YJL112W / MDV1

Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL112W / MDV1

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:5.09|P-value:1.41E-6 ID:SGTC_65|Compound:0798-0905|FD-Score:3.93|P-value:1.52E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.56|P-value:5.10E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:5.05|P-value:1.68E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:3.43|P-value:8.11E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:4.08|P-value:8.88E-5 ID:SGTC_554|Compound:4483-2211|FD-Score:3.83|P-value:2.15E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.74|P-value:2.87E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.50|P-value:6.10E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:-3.69|P-value:3.29E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.87|P-value:1.84E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.63|P-value:4.19E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.63|P-value:4.04E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.81|P-value:2.19E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-5.11|P-value:1.23E-6 ID:SGTC_769|Compound:0302-0231|FD-Score:-6.23|P-value:4.58E-9 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.88|P-value:1.73E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.89|P-value:3.46E-6 ID:SGTC_1023|Compound:4482-3888|FD-Score:-4.72|P-value:6.70E-6 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.40|P-value:8.37E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:4.14|P-value:6.92E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.94|P-value:1.46E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:-4.18|P-value:5.80E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:5.85|P-value:3.69E-8 ID:SGTC_1652|Compound:st011932|FD-Score:3.67|P-value:3.71E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.71|P-value:3.18E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.73|P-value:3.01E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.91|P-value:1.64E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.48|P-value:6.82E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.91|P-value:1.60E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.43|P-value:8.12E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.69|P-value:3.27E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.40|P-value:8.50E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.56|P-value:5.35E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.68|P-value:3.57E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.54|P-value:5.35E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.74|P-value:2.89E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.71|P-value:3.22E-4 ID:SGTC_3009|Compound:9080819|FD-Score:4.73|P-value:6.78E-6 ID:SGTC_3096|Compound:9117468|FD-Score:3.57|P-value:5.10E-4 ID:SGTC_3253|Compound:9135987|FD-Score:5.40|P-value:3.43E-7 ID:SGTC_18|Compound:0111-0177|FD-Score:5.09|P-value:1.41E-6 ID:SGTC_65|Compound:0798-0905|FD-Score:3.93|P-value:1.52E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.56|P-value:5.10E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:5.05|P-value:1.68E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:3.43|P-value:8.11E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:4.08|P-value:8.88E-5 ID:SGTC_554|Compound:4483-2211|FD-Score:3.83|P-value:2.15E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.74|P-value:2.87E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.50|P-value:6.10E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:-3.69|P-value:3.29E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.87|P-value:1.84E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.63|P-value:4.19E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.63|P-value:4.04E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.81|P-value:2.19E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-5.11|P-value:1.23E-6 ID:SGTC_769|Compound:0302-0231|FD-Score:-6.23|P-value:4.58E-9 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.88|P-value:1.73E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.89|P-value:3.46E-6 ID:SGTC_1023|Compound:4482-3888|FD-Score:-4.72|P-value:6.70E-6 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.40|P-value:8.37E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:4.14|P-value:6.92E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.94|P-value:1.46E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:-4.18|P-value:5.80E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:5.85|P-value:3.69E-8 ID:SGTC_1652|Compound:st011932|FD-Score:3.67|P-value:3.71E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.71|P-value:3.18E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.73|P-value:3.01E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.91|P-value:1.64E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.48|P-value:6.82E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.91|P-value:1.60E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.43|P-value:8.12E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.69|P-value:3.27E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.40|P-value:8.50E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.56|P-value:5.35E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.68|P-value:3.57E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.54|P-value:5.35E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.74|P-value:2.89E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.71|P-value:3.22E-4 ID:SGTC_3009|Compound:9080819|FD-Score:4.73|P-value:6.78E-6 ID:SGTC_3096|Compound:9117468|FD-Score:3.57|P-value:5.10E-4 ID:SGTC_3253|Compound:9135987|FD-Score:5.40|P-value:3.43E-7

Top fitness defect scores for YJL112W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1473 k844-0725 5.85 134.0 µM 3.69E-8 1 2.48E-9
2 SGTC_3253 9135987 5.40 49.5 µM 3.43E-7 60S ribosome export 2 3.41E-8
3 SGTC_18 0111-0177 5.09 500.0 nM 1.41E-6 32 1.79E-7
4 SGTC_115 0527-0192 5.05 112.0 µM 1.68E-6 32 2.20E-7
5 SGTC_1016 4226-1401 4.89 38.0 µM 3.46E-6 RNA pol III & RNase P/MRP 7 5.12E-7
6 SGTC_3009 9080819 4.73 71.4 µM 6.78E-6 7 1.13E-6
7 SGTC_1123 mangostin 4.14 811.3 nM 6.92E-5 mitochondrial response to ROS 31 1.71E-5
8 SGTC_175 3793-3120 4.08 23.7 µM 8.88E-5 12 2.29E-5
9 SGTC_1241 0364-0022 3.94 50.8 µM 1.46E-4 ERG2 29 4.10E-5
10 SGTC_65 0798-0905 3.93 35.0 µM 1.52E-4 calcium & mitochondrial duress 85 4.31E-5
11 SGTC_2423 st077119 3.91 87.2 µM 1.60E-4 10 4.56E-5
12 SGTC_1733 st037357 3.91 54.9 µM 1.64E-4 60S ribosome export 26 4.69E-5
13 SGTC_644 1498-1197 3.87 63.3 µM 1.84E-4 23 5.39E-5
14 SGTC_554 4483-2211 3.83 187.0 µM 2.15E-4 18 6.46E-5
15 SGTC_584 0986-0246 3.74 15.4 µM 2.87E-4 heme requiring 16 9.03E-5
16 SGTC_2837 9008476 3.74 45.5 µM 2.89E-4 43 9.13E-5
17 SGTC_1702 st027038 3.73 51.0 µM 3.01E-4 17 9.58E-5
18 SGTC_1653 st012112 3.71 65.0 µM 3.18E-4 18 1.02E-4
19 SGTC_2870 9038528 3.71 13.0 µM 3.22E-4 22 1.03E-4
20 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 3.68 100.0 µM 3.57E-4 60S ribosome export 27 1.17E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 1.26E-9 YJL167W ERG20 het Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
0.102 3.03E-9 YIL115C NUP159 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
0.098 1.18E-8 YOR004W UTP23 het Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein
0.094 5.53E-8 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.089 2.09E-7 YKL186C MTR2 het mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
0.089 2.71E-7 YOR327C SNC2 hom Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication
0.084 1.22E-6 YDR083W RRP8 hom Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1
0.083 1.48E-6 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.079 4.20E-6 YKL187C FAT3 hom Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.079 4.11E-6 YKL014C URB1 het Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
0.079 4.55E-6 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.077 7.08E-6 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.073 2.34E-5 YBR227C MCX1 hom Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins
0.073 2.52E-5 YBR028C YPK3 hom An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner
0.072 2.73E-5 YPL267W ACM1 hom Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein