YJL111W / CCT7

Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL111W / CCT7

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:5.03|P-value:8.39E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:4.85|P-value:1.45E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:4.60|P-value:2.90E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:-4.18|P-value:6.53E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.37|P-value:5.44E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:4.31|P-value:6.48E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:6.17|P-value:1.89E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:5.53|P-value:1.71E-5 ID:SGTC_229|Compound:benomyl|FD-Score:5.97|P-value:3.84E-6 ID:SGTC_245|Compound:methotrexate|FD-Score:-4.80|P-value:1.14E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:-6.05|P-value:1.86E-6 ID:SGTC_253|Compound:dyclonine|FD-Score:4.58|P-value:3.10E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:-4.10|P-value:8.06E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:-4.40|P-value:3.66E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-4.11|P-value:7.83E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.26|P-value:5.31E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-9.38|P-value:4.43E-13 ID:SGTC_435|Compound:c-PAF|FD-Score:4.20|P-value:8.64E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-10.30|P-value:2.56E-15 ID:SGTC_601|Compound:0986-0029|FD-Score:-4.76|P-value:1.30E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-4.92|P-value:8.13E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:-4.48|P-value:2.94E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:-5.10|P-value:4.65E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:-4.68|P-value:1.63E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:-4.07|P-value:8.76E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:-5.65|P-value:7.67E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:-6.05|P-value:1.85E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.44|P-value:3.22E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:-6.09|P-value:1.58E-6 ID:SGTC_806|Compound:3966-4455|FD-Score:4.29|P-value:6.77E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:-5.57|P-value:9.99E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:-4.13|P-value:7.48E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:6.62|P-value:3.37E-7 ID:SGTC_892|Compound:0929-0076|FD-Score:-4.37|P-value:3.98E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:-6.67|P-value:1.72E-7 ID:SGTC_945|Compound:3381-0768|FD-Score:4.67|P-value:2.40E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-4.62|P-value:1.98E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:-4.16|P-value:6.91E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:6.84|P-value:1.41E-7 ID:SGTC_1015|Compound:4130-4525|FD-Score:-4.02|P-value:9.98E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:5.82|P-value:6.49E-6 ID:SGTC_1057|Compound:3448-5381|FD-Score:-6.96|P-value:5.28E-8 ID:SGTC_1064|Compound:honokiol|FD-Score:4.56|P-value:3.24E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.59|P-value:3.06E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-4.20|P-value:6.23E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:5.05|P-value:7.85E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.68|P-value:2.35E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-4.56|P-value:2.36E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:-5.49|P-value:1.31E-5 ID:SGTC_1405|Compound:3909-7894|FD-Score:-7.10|P-value:2.94E-8 ID:SGTC_1406|Compound:3909-7906|FD-Score:-7.73|P-value:1.85E-9 ID:SGTC_1407|Compound:3909-7909|FD-Score:-5.45|P-value:1.48E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:-4.25|P-value:5.52E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:5.24|P-value:4.35E-5 ID:SGTC_1547|Compound:harmine|FD-Score:-4.14|P-value:7.40E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-4.71|P-value:1.49E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:5.78|P-value:7.35E-6 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-4.99|P-value:6.60E-5 ID:SGTC_1607|Compound:st000305|FD-Score:-5.28|P-value:2.63E-5 ID:SGTC_1622|Compound:st003707|FD-Score:4.75|P-value:1.92E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-4.18|P-value:6.52E-4 ID:SGTC_1641|Compound:st009299|FD-Score:4.16|P-value:9.53E-4 ID:SGTC_1643|Compound:st009866|FD-Score:5.78|P-value:7.50E-6 ID:SGTC_1661|Compound:st013063|FD-Score:5.26|P-value:4.15E-5 ID:SGTC_1731|Compound:st035964|FD-Score:-4.38|P-value:3.83E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-6.36|P-value:5.78E-7 ID:SGTC_1757|Compound:st041620|FD-Score:-7.10|P-value:2.91E-8 ID:SGTC_1766|Compound:st045414|FD-Score:-4.75|P-value:1.34E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.80|P-value:1.15E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-4.21|P-value:6.07E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-5.53|P-value:1.13E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.29|P-value:1.19E-6 ID:SGTC_1880|Compound:MG-132|FD-Score:-5.96|P-value:2.57E-6 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-4.10|P-value:8.17E-4 ID:SGTC_1953|Compound:st076800|FD-Score:4.97|P-value:1.00E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-4.12|P-value:7.79E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-5.17|P-value:3.67E-5 ID:SGTC_1981|Compound:st071826|FD-Score:4.39|P-value:5.21E-4 ID:SGTC_1982|Compound:st072467|FD-Score:5.37|P-value:2.90E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-4.31|P-value:4.63E-4 ID:SGTC_2065|Compound:5221596|FD-Score:6.04|P-value:2.98E-6 ID:SGTC_2067|Compound:5224629|FD-Score:5.18|P-value:5.25E-5 ID:SGTC_2089|Compound:5281248|FD-Score:6.34|P-value:9.84E-7 ID:SGTC_2174|Compound:5790901|FD-Score:6.84|P-value:1.40E-7 ID:SGTC_2177|Compound:5811945|FD-Score:-4.08|P-value:8.66E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.36|P-value:5.60E-4 ID:SGTC_2319|Compound:6033012|FD-Score:4.25|P-value:7.53E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:7.36|P-value:1.59E-8 ID:SGTC_2411|Compound:st077133|FD-Score:-4.91|P-value:8.29E-5 ID:SGTC_2413|Compound:inermin|FD-Score:-8.20|P-value:1.93E-10 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.43|P-value:3.35E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-4.18|P-value:6.56E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-4.22|P-value:5.92E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:4.61|P-value:2.83E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.92|P-value:8.11E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.37|P-value:3.93E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-5.46|P-value:1.45E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:4.66|P-value:2.46E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-7.97|P-value:5.76E-10 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.18|P-value:9.02E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-9.35|P-value:5.11E-13 ID:SGTC_2776|Compound:terbinafine|FD-Score:-7.02|P-value:4.10E-8 ID:SGTC_2779|Compound:methotrexate|FD-Score:-5.40|P-value:1.78E-5 ID:SGTC_2838|Compound:9002687|FD-Score:5.85|P-value:5.76E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-4.19|P-value:6.41E-4 ID:SGTC_2913|Compound:7966556|FD-Score:-4.21|P-value:6.11E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.27|P-value:7.24E-4 ID:SGTC_2981|Compound:9013952|FD-Score:6.75|P-value:2.02E-7 ID:SGTC_2983|Compound:9022671|FD-Score:5.09|P-value:6.93E-5 ID:SGTC_3222|Compound:9128301|FD-Score:-4.08|P-value:8.59E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:5.03|P-value:8.39E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:4.85|P-value:1.45E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:4.60|P-value:2.90E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:-4.18|P-value:6.53E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.37|P-value:5.44E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:4.31|P-value:6.48E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:6.17|P-value:1.89E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:5.53|P-value:1.71E-5 ID:SGTC_229|Compound:benomyl|FD-Score:5.97|P-value:3.84E-6 ID:SGTC_245|Compound:methotrexate|FD-Score:-4.80|P-value:1.14E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:-6.05|P-value:1.86E-6 ID:SGTC_253|Compound:dyclonine|FD-Score:4.58|P-value:3.10E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:-4.10|P-value:8.06E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:-4.40|P-value:3.66E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-4.11|P-value:7.83E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.26|P-value:5.31E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-9.38|P-value:4.43E-13 ID:SGTC_435|Compound:c-PAF|FD-Score:4.20|P-value:8.64E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-10.30|P-value:2.56E-15 ID:SGTC_601|Compound:0986-0029|FD-Score:-4.76|P-value:1.30E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-4.92|P-value:8.13E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:-4.48|P-value:2.94E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:-5.10|P-value:4.65E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:-4.68|P-value:1.63E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:-4.07|P-value:8.76E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:-5.65|P-value:7.67E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:-6.05|P-value:1.85E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.44|P-value:3.22E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:-6.09|P-value:1.58E-6 ID:SGTC_806|Compound:3966-4455|FD-Score:4.29|P-value:6.77E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:-5.57|P-value:9.99E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:-4.13|P-value:7.48E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:6.62|P-value:3.37E-7 ID:SGTC_892|Compound:0929-0076|FD-Score:-4.37|P-value:3.98E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:-6.67|P-value:1.72E-7 ID:SGTC_945|Compound:3381-0768|FD-Score:4.67|P-value:2.40E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-4.62|P-value:1.98E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:-4.16|P-value:6.91E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:6.84|P-value:1.41E-7 ID:SGTC_1015|Compound:4130-4525|FD-Score:-4.02|P-value:9.98E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:5.82|P-value:6.49E-6 ID:SGTC_1057|Compound:3448-5381|FD-Score:-6.96|P-value:5.28E-8 ID:SGTC_1064|Compound:honokiol|FD-Score:4.56|P-value:3.24E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.59|P-value:3.06E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-4.20|P-value:6.23E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:5.05|P-value:7.85E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.68|P-value:2.35E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-4.56|P-value:2.36E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:-5.49|P-value:1.31E-5 ID:SGTC_1405|Compound:3909-7894|FD-Score:-7.10|P-value:2.94E-8 ID:SGTC_1406|Compound:3909-7906|FD-Score:-7.73|P-value:1.85E-9 ID:SGTC_1407|Compound:3909-7909|FD-Score:-5.45|P-value:1.48E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:-4.25|P-value:5.52E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:5.24|P-value:4.35E-5 ID:SGTC_1547|Compound:harmine|FD-Score:-4.14|P-value:7.40E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-4.71|P-value:1.49E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:5.78|P-value:7.35E-6 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-4.99|P-value:6.60E-5 ID:SGTC_1607|Compound:st000305|FD-Score:-5.28|P-value:2.63E-5 ID:SGTC_1622|Compound:st003707|FD-Score:4.75|P-value:1.92E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-4.18|P-value:6.52E-4 ID:SGTC_1641|Compound:st009299|FD-Score:4.16|P-value:9.53E-4 ID:SGTC_1643|Compound:st009866|FD-Score:5.78|P-value:7.50E-6 ID:SGTC_1661|Compound:st013063|FD-Score:5.26|P-value:4.15E-5 ID:SGTC_1731|Compound:st035964|FD-Score:-4.38|P-value:3.83E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-6.36|P-value:5.78E-7 ID:SGTC_1757|Compound:st041620|FD-Score:-7.10|P-value:2.91E-8 ID:SGTC_1766|Compound:st045414|FD-Score:-4.75|P-value:1.34E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.80|P-value:1.15E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-4.21|P-value:6.07E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-5.53|P-value:1.13E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.29|P-value:1.19E-6 ID:SGTC_1880|Compound:MG-132|FD-Score:-5.96|P-value:2.57E-6 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-4.10|P-value:8.17E-4 ID:SGTC_1953|Compound:st076800|FD-Score:4.97|P-value:1.00E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-4.12|P-value:7.79E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-5.17|P-value:3.67E-5 ID:SGTC_1981|Compound:st071826|FD-Score:4.39|P-value:5.21E-4 ID:SGTC_1982|Compound:st072467|FD-Score:5.37|P-value:2.90E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-4.31|P-value:4.63E-4 ID:SGTC_2065|Compound:5221596|FD-Score:6.04|P-value:2.98E-6 ID:SGTC_2067|Compound:5224629|FD-Score:5.18|P-value:5.25E-5 ID:SGTC_2089|Compound:5281248|FD-Score:6.34|P-value:9.84E-7 ID:SGTC_2174|Compound:5790901|FD-Score:6.84|P-value:1.40E-7 ID:SGTC_2177|Compound:5811945|FD-Score:-4.08|P-value:8.66E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.36|P-value:5.60E-4 ID:SGTC_2319|Compound:6033012|FD-Score:4.25|P-value:7.53E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:7.36|P-value:1.59E-8 ID:SGTC_2411|Compound:st077133|FD-Score:-4.91|P-value:8.29E-5 ID:SGTC_2413|Compound:inermin|FD-Score:-8.20|P-value:1.93E-10 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.43|P-value:3.35E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-4.18|P-value:6.56E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-4.22|P-value:5.92E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:4.61|P-value:2.83E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.92|P-value:8.11E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.37|P-value:3.93E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-5.46|P-value:1.45E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:4.66|P-value:2.46E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-7.97|P-value:5.76E-10 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.18|P-value:9.02E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-9.35|P-value:5.11E-13 ID:SGTC_2776|Compound:terbinafine|FD-Score:-7.02|P-value:4.10E-8 ID:SGTC_2779|Compound:methotrexate|FD-Score:-5.40|P-value:1.78E-5 ID:SGTC_2838|Compound:9002687|FD-Score:5.85|P-value:5.76E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-4.19|P-value:6.41E-4 ID:SGTC_2913|Compound:7966556|FD-Score:-4.21|P-value:6.11E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.27|P-value:7.24E-4 ID:SGTC_2981|Compound:9013952|FD-Score:6.75|P-value:2.02E-7 ID:SGTC_2983|Compound:9022671|FD-Score:5.09|P-value:6.93E-5 ID:SGTC_3222|Compound:9128301|FD-Score:-4.08|P-value:8.59E-4

Top fitness defect scores for YJL111W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2405 ticlatone 7.36 3.5 µM 1.59E-8 4 8.90E-14 0.24
2 SGTC_2174 5790901 6.84 200.0 µM 1.40E-7 tubulin folding & SWR complex 4 3.87E-12 1.23
3 SGTC_1009 4106-0057 6.84 9.9 µM 1.41E-7 1 3.94E-12 0.88
4 SGTC_2981 9013952 6.75 39.0 µM 2.02E-7 1 7.29E-12 1.76
5 SGTC_887 0885-0007 6.62 9.6 µM 3.37E-7 endomembrane recycling 5 1.78E-11 0.06
6 SGTC_2089 5281248 6.34 129.7 µM 9.84E-7 superoxide 3 1.14E-10 1.17
7 SGTC_1875 nocodazole 6.29 6.0 µM 1.19E-6 tubulin folding & SWR complex 15 1.57E-10 0.36
8 SGTC_176 1486-1328 6.17 72.8 µM 1.89E-6 3 3.52E-10 0.92
9 SGTC_2065 5221596 6.04 34.3 µM 2.98E-6 1 7.71E-10 1.40
10 SGTC_229 benomyl 5.97 22.9 µM 3.84E-6 tubulin folding & SWR complex 9 1.19E-9 0.12
11 SGTC_2838 9002687 5.85 71.4 µM 5.76E-6 fatty acid desaturase (OLE1) 6 2.41E-9 0.34
12 SGTC_1023 4482-3888 5.82 16.0 µM 6.49E-6 TSC3-RPN4 3 2.97E-9 0.95
13 SGTC_1585 2',4'-dihydroxychalcone 5.78 10.4 µM 7.35E-6 4 3.68E-9 0.86
14 SGTC_1643 st009866 5.78 20.2 µM 7.50E-6 10 3.81E-9 0.21
15 SGTC_180 1486-1293 5.53 102.8 µM 1.71E-5 1 1.58E-8 0.59
16 SGTC_1982 st072467 5.37 71.9 µM 2.90E-5 2 3.93E-8 0.51
17 SGTC_1661 st013063 5.26 9.7 µM 4.15E-5 6 7.29E-8 1.12
18 SGTC_1520 flindersine 5.24 88.0 µM 4.35E-5 3 7.91E-8 0.47
19 SGTC_2067 5224629 5.18 34.1 µM 5.25E-5 8 1.10E-7 1.06
20 SGTC_2983 9022671 5.09 13.0 µM 6.93E-5 60S ribosome export 4 1.76E-7 0.35

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.370 3.11E-109 YJL014W CCT3 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.287 9.17E-65 YIL142W CCT2 het Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.267 8.34E-56 YDL143W CCT4 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.253 3.72E-50 YJR064W CCT5 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.222 9.74E-39 YDR188W CCT6 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
0.216 1.08E-36 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.195 3.96E-30 YDR212W TCP1 het Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.189 2.13E-28 YDR187C_d YDR187C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
0.184 6.63E-27 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.167 2.28E-22 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.165 7.37E-22 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.163 1.71E-21 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.154 2.61E-19 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.153 5.94E-19 YLR163C MAS1 het Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
0.150 2.09E-18 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10