YJL106W / IME2

Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL106W / IME2

Click on Significant Values for Screen Details ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.10|P-value:6.81E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-4.44|P-value:2.36E-6 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.95|P-value:2.36E-5 ID:SGTC_459|Compound:nigericin|FD-Score:-3.35|P-value:2.82E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.05|P-value:7.94E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.11|P-value:6.39E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.00|P-value:9.38E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.16|P-value:5.57E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.22|P-value:4.30E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.57|P-value:1.10E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:-4.03|P-value:1.62E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.04|P-value:8.32E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:-4.14|P-value:1.00E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.31|P-value:3.09E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.14|P-value:5.71E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.00|P-value:1.75E-5 ID:SGTC_1678|Compound:st019265|FD-Score:4.42|P-value:2.42E-6 ID:SGTC_1726|Compound:st035556|FD-Score:4.33|P-value:3.85E-6 ID:SGTC_1900|Compound:st060200|FD-Score:-3.63|P-value:9.00E-5 ID:SGTC_1953|Compound:st076800|FD-Score:4.21|P-value:6.80E-6 ID:SGTC_2005|Compound:4024620|FD-Score:3.90|P-value:2.75E-5 ID:SGTC_2006|Compound:4011487|FD-Score:4.68|P-value:6.38E-7 ID:SGTC_2010|Compound:4012422|FD-Score:-3.92|P-value:2.69E-5 ID:SGTC_2258|Compound:7960471|FD-Score:-3.62|P-value:9.58E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:3.04|P-value:8.37E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.03|P-value:8.53E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.35|P-value:2.68E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.17|P-value:5.47E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.13|P-value:6.28E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:5.46|P-value:8.09E-9 ID:SGTC_2831|Compound:7999036|FD-Score:-3.14|P-value:6.15E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.82|P-value:4.03E-5 ID:SGTC_3082|Compound:9117008|FD-Score:3.22|P-value:4.34E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.13|P-value:6.09E-4 ID:SGTC_3330|Compound:9141424|FD-Score:4.20|P-value:7.00E-6 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.10|P-value:6.81E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-4.44|P-value:2.36E-6 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.95|P-value:2.36E-5 ID:SGTC_459|Compound:nigericin|FD-Score:-3.35|P-value:2.82E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.05|P-value:7.94E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.11|P-value:6.39E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.00|P-value:9.38E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.16|P-value:5.57E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.22|P-value:4.30E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.57|P-value:1.10E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:-4.03|P-value:1.62E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.04|P-value:8.32E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:-4.14|P-value:1.00E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.31|P-value:3.09E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.14|P-value:5.71E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.00|P-value:1.75E-5 ID:SGTC_1678|Compound:st019265|FD-Score:4.42|P-value:2.42E-6 ID:SGTC_1726|Compound:st035556|FD-Score:4.33|P-value:3.85E-6 ID:SGTC_1900|Compound:st060200|FD-Score:-3.63|P-value:9.00E-5 ID:SGTC_1953|Compound:st076800|FD-Score:4.21|P-value:6.80E-6 ID:SGTC_2005|Compound:4024620|FD-Score:3.90|P-value:2.75E-5 ID:SGTC_2006|Compound:4011487|FD-Score:4.68|P-value:6.38E-7 ID:SGTC_2010|Compound:4012422|FD-Score:-3.92|P-value:2.69E-5 ID:SGTC_2258|Compound:7960471|FD-Score:-3.62|P-value:9.58E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:3.04|P-value:8.37E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.03|P-value:8.53E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.35|P-value:2.68E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.17|P-value:5.47E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.13|P-value:6.28E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:5.46|P-value:8.09E-9 ID:SGTC_2831|Compound:7999036|FD-Score:-3.14|P-value:6.15E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.82|P-value:4.03E-5 ID:SGTC_3082|Compound:9117008|FD-Score:3.22|P-value:4.34E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.13|P-value:6.09E-4 ID:SGTC_3330|Compound:9141424|FD-Score:4.20|P-value:7.00E-6

Top fitness defect scores for YJL106W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2757 clomiphene 5.46 4.2 µM 8.09E-9 fatty acid desaturase (OLE1) 14 2.33E-8
2 SGTC_2006 4011487 4.68 200.0 µM 6.38E-7 endomembrane recycling 61 1.40E-6
3 SGTC_1678 st019265 4.42 80.2 µM 2.42E-6 60S ribosome export 12 4.91E-6
4 SGTC_1726 st035556 4.33 14.6 µM 3.85E-6 29 7.60E-6
5 SGTC_1953 st076800 4.21 12.1 µM 6.80E-6 41 1.30E-5
6 SGTC_3330 9141424 4.20 71.4 µM 7.00E-6 amide catabolism 14 1.33E-5
7 SGTC_1367 1812-0510 4.00 76.9 µM 1.75E-5 19 3.15E-5
8 SGTC_2005 4024620 3.90 188.0 µM 2.75E-5 20 4.82E-5
9 SGTC_1172 0370-0043 3.57 85.0 µM 1.10E-4 34 1.78E-4
10 SGTC_2604 4'-hydroxychalcone 3.35 11.3 µM 2.68E-4 61 4.10E-4
11 SGTC_1291 0993-0025 3.31 5.8 µM 3.09E-4 22 4.67E-4
12 SGTC_1109 tnp00067 3.22 928.3 nM 4.30E-4 39 6.38E-4
13 SGTC_3082 9117008 3.22 49.5 µM 4.34E-4 43 6.44E-4
14 SGTC_1342 1486-1464 3.14 234.0 µM 5.71E-4 49 8.34E-4
15 SGTC_3211 9128781 3.13 49.5 µM 6.09E-4 113 8.86E-4
16 SGTC_771 0250-0039 3.11 27.3 µM 6.39E-4 35 9.27E-4
17 SGTC_416 estradiol valerate 3.10 100.0 µM 6.81E-4 40 9.84E-4
18 SGTC_551 k048-0028 3.05 34.9 µM 7.94E-4 59 0.00114
19 SGTC_1267 0828-0272 3.04 9.5 µM 8.32E-4 55 0.00119
20 SGTC_2515 chrysin 3.04 20.8 µM 8.37E-4 RPP1 & pyrimidine depletion 33 0.00119

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.24E-12 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.122 1.29E-12 YLR211C_p YLR211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
0.109 2.60E-10 YGR177C ATF2 hom Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking
0.105 1.18E-9 YFL030W AGX1 hom Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
0.104 1.63E-9 YDR258C HSP78 hom Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates
0.102 3.39E-9 YCR006C_d YCR006C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.097 1.59E-8 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.096 2.60E-8 YAR031W PRM9 hom Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family
0.094 5.13E-8 YOR060C SLD7 het Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
0.094 5.37E-8 YBR265W TSC10 het 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
0.088 3.76E-7 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.085 9.06E-7 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.084 1.17E-6 YPR093C ASR1 hom Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein
0.083 1.61E-6 YOR118W RTC5 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity
0.083 1.65E-6 YBR014C GRX7 hom Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication