|Compound:4092-1169|FD-Score:5.07|P-value:1.81E-8 ID:SGTC_339|Compound:3091-4833|FD-Score:3.56|P-value:5.57E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:3.63|P-value:3.91E-5 ID:SGTC_394|Compound:menadione|FD-Score:3.71|P-value:2.70E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:-2.85|P-value:9.43E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.70|P-value:2.71E-5 ID:SGTC_444|Compound:curcumin|FD-Score:3.20|P-value:2.52E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:7.38|P-value:4.68E-16 ID:SGTC_699|Compound:0375-0592|FD-Score:3.36|P-value:1.29E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.18|P-value:2.56E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.30|P-value:1.56E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.55|P-value:5.76E-5 ID:SGTC_848|Compound:0368-0089|FD-Score:3.87|P-value:1.27E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:3.26|P-value:1.99E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.70|P-value:2.95E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:3.08|P-value:4.04E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:5.24|P-value:6.08E-9 ID:SGTC_1145|Compound:3546-0597|FD-Score:5.16|P-value:9.86E-9 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.03|P-value:2.64E-11 ID:SGTC_1163|Compound:k060-0048|FD-Score:5.89|P-value:7.47E-11 ID:SGTC_1230|Compound:0170-0365|FD-Score:9.05|P-value:3.30E-23 ID:SGTC_1244|Compound:0416-0015|FD-Score:2.90|P-value:8.00E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:-2.86|P-value:8.87E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.80|P-value:1.78E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:-3.12|P-value:3.25E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.65|P-value:3.46E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:2.95|P-value:6.66E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.46|P-value:8.62E-5 ID:SGTC_1652|Compound:st011932|FD-Score:3.63|P-value:3.91E-5 ID:SGTC_1658|Compound:st012944|FD-Score:6.53|P-value:6.24E-13 ID:SGTC_1660|Compound:st012960|FD-Score:3.03|P-value:5.01E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.17|P-value:2.94E-6 ID:SGTC_1712|Compound:st032288|FD-Score:5.99|P-value:3.53E-11 ID:SGTC_1754|Compound:st042065|FD-Score:-3.22|P-value:2.16E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.74|P-value:2.37E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.23|P-value:2.13E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.93|P-value:9.70E-6 ID:SGTC_2006|Compound:4011487|FD-Score:5.66|P-value:3.67E-10 ID:SGTC_2014|Compound:4013930|FD-Score:2.87|P-value:9.11E-4 ID:SGTC_2021|Compound:4019055|FD-Score:9.35|P-value:1.23E-24 ID:SGTC_2046|Compound:4110841|FD-Score:3.83|P-value:1.53E-5 ID:SGTC_2090|Compound:5301565|FD-Score:4.04|P-value:5.64E-6 ID:SGTC_2100|Compound:5377183|FD-Score:-3.71|P-value:2.52E-5 ID:SGTC_2153|Compound:5569715|FD-Score:3.56|P-value:5.57E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:8.14|P-value:4.01E-19 ID:SGTC_2257|Compound:7960413|FD-Score:3.00|P-value:5.52E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.11|P-value:3.70E-4 ID:SGTC_2275|Compound:7947463|FD-Score:10.70|P-value:1.02E-31 ID:SGTC_2291|Compound:7917025|FD-Score:3.51|P-value:6.78E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.96|P-value:8.31E-6 ID:SGTC_2381|Compound:9035592|FD-Score:-3.32|P-value:1.46E-4 ID:SGTC_2389|Compound:9091542|FD-Score:12.50|P-value:8.98E-43 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.63|P-value:3.97E-5 ID:SGTC_2551|Compound:apiole|FD-Score:3.28|P-value:1.81E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:-3.90|P-value:1.06E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.90|P-value:4.86E-8 ID:SGTC_2586|Compound:curcumin|FD-Score:10.60|P-value:4.28E-31 ID:SGTC_2591|Compound:skatole|FD-Score:-3.16|P-value:2.80E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:5.66|P-value:3.80E-10 ID:SGTC_2619|Compound:obliquin|FD-Score:6.05|P-value:2.30E-11 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.47|P-value:7.63E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-4.51|P-value:4.21E-7 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.18|P-value:2.79E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.04|P-value:5.60E-6 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.54|P-value:5.84E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:3.46|P-value:8.58E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:12.70|P-value:1.15E-43 ID:SGTC_2742|Compound:clothiapine|FD-Score:2.90|P-value:8.14E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.24|P-value:2.19E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.26|P-value:1.96E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.00|P-value:5.53E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.06|P-value:5.02E-6 ID:SGTC_3152|Compound:9099253|FD-Score:3.79|P-value:1.87E-5 ID:SGTC_3202|Compound:9113761|FD-Score:3.18|P-value:2.69E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.27|P-value:1.79E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.02|P-value:4.85E-4

Top fitness defect scores for YJL094C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_157 1348-1695 18.60 65.8 µM 4.13E-91 iron homeostasis 6 3.39E-77
2 SGTC_2688 kanamycin b 12.70 96.7 µM 1.15E-43 calcium & mitochondrial duress 8 3.66E-37
3 SGTC_2389 9091542 12.50 195.5 µM 8.98E-43 iron homeostasis 1 2.07E-36
4 SGTC_2275 7947463 10.70 200.0 µM 1.02E-31 iron homeostasis 4 4.45E-27
5 SGTC_2586 curcumin 10.60 80.0 µM 4.28E-31 iron homeostasis 1 1.50E-26
6 SGTC_263 alizarin 9.70 107.9 µM 2.45E-26 iron homeostasis 4 1.57E-22
7 SGTC_2021 4019055 9.35 173.0 µM 1.23E-24 endomembrane recycling 13 4.26E-21
8 SGTC_1230 0170-0365 9.05 3.8 µM 3.30E-23 endomembrane recycling 6 6.90E-20
9 SGTC_2249 haloperidol 8.14 116.4 µM 4.01E-19 ergosterol depletion effects on membrane 22 1.95E-16
10 SGTC_649 1123-0311 7.38 367.0 µM 4.68E-16 endomembrane recycling 17 7.67E-14
11 SGTC_1658 st012944 6.53 20.0 µM 6.24E-13 iron homeostasis 24 3.38E-11
12 SGTC_2619 obliquin 6.05 87.9 µM 2.30E-11 cell wall 72 7.17E-10
13 SGTC_1161 k007-0610 6.03 110.0 µM 2.64E-11 ERAD & cell cycle 60 8.05E-10
14 SGTC_1712 st032288 5.99 53.4 µM 3.53E-11 calcium & mitochondrial duress 75 1.03E-9
15 SGTC_1163 k060-0048 5.89 49.9 µM 7.47E-11 4 1.95E-9
16 SGTC_178 4092-0806 5.70 87.5 µM 2.73E-10 ergosterol depletion effects on membrane 45 5.83E-9
17 SGTC_2006 4011487 5.66 200.0 µM 3.67E-10 endomembrane recycling 47 7.51E-9
18 SGTC_2597 laccaic acid a 5.66 100.0 µM 3.80E-10 9 7.72E-9
19 SGTC_1110 3-hydroxy-3'-methoxyflavone 5.24 1.2 µM 6.08E-9 iron homeostasis 22 8.10E-8
20 SGTC_1145 3546-0597 5.16 10.2 µM 9.86E-9 mitochondrial processes 6 1.22E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.594 1.25E-318 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.575 6.20E-294 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.480 2.15E-192 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.411 1.32E-136 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.388 1.45E-120 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.356 7.85E-101 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.315 4.20E-78 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.306 9.53E-74 YDR203W_d YDR203W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.253 6.71E-50 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.241 1.32E-45 YEL022W GEA2 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication
0.238 3.36E-44 YMR057C_d YMR057C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
0.223 4.81E-39 YPL120W VPS30 hom Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1
0.223 5.74E-39 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.219 1.22E-37 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.214 4.72E-36 YGR261C APL6 hom Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools