YJL103C / GSM1

Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL103C / GSM1

Click on Significant Values for Screen Details ID:SGTC_139|Compound:0099-0334|FD-Score:-3.48|P-value:3.40E-4 ID:SGTC_460|Compound:trequinsin|FD-Score:3.45|P-value:3.79E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.83|P-value:9.19E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:4.28|P-value:1.49E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:3.46|P-value:3.72E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.19|P-value:9.16E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.18|P-value:2.28E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.21|P-value:8.62E-4 ID:SGTC_1841|Compound:st054148|FD-Score:4.32|P-value:1.25E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.20|P-value:8.98E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.26|P-value:1.63E-5 ID:SGTC_1959|Compound:st077091|FD-Score:-3.47|P-value:3.53E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.45|P-value:3.71E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.18|P-value:9.54E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.38|P-value:4.85E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-3.17|P-value:9.94E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-5.28|P-value:1.23E-7 ID:SGTC_2460|Compound:5552655|FD-Score:-4.18|P-value:2.22E-5 ID:SGTC_2468|Compound:5987765|FD-Score:4.19|P-value:2.17E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.69|P-value:2.36E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.20|P-value:8.93E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.89|P-value:7.35E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.70|P-value:1.55E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.62|P-value:2.06E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.69|P-value:1.59E-4 ID:SGTC_2974|Compound:9094440|FD-Score:6.29|P-value:4.05E-10 ID:SGTC_3046|Compound:9092212|FD-Score:3.88|P-value:7.67E-5 ID:SGTC_3092|Compound:9117248|FD-Score:3.60|P-value:2.19E-4 ID:SGTC_3177|Compound:9107506|FD-Score:-3.88|P-value:7.59E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.48|P-value:3.40E-4 ID:SGTC_460|Compound:trequinsin|FD-Score:3.45|P-value:3.79E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.83|P-value:9.19E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:4.28|P-value:1.49E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:3.46|P-value:3.72E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.19|P-value:9.16E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.18|P-value:2.28E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.21|P-value:8.62E-4 ID:SGTC_1841|Compound:st054148|FD-Score:4.32|P-value:1.25E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.20|P-value:8.98E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.26|P-value:1.63E-5 ID:SGTC_1959|Compound:st077091|FD-Score:-3.47|P-value:3.53E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.45|P-value:3.71E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.18|P-value:9.54E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.38|P-value:4.85E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-3.17|P-value:9.94E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-5.28|P-value:1.23E-7 ID:SGTC_2460|Compound:5552655|FD-Score:-4.18|P-value:2.22E-5 ID:SGTC_2468|Compound:5987765|FD-Score:4.19|P-value:2.17E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.69|P-value:2.36E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.20|P-value:8.93E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.89|P-value:7.35E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.70|P-value:1.55E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.62|P-value:2.06E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.69|P-value:1.59E-4 ID:SGTC_2974|Compound:9094440|FD-Score:6.29|P-value:4.05E-10 ID:SGTC_3046|Compound:9092212|FD-Score:3.88|P-value:7.67E-5 ID:SGTC_3092|Compound:9117248|FD-Score:3.60|P-value:2.19E-4 ID:SGTC_3177|Compound:9107506|FD-Score:-3.88|P-value:7.59E-5

Top fitness defect scores for YJL103C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2974 9094440 6.29 9.7 µM 4.05E-10 ergosterol biosynthesis 9 1.56E-10
2 SGTC_2498 4'-Methoxychalcone 4.69 54.6 µM 2.36E-6 RPP1 & pyrimidine depletion 17 1.38E-6
3 SGTC_1841 st054148 4.32 70.0 µM 1.25E-5 6 7.86E-6
4 SGTC_736 0958-0254 4.28 92.6 µM 1.49E-5 Golgi 22 9.46E-6
5 SGTC_1942 st076330 4.26 65.2 µM 1.63E-5 22 1.04E-5
6 SGTC_2468 5987765 4.19 72.9 µM 2.17E-5 9 1.40E-5
7 SGTC_1608 st001473 4.18 40.5 µM 2.28E-5 31 1.47E-5
8 SGTC_3046 9092212 3.88 49.5 µM 7.67E-5 6 5.25E-5
9 SGTC_2658 polymyxin b sulfate 3.70 77.0 µM 1.55E-4 NEO1 52 1.10E-4
10 SGTC_2970 9090938 3.69 41.9 µM 1.59E-4 RNA processing & uracil transport 52 1.13E-4
11 SGTC_2683 piperine 3.62 63.0 µM 2.06E-4 20 1.48E-4
12 SGTC_3092 9117248 3.60 49.5 µM 2.19E-4 cell wall signaling 7 1.58E-4
13 SGTC_840 0245-0196 3.46 390.0 µM 3.72E-4 23 2.74E-4
14 SGTC_460 trequinsin 3.45 123.0 µM 3.79E-4 7 2.80E-4
15 SGTC_2314 7727897 3.38 200.0 µM 4.85E-4 42 3.62E-4
16 SGTC_1728 st035614 3.21 33.8 µM 8.62E-4 92 6.61E-4
17 SGTC_1844 rapamycin 3.20 4.0 nM 8.98E-4 218 6.89E-4
18 SGTC_2305 7443522 3.18 69.2 µM 9.54E-4 36 7.34E-4
19 SGTC_430 0958-0115 3.14 16.4 µM 0.00108 72 8.33E-4
20 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 3.10 100.0 µM 0.00126 58 9.80E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.59E-11 YIL056W VHR1 hom Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication
0.111 1.12E-10 YCL039W GID7 hom Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions
0.091 1.43E-7 YGL059W PKP2 hom Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.089 2.08E-7 YGL056C SDS23 hom One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication
0.088 3.21E-7 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.088 3.77E-7 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.085 8.18E-7 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.083 1.53E-6 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.083 1.64E-6 YPL096W PNG1 hom Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p
0.082 1.77E-6 YFR047C BNA6 hom Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
0.077 8.53E-6 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.077 8.87E-6 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.076 1.01E-5 YPR037C ERV2 hom Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
0.075 1.50E-5 YJR128W_d YJR128W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
0.074 1.74E-5 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress