YJL108C / PRM10

Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL108C / PRM10

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.98|P-value:7.16E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:3.74|P-value:1.77E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.40|P-value:5.01E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:5.56|P-value:5.16E-8 ID:SGTC_160|Compound:3453-0671|FD-Score:6.18|P-value:1.64E-9 ID:SGTC_161|Compound:4065-0411|FD-Score:-3.97|P-value:6.13E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:5.15|P-value:4.14E-7 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.64|P-value:2.14E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:4.59|P-value:5.78E-6 ID:SGTC_709|Compound:3807-1509|FD-Score:3.59|P-value:3.06E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:4.09|P-value:4.70E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:3.86|P-value:1.13E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.79|P-value:1.49E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.39|P-value:6.08E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.61|P-value:2.78E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.29|P-value:8.56E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.47|P-value:4.60E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.27|P-value:9.06E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.44|P-value:5.03E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:-4.10|P-value:3.75E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.68|P-value:1.85E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.29|P-value:8.33E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-3.88|P-value:8.80E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.27|P-value:9.05E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.37|P-value:6.39E-4 ID:SGTC_2446|Compound:5162541|FD-Score:3.70|P-value:2.04E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-4.33|P-value:1.44E-5 ID:SGTC_2486|Compound:5283202|FD-Score:3.42|P-value:5.53E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.51|P-value:4.03E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.53|P-value:3.78E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.64|P-value:2.53E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.53|P-value:3.80E-4 ID:SGTC_2979|Compound:9012552|FD-Score:3.77|P-value:1.57E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.33|P-value:7.49E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.53|P-value:3.22E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.24|P-value:9.97E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.98|P-value:7.16E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:3.74|P-value:1.77E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.40|P-value:5.01E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:5.56|P-value:5.16E-8 ID:SGTC_160|Compound:3453-0671|FD-Score:6.18|P-value:1.64E-9 ID:SGTC_161|Compound:4065-0411|FD-Score:-3.97|P-value:6.13E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:5.15|P-value:4.14E-7 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.64|P-value:2.14E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:4.59|P-value:5.78E-6 ID:SGTC_709|Compound:3807-1509|FD-Score:3.59|P-value:3.06E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:4.09|P-value:4.70E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:3.86|P-value:1.13E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.79|P-value:1.49E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.39|P-value:6.08E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.61|P-value:2.78E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.29|P-value:8.56E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.47|P-value:4.60E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.27|P-value:9.06E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.44|P-value:5.03E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:-4.10|P-value:3.75E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.68|P-value:1.85E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.29|P-value:8.33E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-3.88|P-value:8.80E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.27|P-value:9.05E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.37|P-value:6.39E-4 ID:SGTC_2446|Compound:5162541|FD-Score:3.70|P-value:2.04E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-4.33|P-value:1.44E-5 ID:SGTC_2486|Compound:5283202|FD-Score:3.42|P-value:5.53E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.51|P-value:4.03E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.53|P-value:3.78E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.64|P-value:2.53E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.53|P-value:3.80E-4 ID:SGTC_2979|Compound:9012552|FD-Score:3.77|P-value:1.57E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.33|P-value:7.49E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.53|P-value:3.22E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.24|P-value:9.97E-4

Top fitness defect scores for YJL108C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_160 3453-0671 6.18 289.7 µM 1.64E-9 8 3.21E-10
2 SGTC_147 4466-0538 5.56 29.2 µM 5.16E-8 ergosterol biosynthesis 5 1.35E-8
3 SGTC_170 4197-0004 5.15 226.0 µM 4.14E-7 6 1.30E-7
4 SGTC_693 4161-2696 4.59 114.0 µM 5.78E-6 3 2.26E-6
5 SGTC_760 0568-0725 4.09 82.9 µM 4.70E-5 9 2.19E-5
6 SGTC_6 0844-0013 3.98 19.8 µM 7.16E-5 85 3.45E-5
7 SGTC_999 4022-0066 3.86 22.7 µM 1.13E-4 Golgi 48 5.66E-5
8 SGTC_1131 3454-3128 3.79 32.3 µM 1.49E-4 52 7.64E-5
9 SGTC_2979 9012552 3.77 45.5 µM 1.57E-4 11 8.08E-5
10 SGTC_50 0929-0078 3.74 56.4 µM 1.77E-4 56 9.22E-5
11 SGTC_2446 5162541 3.70 200.0 µM 2.04E-4 13 1.07E-4
12 SGTC_2782 7736369 3.64 71.4 µM 2.53E-4 53 1.35E-4
13 SGTC_1154 4088-0362 3.61 150.0 µM 2.78E-4 32 1.50E-4
14 SGTC_709 3807-1509 3.59 243.0 µM 3.06E-4 RSC complex & mRNA processing 25 1.67E-4
15 SGTC_2781 5567276 3.53 71.4 µM 3.78E-4 72 2.10E-4
16 SGTC_2855 9016525 3.53 58.4 µM 3.80E-4 31 2.10E-4
17 SGTC_2516 gossypol 3.51 71.5 µM 4.03E-4 25 2.24E-4
18 SGTC_1358 1509-0022 3.47 2.5 µM 4.60E-4 23 2.59E-4
19 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 3.44 61.9 µM 5.03E-4 33 2.86E-4
20 SGTC_2486 5283202 3.42 22.4 µM 5.53E-4 59 3.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.83E-10 YLL052C AQY2 hom Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
0.106 6.19E-10 YOR308C SNU66 hom Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1
0.104 1.39E-9 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.104 1.74E-9 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.103 2.43E-9 YDR068W DOS2 hom Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.094 5.13E-8 YNL113W RPC19 het RNA polymerase subunit AC19, common to RNA polymerases I and III
0.090 1.67E-7 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.089 2.10E-7 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.089 2.42E-7 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.088 2.94E-7 YJR051W OSM1 hom Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication
0.087 3.99E-7 YIL131C FKH1 hom Forkhead family transcription factor; has a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; binds to the recombination enhancer near HML, and regulates donor preference during mating-type switching by positioning HML near the MAT locus through FHA-domain mediated interactions with proteins near the DSB; FKH1 has a paralog, FKH2, that arose from the whole genome duplication
0.087 4.06E-7 YMR145C NDE1 hom Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
0.085 9.07E-7 YKR047W_d YKR047W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1
0.084 1.21E-6 YGR242W_d YGR242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
0.083 1.47E-6 YKL102C_d YKL102C_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site