YJL102W / MEF2

Mitochondrial elongation factor involved in translational elongation

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL102W / MEF2

Click on Significant Values for Screen Details ID:SGTC_84|Compound:0443-0269|FD-Score:3.98|P-value:1.23E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.55|P-value:1.38E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.71|P-value:3.11E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.59|P-value:4.68E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:10.50|P-value:1.77E-22 ID:SGTC_275|Compound:trichlorophene|FD-Score:-6.42|P-value:1.62E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:10.50|P-value:1.78E-22 ID:SGTC_372|Compound:0155-0182|FD-Score:-8.78|P-value:2.77E-16 ID:SGTC_397|Compound:arbidol|FD-Score:3.45|P-value:7.30E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-4.08|P-value:8.45E-5 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.56|P-value:5.24E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.87|P-value:1.83E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.89|P-value:1.67E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.10|P-value:7.89E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.04|P-value:9.91E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:4.85|P-value:3.94E-6 ID:SGTC_684|Compound:1140-0066|FD-Score:4.28|P-value:4.03E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:4.05|P-value:9.46E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-8.49|P-value:2.54E-15 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.98|P-value:1.22E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.38|P-value:9.07E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:5.89|P-value:2.79E-8 ID:SGTC_908|Compound:3448-7491|FD-Score:5.21|P-value:7.85E-7 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.85|P-value:1.92E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:4.30|P-value:3.73E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:3.38|P-value:9.22E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.43|P-value:7.86E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:4.13|P-value:7.07E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:4.51|P-value:1.58E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.91|P-value:1.58E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-4.02|P-value:1.05E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.12|P-value:7.18E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.27|P-value:4.19E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.84|P-value:1.99E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:-3.79|P-value:2.34E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:7.69|P-value:6.71E-13 ID:SGTC_1353|Compound:1498-1206|FD-Score:6.84|P-value:1.45E-10 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.92|P-value:1.51E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:-3.44|P-value:7.55E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-4.36|P-value:2.86E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.49|P-value:1.76E-5 ID:SGTC_1623|Compound:st003709|FD-Score:3.42|P-value:8.05E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.81|P-value:2.18E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.55|P-value:5.36E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.24|P-value:4.66E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.56|P-value:5.12E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.44|P-value:7.63E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.42|P-value:8.14E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-18.20|P-value:3.42E-63 ID:SGTC_1998|Compound:st075797|FD-Score:3.41|P-value:8.37E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-10.20|P-value:3.49E-21 ID:SGTC_2165|Compound:5727197|FD-Score:3.76|P-value:2.62E-4 ID:SGTC_2184|Compound:6075246|FD-Score:-4.12|P-value:7.15E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.71|P-value:3.09E-4 ID:SGTC_2426|Compound:5582046|FD-Score:4.03|P-value:1.01E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-5.24|P-value:6.80E-7 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.47|P-value:6.95E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:5.03|P-value:1.78E-6 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.66|P-value:3.66E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.54|P-value:1.41E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.99|P-value:1.19E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-4.49|P-value:1.74E-5 ID:SGTC_2796|Compound:7949634|FD-Score:5.76|P-value:5.45E-8 ID:SGTC_2835|Compound:9006588|FD-Score:-6.90|P-value:9.85E-11 ID:SGTC_2844|Compound:9010103|FD-Score:-4.16|P-value:6.33E-5 ID:SGTC_2856|Compound:9022925|FD-Score:4.34|P-value:3.15E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-5.32|P-value:4.66E-7 ID:SGTC_2887|Compound:9044784|FD-Score:-3.38|P-value:9.28E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.47|P-value:1.19E-9 ID:SGTC_2929|Compound:9013348|FD-Score:3.79|P-value:2.34E-4 ID:SGTC_2948|Compound:9070189|FD-Score:4.55|P-value:1.40E-5 ID:SGTC_2965|Compound:9082772|FD-Score:3.82|P-value:2.12E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-4.46|P-value:1.93E-5 ID:SGTC_3218|Compound:9131285|FD-Score:3.81|P-value:2.19E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:3.98|P-value:1.23E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.55|P-value:1.38E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.71|P-value:3.11E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.59|P-value:4.68E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:10.50|P-value:1.77E-22 ID:SGTC_275|Compound:trichlorophene|FD-Score:-6.42|P-value:1.62E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:10.50|P-value:1.78E-22 ID:SGTC_372|Compound:0155-0182|FD-Score:-8.78|P-value:2.77E-16 ID:SGTC_397|Compound:arbidol|FD-Score:3.45|P-value:7.30E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-4.08|P-value:8.45E-5 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.56|P-value:5.24E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.87|P-value:1.83E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.89|P-value:1.67E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.10|P-value:7.89E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.04|P-value:9.91E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:4.85|P-value:3.94E-6 ID:SGTC_684|Compound:1140-0066|FD-Score:4.28|P-value:4.03E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:4.05|P-value:9.46E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-8.49|P-value:2.54E-15 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.98|P-value:1.22E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.38|P-value:9.07E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:5.89|P-value:2.79E-8 ID:SGTC_908|Compound:3448-7491|FD-Score:5.21|P-value:7.85E-7 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.85|P-value:1.92E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:4.30|P-value:3.73E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:3.38|P-value:9.22E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.43|P-value:7.86E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:4.13|P-value:7.07E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:4.51|P-value:1.58E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.91|P-value:1.58E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-4.02|P-value:1.05E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.12|P-value:7.18E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.27|P-value:4.19E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.84|P-value:1.99E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:-3.79|P-value:2.34E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:7.69|P-value:6.71E-13 ID:SGTC_1353|Compound:1498-1206|FD-Score:6.84|P-value:1.45E-10 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.92|P-value:1.51E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:-3.44|P-value:7.55E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-4.36|P-value:2.86E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.49|P-value:1.76E-5 ID:SGTC_1623|Compound:st003709|FD-Score:3.42|P-value:8.05E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.81|P-value:2.18E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.55|P-value:5.36E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.24|P-value:4.66E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.56|P-value:5.12E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.44|P-value:7.63E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.42|P-value:8.14E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-18.20|P-value:3.42E-63 ID:SGTC_1998|Compound:st075797|FD-Score:3.41|P-value:8.37E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-10.20|P-value:3.49E-21 ID:SGTC_2165|Compound:5727197|FD-Score:3.76|P-value:2.62E-4 ID:SGTC_2184|Compound:6075246|FD-Score:-4.12|P-value:7.15E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.71|P-value:3.09E-4 ID:SGTC_2426|Compound:5582046|FD-Score:4.03|P-value:1.01E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-5.24|P-value:6.80E-7 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.47|P-value:6.95E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:5.03|P-value:1.78E-6 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.66|P-value:3.66E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.54|P-value:1.41E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.99|P-value:1.19E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-4.49|P-value:1.74E-5 ID:SGTC_2796|Compound:7949634|FD-Score:5.76|P-value:5.45E-8 ID:SGTC_2835|Compound:9006588|FD-Score:-6.90|P-value:9.85E-11 ID:SGTC_2844|Compound:9010103|FD-Score:-4.16|P-value:6.33E-5 ID:SGTC_2856|Compound:9022925|FD-Score:4.34|P-value:3.15E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-5.32|P-value:4.66E-7 ID:SGTC_2887|Compound:9044784|FD-Score:-3.38|P-value:9.28E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.47|P-value:1.19E-9 ID:SGTC_2929|Compound:9013348|FD-Score:3.79|P-value:2.34E-4 ID:SGTC_2948|Compound:9070189|FD-Score:4.55|P-value:1.40E-5 ID:SGTC_2965|Compound:9082772|FD-Score:3.82|P-value:2.12E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-4.46|P-value:1.93E-5 ID:SGTC_3218|Compound:9131285|FD-Score:3.81|P-value:2.19E-4

