YJL120W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL120W / YJL120W

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:7.19|P-value:4.51E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:12.40|P-value:1.23E-23 ID:SGTC_59|Compound:0330-0160|FD-Score:6.01|P-value:8.03E-7 ID:SGTC_84|Compound:0443-0269|FD-Score:4.21|P-value:4.16E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.59|P-value:1.33E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:7.03|P-value:9.94E-9 ID:SGTC_118|Compound:0083-0097|FD-Score:4.07|P-value:6.14E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.49|P-value:1.09E-7 ID:SGTC_140|Compound:0062-0056|FD-Score:5.67|P-value:3.04E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:4.47|P-value:1.92E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:7.16|P-value:5.24E-9 ID:SGTC_252|Compound:miconazole|FD-Score:-4.74|P-value:5.39E-5 ID:SGTC_253|Compound:dyclonine|FD-Score:4.58|P-value:1.37E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.91|P-value:9.58E-4 ID:SGTC_394|Compound:menadione|FD-Score:13.70|P-value:2.51E-28 ID:SGTC_451|Compound:chloral hydrate|FD-Score:7.77|P-value:2.64E-10 ID:SGTC_470|Compound:aa-861|FD-Score:15.60|P-value:3.71E-36 ID:SGTC_513|Compound:4245-1575|FD-Score:8.31|P-value:1.50E-11 ID:SGTC_548|Compound:1436-0017|FD-Score:4.91|P-value:4.59E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:6.13|P-value:5.01E-7 ID:SGTC_580|Compound:1123-0028|FD-Score:4.82|P-value:6.27E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:7.40|P-value:1.69E-9 ID:SGTC_586|Compound:0957-0265|FD-Score:4.35|P-value:2.78E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:6.29|P-value:2.56E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:5.38|P-value:9.07E-6 ID:SGTC_704|Compound:1310-0270|FD-Score:6.14|P-value:4.88E-7 ID:SGTC_720|Compound:r052-1644|FD-Score:4.36|P-value:2.67E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:5.67|P-value:3.14E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:6.14|P-value:4.76E-7 ID:SGTC_782|Compound:0083-0095|FD-Score:4.70|P-value:9.24E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:7.98|P-value:8.97E-11 ID:SGTC_871|Compound:0574-0004|FD-Score:4.76|P-value:7.57E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:4.47|P-value:1.91E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.49|P-value:1.23E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:4.63|P-value:1.16E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:6.02|P-value:7.98E-7 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.50|P-value:5.80E-6 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.20|P-value:4.20E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:5.80|P-value:1.90E-6 ID:SGTC_1377|Compound:2944-0135|FD-Score:-4.27|P-value:2.43E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.14|P-value:5.11E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.41|P-value:2.30E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:10.50|P-value:2.02E-17 ID:SGTC_1556|Compound:plumbagin|FD-Score:12.30|P-value:2.08E-23 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:5.16|P-value:2.00E-5 ID:SGTC_1608|Compound:st001473|FD-Score:9.51|P-value:1.33E-14 ID:SGTC_1643|Compound:st009866|FD-Score:4.43|P-value:2.18E-4 ID:SGTC_1661|Compound:st013063|FD-Score:5.76|P-value:2.22E-6 ID:SGTC_1663|Compound:st014140|FD-Score:6.81|P-value:2.73E-8 ID:SGTC_1717|Compound:st033143|FD-Score:4.00|P-value:7.51E-4 ID:SGTC_1722|Compound:st034304|FD-Score:4.85|P-value:5.77E-5 ID:SGTC_1779|Compound:st039427|FD-Score:-4.33|P-value:2.04E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-4.03|P-value:4.89E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-3.80|P-value:9.41E-4 ID:SGTC_2040|Compound:5100729|FD-Score:4.29|P-value:3.24E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.90|P-value:7.08E-4 ID:SGTC_2085|Compound:5307070|FD-Score:7.57|P-value:7.05E-10 ID:SGTC_2089|Compound:5281248|FD-Score:7.06|P-value:8.60E-9 ID:SGTC_2139|Compound:5578692|FD-Score:11.60|P-value:8.02E-21 ID:SGTC_2151|Compound:5563267|FD-Score:7.42|P-value:1.51E-9 ID:SGTC_2214|Compound:7179297|FD-Score:5.95|P-value:1.03E-6 ID:SGTC_2223|Compound:6903751|FD-Score:5.08|P-value:2.58E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.17|P-value:4.63E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:8.35|P-value:1.18E-11 ID:SGTC_2259|Compound:7964009|FD-Score:11.10|P-value:2.85E-19 ID:SGTC_2266|Compound:7929956|FD-Score:3.99|P-value:7.71E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.25|P-value:3.65E-4 ID:SGTC_2289|Compound:7946404|FD-Score:5.63|P-value:3.56E-6 ID:SGTC_2306|Compound:7482397|FD-Score:-4.17|P-value:3.26E-4 ID:SGTC_2311|Compound:7694451|FD-Score:5.22|P-value:1.58E-5 ID:SGTC_2313|Compound:7726885|FD-Score:5.94|P-value:1.09E-6 ID:SGTC_2325|Compound:6158266|FD-Score:5.19|P-value:1.81E-5 ID:SGTC_2332|Compound:7982454|FD-Score:4.06|P-value:6.32E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.20|P-value:4.21E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.26|P-value:3.54E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.69|P-value:9.63E-5 ID:SGTC_2462|Compound:5162487|FD-Score:5.49|P-value:6.13E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.98|P-value:7.89E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:6.22|P-value:3.43E-7 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:5.82|P-value:1.73E-6 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.10|P-value:5.63E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.46|P-value:1.97E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:24.70|P-value:3.62E-88 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:5.08|P-value:2.66E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.91|P-value:1.25E-10 ID:SGTC_2681|Compound:menadione|FD-Score:13.00|P-value:8.65E-26 ID:SGTC_2701|Compound:st077767|FD-Score:7.56|P-value:7.47E-10 ID:SGTC_2714|Compound:st079313|FD-Score:4.80|P-value:6.74E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.91|P-value:4.71E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.93|P-value:4.30E-5 ID:SGTC_2781|Compound:5567276|FD-Score:7.54|P-value:8.52E-10 ID:SGTC_2799|Compound:7812892|FD-Score:5.06|P-value:2.85E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.95|P-value:8.64E-4 ID:SGTC_2912|Compound:7964298|FD-Score:10.00|P-value:4.81E-16 ID:SGTC_3072|Compound:9116419|FD-Score:-5.04|P-value:1.98E-5 ID:SGTC_3140|Compound:9094243|FD-Score:5.07|P-value:2.68E-5 ID:SGTC_3201|Compound:9113999|FD-Score:-4.77|P-value:4.93E-5 ID:SGTC_3208|Compound:9114115|FD-Score:3.99|P-value:7.68E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.93|P-value:9.09E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:7.19|P-value:4.51E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:12.40|P-value:1.23E-23 ID:SGTC_59|Compound:0330-0160|FD-Score:6.01|P-value:8.03E-7 ID:SGTC_84|Compound:0443-0269|FD-Score:4.21|P-value:4.16E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.59|P-value:1.33E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:7.03|P-value:9.94E-9 ID:SGTC_118|Compound:0083-0097|FD-Score:4.07|P-value:6.14E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.49|P-value:1.09E-7 ID:SGTC_140|Compound:0062-0056|FD-Score:5.67|P-value:3.04E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:4.47|P-value:1.92E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:7.16|P-value:5.24E-9 ID:SGTC_252|Compound:miconazole|FD-Score:-4.74|P-value:5.39E-5 ID:SGTC_253|Compound:dyclonine|FD-Score:4.58|P-value:1.37E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.91|P-value:9.58E-4 ID:SGTC_394|Compound:menadione|FD-Score:13.70|P-value:2.51E-28 ID:SGTC_451|Compound:chloral hydrate|FD-Score:7.77|P-value:2.64E-10 ID:SGTC_470|Compound:aa-861|FD-Score:15.60|P-value:3.71E-36 ID:SGTC_513|Compound:4245-1575|FD-Score:8.31|P-value:1.50E-11 ID:SGTC_548|Compound:1436-0017|FD-Score:4.91|P-value:4.59E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:6.13|P-value:5.01E-7 ID:SGTC_580|Compound:1123-0028|FD-Score:4.82|P-value:6.27E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:7.40|P-value:1.69E-9 ID:SGTC_586|Compound:0957-0265|FD-Score:4.35|P-value:2.78E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:6.29|P-value:2.56E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:5.38|P-value:9.07E-6 ID:SGTC_704|Compound:1310-0270|FD-Score:6.14|P-value:4.88E-7 ID:SGTC_720|Compound:r052-1644|FD-Score:4.36|P-value:2.67E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:5.67|P-value:3.14E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:6.14|P-value:4.76E-7 ID:SGTC_782|Compound:0083-0095|FD-Score:4.70|P-value:9.24E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:7.98|P-value:8.97E-11 ID:SGTC_871|Compound:0574-0004|FD-Score:4.76|P-value:7.57E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:4.47|P-value:1.91E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.49|P-value:1.23E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:4.63|P-value:1.16E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:6.02|P-value:7.98E-7 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.50|P-value:5.80E-6 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.20|P-value:4.20E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:5.80|P-value:1.90E-6 ID:SGTC_1377|Compound:2944-0135|FD-Score:-4.27|P-value:2.43E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.14|P-value:5.11E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.41|P-value:2.30E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:10.50|P-value:2.02E-17 ID:SGTC_1556|Compound:plumbagin|FD-Score:12.30|P-value:2.08E-23 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:5.16|P-value:2.00E-5 ID:SGTC_1608|Compound:st001473|FD-Score:9.51|P-value:1.33E-14 ID:SGTC_1643|Compound:st009866|FD-Score:4.43|P-value:2.18E-4 ID:SGTC_1661|Compound:st013063|FD-Score:5.76|P-value:2.22E-6 ID:SGTC_1663|Compound:st014140|FD-Score:6.81|P-value:2.73E-8 ID:SGTC_1717|Compound:st033143|FD-Score:4.00|P-value:7.51E-4 ID:SGTC_1722|Compound:st034304|FD-Score:4.85|P-value:5.77E-5 ID:SGTC_1779|Compound:st039427|FD-Score:-4.33|P-value:2.04E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-4.03|P-value:4.89E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-3.80|P-value:9.41E-4 ID:SGTC_2040|Compound:5100729|FD-Score:4.29|P-value:3.24E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.90|P-value:7.08E-4 ID:SGTC_2085|Compound:5307070|FD-Score:7.57|P-value:7.05E-10 ID:SGTC_2089|Compound:5281248|FD-Score:7.06|P-value:8.60E-9 ID:SGTC_2139|Compound:5578692|FD-Score:11.60|P-value:8.02E-21 ID:SGTC_2151|Compound:5563267|FD-Score:7.42|P-value:1.51E-9 ID:SGTC_2214|Compound:7179297|FD-Score:5.95|P-value:1.03E-6 ID:SGTC_2223|Compound:6903751|FD-Score:5.08|P-value:2.58E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.17|P-value:4.63E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:8.35|P-value:1.18E-11 ID:SGTC_2259|Compound:7964009|FD-Score:11.10|P-value:2.85E-19 ID:SGTC_2266|Compound:7929956|FD-Score:3.99|P-value:7.71E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.25|P-value:3.65E-4 ID:SGTC_2289|Compound:7946404|FD-Score:5.63|P-value:3.56E-6 ID:SGTC_2306|Compound:7482397|FD-Score:-4.17|P-value:3.26E-4 ID:SGTC_2311|Compound:7694451|FD-Score:5.22|P-value:1.58E-5 ID:SGTC_2313|Compound:7726885|FD-Score:5.94|P-value:1.09E-6 ID:SGTC_2325|Compound:6158266|FD-Score:5.19|P-value:1.81E-5 ID:SGTC_2332|Compound:7982454|FD-Score:4.06|P-value:6.32E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.20|P-value:4.21E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.26|P-value:3.54E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.69|P-value:9.63E-5 ID:SGTC_2462|Compound:5162487|FD-Score:5.49|P-value:6.13E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.98|P-value:7.89E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:6.22|P-value:3.43E-7 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:5.82|P-value:1.73E-6 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.10|P-value:5.63E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.46|P-value:1.97E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:24.70|P-value:3.62E-88 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:5.08|P-value:2.66E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.91|P-value:1.25E-10 ID:SGTC_2681|Compound:menadione|FD-Score:13.00|P-value:8.65E-26 ID:SGTC_2701|Compound:st077767|FD-Score:7.56|P-value:7.47E-10 ID:SGTC_2714|Compound:st079313|FD-Score:4.80|P-value:6.74E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.91|P-value:4.71E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.93|P-value:4.30E-5 ID:SGTC_2781|Compound:5567276|FD-Score:7.54|P-value:8.52E-10 ID:SGTC_2799|Compound:7812892|FD-Score:5.06|P-value:2.85E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.95|P-value:8.64E-4 ID:SGTC_2912|Compound:7964298|FD-Score:10.00|P-value:4.81E-16 ID:SGTC_3072|Compound:9116419|FD-Score:-5.04|P-value:1.98E-5 ID:SGTC_3140|Compound:9094243|FD-Score:5.07|P-value:2.68E-5 ID:SGTC_3201|Compound:9113999|FD-Score:-4.77|P-value:4.93E-5 ID:SGTC_3208|Compound:9114115|FD-Score:3.99|P-value:7.68E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.93|P-value:9.09E-4

Top fitness defect scores for YJL120W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2575 plumbagin 24.70 510.0 nM 3.62E-88 superoxide 1 3.30E-135
2 SGTC_470 aa-861 15.60 153.0 µM 3.71E-36 sphingolipid biosynthesis & PDR1 2 5.55E-55
3 SGTC_394 menadione 13.70 8.3 µM 2.51E-28 superoxide 1 6.65E-43
4 SGTC_2681 menadione 13.00 3.2 µM 8.65E-26 superoxide 5 5.44E-39
5 SGTC_58 0957-0393 12.40 9.0 µM 1.23E-23 cell wall 49 1.13E-35
6 SGTC_1556 plumbagin 12.30 1.5 µM 2.08E-23 superoxide 5 2.56E-35
7 SGTC_2139 5578692 11.60 56.5 µM 8.02E-21 superoxide 2 2.48E-31
8 SGTC_2259 7964009 11.10 200.0 µM 2.85E-19 superoxide 5 6.10E-29
9 SGTC_1552 6-methylflavone 10.50 10.6 µM 2.02E-17 superoxide 3 4.34E-26
10 SGTC_2912 7964298 10.00 10.9 µM 4.81E-16 cell wall 16 5.77E-24
11 SGTC_1608 st001473 9.51 40.5 µM 1.33E-14 3 9.63E-22
12 SGTC_2233 sulbentine 8.35 40.4 µM 1.18E-11 11 3.36E-17
13 SGTC_513 4245-1575 8.31 41.7 µM 1.50E-11 unfolded protein response 26 4.86E-17
14 SGTC_799 1310-0557 7.98 151.0 µM 8.97E-11 superoxide 2 7.58E-16
15 SGTC_2582 agaric acid 7.91 100.0 µM 1.25E-10 redox potentiating 105 1.26E-15
16 SGTC_451 chloral hydrate 7.77 100.0 µM 2.64E-10 6 3.98E-15
17 SGTC_2085 5307070 7.57 144.1 µM 7.05E-10 superoxide 3 1.81E-14
18 SGTC_2701 st077767 7.56 14.7 µM 7.47E-10 6 1.98E-14
19 SGTC_2781 5567276 7.54 71.4 µM 8.52E-10 7 2.42E-14
20 SGTC_2151 5563267 7.42 85.4 µM 1.51E-9 5 5.87E-14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.459 2.33E-174 YPR074C TKL1 hom Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
0.367 9.94E-108 YJL121C RPE1 hom D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
0.305 4.32E-73 YML007W YAP1 hom Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.285 5.43E-64 YNL241C ZWF1 hom Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress
0.262 1.83E-53 YMR038C CCS1 hom Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress
0.261 3.26E-53 YJR104C SOD1 hom Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
0.253 2.95E-50 YHR206W SKN7 hom Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; SKN7 has a paralog, HMS2, that arose from the whole genome duplication
0.224 1.71E-39 YOR209C NPT1 hom Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus
0.196 1.94E-30 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.192 2.59E-29 YJR049C UTR1 hom ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication
0.187 1.17E-27 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.161 6.37E-21 YPL161C BEM4 hom Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length
0.160 1.36E-20 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.154 2.57E-19 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.148 6.78E-18 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress