YJL118W

Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL118W / YJL118W

Click on Significant Values for Screen Details ID:SGTC_275|Compound:trichlorophene|FD-Score:3.15|P-value:3.13E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.25|P-value:2.13E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.08|P-value:4.22E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.43|P-value:9.80E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:3.37|P-value:1.27E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.02|P-value:5.31E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.14|P-value:3.28E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.19|P-value:2.68E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:2.92|P-value:7.60E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.36|P-value:1.36E-4 ID:SGTC_1837|Compound:st055472|FD-Score:2.90|P-value:8.22E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-4.11|P-value:4.35E-6 ID:SGTC_1853|Compound:st056710|FD-Score:-4.91|P-value:5.38E-8 ID:SGTC_1857|Compound:st056007|FD-Score:-5.19|P-value:1.02E-8 ID:SGTC_1911|Compound:st060208|FD-Score:-3.07|P-value:4.59E-4 ID:SGTC_1991|Compound:st073000|FD-Score:-3.01|P-value:5.68E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.14|P-value:3.28E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.21|P-value:2.48E-4 ID:SGTC_2324|Compound:6149169|FD-Score:3.73|P-value:2.57E-5 ID:SGTC_2326|Compound:6164455|FD-Score:-5.68|P-value:4.19E-10 ID:SGTC_2716|Compound:st080858|FD-Score:3.50|P-value:7.31E-5 ID:SGTC_2802|Compound:7925815|FD-Score:-3.21|P-value:2.64E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.33|P-value:1.50E-4 ID:SGTC_3336|Compound:9143619|FD-Score:4.38|P-value:1.05E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.15|P-value:3.13E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.25|P-value:2.13E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.08|P-value:4.22E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.43|P-value:9.80E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:3.37|P-value:1.27E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.02|P-value:5.31E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.14|P-value:3.28E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.19|P-value:2.68E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:2.92|P-value:7.60E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.36|P-value:1.36E-4 ID:SGTC_1837|Compound:st055472|FD-Score:2.90|P-value:8.22E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-4.11|P-value:4.35E-6 ID:SGTC_1853|Compound:st056710|FD-Score:-4.91|P-value:5.38E-8 ID:SGTC_1857|Compound:st056007|FD-Score:-5.19|P-value:1.02E-8 ID:SGTC_1911|Compound:st060208|FD-Score:-3.07|P-value:4.59E-4 ID:SGTC_1991|Compound:st073000|FD-Score:-3.01|P-value:5.68E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.14|P-value:3.28E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.21|P-value:2.48E-4 ID:SGTC_2324|Compound:6149169|FD-Score:3.73|P-value:2.57E-5 ID:SGTC_2326|Compound:6164455|FD-Score:-5.68|P-value:4.19E-10 ID:SGTC_2716|Compound:st080858|FD-Score:3.50|P-value:7.31E-5 ID:SGTC_2802|Compound:7925815|FD-Score:-3.21|P-value:2.64E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.33|P-value:1.50E-4 ID:SGTC_3336|Compound:9143619|FD-Score:4.38|P-value:1.05E-6

Top fitness defect scores for YJL118W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3336 9143619 4.38 71.4 µM 1.05E-6 11 6.06E-6
2 SGTC_2324 6149169 3.73 200.0 µM 2.57E-5 23 9.40E-5
3 SGTC_2716 st080858 3.50 38.6 µM 7.31E-5 60S ribosome export 28 2.31E-4
4 SGTC_813 k007-0158 3.43 173.0 µM 9.80E-5 fatty acid desaturase (OLE1) 68 2.97E-4
5 SGTC_865 0488-0499 3.37 301.0 µM 1.27E-4 34 3.70E-4
6 SGTC_1332 1480-0653 3.36 17.5 µM 1.36E-4 TSC3-RPN4 33 3.93E-4
7 SGTC_2809 7964133 3.33 13.0 µM 1.50E-4 60S ribosome export 71 4.29E-4
8 SGTC_440 fluspirilene 3.25 35.1 µM 2.13E-4 41 5.80E-4
9 SGTC_2176 5809774 3.21 34.0 µM 2.48E-4 mitochondrial processes 35 6.60E-4
10 SGTC_1138 3761-0006 3.19 1.0 µM 2.68E-4 23 7.05E-4
11 SGTC_275 trichlorophene 3.15 5.7 µM 3.13E-4 mitochondrial stress 283 8.07E-4
12 SGTC_2032 5185112 3.14 26.0 µM 3.28E-4 27 8.40E-4
13 SGTC_1094 duloxetine 3.14 25.4 µM 3.28E-4 RPP1 & pyrimidine depletion 54 8.41E-4
14 SGTC_576 1073-0113 3.08 22.7 µM 4.22E-4 redox potentiating 126 0.00104
15 SGTC_881 0833-0569 3.02 170.0 µM 5.31E-4 76 0.00127
16 SGTC_1186 1319-0216 2.92 26.0 µM 7.60E-4 67 0.00173
17 SGTC_1837 st055472 2.90 66.5 µM 8.22E-4 61 0.00185
18 SGTC_556 4058-0063 2.83 51.5 µM 0.00107 79 0.00233
19 SGTC_716 1683-5115 2.82 658.0 µM 0.00111 85 0.00240
20 SGTC_978 1416-0512 2.81 87.4 µM 0.00116 redox potentiating 89 0.00250

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.24E-15 YOL158C ENB1 hom Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment
0.137 1.98E-15 YIR014W_p YIR014W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene
0.119 3.83E-12 YDR480W DIG2 hom MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p
0.119 4.78E-12 YAL019W FUN30 hom Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate
0.108 3.54E-10 YDR191W HST4 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.104 1.76E-9 YOL013C HRD1 hom Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon
0.103 2.01E-9 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.103 2.39E-9 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.100 7.53E-9 YFL052W_p YFL052W_p hom Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity
0.095 3.13E-8 YDL129W YDL129W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress
0.093 6.03E-8 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.088 3.79E-7 YOL027C MDM38 hom Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome
0.086 6.92E-7 YMR193C-A_d YMR193C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.085 7.89E-7 YLL057C JLP1 hom Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation
0.083 1.39E-6 YGR023W MTL1 hom Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p