YJL098W / SAP185

Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL098W / SAP185

Click on Significant Values for Screen Details ID:SGTC_227|Compound:fluconazole|FD-Score:3.75|P-value:5.35E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:3.10|P-value:6.81E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.87|P-value:3.12E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:3.29|P-value:3.41E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:4.56|P-value:1.15E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.86|P-value:2.55E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:3.25|P-value:4.00E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.23|P-value:4.22E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:-4.93|P-value:1.22E-7 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.70|P-value:5.64E-7 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.21|P-value:4.51E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.84|P-value:3.49E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:5.61|P-value:3.08E-9 ID:SGTC_1407|Compound:3909-7909|FD-Score:-3.27|P-value:2.97E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:5.64|P-value:2.45E-9 ID:SGTC_1460|Compound:k062-0059|FD-Score:4.90|P-value:1.94E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.36|P-value:2.47E-6 ID:SGTC_1634|Compound:st006576|FD-Score:3.39|P-value:2.32E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.47|P-value:1.70E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.07|P-value:7.75E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.87|P-value:3.06E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.51|P-value:1.44E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.50|P-value:1.47E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-4.66|P-value:5.35E-7 ID:SGTC_2086|Compound:5274770|FD-Score:3.04|P-value:8.48E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.91|P-value:2.57E-5 ID:SGTC_2336|Compound:9001819|FD-Score:4.38|P-value:2.94E-6 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-5.55|P-value:3.16E-9 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.99|P-value:1.43E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.41|P-value:2.09E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.15|P-value:5.61E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.08|P-value:7.45E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-3.81|P-value:3.20E-5 ID:SGTC_2856|Compound:9022925|FD-Score:5.98|P-value:2.77E-10 ID:SGTC_2969|Compound:9091408|FD-Score:3.74|P-value:5.45E-5 ID:SGTC_3072|Compound:9116419|FD-Score:4.40|P-value:2.65E-6 ID:SGTC_3296|Compound:9122258|FD-Score:3.05|P-value:8.19E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.75|P-value:5.35E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:3.10|P-value:6.81E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.87|P-value:3.12E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:3.29|P-value:3.41E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:4.56|P-value:1.15E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.86|P-value:2.55E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:3.25|P-value:4.00E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.23|P-value:4.22E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:-4.93|P-value:1.22E-7 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.70|P-value:5.64E-7 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.21|P-value:4.51E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.84|P-value:3.49E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:5.61|P-value:3.08E-9 ID:SGTC_1407|Compound:3909-7909|FD-Score:-3.27|P-value:2.97E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:5.64|P-value:2.45E-9 ID:SGTC_1460|Compound:k062-0059|FD-Score:4.90|P-value:1.94E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.36|P-value:2.47E-6 ID:SGTC_1634|Compound:st006576|FD-Score:3.39|P-value:2.32E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.47|P-value:1.70E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.07|P-value:7.75E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.87|P-value:3.06E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.51|P-value:1.44E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.50|P-value:1.47E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-4.66|P-value:5.35E-7 ID:SGTC_2086|Compound:5274770|FD-Score:3.04|P-value:8.48E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.91|P-value:2.57E-5 ID:SGTC_2336|Compound:9001819|FD-Score:4.38|P-value:2.94E-6 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-5.55|P-value:3.16E-9 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.99|P-value:1.43E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.41|P-value:2.09E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.15|P-value:5.61E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.08|P-value:7.45E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-3.81|P-value:3.20E-5 ID:SGTC_2856|Compound:9022925|FD-Score:5.98|P-value:2.77E-10 ID:SGTC_2969|Compound:9091408|FD-Score:3.74|P-value:5.45E-5 ID:SGTC_3072|Compound:9116419|FD-Score:4.40|P-value:2.65E-6 ID:SGTC_3296|Compound:9122258|FD-Score:3.05|P-value:8.19E-4

Top fitness defect scores for YJL098W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2856 9022925 5.98 19.5 µM 2.77E-10 5 1.10E-9
2 SGTC_1458 k015-0034 5.64 6.3 µM 2.45E-9 6 8.32E-9
3 SGTC_1396 3511-0007 5.61 98.6 µM 3.08E-9 mitochondrial processes 3 1.03E-8
4 SGTC_1460 k062-0059 4.90 9.2 µM 1.94E-7 Golgi 1 4.83E-7
5 SGTC_1244 0416-0015 4.70 52.5 µM 5.64E-7 ERG2 15 1.30E-6
6 SGTC_802 4112-3352 4.56 742.0 µM 1.15E-6 12 2.51E-6
7 SGTC_3072 9116419 4.40 49.5 µM 2.65E-6 ERG2 8 5.48E-6
8 SGTC_2336 9001819 4.38 198.7 µM 2.94E-6 heme biosynthesis & mitochondrial translocase 37 6.03E-6
9 SGTC_2333 9017922 3.91 200.0 µM 2.57E-5 27 4.54E-5
10 SGTC_1940 st075990 3.87 51.1 µM 3.06E-5 60S ribosome export 23 5.34E-5
11 SGTC_453 enantio-paf c16 3.87 10.0 µM 3.12E-5 149 5.43E-5
12 SGTC_1387 3342-1166 3.84 1.8 µM 3.49E-5 mitochondrial processes 17 6.03E-5
13 SGTC_227 fluconazole 3.75 33.5 µM 5.35E-5 azole & statin 97 8.99E-5
14 SGTC_2969 9091408 3.74 28.7 µM 5.45E-5 33 9.14E-5
15 SGTC_1941 st076221 3.51 61.8 µM 1.44E-4 sphingolipid biosynthesis & PDR1 100 2.25E-4
16 SGTC_1947 st076332 3.50 61.6 µM 1.47E-4 21 2.30E-4
17 SGTC_1741 st038134 3.47 10.2 µM 1.70E-4 44 2.64E-4
18 SGTC_2594 a-mangostin 3.41 100.0 µM 2.09E-4 51 3.20E-4
19 SGTC_1634 st006576 3.39 41.0 µM 2.32E-4 TSC3-RPN4 34 3.53E-4
20 SGTC_533 1222-0222 3.29 6.7 µM 3.41E-4 PDR1 57 5.05E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.86E-12 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.108 3.39E-10 YOR174W MED4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.102 2.76E-9 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.101 4.76E-9 YLR071C RGR1 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
0.097 1.79E-8 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.090 1.70E-7 YHR203C RPS4B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication
0.088 3.23E-7 YDR073W SNF11 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions
0.086 6.79E-7 YOL022C TSR4 het Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2
0.081 2.64E-6 YOR332W VMA4 hom Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress
0.078 5.76E-6 YER038W-A_d YER038W-A_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria
0.077 7.23E-6 YHL015W-A_p YHL015W-A_p hom Putative protein of unknown function
0.077 8.48E-6 YDR255C RMD5 hom Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain
0.077 8.66E-6 YLR176C RFX1 hom Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins
0.077 9.00E-6 YER045C ACA1 hom ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication
0.076 9.57E-6 YJL035C TAD2 het Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs