YJL107C_p

Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL107C / YJL107C

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:-3.38|P-value:1.57E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:4.12|P-value:5.11E-6 ID:SGTC_121|Compound:0557-0495|FD-Score:2.92|P-value:8.77E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.17|P-value:3.65E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.44|P-value:1.16E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:2.93|P-value:8.36E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-2.94|P-value:8.82E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:2.89|P-value:9.99E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:2.89|P-value:9.90E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.54|P-value:7.69E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:2.91|P-value:9.21E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:5.63|P-value:8.49E-10 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.07|P-value:4.98E-4 ID:SGTC_1530|Compound:rhein|FD-Score:2.90|P-value:9.34E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.15|P-value:3.98E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.62|P-value:5.42E-5 ID:SGTC_1989|Compound:st071868|FD-Score:3.33|P-value:1.81E-4 ID:SGTC_2034|Compound:5197015|FD-Score:2.91|P-value:9.14E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.07|P-value:5.14E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.58|P-value:6.26E-5 ID:SGTC_2263|Compound:7948595|FD-Score:3.37|P-value:1.56E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.33|P-value:1.80E-6 ID:SGTC_2463|Compound:5473429|FD-Score:3.31|P-value:1.99E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.24|P-value:2.62E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.24|P-value:2.57E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-4.11|P-value:5.82E-6 ID:SGTC_2505|Compound:galangin|FD-Score:2.96|P-value:7.57E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.76|P-value:2.83E-5 ID:SGTC_2803|Compound:7707263|FD-Score:2.95|P-value:7.81E-4 ID:SGTC_2831|Compound:7999036|FD-Score:2.92|P-value:8.77E-4 ID:SGTC_2909|Compound:7941780|FD-Score:2.94|P-value:8.08E-4 ID:SGTC_2921|Compound:7974240|FD-Score:2.90|P-value:9.33E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.38|P-value:1.57E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:4.12|P-value:5.11E-6 ID:SGTC_121|Compound:0557-0495|FD-Score:2.92|P-value:8.77E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.17|P-value:3.65E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.44|P-value:1.16E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:2.93|P-value:8.36E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-2.94|P-value:8.82E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:2.89|P-value:9.99E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:2.89|P-value:9.90E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.54|P-value:7.69E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:2.91|P-value:9.21E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:5.63|P-value:8.49E-10 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.07|P-value:4.98E-4 ID:SGTC_1530|Compound:rhein|FD-Score:2.90|P-value:9.34E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.15|P-value:3.98E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.62|P-value:5.42E-5 ID:SGTC_1989|Compound:st071868|FD-Score:3.33|P-value:1.81E-4 ID:SGTC_2034|Compound:5197015|FD-Score:2.91|P-value:9.14E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.07|P-value:5.14E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.58|P-value:6.26E-5 ID:SGTC_2263|Compound:7948595|FD-Score:3.37|P-value:1.56E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.33|P-value:1.80E-6 ID:SGTC_2463|Compound:5473429|FD-Score:3.31|P-value:1.99E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.24|P-value:2.62E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.24|P-value:2.57E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-4.11|P-value:5.82E-6 ID:SGTC_2505|Compound:galangin|FD-Score:2.96|P-value:7.57E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.76|P-value:2.83E-5 ID:SGTC_2803|Compound:7707263|FD-Score:2.95|P-value:7.81E-4 ID:SGTC_2831|Compound:7999036|FD-Score:2.92|P-value:8.77E-4 ID:SGTC_2909|Compound:7941780|FD-Score:2.94|P-value:8.08E-4 ID:SGTC_2921|Compound:7974240|FD-Score:2.90|P-value:9.33E-4

Top fitness defect scores for YJL107C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1375 2910-0797 5.63 186.0 µM 8.49E-10 7 8.88E-9
2 SGTC_2268 7933382 4.33 153.8 µM 1.80E-6 30 7.45E-6
3 SGTC_61 0978-8327 4.12 98.6 µM 5.11E-6 ergosterol biosynthesis 30 1.87E-5
4 SGTC_2639 lactacystin 3.76 53.0 µM 2.83E-5 32 8.42E-5
5 SGTC_1767 st044992 3.62 70.3 µM 5.42E-5 28 1.49E-4
6 SGTC_2136 5328288 3.58 199.3 µM 6.26E-5 28 1.69E-4
7 SGTC_1121 fusaric acid 3.54 630.5 nM 7.69E-5 48 2.03E-4
8 SGTC_306 1672-3436 3.44 11.6 µM 1.16E-4 Golgi 27 2.92E-4
9 SGTC_2263 7948595 3.37 193.3 µM 1.56E-4 19 3.80E-4
10 SGTC_1989 st071868 3.33 50.2 µM 1.81E-4 24 4.33E-4
11 SGTC_2463 5473429 3.31 200.0 µM 1.99E-4 ERG2 35 4.71E-4
12 SGTC_2495 cafestol 3.24 54.5 µM 2.57E-4 Golgi 55 5.89E-4
13 SGTC_2466 5983409 3.24 37.1 µM 2.62E-4 43 6.00E-4
14 SGTC_1379 2144-0755 3.07 36.5 µM 4.98E-4 53 0.00105
15 SGTC_2097 5376186 3.07 200.0 µM 5.14E-4 65 0.00109
16 SGTC_2505 galangin 2.96 7.9 µM 7.57E-4 RPP1 & pyrimidine depletion 33 0.00153
17 SGTC_2803 7707263 2.95 71.4 µM 7.81E-4 73 0.00157
18 SGTC_2909 7941780 2.94 10.5 µM 8.08E-4 56 0.00162
19 SGTC_426 0988-0037 2.93 14.6 µM 8.36E-4 ERAD & cell cycle 88 0.00167
20 SGTC_2831 7999036 2.92 19.5 µM 8.77E-4 116 0.00174

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 2.11E-16 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.138 1.14E-15 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.134 6.97E-15 YEL023C_p YEL023C_p hom Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene
0.124 6.81E-13 YJL064W_d YJL064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1
0.122 1.09E-12 YKL222C YKL222C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
0.122 1.35E-12 YLR129W DIP2 het Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
0.119 5.63E-12 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.115 2.74E-11 YOR257W CDC31 het Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
0.109 2.48E-10 YMR167W MLH1 hom Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer
0.099 9.85E-9 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.098 1.12E-8 YHR076W PTC7 hom Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope
0.086 5.61E-7 YHR137W ARO9 hom Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
0.085 7.78E-7 YER036C ARB1 het ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
0.083 1.47E-6 YJR004C SAG1 hom Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
0.081 2.55E-6 YOR186W_p YOR186W_p hom Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication