YJL096W / MRPL49

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL096W / MRPL49

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.03|P-value:2.72E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.83|P-value:6.39E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:8.16|P-value:8.43E-14 ID:SGTC_236|Compound:1509-0011|FD-Score:5.02|P-value:2.94E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.49|P-value:7.99E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.39|P-value:1.23E-11 ID:SGTC_310|Compound:1273-0058|FD-Score:8.12|P-value:1.11E-13 ID:SGTC_367|Compound:0335-0881|FD-Score:-4.78|P-value:7.62E-6 ID:SGTC_462|Compound:ag-879|FD-Score:4.67|P-value:1.22E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.98|P-value:3.44E-6 ID:SGTC_502|Compound:l-744,832|FD-Score:3.99|P-value:1.56E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.74|P-value:9.36E-6 ID:SGTC_692|Compound:k241-0027|FD-Score:-4.54|P-value:1.99E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.21|P-value:7.20E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:3.61|P-value:5.55E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.66|P-value:1.56E-7 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.97|P-value:3.59E-6 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.21|P-value:7.07E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.06|P-value:1.24E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.85|P-value:2.45E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-4.63|P-value:1.38E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:7.88|P-value:5.38E-13 ID:SGTC_1176|Compound:0848-0131|FD-Score:-3.53|P-value:6.96E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:8.85|P-value:6.39E-16 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.11|P-value:1.03E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.99|P-value:3.29E-6 ID:SGTC_1627|Compound:st003713|FD-Score:4.84|P-value:6.25E-6 ID:SGTC_1782|Compound:st039423|FD-Score:4.39|P-value:3.66E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.20|P-value:3.80E-11 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-4.13|P-value:9.43E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.80|P-value:3.03E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.46|P-value:2.85E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.54|P-value:6.94E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.72|P-value:3.96E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-3.85|P-value:2.51E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.86|P-value:2.45E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.71|P-value:3.98E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.04|P-value:1.32E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.92|P-value:1.99E-4 ID:SGTC_2716|Compound:st080858|FD-Score:-4.16|P-value:8.43E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.38|P-value:3.69E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.96|P-value:1.75E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.37|P-value:3.89E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:5.03|P-value:2.72E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.83|P-value:6.39E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:8.16|P-value:8.43E-14 ID:SGTC_236|Compound:1509-0011|FD-Score:5.02|P-value:2.94E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.49|P-value:7.99E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.39|P-value:1.23E-11 ID:SGTC_310|Compound:1273-0058|FD-Score:8.12|P-value:1.11E-13 ID:SGTC_367|Compound:0335-0881|FD-Score:-4.78|P-value:7.62E-6 ID:SGTC_462|Compound:ag-879|FD-Score:4.67|P-value:1.22E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.98|P-value:3.44E-6 ID:SGTC_502|Compound:l-744,832|FD-Score:3.99|P-value:1.56E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.74|P-value:9.36E-6 ID:SGTC_692|Compound:k241-0027|FD-Score:-4.54|P-value:1.99E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.21|P-value:7.20E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:3.61|P-value:5.55E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.66|P-value:1.56E-7 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.97|P-value:3.59E-6 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.21|P-value:7.07E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.06|P-value:1.24E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.85|P-value:2.45E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-4.63|P-value:1.38E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:7.88|P-value:5.38E-13 ID:SGTC_1176|Compound:0848-0131|FD-Score:-3.53|P-value:6.96E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:8.85|P-value:6.39E-16 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.11|P-value:1.03E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.99|P-value:3.29E-6 ID:SGTC_1627|Compound:st003713|FD-Score:4.84|P-value:6.25E-6 ID:SGTC_1782|Compound:st039423|FD-Score:4.39|P-value:3.66E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.20|P-value:3.80E-11 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-4.13|P-value:9.43E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.80|P-value:3.03E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.46|P-value:2.85E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.54|P-value:6.94E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.72|P-value:3.96E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-3.85|P-value:2.51E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.86|P-value:2.45E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.71|P-value:3.98E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.04|P-value:1.32E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.92|P-value:1.99E-4 ID:SGTC_2716|Compound:st080858|FD-Score:-4.16|P-value:8.43E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.38|P-value:3.69E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.96|P-value:1.75E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.37|P-value:3.89E-5

Top fitness defect scores for YJL096W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1179 1021-1431 8.85 9.3 µM 6.39E-16 3 4.38E-19
2 SGTC_173 1273-0061 8.16 2.7 µM 8.43E-14 mitochondrial stress 63 1.70E-16
3 SGTC_310 1273-0058 8.12 1.1 µM 1.11E-13 mitochondrial stress 85 2.37E-16
4 SGTC_1137 ixabepilone 7.88 100.0 µM 5.38E-13 3 1.63E-15
5 SGTC_275 trichlorophene 7.39 5.7 µM 1.23E-11 mitochondrial stress 87 7.42E-14
6 SGTC_908 3448-7491 5.66 47.7 µM 1.56E-7 mitochondrial stress 57 7.44E-9
7 SGTC_10 0279-0212 5.03 42.6 µM 2.72E-6 TRP & mitochondrial translation 59 2.40E-7
8 SGTC_236 1509-0011 5.02 5.3 µM 2.94E-6 326 2.65E-7
9 SGTC_1623 st003709 4.99 20.3 µM 3.29E-6 calcium & mitochondrial duress 31 3.02E-7
10 SGTC_467 ro 31-8220 4.98 72.8 µM 3.44E-6 calcium & mitochondrial duress 49 3.19E-7
11 SGTC_1122 capsaicin 4.97 818.6 nM 3.59E-6 12 3.37E-7
12 SGTC_1627 st003713 4.84 25.6 µM 6.25E-6 calcium & mitochondrial duress 43 6.61E-7
13 SGTC_28 pentachloropyridine N-oxide 4.83 1.6 µM 6.39E-6 TSC3-RPN4 33 6.78E-7
14 SGTC_679 0422-0091 4.74 41.4 µM 9.36E-6 Golgi 14 1.08E-6
15 SGTC_462 ag-879 4.67 158.0 µM 1.22E-5 16 1.48E-6
16 SGTC_2232 chlorophetanol 4.46 41.5 µM 2.85E-5 TRP & mitochondrial translation 102 4.17E-6
17 SGTC_1782 st039423 4.39 80.6 µM 3.66E-5 13 5.65E-6
18 SGTC_1125 tnp00248 4.21 1.3 µM 7.07E-5 18 1.26E-5
19 SGTC_767 0929-0023 4.21 86.0 µM 7.20E-5 TRP & mitochondrial translation 62 1.28E-5
20 SGTC_1474 0330-0125 4.11 5.3 µM 1.03E-4 26 1.97E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.435 7.40E-155 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.396 4.83E-126 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.395 7.97E-126 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.388 4.66E-121 YLR091W GEP5 hom Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine
0.384 1.58E-118 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.376 2.28E-113 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.374 1.15E-111 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.366 1.07E-106 YIL060W_p YIL060W_p hom Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene
0.364 7.98E-106 YDR347W MRP1 hom Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein
0.364 1.61E-105 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.363 2.41E-104 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.361 1.32E-103 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.359 1.05E-102 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.357 3.52E-101 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.351 4.72E-98 YMR293C HER2 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase