YJL099W / CHS6

Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL099W / CHS6

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:4.39|P-value:2.29E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:3.96|P-value:1.20E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:4.03|P-value:9.07E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:7.96|P-value:6.11E-14 ID:SGTC_138|Compound:0850-0259|FD-Score:19.30|P-value:4.02E-73 ID:SGTC_255|Compound:tunicamycin|FD-Score:-4.53|P-value:1.03E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:8.43|P-value:2.02E-15 ID:SGTC_351|Compound:caspofungin|FD-Score:8.39|P-value:2.81E-15 ID:SGTC_354|Compound:2783-3500|FD-Score:8.63|P-value:4.50E-16 ID:SGTC_360|Compound:0957-0399|FD-Score:4.96|P-value:2.06E-6 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.78|P-value:1.85E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:8.25|P-value:7.62E-15 ID:SGTC_556|Compound:4058-0063|FD-Score:4.29|P-value:3.39E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:12.70|P-value:1.54E-32 ID:SGTC_615|Compound:k087-0205|FD-Score:3.49|P-value:5.97E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.37|P-value:8.89E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.87|P-value:1.65E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:4.41|P-value:2.08E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:3.94|P-value:1.26E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:3.75|P-value:2.53E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:22.10|P-value:1.75E-94 ID:SGTC_916|Compound:4466-0038|FD-Score:7.48|P-value:1.67E-12 ID:SGTC_928|Compound:2764-0428|FD-Score:6.51|P-value:6.83E-10 ID:SGTC_951|Compound:1171-0579|FD-Score:6.10|P-value:7.03E-9 ID:SGTC_964|Compound:1287-0107|FD-Score:5.76|P-value:4.29E-8 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.65|P-value:3.55E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:5.50|P-value:1.57E-7 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:4.41|P-value:2.11E-5 ID:SGTC_1654|Compound:st012436|FD-Score:-3.91|P-value:1.15E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.35|P-value:8.08E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.60|P-value:4.22E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.37|P-value:8.82E-4 ID:SGTC_2105|Compound:5350118|FD-Score:4.12|P-value:6.50E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.43|P-value:7.46E-4 ID:SGTC_2121|Compound:5257820|FD-Score:-3.68|P-value:2.63E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.61|P-value:9.42E-6 ID:SGTC_2210|Compound:7115885|FD-Score:5.01|P-value:1.58E-6 ID:SGTC_2264|Compound:7948757|FD-Score:3.35|P-value:9.39E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.58|P-value:4.47E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.71|P-value:2.90E-4 ID:SGTC_2481|Compound:5478948|FD-Score:4.18|P-value:5.13E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.57|P-value:3.82E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.30|P-value:3.93E-26 ID:SGTC_2584|Compound:androsterone|FD-Score:14.20|P-value:1.96E-40 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.91|P-value:1.43E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.39|P-value:6.99E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.03|P-value:1.46E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:3.43|P-value:7.44E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.37|P-value:8.81E-4 ID:SGTC_2912|Compound:7964298|FD-Score:20.00|P-value:2.55E-78 ID:SGTC_2928|Compound:9011484|FD-Score:-3.33|P-value:8.65E-4 ID:SGTC_3053|Compound:9095903|FD-Score:3.95|P-value:1.24E-4 ID:SGTC_3118|Compound:9124250|FD-Score:4.67|P-value:7.19E-6 ID:SGTC_3207|Compound:9114163|FD-Score:-4.13|P-value:5.15E-5 ID:SGTC_3253|Compound:9135987|FD-Score:3.42|P-value:7.66E-4 ID:SGTC_3266|Compound:9136860|FD-Score:8.23|P-value:8.94E-15 ID:SGTC_3311|Compound:9131146|FD-Score:15.80|P-value:1.23E-49 ID:SGTC_3321|Compound:9137793|FD-Score:14.00|P-value:3.23E-39 ID:SGTC_17|Compound:0960-0276|FD-Score:4.39|P-value:2.29E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:3.96|P-value:1.20E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:4.03|P-value:9.07E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:7.96|P-value:6.11E-14 ID:SGTC_138|Compound:0850-0259|FD-Score:19.30|P-value:4.02E-73 ID:SGTC_255|Compound:tunicamycin|FD-Score:-4.53|P-value:1.03E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:8.43|P-value:2.02E-15 ID:SGTC_351|Compound:caspofungin|FD-Score:8.39|P-value:2.81E-15 ID:SGTC_354|Compound:2783-3500|FD-Score:8.63|P-value:4.50E-16 ID:SGTC_360|Compound:0957-0399|FD-Score:4.96|P-value:2.06E-6 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.78|P-value:1.85E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:8.25|P-value:7.62E-15 ID:SGTC_556|Compound:4058-0063|FD-Score:4.29|P-value:3.39E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:12.70|P-value:1.54E-32 ID:SGTC_615|Compound:k087-0205|FD-Score:3.49|P-value:5.97E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.37|P-value:8.89E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.87|P-value:1.65E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:4.41|P-value:2.08E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:3.94|P-value:1.26E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:3.75|P-value:2.53E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:22.10|P-value:1.75E-94 ID:SGTC_916|Compound:4466-0038|FD-Score:7.48|P-value:1.67E-12 ID:SGTC_928|Compound:2764-0428|FD-Score:6.51|P-value:6.83E-10 ID:SGTC_951|Compound:1171-0579|FD-Score:6.10|P-value:7.03E-9 ID:SGTC_964|Compound:1287-0107|FD-Score:5.76|P-value:4.29E-8 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.65|P-value:3.55E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:5.50|P-value:1.57E-7 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:4.41|P-value:2.11E-5 ID:SGTC_1654|Compound:st012436|FD-Score:-3.91|P-value:1.15E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.35|P-value:8.08E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.60|P-value:4.22E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.37|P-value:8.82E-4 ID:SGTC_2105|Compound:5350118|FD-Score:4.12|P-value:6.50E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.43|P-value:7.46E-4 ID:SGTC_2121|Compound:5257820|FD-Score:-3.68|P-value:2.63E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.61|P-value:9.42E-6 ID:SGTC_2210|Compound:7115885|FD-Score:5.01|P-value:1.58E-6 ID:SGTC_2264|Compound:7948757|FD-Score:3.35|P-value:9.39E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.58|P-value:4.47E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.71|P-value:2.90E-4 ID:SGTC_2481|Compound:5478948|FD-Score:4.18|P-value:5.13E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.57|P-value:3.82E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.30|P-value:3.93E-26 ID:SGTC_2584|Compound:androsterone|FD-Score:14.20|P-value:1.96E-40 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.91|P-value:1.43E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.39|P-value:6.99E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.03|P-value:1.46E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:3.43|P-value:7.44E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.37|P-value:8.81E-4 ID:SGTC_2912|Compound:7964298|FD-Score:20.00|P-value:2.55E-78 ID:SGTC_2928|Compound:9011484|FD-Score:-3.33|P-value:8.65E-4 ID:SGTC_3053|Compound:9095903|FD-Score:3.95|P-value:1.24E-4 ID:SGTC_3118|Compound:9124250|FD-Score:4.67|P-value:7.19E-6 ID:SGTC_3207|Compound:9114163|FD-Score:-4.13|P-value:5.15E-5 ID:SGTC_3253|Compound:9135987|FD-Score:3.42|P-value:7.66E-4 ID:SGTC_3266|Compound:9136860|FD-Score:8.23|P-value:8.94E-15 ID:SGTC_3311|Compound:9131146|FD-Score:15.80|P-value:1.23E-49 ID:SGTC_3321|Compound:9137793|FD-Score:14.00|P-value:3.23E-39

Top fitness defect scores for YJL099W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_863 0466-0191 22.10 129.0 µM 1.75E-94 cell wall 2 3.76E-108
2 SGTC_2912 7964298 20.00 10.9 µM 2.55E-78 cell wall 4 1.27E-89
3 SGTC_138 0850-0259 19.30 40.9 µM 4.02E-73 cell wall 6 1.16E-83
4 SGTC_3311 9131146 15.80 2.9 µM 1.23E-49 cell wall 4 9.81E-57
5 SGTC_2584 androsterone 14.20 48.7 µM 1.96E-40 cell wall 6 3.51E-46
6 SGTC_3321 9137793 14.00 26.8 µM 3.23E-39 cell wall 4 8.71E-45
7 SGTC_586 0957-0265 12.70 8.2 µM 1.54E-32 cell wall 2 3.96E-37
8 SGTC_2582 agaric acid 11.30 100.0 µM 3.93E-26 redox potentiating 49 8.83E-30
9 SGTC_354 2783-3500 8.63 4.9 µM 4.50E-16 cell wall 8 3.03E-18
10 SGTC_304 1310-0298 8.43 97.0 µM 2.02E-15 cell wall 5 1.70E-17
11 SGTC_351 caspofungin 8.39 25.0 nM 2.81E-15 cell wall 15 2.47E-17
12 SGTC_514 4466-0038 8.25 2.6 nM 7.62E-15 cell wall 36 7.77E-17
13 SGTC_3266 9136860 8.23 49.5 µM 8.94E-15 cell wall 12 9.33E-17
14 SGTC_58 0957-0393 7.96 9.0 µM 6.11E-14 cell wall 124 8.44E-16
15 SGTC_916 4466-0038 7.48 42.0 nM 1.67E-12 cell wall 14 3.75E-14
16 SGTC_928 2764-0428 6.51 58.7 µM 6.83E-10 cell wall 11 3.70E-11
17 SGTC_951 1171-0579 6.10 82.7 µM 7.03E-9 cell wall 33 5.37E-10
18 SGTC_964 1287-0107 5.76 19.4 µM 4.29E-8 cell wall 15 4.27E-9
19 SGTC_1465 k213-0056 5.50 144.0 µM 1.57E-7 DNA intercalators 5 1.88E-8
20 SGTC_2619 obliquin 5.03 87.9 µM 1.46E-6 cell wall 98 2.43E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.615 0 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.587 1.12E-309 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.569 4.78E-287 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.501 6.47E-213 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.498 2.43E-209 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.490 1.59E-202 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.464 2.62E-178 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.462 3.26E-177 YBL062W_d YBL062W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.456 5.61E-172 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.454 4.69E-170 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.451 2.71E-167 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.443 5.34E-161 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.438 1.51E-157 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.436 6.86E-156 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.427 4.98E-149 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress