YJL110C / GZF3

GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL110C / GZF3

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.75|P-value:2.35E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.68|P-value:4.24E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.72|P-value:2.60E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:3.72|P-value:2.66E-4 ID:SGTC_480|Compound:am 92016|FD-Score:4.56|P-value:1.14E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.70|P-value:3.95E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:12.40|P-value:1.92E-30 ID:SGTC_745|Compound:0469-0705|FD-Score:3.84|P-value:1.72E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.96|P-value:1.63E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:4.50|P-value:1.42E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:-5.76|P-value:7.31E-8 ID:SGTC_912|Compound:3474-0017|FD-Score:6.65|P-value:3.68E-10 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:6.99|P-value:4.66E-11 ID:SGTC_917|Compound:harmaline|FD-Score:5.61|P-value:9.55E-8 ID:SGTC_919|Compound:tnp00227|FD-Score:4.16|P-value:5.37E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.95|P-value:1.63E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.41|P-value:2.04E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.93|P-value:1.75E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.04|P-value:8.42E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.71|P-value:6.10E-6 ID:SGTC_1303|Compound:1160-0052|FD-Score:-4.45|P-value:2.54E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.49|P-value:5.76E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.50|P-value:5.48E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.99|P-value:1.02E-4 ID:SGTC_1964|Compound:st076914|FD-Score:4.00|P-value:9.87E-5 ID:SGTC_1974|Compound:st069448|FD-Score:3.70|P-value:2.81E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.68|P-value:3.00E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-4.85|P-value:4.91E-6 ID:SGTC_2063|Compound:5246145|FD-Score:-5.84|P-value:5.06E-8 ID:SGTC_2067|Compound:5224629|FD-Score:-3.70|P-value:3.89E-4 ID:SGTC_2105|Compound:5350118|FD-Score:10.10|P-value:5.47E-21 ID:SGTC_2107|Compound:5363541|FD-Score:-5.09|P-value:1.76E-6 ID:SGTC_2111|Compound:5486399|FD-Score:-3.68|P-value:4.21E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-4.31|P-value:4.35E-5 ID:SGTC_2116|Compound:5511452|FD-Score:5.13|P-value:9.58E-7 ID:SGTC_2118|Compound:5526350|FD-Score:-3.56|P-value:6.19E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-5.38|P-value:4.75E-7 ID:SGTC_2425|Compound:5628681|FD-Score:4.31|P-value:3.04E-5 ID:SGTC_2705|Compound:st078069|FD-Score:3.34|P-value:9.08E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.44|P-value:6.70E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.68|P-value:3.06E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.49|P-value:5.60E-4 ID:SGTC_2878|Compound:9043973|FD-Score:4.24|P-value:4.05E-5 ID:SGTC_2947|Compound:9072639|FD-Score:4.79|P-value:4.26E-6 ID:SGTC_3147|Compound:9097027|FD-Score:4.15|P-value:5.75E-5 ID:SGTC_3217|Compound:9129673|FD-Score:7.16|P-value:1.67E-11 ID:SGTC_6|Compound:0844-0013|FD-Score:3.75|P-value:2.35E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.68|P-value:4.24E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.72|P-value:2.60E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:3.72|P-value:2.66E-4 ID:SGTC_480|Compound:am 92016|FD-Score:4.56|P-value:1.14E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.70|P-value:3.95E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:12.40|P-value:1.92E-30 ID:SGTC_745|Compound:0469-0705|FD-Score:3.84|P-value:1.72E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.96|P-value:1.63E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:4.50|P-value:1.42E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:-5.76|P-value:7.31E-8 ID:SGTC_912|Compound:3474-0017|FD-Score:6.65|P-value:3.68E-10 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:6.99|P-value:4.66E-11 ID:SGTC_917|Compound:harmaline|FD-Score:5.61|P-value:9.55E-8 ID:SGTC_919|Compound:tnp00227|FD-Score:4.16|P-value:5.37E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.95|P-value:1.63E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.41|P-value:2.04E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.93|P-value:1.75E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.04|P-value:8.42E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.71|P-value:6.10E-6 ID:SGTC_1303|Compound:1160-0052|FD-Score:-4.45|P-value:2.54E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.49|P-value:5.76E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.50|P-value:5.48E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.99|P-value:1.02E-4 ID:SGTC_1964|Compound:st076914|FD-Score:4.00|P-value:9.87E-5 ID:SGTC_1974|Compound:st069448|FD-Score:3.70|P-value:2.81E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.68|P-value:3.00E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-4.85|P-value:4.91E-6 ID:SGTC_2063|Compound:5246145|FD-Score:-5.84|P-value:5.06E-8 ID:SGTC_2067|Compound:5224629|FD-Score:-3.70|P-value:3.89E-4 ID:SGTC_2105|Compound:5350118|FD-Score:10.10|P-value:5.47E-21 ID:SGTC_2107|Compound:5363541|FD-Score:-5.09|P-value:1.76E-6 ID:SGTC_2111|Compound:5486399|FD-Score:-3.68|P-value:4.21E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-4.31|P-value:4.35E-5 ID:SGTC_2116|Compound:5511452|FD-Score:5.13|P-value:9.58E-7 ID:SGTC_2118|Compound:5526350|FD-Score:-3.56|P-value:6.19E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-5.38|P-value:4.75E-7 ID:SGTC_2425|Compound:5628681|FD-Score:4.31|P-value:3.04E-5 ID:SGTC_2705|Compound:st078069|FD-Score:3.34|P-value:9.08E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.44|P-value:6.70E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.68|P-value:3.06E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.49|P-value:5.60E-4 ID:SGTC_2878|Compound:9043973|FD-Score:4.24|P-value:4.05E-5 ID:SGTC_2947|Compound:9072639|FD-Score:4.79|P-value:4.26E-6 ID:SGTC_3147|Compound:9097027|FD-Score:4.15|P-value:5.75E-5 ID:SGTC_3217|Compound:9129673|FD-Score:7.16|P-value:1.67E-11

Top fitness defect scores for YJL110C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_690 glyoxal 12.40 20.3 µM 1.92E-30 10 2.31E-35
2 SGTC_2105 5350118 10.10 200.0 µM 5.47E-21 1 3.00E-24
3 SGTC_3217 9129673 7.16 49.5 µM 1.67E-11 2 4.00E-13
4 SGTC_915 methyl methanesulfonate (MMS) 6.99 110.0 mM 4.66E-11 DNA damage response 7 1.33E-12
5 SGTC_912 3474-0017 6.65 2.2 µM 3.68E-10 2 1.49E-11
6 SGTC_917 harmaline 5.61 728.1 nM 9.55E-8 ergosterol biosynthesis 7 9.88E-9
7 SGTC_2116 5511452 5.13 16.9 µM 9.58E-7 3 1.45E-7
8 SGTC_2947 9072639 4.79 7.7 µM 4.26E-6 tubulin folding & SWR complex 21 8.26E-7
9 SGTC_1083 didemethylchlorpromazine sulfoxide 4.71 707.4 nM 6.10E-6 redox potentiating 51 1.25E-6
10 SGTC_480 am 92016 4.56 50.0 µM 1.14E-5 5 2.58E-6
11 SGTC_752 1896-0090 4.50 130.0 µM 1.42E-5 TSC3-RPN4 8 3.35E-6
12 SGTC_999 4022-0066 4.41 22.7 µM 2.04E-5 Golgi 30 5.09E-6
13 SGTC_2425 5628681 4.31 7.8 µM 3.04E-5 12 8.13E-6
14 SGTC_2878 9043973 4.24 26.0 µM 4.05E-5 15 1.13E-5
15 SGTC_919 tnp00227 4.16 403.6 nM 5.37E-5 RNA pol III & RNase P/MRP 30 1.57E-5
16 SGTC_3147 9097027 4.15 49.5 µM 5.75E-5 17 1.70E-5
17 SGTC_1062 mesoridazine 4.04 14.2 µM 8.42E-5 18 2.65E-5
18 SGTC_1964 st076914 4.00 61.0 µM 9.87E-5 RPP1 & pyrimidine depletion 18 3.18E-5
19 SGTC_1855 st056195 3.99 39.6 µM 1.02E-4 60S ribosome export 20 3.30E-5
20 SGTC_745 0469-0705 3.84 296.0 µM 1.72E-4 mitochondrial processes 25 6.05E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.199 3.33E-31 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.175 1.85E-24 YOR364W_d YOR364W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
0.170 3.92E-23 YBL024W NCL1 hom S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120
0.160 1.07E-20 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.154 2.60E-19 YNR031C SSK2 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress
0.152 7.65E-19 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene
0.143 7.75E-17 YLR113W HOG1 hom Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress
0.141 2.09E-16 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.124 4.72E-13 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.122 1.34E-12 YNL307C MCK1 hom Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family
0.117 1.01E-11 YGR191W HIP1 het High-affinity histidine permease, also involved in the transport of manganese ions
0.113 5.68E-11 YML113W DAT1 hom DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability
0.113 5.95E-11 YGL087C MMS2 hom Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress
0.108 3.38E-10 YGL133W ITC1 hom Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex
0.107 4.40E-10 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C