Top fitness defect scores for YJL102W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 10.50 5.3 µM 1.77E-22 187 4.11E-26
2 SGTC_310 1273-0058 10.50 1.1 µM 1.78E-22 mitochondrial stress 37 4.13E-26
3 SGTC_1240 0356-0016 7.69 42.1 µM 6.71E-13 mitochondrial response to ROS 4 7.29E-15
4 SGTC_1353 1498-1206 6.84 8.1 µM 1.45E-10 mitochondrial response to ROS 8 3.99E-12
5 SGTC_899 1083-0020 5.89 478.0 µM 2.79E-8 1 1.90E-9
6 SGTC_2796 7949634 5.76 45.5 µM 5.45E-8 4 4.16E-9
7 SGTC_908 3448-7491 5.21 47.7 µM 7.85E-7 mitochondrial stress 71 9.46E-8
8 SGTC_2533 agelasine 5.03 13.7 µM 1.78E-6 ERG2 23 2.47E-7
9 SGTC_679 0422-0091 4.85 41.4 µM 3.94E-6 Golgi 12 6.25E-7
10 SGTC_87 0100-0052 4.55 35.5 µM 1.38E-5 72 2.70E-6
11 SGTC_2948 9070189 4.55 9.4 µM 1.40E-5 plasma membrane duress 38 2.74E-6
12 SGTC_2688 kanamycin b 4.54 96.7 µM 1.41E-5 calcium & mitochondrial duress 295 2.77E-6
13 SGTC_972 1319-0219 4.51 195.0 µM 1.58E-5 13 3.17E-6
14 SGTC_1597 7-benzyloxygramine 4.49 47.5 µM 1.76E-5 calcium & mitochondrial duress 90 3.59E-6
15 SGTC_2856 9022925 4.34 19.5 µM 3.15E-5 12 7.08E-6
16 SGTC_948 3448-0295 4.30 75.3 µM 3.73E-5 19 8.63E-6
17 SGTC_684 1140-0066 4.28 328.0 µM 4.03E-5 Golgi 16 9.46E-6
18 SGTC_969 1313-0238 4.13 134.0 µM 7.07E-5 mitochondrial processes 21 1.82E-5
19 SGTC_1075 aripiprazole 4.12 15.2 µM 7.18E-5 24 1.86E-5
20 SGTC_625 k213-0058 4.10 121.0 µM 7.89E-5 translation 95 2.07E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.283 4.76E-63 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.263 8.91E-54 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.250 4.95E-49 YMR282C AEP2 hom Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.244 1.54E-46 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.231 1.11E-41 YNL284C MRPL10 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
0.227 1.73E-40 YIL060W_p YIL060W_p hom Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene
0.227 1.97E-40 YDR347W MRP1 hom Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein
0.221 2.22E-38 YMR097C MTG1 hom Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
0.216 8.54E-37 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.216 1.08E-36 YLR139C SLS1 hom Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery
0.214 6.12E-36 YGR165W MRPS35 hom Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
0.213 6.82E-36 YER028C MIG3 hom Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
0.213 7.49E-36 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.213 9.15E-36 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.209 1.49E-34 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated