YJL115W / ASF1

Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL115W / ASF1

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:-3.71|P-value:3.55E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.91|P-value:1.75E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.71|P-value:7.32E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:3.23|P-value:7.57E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:-3.69|P-value:3.74E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.44|P-value:2.28E-5 ID:SGTC_393|Compound:acivicin|FD-Score:3.31|P-value:5.83E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.51|P-value:2.96E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:-3.56|P-value:5.85E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:-3.52|P-value:6.74E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.41|P-value:4.11E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:-3.56|P-value:5.88E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.28|P-value:6.35E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:-4.16|P-value:6.76E-5 ID:SGTC_1591|Compound:genipin|FD-Score:3.26|P-value:6.83E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.71|P-value:1.44E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.86|P-value:8.14E-5 ID:SGTC_2002|Compound:4023503|FD-Score:-4.79|P-value:5.30E-6 ID:SGTC_2004|Compound:4023728|FD-Score:-3.67|P-value:3.99E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-3.62|P-value:4.81E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.63|P-value:4.64E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-5.05|P-value:1.61E-6 ID:SGTC_2110|Compound:5483698|FD-Score:4.28|P-value:1.58E-5 ID:SGTC_2123|Compound:5259487|FD-Score:4.69|P-value:2.66E-6 ID:SGTC_2282|Compound:7944268|FD-Score:3.23|P-value:7.55E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-3.80|P-value:2.58E-4 ID:SGTC_2369|Compound:9071472|FD-Score:-6.18|P-value:5.35E-9 ID:SGTC_2380|Compound:9035439|FD-Score:-6.47|P-value:1.01E-9 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-6.23|P-value:3.88E-9 ID:SGTC_2407|Compound:paclitaxel|FD-Score:5.23|P-value:2.10E-7 ID:SGTC_2416|Compound:tofa|FD-Score:-3.75|P-value:3.06E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.97|P-value:5.36E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:6.15|P-value:1.52E-9 ID:SGTC_2534|Compound:helenine|FD-Score:-3.54|P-value:6.24E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.44|P-value:3.77E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.20|P-value:8.39E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.43|P-value:2.38E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.86|P-value:8.33E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:5.29|P-value:1.55E-7 ID:SGTC_2814|Compound:7977482|FD-Score:3.75|P-value:1.27E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.43|P-value:3.96E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.29|P-value:1.52E-5 ID:SGTC_3129|Compound:9127257|FD-Score:-4.09|P-value:8.87E-5 ID:SGTC_3182|Compound:9108849|FD-Score:-4.46|P-value:2.06E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-4.02|P-value:1.16E-4 ID:SGTC_3322|Compound:9139058|FD-Score:-3.94|P-value:1.54E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:-3.71|P-value:3.55E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.91|P-value:1.75E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.71|P-value:7.32E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:3.23|P-value:7.57E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:-3.69|P-value:3.74E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.44|P-value:2.28E-5 ID:SGTC_393|Compound:acivicin|FD-Score:3.31|P-value:5.83E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.51|P-value:2.96E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:-3.56|P-value:5.85E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:-3.52|P-value:6.74E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.41|P-value:4.11E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:-3.56|P-value:5.88E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.28|P-value:6.35E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:-4.16|P-value:6.76E-5 ID:SGTC_1591|Compound:genipin|FD-Score:3.26|P-value:6.83E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.71|P-value:1.44E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.86|P-value:8.14E-5 ID:SGTC_2002|Compound:4023503|FD-Score:-4.79|P-value:5.30E-6 ID:SGTC_2004|Compound:4023728|FD-Score:-3.67|P-value:3.99E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-3.62|P-value:4.81E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.63|P-value:4.64E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-5.05|P-value:1.61E-6 ID:SGTC_2110|Compound:5483698|FD-Score:4.28|P-value:1.58E-5 ID:SGTC_2123|Compound:5259487|FD-Score:4.69|P-value:2.66E-6 ID:SGTC_2282|Compound:7944268|FD-Score:3.23|P-value:7.55E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-3.80|P-value:2.58E-4 ID:SGTC_2369|Compound:9071472|FD-Score:-6.18|P-value:5.35E-9 ID:SGTC_2380|Compound:9035439|FD-Score:-6.47|P-value:1.01E-9 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-6.23|P-value:3.88E-9 ID:SGTC_2407|Compound:paclitaxel|FD-Score:5.23|P-value:2.10E-7 ID:SGTC_2416|Compound:tofa|FD-Score:-3.75|P-value:3.06E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.97|P-value:5.36E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:6.15|P-value:1.52E-9 ID:SGTC_2534|Compound:helenine|FD-Score:-3.54|P-value:6.24E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.44|P-value:3.77E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.20|P-value:8.39E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.43|P-value:2.38E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.86|P-value:8.33E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:5.29|P-value:1.55E-7 ID:SGTC_2814|Compound:7977482|FD-Score:3.75|P-value:1.27E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.43|P-value:3.96E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.29|P-value:1.52E-5 ID:SGTC_3129|Compound:9127257|FD-Score:-4.09|P-value:8.87E-5 ID:SGTC_3182|Compound:9108849|FD-Score:-4.46|P-value:2.06E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-4.02|P-value:1.16E-4 ID:SGTC_3322|Compound:9139058|FD-Score:-3.94|P-value:1.54E-4

Top fitness defect scores for YJL115W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 6.15 92.6 µM 1.52E-9 6 3.90E-10
2 SGTC_2751 anetholtrithion 5.29 17.2 µM 1.55E-7 9 6.15E-8
3 SGTC_2407 paclitaxel 5.23 400.0 µM 2.10E-7 13 8.53E-8
4 SGTC_2123 5259487 4.69 200.0 µM 2.66E-6 10 1.36E-6
5 SGTC_2934 9036370 4.29 36.9 µM 1.52E-5 23 9.05E-6
6 SGTC_2110 5483698 4.28 200.0 µM 1.58E-5 TSC3-RPN4 15 9.43E-6
7 SGTC_2421 5690543 3.97 90.7 µM 5.36E-5 18 3.54E-5
8 SGTC_1944 st076371 3.86 56.9 µM 8.14E-5 22 5.56E-5
9 SGTC_2662 daunorubicin 3.86 22.4 µM 8.33E-5 anthracycline transcription coupled DNA repair 16 5.70E-5
10 SGTC_2814 7977482 3.75 43.0 µM 1.27E-4 59 8.97E-5
11 SGTC_1836 st055642 3.71 81.0 µM 1.44E-4 20 1.03E-4
12 SGTC_417 st075190 3.51 100.0 µM 2.96E-4 21 2.24E-4
13 SGTC_2546 rhodinyl acetate 3.44 100.0 µM 3.77E-4 22 2.91E-4
14 SGTC_2907 7721985 3.43 69.9 µM 3.96E-4 45 3.07E-4
15 SGTC_710 3448-4187 3.41 58.0 µM 4.11E-4 fatty acid desaturase (OLE1) 81 3.19E-4
16 SGTC_393 acivicin 3.31 6.2 µM 5.83E-4 32 4.65E-4
17 SGTC_1423 4048-0112 3.28 5.6 µM 6.35E-4 48 5.10E-4
18 SGTC_1591 genipin 3.26 88.4 µM 6.83E-4 mitochondrial processes 30 5.52E-4
19 SGTC_2282 7944268 3.23 200.0 µM 7.55E-4 RPP1 & pyrimidine depletion 68 6.15E-4
20 SGTC_176 1486-1328 3.23 72.8 µM 7.57E-4 98 6.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.224 4.89E-39 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.198 6.06E-31 YFL034C-B MOB2 het Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
0.104 1.77E-9 YBL087C RPL23A hom Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication
0.099 9.18E-9 YPR035W GLN1 het Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.093 8.32E-8 YMR221C_p YMR221C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy
0.092 1.01E-7 YBL058W SHP1 hom UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate
0.089 2.31E-7 YOR314W_d YOR314W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.089 2.63E-7 YBR196C-A_p YBR196C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.080 3.61E-6 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.080 3.62E-6 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.080 4.06E-6 YFL045C SEC53 het Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen
0.076 1.01E-5 YCL001W-B_p YCL001W-B_p hom Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication
0.076 1.04E-5 YNL026W SAM50 het Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85
0.072 3.15E-5 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.070 5.18E-5 YBR283C SSH1 hom Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential