YJL104W / PAM16

Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL104W / PAM16

Click on Significant Values for Screen Details ID:SGTC_140|Compound:0062-0056|FD-Score:-5.55|P-value:1.30E-9 ID:SGTC_179|Compound:1273-0063|FD-Score:4.10|P-value:5.85E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:3.48|P-value:1.01E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:-2.88|P-value:9.92E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.04|P-value:7.77E-6 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.03|P-value:6.16E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-2.89|P-value:9.34E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:2.97|P-value:7.70E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:4.05|P-value:7.36E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.91|P-value:1.31E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:-4.79|P-value:1.34E-7 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.93|P-value:8.68E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.10|P-value:4.69E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.22|P-value:2.88E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.72|P-value:3.25E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.01|P-value:6.57E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:4.47|P-value:8.94E-7 ID:SGTC_1714|Compound:st033236|FD-Score:-3.04|P-value:5.44E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.34|P-value:1.63E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.02|P-value:6.30E-4 ID:SGTC_1765|Compound:st044815|FD-Score:-2.99|P-value:6.64E-4 ID:SGTC_2067|Compound:5224629|FD-Score:-3.23|P-value:2.56E-4 ID:SGTC_2159|Compound:5658611|FD-Score:3.78|P-value:2.68E-5 ID:SGTC_2177|Compound:5811945|FD-Score:-3.79|P-value:2.38E-5 ID:SGTC_2188|Compound:6126565|FD-Score:3.30|P-value:2.10E-4 ID:SGTC_2191|Compound:5911152|FD-Score:4.03|P-value:8.39E-6 ID:SGTC_2194|Compound:5927483|FD-Score:3.34|P-value:1.78E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.32|P-value:1.96E-4 ID:SGTC_2297|Compound:7971671|FD-Score:2.95|P-value:8.23E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.66|P-value:4.57E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.02|P-value:6.42E-4 ID:SGTC_2376|Compound:9072922|FD-Score:6.27|P-value:1.02E-11 ID:SGTC_2387|Compound:9077560|FD-Score:-3.10|P-value:4.29E-4 ID:SGTC_2537|Compound:larixol|FD-Score:4.07|P-value:6.74E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.85|P-value:1.92E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.19|P-value:3.77E-6 ID:SGTC_2781|Compound:5567276|FD-Score:3.82|P-value:2.26E-5 ID:SGTC_2784|Compound:7567673|FD-Score:-3.14|P-value:3.76E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.48|P-value:1.02E-4 ID:SGTC_2900|Compound:5328528|FD-Score:5.04|P-value:3.46E-8 ID:SGTC_2921|Compound:7974240|FD-Score:3.68|P-value:4.18E-5 ID:SGTC_2928|Compound:9011484|FD-Score:-2.92|P-value:8.61E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-4.66|P-value:2.77E-7 ID:SGTC_3056|Compound:9094900|FD-Score:4.40|P-value:1.29E-6 ID:SGTC_3285|Compound:9112818|FD-Score:-3.31|P-value:1.84E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.48|P-value:9.09E-5 ID:SGTC_3295|Compound:9122362|FD-Score:-4.12|P-value:4.81E-6 ID:SGTC_3311|Compound:9131146|FD-Score:3.13|P-value:4.13E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-5.55|P-value:1.30E-9 ID:SGTC_179|Compound:1273-0063|FD-Score:4.10|P-value:5.85E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:3.48|P-value:1.01E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:-2.88|P-value:9.92E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.04|P-value:7.77E-6 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.03|P-value:6.16E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-2.89|P-value:9.34E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:2.97|P-value:7.70E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:4.05|P-value:7.36E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.91|P-value:1.31E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:-4.79|P-value:1.34E-7 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.93|P-value:8.68E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.10|P-value:4.69E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.22|P-value:2.88E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.72|P-value:3.25E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.01|P-value:6.57E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:4.47|P-value:8.94E-7 ID:SGTC_1714|Compound:st033236|FD-Score:-3.04|P-value:5.44E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.34|P-value:1.63E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.02|P-value:6.30E-4 ID:SGTC_1765|Compound:st044815|FD-Score:-2.99|P-value:6.64E-4 ID:SGTC_2067|Compound:5224629|FD-Score:-3.23|P-value:2.56E-4 ID:SGTC_2159|Compound:5658611|FD-Score:3.78|P-value:2.68E-5 ID:SGTC_2177|Compound:5811945|FD-Score:-3.79|P-value:2.38E-5 ID:SGTC_2188|Compound:6126565|FD-Score:3.30|P-value:2.10E-4 ID:SGTC_2191|Compound:5911152|FD-Score:4.03|P-value:8.39E-6 ID:SGTC_2194|Compound:5927483|FD-Score:3.34|P-value:1.78E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.32|P-value:1.96E-4 ID:SGTC_2297|Compound:7971671|FD-Score:2.95|P-value:8.23E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.66|P-value:4.57E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.02|P-value:6.42E-4 ID:SGTC_2376|Compound:9072922|FD-Score:6.27|P-value:1.02E-11 ID:SGTC_2387|Compound:9077560|FD-Score:-3.10|P-value:4.29E-4 ID:SGTC_2537|Compound:larixol|FD-Score:4.07|P-value:6.74E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.85|P-value:1.92E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.19|P-value:3.77E-6 ID:SGTC_2781|Compound:5567276|FD-Score:3.82|P-value:2.26E-5 ID:SGTC_2784|Compound:7567673|FD-Score:-3.14|P-value:3.76E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.48|P-value:1.02E-4 ID:SGTC_2900|Compound:5328528|FD-Score:5.04|P-value:3.46E-8 ID:SGTC_2921|Compound:7974240|FD-Score:3.68|P-value:4.18E-5 ID:SGTC_2928|Compound:9011484|FD-Score:-2.92|P-value:8.61E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-4.66|P-value:2.77E-7 ID:SGTC_3056|Compound:9094900|FD-Score:4.40|P-value:1.29E-6 ID:SGTC_3285|Compound:9112818|FD-Score:-3.31|P-value:1.84E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.48|P-value:9.09E-5 ID:SGTC_3295|Compound:9122362|FD-Score:-4.12|P-value:4.81E-6 ID:SGTC_3311|Compound:9131146|FD-Score:3.13|P-value:4.13E-4

Top fitness defect scores for YJL104W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2376 9072922 6.27 81.3 µM 1.02E-11 1 1.85E-10 1.74
2 SGTC_2900 5328528 5.04 85.3 µM 3.46E-8 Golgi 2 2.28E-7 0.71
3 SGTC_1220 1838-0075 4.47 193.0 µM 8.94E-7 2 3.94E-6 0.82
4 SGTC_3056 9094900 4.40 49.5 µM 1.29E-6 5 5.45E-6 0.62
5 SGTC_2729 fluphenazine 4.19 10.7 µM 3.77E-6 6 1.40E-5 0.06
6 SGTC_179 1273-0063 4.10 6.8 µM 5.85E-6 4 2.05E-5 0.06
7 SGTC_2537 larixol 4.07 68.9 µM 6.74E-6 5 2.32E-5 0.27
8 SGTC_876 0720-0963 4.05 56.8 µM 7.36E-6 5 2.51E-5 0.20
9 SGTC_360 0957-0399 4.04 1.0 µM 7.77E-6 cell wall 12 2.64E-5 0.04
10 SGTC_2191 5911152 4.03 200.0 µM 8.39E-6 2 2.82E-5 0.35
11 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.85 70.0 µM 1.92E-5 redox potentiating 11 5.83E-5 0.04
12 SGTC_2781 5567276 3.82 71.4 µM 2.26E-5 10 6.74E-5 0.08
13 SGTC_2159 5658611 3.78 73.8 µM 2.68E-5 7 7.83E-5 0.02
14 SGTC_2921 7974240 3.68 10.7 µM 4.18E-5 19 1.16E-4 0.11
15 SGTC_2303 7774051 3.66 200.0 µM 4.57E-5 9 1.25E-4 0.04
16 SGTC_188 3229-0966 3.48 278.5 µM 1.01E-4 27 2.52E-4 0.08
17 SGTC_2791 5663188 3.48 71.4 µM 1.02E-4 RPP1 & pyrimidine depletion 16 2.54E-4 0.15
18 SGTC_2194 5927483 3.34 104.5 µM 1.78E-4 11 4.14E-4 0.28
19 SGTC_2204 7233102 3.32 200.0 µM 1.96E-4 60S ribosome export 7 4.52E-4 0.05
20 SGTC_2188 6126565 3.30 140.7 µM 2.10E-4 mitochondrial processes 13 4.80E-4 0.17

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.52E-9 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.103 2.31E-9 YJR080C AIM24 hom Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss
0.098 1.43E-8 YER075C PTP3 hom Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
0.097 1.84E-8 YLR011W LOT6 hom FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions
0.095 3.85E-8 YDL050C_d YDL050C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.083 1.56E-6 YOL075C_p YOL075C_p hom Putative ABC transporter
0.082 2.21E-6 YPL152W RRD2 hom Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress
0.079 5.02E-6 YER044C-A MEI4 hom Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores
0.077 7.71E-6 YPL243W SRP68 het Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.074 1.59E-5 YDR420W HKR1 hom Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
0.072 2.66E-5 YLR111W_d YLR111W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.070 4.87E-5 YER027C GAL83 hom One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain
0.069 6.50E-5 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.069 7.09E-5 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.068 8.55E-5 YBL049W MOH1 hom Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase