YJL095W / BCK1

Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL095W / BCK1

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:5.41|P-value:1.61E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:-4.68|P-value:9.31E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-12.00|P-value:7.68E-16 ID:SGTC_57|Compound:miconazole|FD-Score:-10.30|P-value:3.66E-12 ID:SGTC_58|Compound:0957-0393|FD-Score:-9.75|P-value:4.73E-11 ID:SGTC_59|Compound:0330-0160|FD-Score:-13.30|P-value:6.50E-19 ID:SGTC_62|Compound:0180-0423|FD-Score:-8.21|P-value:2.47E-8 ID:SGTC_64|Compound:000l-0018|FD-Score:8.51|P-value:7.91E-9 ID:SGTC_65|Compound:0798-0905|FD-Score:9.34|P-value:2.74E-10 ID:SGTC_71|Compound:0417-1750|FD-Score:25.20|P-value:2.11E-63 ID:SGTC_77|Compound:0828-0286|FD-Score:4.66|P-value:9.76E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-5.43|P-value:1.56E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:11.90|P-value:1.72E-15 ID:SGTC_91|Compound:0417-1751|FD-Score:13.20|P-value:9.45E-19 ID:SGTC_118|Compound:0083-0097|FD-Score:-6.33|P-value:1.31E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:10.40|P-value:2.53E-12 ID:SGTC_137|Compound:0438-0332|FD-Score:36.90|P-value:3.42E-133 ID:SGTC_138|Compound:0850-0259|FD-Score:33.40|P-value:4.17E-109 ID:SGTC_142|Compound:0335-0849|FD-Score:29.30|P-value:1.52E-84 ID:SGTC_158|Compound:k038-0087|FD-Score:7.17|P-value:9.51E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:18.10|P-value:1.31E-33 ID:SGTC_181|Compound:1447-1644|FD-Score:9.48|P-value:1.52E-10 ID:SGTC_188|Compound:3229-0966|FD-Score:-6.35|P-value:1.23E-5 ID:SGTC_193|Compound:1273-0060|FD-Score:4.86|P-value:6.28E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:7.70|P-value:1.58E-7 ID:SGTC_207|Compound:4185-0010|FD-Score:4.75|P-value:8.01E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:4.84|P-value:6.56E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:14.30|P-value:1.15E-21 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:8.50|P-value:8.26E-9 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:14.70|P-value:6.10E-23 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:41.40|P-value:4.18E-167 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:14.00|P-value:5.58E-21 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:14.30|P-value:8.42E-22 ID:SGTC_244|Compound:nsc-207895|FD-Score:5.86|P-value:4.91E-5 ID:SGTC_252|Compound:miconazole|FD-Score:5.96|P-value:3.77E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:8.99|P-value:1.19E-9 ID:SGTC_294|Compound:k038-0071|FD-Score:7.90|P-value:7.56E-8 ID:SGTC_298|Compound:1391-0729|FD-Score:5.43|P-value:1.56E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.00|P-value:4.49E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:7.27|P-value:6.86E-7 ID:SGTC_340|Compound:k038-0059|FD-Score:8.45|P-value:1.00E-8 ID:SGTC_346|Compound:4513-0042|FD-Score:5.75|P-value:6.60E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:17.70|P-value:3.29E-32 ID:SGTC_353|Compound:1988-1175|FD-Score:16.00|P-value:9.77E-27 ID:SGTC_354|Compound:2783-3500|FD-Score:19.40|P-value:2.61E-38 ID:SGTC_360|Compound:0957-0399|FD-Score:20.00|P-value:1.79E-40 ID:SGTC_367|Compound:0335-0881|FD-Score:15.30|P-value:1.72E-24 ID:SGTC_369|Compound:0957-0393|FD-Score:12.10|P-value:5.72E-16 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:6.44|P-value:9.49E-6 ID:SGTC_397|Compound:arbidol|FD-Score:5.28|P-value:2.26E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:28.90|P-value:3.00E-82 ID:SGTC_422|Compound:cantharidin|FD-Score:43.90|P-value:1.36E-187 ID:SGTC_439|Compound:amiodarone|FD-Score:5.73|P-value:7.06E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-12.00|P-value:7.39E-16 ID:SGTC_459|Compound:nigericin|FD-Score:7.61|P-value:2.13E-7 ID:SGTC_483|Compound:fpl-64176|FD-Score:6.23|P-value:1.77E-5 ID:SGTC_500|Compound:h-89|FD-Score:17.70|P-value:4.21E-32 ID:SGTC_531|Compound:3788-1495|FD-Score:11.80|P-value:2.24E-15 ID:SGTC_542|Compound:3381-0244|FD-Score:7.04|P-value:1.44E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.05|P-value:3.99E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:7.12|P-value:1.12E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:5.72|P-value:7.21E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:4.87|P-value:6.12E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:5.31|P-value:2.11E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:12.30|P-value:1.64E-16 ID:SGTC_637|Compound:1181-0519|FD-Score:18.90|P-value:1.49E-36 ID:SGTC_642|Compound:0335-0876|FD-Score:15.30|P-value:1.29E-24 ID:SGTC_649|Compound:1123-0311|FD-Score:8.63|P-value:4.86E-9 ID:SGTC_663|Compound:1486-0733|FD-Score:31.00|P-value:1.22E-94 ID:SGTC_666|Compound:0272-0154|FD-Score:7.33|P-value:5.68E-7 ID:SGTC_710|Compound:3448-4187|FD-Score:6.86|P-value:2.58E-6 ID:SGTC_716|Compound:1683-5115|FD-Score:6.72|P-value:3.99E-6 ID:SGTC_718|Compound:1130-0073|FD-Score:5.93|P-value:4.12E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:9.75|P-value:4.73E-11 ID:SGTC_743|Compound:1275-0778|FD-Score:4.81|P-value:7.06E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:6.32|P-value:1.32E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:9.27|P-value:3.67E-10 ID:SGTC_825|Compound:1988-2224|FD-Score:24.80|P-value:3.81E-61 ID:SGTC_837|Compound:0091-0265|FD-Score:10.50|P-value:1.72E-12 ID:SGTC_839|Compound:0122-0028|FD-Score:6.66|P-value:4.78E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:7.09|P-value:1.25E-6 ID:SGTC_852|Compound:0418-0143|FD-Score:8.33|P-value:1.58E-8 ID:SGTC_863|Compound:0466-0191|FD-Score:9.15|P-value:6.08E-10 ID:SGTC_875|Compound:0709-0210|FD-Score:7.83|P-value:9.99E-8 ID:SGTC_878|Compound:0828-0289|FD-Score:11.00|P-value:1.61E-13 ID:SGTC_883|Compound:0850-0245|FD-Score:12.60|P-value:2.82E-17 ID:SGTC_887|Compound:0885-0007|FD-Score:9.01|P-value:1.07E-9 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:28.40|P-value:2.04E-79 ID:SGTC_932|Compound:2857-0803|FD-Score:4.69|P-value:9.14E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:8.17|P-value:2.84E-8 ID:SGTC_951|Compound:1171-0579|FD-Score:15.70|P-value:7.80E-26 ID:SGTC_964|Compound:1287-0107|FD-Score:15.20|P-value:2.06E-24 ID:SGTC_971|Compound:1315-0384|FD-Score:8.66|P-value:4.33E-9 ID:SGTC_994|Compound:3910-0338|FD-Score:5.79|P-value:5.99E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:7.67|P-value:1.74E-7 ID:SGTC_1053|Compound:3366-3204|FD-Score:8.57|P-value:6.16E-9 ID:SGTC_1063|Compound:disulfiram|FD-Score:7.08|P-value:1.26E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:8.70|P-value:3.69E-9 ID:SGTC_1136|Compound:pergolide|FD-Score:6.35|P-value:1.23E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.53|P-value:7.24E-6 ID:SGTC_1164|Compound:k060-0068|FD-Score:-5.01|P-value:4.38E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:7.24|P-value:7.44E-7 ID:SGTC_1244|Compound:0416-0015|FD-Score:5.03|P-value:4.12E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-8.34|P-value:1.50E-8 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.34|P-value:1.93E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:6.07|P-value:2.76E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:5.08|P-value:3.67E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:6.31|P-value:1.38E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:9.53|P-value:1.22E-10 ID:SGTC_1482|Compound:3346-2049|FD-Score:14.50|P-value:2.57E-22 ID:SGTC_1547|Compound:harmine|FD-Score:10.70|P-value:5.31E-13 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:7.41|P-value:4.31E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.29|P-value:2.20E-4 ID:SGTC_1633|Compound:st005664|FD-Score:5.44|P-value:1.52E-4 ID:SGTC_1649|Compound:st011737|FD-Score:5.77|P-value:6.33E-5 ID:SGTC_1656|Compound:st012921|FD-Score:8.18|P-value:2.77E-8 ID:SGTC_1715|Compound:st032160|FD-Score:4.93|P-value:5.32E-4 ID:SGTC_1760|Compound:st045453|FD-Score:4.98|P-value:4.70E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.16|P-value:2.15E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:13.00|P-value:2.71E-18 ID:SGTC_1797|Compound:st048695|FD-Score:5.46|P-value:1.44E-4 ID:SGTC_1803|Compound:st050068|FD-Score:6.38|P-value:1.13E-5 ID:SGTC_1834|Compound:st055981|FD-Score:5.12|P-value:3.34E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:20.80|P-value:1.21E-43 ID:SGTC_1877|Compound:wortmannin|FD-Score:10.40|P-value:3.03E-12 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:5.06|P-value:3.90E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.84|P-value:6.49E-4 ID:SGTC_1941|Compound:st076221|FD-Score:5.42|P-value:1.60E-4 ID:SGTC_1959|Compound:st077091|FD-Score:4.75|P-value:7.95E-4 ID:SGTC_2003|Compound:4023581|FD-Score:20.20|P-value:1.96E-41 ID:SGTC_2005|Compound:4024620|FD-Score:5.94|P-value:3.95E-5 ID:SGTC_2007|Compound:4011539|FD-Score:37.10|P-value:2.47E-134 ID:SGTC_2009|Compound:4012297|FD-Score:40.30|P-value:5.92E-158 ID:SGTC_2028|Compound:5153890|FD-Score:23.30|P-value:2.02E-54 ID:SGTC_2031|Compound:5180455|FD-Score:6.69|P-value:4.43E-6 ID:SGTC_2036|Compound:5160441|FD-Score:11.50|P-value:9.11E-15 ID:SGTC_2038|Compound:4100038|FD-Score:6.45|P-value:9.04E-6 ID:SGTC_2082|Compound:5219693|FD-Score:4.88|P-value:5.95E-4 ID:SGTC_2149|Compound:5554786|FD-Score:19.70|P-value:2.95E-39 ID:SGTC_2210|Compound:7115885|FD-Score:11.10|P-value:7.84E-14 ID:SGTC_2264|Compound:7948757|FD-Score:-6.19|P-value:1.95E-5 ID:SGTC_2272|Compound:7805186|FD-Score:43.50|P-value:2.60E-184 ID:SGTC_2278|Compound:7948257|FD-Score:5.35|P-value:1.88E-4 ID:SGTC_2286|Compound:7945697|FD-Score:9.13|P-value:6.59E-10 ID:SGTC_2300|Compound:7976697|FD-Score:9.79|P-value:3.99E-11 ID:SGTC_2311|Compound:7694451|FD-Score:6.70|P-value:4.28E-6 ID:SGTC_2317|Compound:5986382|FD-Score:-4.80|P-value:7.13E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.09|P-value:3.61E-4 ID:SGTC_2342|Compound:7990637|FD-Score:5.34|P-value:1.95E-4 ID:SGTC_2365|Compound:9042475|FD-Score:6.23|P-value:1.75E-5 ID:SGTC_2399|Compound:5884133|FD-Score:13.60|P-value:7.04E-20 ID:SGTC_2400|Compound:5203494|FD-Score:7.00|P-value:1.64E-6 ID:SGTC_2401|Compound:5128683|FD-Score:4.79|P-value:7.32E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:18.20|P-value:4.51E-34 ID:SGTC_2523|Compound:spermine|FD-Score:4.98|P-value:4.71E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:4.88|P-value:5.99E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:5.20|P-value:2.78E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:5.45|P-value:1.48E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-6.29|P-value:1.46E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:4.78|P-value:7.46E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:15.70|P-value:1.28E-25 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:11.40|P-value:1.90E-14 ID:SGTC_2619|Compound:obliquin|FD-Score:15.80|P-value:5.07E-26 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.81|P-value:1.05E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-5.40|P-value:1.66E-4 ID:SGTC_2694|Compound:st077685|FD-Score:5.22|P-value:2.63E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.47|P-value:1.40E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:5.23|P-value:2.57E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:18.30|P-value:3.81E-34 ID:SGTC_2776|Compound:terbinafine|FD-Score:17.80|P-value:1.17E-32 ID:SGTC_2795|Compound:7780010|FD-Score:-5.70|P-value:7.60E-5 ID:SGTC_2838|Compound:9002687|FD-Score:7.30|P-value:6.18E-7 ID:SGTC_2844|Compound:9010103|FD-Score:-4.80|P-value:7.10E-4 ID:SGTC_2890|Compound:9046729|FD-Score:6.51|P-value:7.61E-6 ID:SGTC_2912|Compound:7964298|FD-Score:37.60|P-value:3.34E-138 ID:SGTC_2924|Compound:9010168|FD-Score:16.70|P-value:7.97E-29 ID:SGTC_2929|Compound:9013348|FD-Score:11.60|P-value:7.95E-15 ID:SGTC_2997|Compound:9067075|FD-Score:10.80|P-value:3.38E-13 ID:SGTC_3020|Compound:9089140|FD-Score:10.60|P-value:1.15E-12 ID:SGTC_3022|Compound:9087993|FD-Score:5.50|P-value:1.30E-4 ID:SGTC_3037|Compound:9091026|FD-Score:8.65|P-value:4.62E-9 ID:SGTC_3059|Compound:1327-0034|FD-Score:16.50|P-value:2.61E-28 ID:SGTC_3060|Compound:1327-0027|FD-Score:16.90|P-value:1.15E-29 ID:SGTC_3063|Compound:1327-0034|FD-Score:14.10|P-value:2.79E-21 ID:SGTC_3064|Compound:1327-0027|FD-Score:7.21|P-value:8.23E-7 ID:SGTC_3078|Compound:9116413|FD-Score:12.90|P-value:4.26E-18 ID:SGTC_3092|Compound:9117248|FD-Score:6.47|P-value:8.73E-6 ID:SGTC_3100|Compound:9120536|FD-Score:13.00|P-value:2.55E-18 ID:SGTC_3104|Compound:9120930|FD-Score:-5.22|P-value:2.64E-4 ID:SGTC_3114|Compound:9122766|FD-Score:7.15|P-value:1.03E-6 ID:SGTC_3118|Compound:9124250|FD-Score:5.64|P-value:8.94E-5 ID:SGTC_3122|Compound:9126309|FD-Score:14.40|P-value:6.26E-22 ID:SGTC_3166|Compound:9102297|FD-Score:6.74|P-value:3.78E-6 ID:SGTC_3189|Compound:9110682|FD-Score:-4.79|P-value:7.25E-4 ID:SGTC_3266|Compound:9136860|FD-Score:11.90|P-value:1.08E-15 ID:SGTC_3293|Compound:9120939|FD-Score:5.89|P-value:4.58E-5 ID:SGTC_3311|Compound:9131146|FD-Score:13.20|P-value:8.19E-19 ID:SGTC_3321|Compound:9137793|FD-Score:15.60|P-value:1.41E-25 ID:SGTC_3331|Compound:9141060|FD-Score:7.85|P-value:9.06E-8 ID:SGTC_3350|Compound:9150499|FD-Score:7.17|P-value:9.44E-7 ID:SGTC_22|Compound:0964-0034|FD-Score:5.41|P-value:1.61E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:-4.68|P-value:9.31E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-12.00|P-value:7.68E-16 ID:SGTC_57|Compound:miconazole|FD-Score:-10.30|P-value:3.66E-12 ID:SGTC_58|Compound:0957-0393|FD-Score:-9.75|P-value:4.73E-11 ID:SGTC_59|Compound:0330-0160|FD-Score:-13.30|P-value:6.50E-19 ID:SGTC_62|Compound:0180-0423|FD-Score:-8.21|P-value:2.47E-8 ID:SGTC_64|Compound:000l-0018|FD-Score:8.51|P-value:7.91E-9 ID:SGTC_65|Compound:0798-0905|FD-Score:9.34|P-value:2.74E-10 ID:SGTC_71|Compound:0417-1750|FD-Score:25.20|P-value:2.11E-63 ID:SGTC_77|Compound:0828-0286|FD-Score:4.66|P-value:9.76E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-5.43|P-value:1.56E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:11.90|P-value:1.72E-15 ID:SGTC_91|Compound:0417-1751|FD-Score:13.20|P-value:9.45E-19 ID:SGTC_118|Compound:0083-0097|FD-Score:-6.33|P-value:1.31E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:10.40|P-value:2.53E-12 ID:SGTC_137|Compound:0438-0332|FD-Score:36.90|P-value:3.42E-133 ID:SGTC_138|Compound:0850-0259|FD-Score:33.40|P-value:4.17E-109 ID:SGTC_142|Compound:0335-0849|FD-Score:29.30|P-value:1.52E-84 ID:SGTC_158|Compound:k038-0087|FD-Score:7.17|P-value:9.51E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:18.10|P-value:1.31E-33 ID:SGTC_181|Compound:1447-1644|FD-Score:9.48|P-value:1.52E-10 ID:SGTC_188|Compound:3229-0966|FD-Score:-6.35|P-value:1.23E-5 ID:SGTC_193|Compound:1273-0060|FD-Score:4.86|P-value:6.28E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:7.70|P-value:1.58E-7 ID:SGTC_207|Compound:4185-0010|FD-Score:4.75|P-value:8.01E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:4.84|P-value:6.56E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:14.30|P-value:1.15E-21 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:8.50|P-value:8.26E-9 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:14.70|P-value:6.10E-23 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:41.40|P-value:4.18E-167 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:14.00|P-value:5.58E-21 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:14.30|P-value:8.42E-22 ID:SGTC_244|Compound:nsc-207895|FD-Score:5.86|P-value:4.91E-5 ID:SGTC_252|Compound:miconazole|FD-Score:5.96|P-value:3.77E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:8.99|P-value:1.19E-9 ID:SGTC_294|Compound:k038-0071|FD-Score:7.90|P-value:7.56E-8 ID:SGTC_298|Compound:1391-0729|FD-Score:5.43|P-value:1.56E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.00|P-value:4.49E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:7.27|P-value:6.86E-7 ID:SGTC_340|Compound:k038-0059|FD-Score:8.45|P-value:1.00E-8 ID:SGTC_346|Compound:4513-0042|FD-Score:5.75|P-value:6.60E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:17.70|P-value:3.29E-32 ID:SGTC_353|Compound:1988-1175|FD-Score:16.00|P-value:9.77E-27 ID:SGTC_354|Compound:2783-3500|FD-Score:19.40|P-value:2.61E-38 ID:SGTC_360|Compound:0957-0399|FD-Score:20.00|P-value:1.79E-40 ID:SGTC_367|Compound:0335-0881|FD-Score:15.30|P-value:1.72E-24 ID:SGTC_369|Compound:0957-0393|FD-Score:12.10|P-value:5.72E-16 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:6.44|P-value:9.49E-6 ID:SGTC_397|Compound:arbidol|FD-Score:5.28|P-value:2.26E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:28.90|P-value:3.00E-82 ID:SGTC_422|Compound:cantharidin|FD-Score:43.90|P-value:1.36E-187 ID:SGTC_439|Compound:amiodarone|FD-Score:5.73|P-value:7.06E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-12.00|P-value:7.39E-16 ID:SGTC_459|Compound:nigericin|FD-Score:7.61|P-value:2.13E-7 ID:SGTC_483|Compound:fpl-64176|FD-Score:6.23|P-value:1.77E-5 ID:SGTC_500|Compound:h-89|FD-Score:17.70|P-value:4.21E-32 ID:SGTC_531|Compound:3788-1495|FD-Score:11.80|P-value:2.24E-15 ID:SGTC_542|Compound:3381-0244|FD-Score:7.04|P-value:1.44E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.05|P-value:3.99E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:7.12|P-value:1.12E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:5.72|P-value:7.21E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:4.87|P-value:6.12E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:5.31|P-value:2.11E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:12.30|P-value:1.64E-16 ID:SGTC_637|Compound:1181-0519|FD-Score:18.90|P-value:1.49E-36 ID:SGTC_642|Compound:0335-0876|FD-Score:15.30|P-value:1.29E-24 ID:SGTC_649|Compound:1123-0311|FD-Score:8.63|P-value:4.86E-9 ID:SGTC_663|Compound:1486-0733|FD-Score:31.00|P-value:1.22E-94 ID:SGTC_666|Compound:0272-0154|FD-Score:7.33|P-value:5.68E-7 ID:SGTC_710|Compound:3448-4187|FD-Score:6.86|P-value:2.58E-6 ID:SGTC_716|Compound:1683-5115|FD-Score:6.72|P-value:3.99E-6 ID:SGTC_718|Compound:1130-0073|FD-Score:5.93|P-value:4.12E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:9.75|P-value:4.73E-11 ID:SGTC_743|Compound:1275-0778|FD-Score:4.81|P-value:7.06E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:6.32|P-value:1.32E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:9.27|P-value:3.67E-10 ID:SGTC_825|Compound:1988-2224|FD-Score:24.80|P-value:3.81E-61 ID:SGTC_837|Compound:0091-0265|FD-Score:10.50|P-value:1.72E-12 ID:SGTC_839|Compound:0122-0028|FD-Score:6.66|P-value:4.78E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:7.09|P-value:1.25E-6 ID:SGTC_852|Compound:0418-0143|FD-Score:8.33|P-value:1.58E-8 ID:SGTC_863|Compound:0466-0191|FD-Score:9.15|P-value:6.08E-10 ID:SGTC_875|Compound:0709-0210|FD-Score:7.83|P-value:9.99E-8 ID:SGTC_878|Compound:0828-0289|FD-Score:11.00|P-value:1.61E-13 ID:SGTC_883|Compound:0850-0245|FD-Score:12.60|P-value:2.82E-17 ID:SGTC_887|Compound:0885-0007|FD-Score:9.01|P-value:1.07E-9 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:28.40|P-value:2.04E-79 ID:SGTC_932|Compound:2857-0803|FD-Score:4.69|P-value:9.14E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:8.17|P-value:2.84E-8 ID:SGTC_951|Compound:1171-0579|FD-Score:15.70|P-value:7.80E-26 ID:SGTC_964|Compound:1287-0107|FD-Score:15.20|P-value:2.06E-24 ID:SGTC_971|Compound:1315-0384|FD-Score:8.66|P-value:4.33E-9 ID:SGTC_994|Compound:3910-0338|FD-Score:5.79|P-value:5.99E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:7.67|P-value:1.74E-7 ID:SGTC_1053|Compound:3366-3204|FD-Score:8.57|P-value:6.16E-9 ID:SGTC_1063|Compound:disulfiram|FD-Score:7.08|P-value:1.26E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:8.70|P-value:3.69E-9 ID:SGTC_1136|Compound:pergolide|FD-Score:6.35|P-value:1.23E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.53|P-value:7.24E-6 ID:SGTC_1164|Compound:k060-0068|FD-Score:-5.01|P-value:4.38E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:7.24|P-value:7.44E-7 ID:SGTC_1244|Compound:0416-0015|FD-Score:5.03|P-value:4.12E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-8.34|P-value:1.50E-8 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.34|P-value:1.93E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:6.07|P-value:2.76E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:5.08|P-value:3.67E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:6.31|P-value:1.38E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:9.53|P-value:1.22E-10 ID:SGTC_1482|Compound:3346-2049|FD-Score:14.50|P-value:2.57E-22 ID:SGTC_1547|Compound:harmine|FD-Score:10.70|P-value:5.31E-13 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:7.41|P-value:4.31E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.29|P-value:2.20E-4 ID:SGTC_1633|Compound:st005664|FD-Score:5.44|P-value:1.52E-4 ID:SGTC_1649|Compound:st011737|FD-Score:5.77|P-value:6.33E-5 ID:SGTC_1656|Compound:st012921|FD-Score:8.18|P-value:2.77E-8 ID:SGTC_1715|Compound:st032160|FD-Score:4.93|P-value:5.32E-4 ID:SGTC_1760|Compound:st045453|FD-Score:4.98|P-value:4.70E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.16|P-value:2.15E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:13.00|P-value:2.71E-18 ID:SGTC_1797|Compound:st048695|FD-Score:5.46|P-value:1.44E-4 ID:SGTC_1803|Compound:st050068|FD-Score:6.38|P-value:1.13E-5 ID:SGTC_1834|Compound:st055981|FD-Score:5.12|P-value:3.34E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:20.80|P-value:1.21E-43 ID:SGTC_1877|Compound:wortmannin|FD-Score:10.40|P-value:3.03E-12 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:5.06|P-value:3.90E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.84|P-value:6.49E-4 ID:SGTC_1941|Compound:st076221|FD-Score:5.42|P-value:1.60E-4 ID:SGTC_1959|Compound:st077091|FD-Score:4.75|P-value:7.95E-4 ID:SGTC_2003|Compound:4023581|FD-Score:20.20|P-value:1.96E-41 ID:SGTC_2005|Compound:4024620|FD-Score:5.94|P-value:3.95E-5 ID:SGTC_2007|Compound:4011539|FD-Score:37.10|P-value:2.47E-134 ID:SGTC_2009|Compound:4012297|FD-Score:40.30|P-value:5.92E-158 ID:SGTC_2028|Compound:5153890|FD-Score:23.30|P-value:2.02E-54 ID:SGTC_2031|Compound:5180455|FD-Score:6.69|P-value:4.43E-6 ID:SGTC_2036|Compound:5160441|FD-Score:11.50|P-value:9.11E-15 ID:SGTC_2038|Compound:4100038|FD-Score:6.45|P-value:9.04E-6 ID:SGTC_2082|Compound:5219693|FD-Score:4.88|P-value:5.95E-4 ID:SGTC_2149|Compound:5554786|FD-Score:19.70|P-value:2.95E-39 ID:SGTC_2210|Compound:7115885|FD-Score:11.10|P-value:7.84E-14 ID:SGTC_2264|Compound:7948757|FD-Score:-6.19|P-value:1.95E-5 ID:SGTC_2272|Compound:7805186|FD-Score:43.50|P-value:2.60E-184 ID:SGTC_2278|Compound:7948257|FD-Score:5.35|P-value:1.88E-4 ID:SGTC_2286|Compound:7945697|FD-Score:9.13|P-value:6.59E-10 ID:SGTC_2300|Compound:7976697|FD-Score:9.79|P-value:3.99E-11 ID:SGTC_2311|Compound:7694451|FD-Score:6.70|P-value:4.28E-6 ID:SGTC_2317|Compound:5986382|FD-Score:-4.80|P-value:7.13E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.09|P-value:3.61E-4 ID:SGTC_2342|Compound:7990637|FD-Score:5.34|P-value:1.95E-4 ID:SGTC_2365|Compound:9042475|FD-Score:6.23|P-value:1.75E-5 ID:SGTC_2399|Compound:5884133|FD-Score:13.60|P-value:7.04E-20 ID:SGTC_2400|Compound:5203494|FD-Score:7.00|P-value:1.64E-6 ID:SGTC_2401|Compound:5128683|FD-Score:4.79|P-value:7.32E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:18.20|P-value:4.51E-34 ID:SGTC_2523|Compound:spermine|FD-Score:4.98|P-value:4.71E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:4.88|P-value:5.99E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:5.20|P-value:2.78E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:5.45|P-value:1.48E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-6.29|P-value:1.46E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:4.78|P-value:7.46E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:15.70|P-value:1.28E-25 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:11.40|P-value:1.90E-14 ID:SGTC_2619|Compound:obliquin|FD-Score:15.80|P-value:5.07E-26 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.81|P-value:1.05E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-5.40|P-value:1.66E-4 ID:SGTC_2694|Compound:st077685|FD-Score:5.22|P-value:2.63E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.47|P-value:1.40E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:5.23|P-value:2.57E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:18.30|P-value:3.81E-34 ID:SGTC_2776|Compound:terbinafine|FD-Score:17.80|P-value:1.17E-32 ID:SGTC_2795|Compound:7780010|FD-Score:-5.70|P-value:7.60E-5 ID:SGTC_2838|Compound:9002687|FD-Score:7.30|P-value:6.18E-7 ID:SGTC_2844|Compound:9010103|FD-Score:-4.80|P-value:7.10E-4 ID:SGTC_2890|Compound:9046729|FD-Score:6.51|P-value:7.61E-6 ID:SGTC_2912|Compound:7964298|FD-Score:37.60|P-value:3.34E-138 ID:SGTC_2924|Compound:9010168|FD-Score:16.70|P-value:7.97E-29 ID:SGTC_2929|Compound:9013348|FD-Score:11.60|P-value:7.95E-15 ID:SGTC_2997|Compound:9067075|FD-Score:10.80|P-value:3.38E-13 ID:SGTC_3020|Compound:9089140|FD-Score:10.60|P-value:1.15E-12 ID:SGTC_3022|Compound:9087993|FD-Score:5.50|P-value:1.30E-4 ID:SGTC_3037|Compound:9091026|FD-Score:8.65|P-value:4.62E-9 ID:SGTC_3059|Compound:1327-0034|FD-Score:16.50|P-value:2.61E-28 ID:SGTC_3060|Compound:1327-0027|FD-Score:16.90|P-value:1.15E-29 ID:SGTC_3063|Compound:1327-0034|FD-Score:14.10|P-value:2.79E-21 ID:SGTC_3064|Compound:1327-0027|FD-Score:7.21|P-value:8.23E-7 ID:SGTC_3078|Compound:9116413|FD-Score:12.90|P-value:4.26E-18 ID:SGTC_3092|Compound:9117248|FD-Score:6.47|P-value:8.73E-6 ID:SGTC_3100|Compound:9120536|FD-Score:13.00|P-value:2.55E-18 ID:SGTC_3104|Compound:9120930|FD-Score:-5.22|P-value:2.64E-4 ID:SGTC_3114|Compound:9122766|FD-Score:7.15|P-value:1.03E-6 ID:SGTC_3118|Compound:9124250|FD-Score:5.64|P-value:8.94E-5 ID:SGTC_3122|Compound:9126309|FD-Score:14.40|P-value:6.26E-22 ID:SGTC_3166|Compound:9102297|FD-Score:6.74|P-value:3.78E-6 ID:SGTC_3189|Compound:9110682|FD-Score:-4.79|P-value:7.25E-4 ID:SGTC_3266|Compound:9136860|FD-Score:11.90|P-value:1.08E-15 ID:SGTC_3293|Compound:9120939|FD-Score:5.89|P-value:4.58E-5 ID:SGTC_3311|Compound:9131146|FD-Score:13.20|P-value:8.19E-19 ID:SGTC_3321|Compound:9137793|FD-Score:15.60|P-value:1.41E-25 ID:SGTC_3331|Compound:9141060|FD-Score:7.85|P-value:9.06E-8 ID:SGTC_3350|Compound:9150499|FD-Score:7.17|P-value:9.44E-7

Top fitness defect scores for YJL095W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_422 cantharidin 43.90 155.0 µM 1.36E-187 cell wall signaling 1 0
2 SGTC_2272 7805186 43.50 180.0 µM 2.60E-184 cell wall signaling 1 0
3 SGTC_241 5hr heat shock (37°C) + cantharidin 41.40 155.4 µM 4.18E-167 cell wall signaling 2 0
4 SGTC_2009 4012297 40.30 12.1 µM 5.92E-158 cell wall signaling 1 0
5 SGTC_2912 7964298 37.60 10.9 µM 3.34E-138 cell wall 1 0
6 SGTC_2007 4011539 37.10 71.8 µM 2.47E-134 cell wall signaling 1 2.00E-301
7 SGTC_137 0438-0332 36.90 85.4 µM 3.42E-133 ubiquinone biosynthesis & proteasome 2 7.67E-299
8 SGTC_138 0850-0259 33.40 40.9 µM 4.17E-109 cell wall 1 2.61E-244
9 SGTC_663 1486-0733 31.00 13.9 µM 1.22E-94 cell wall signaling 2 1.44E-211
10 SGTC_142 0335-0849 29.30 62.7 µM 1.52E-84 ubiquinone biosynthesis & proteasome 2 1.02E-188
11 SGTC_408 cantharidin 28.90 100.0 µM 3.00E-82 cell wall signaling 1 1.59E-183
12 SGTC_905 2-aminofluorene 28.40 215.0 µM 2.04E-79 cell wall signaling 1 4.10E-177
13 SGTC_71 0417-1750 25.20 47.8 µM 2.11E-63 Golgi 1 6.98E-141
14 SGTC_825 1988-2224 24.80 89.6 µM 3.81E-61 cell wall signaling 1 8.82E-136
15 SGTC_2028 5153890 23.30 36.4 µM 2.02E-54 cell wall signaling 1 1.42E-120
16 SGTC_1874 staurosporine 20.80 7.6 µM 1.21E-43 cell wall signaling 1 3.26E-96
17 SGTC_2003 4023581 20.20 200.0 µM 1.96E-41 cell wall signaling 1 3.23E-91
18 SGTC_360 0957-0399 20.00 1.0 µM 1.79E-40 cell wall 2 4.73E-89
19 SGTC_2149 5554786 19.70 194.8 µM 2.95E-39 cell wall signaling 1 2.68E-86
20 SGTC_354 2783-3500 19.40 4.9 µM 2.61E-38 cell wall 1 3.67E-84

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.777 0 YHR030C SLT2 hom Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.398 1.88E-127 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.387 4.07E-120 YPR165W RHO1 het GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
0.364 1.00E-105 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.328 9.42E-85 YPL089C RLM1 hom MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication
0.322 5.70E-82 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.311 5.18E-76 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.284 4.12E-63 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.269 1.60E-56 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.266 2.89E-55 YOR008C SLG1 hom Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response
0.260 5.39E-53 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.259 1.02E-52 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.257 7.36E-52 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.249 8.35E-49 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.240 2.32E-45 YNL079C TPM1 hom Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication