YJL121C / RPE1

D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL121C / RPE1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.54|P-value:6.17E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:5.74|P-value:7.69E-8 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:6.37|P-value:2.80E-9 ID:SGTC_29|Compound:0299-0004|FD-Score:6.15|P-value:9.10E-9 ID:SGTC_37|Compound:0566-0070|FD-Score:5.12|P-value:1.40E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:10.60|P-value:2.01E-22 ID:SGTC_106|Compound:0092-0003|FD-Score:4.92|P-value:3.39E-6 ID:SGTC_177|Compound:1327-0068|FD-Score:9.69|P-value:3.34E-19 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.78|P-value:6.24E-6 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.81|P-value:2.51E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.52|P-value:1.52E-5 ID:SGTC_394|Compound:menadione|FD-Score:3.97|P-value:1.44E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.33|P-value:3.17E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:4.37|P-value:3.26E-5 ID:SGTC_470|Compound:aa-861|FD-Score:5.09|P-value:1.64E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.57|P-value:4.79E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.57|P-value:5.58E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:6.50|P-value:1.36E-9 ID:SGTC_785|Compound:1270-0111|FD-Score:3.72|P-value:3.43E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:6.43|P-value:2.05E-9 ID:SGTC_883|Compound:0850-0245|FD-Score:3.71|P-value:3.58E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.09|P-value:9.44E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:4.71|P-value:8.24E-6 ID:SGTC_1035|Compound:k081-0041|FD-Score:-3.76|P-value:2.58E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-4.15|P-value:6.31E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:3.57|P-value:5.63E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.15|P-value:7.60E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.07|P-value:1.02E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.66|P-value:1.03E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:-3.34|P-value:9.99E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:7.83|P-value:3.79E-13 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:4.12|P-value:8.54E-5 ID:SGTC_1608|Compound:st001473|FD-Score:5.60|P-value:1.51E-7 ID:SGTC_1633|Compound:st005664|FD-Score:5.46|P-value:2.98E-7 ID:SGTC_1766|Compound:st045414|FD-Score:3.64|P-value:4.54E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.28|P-value:7.08E-7 ID:SGTC_1853|Compound:st056710|FD-Score:3.46|P-value:7.89E-4 ID:SGTC_2085|Compound:5307070|FD-Score:6.07|P-value:1.44E-8 ID:SGTC_2139|Compound:5578692|FD-Score:3.63|P-value:4.65E-4 ID:SGTC_2198|Compound:6589944|FD-Score:4.16|P-value:7.27E-5 ID:SGTC_2223|Compound:6903751|FD-Score:6.33|P-value:3.49E-9 ID:SGTC_2233|Compound:sulbentine|FD-Score:6.35|P-value:3.08E-9 ID:SGTC_2243|Compound:6634756|FD-Score:4.44|P-value:2.46E-5 ID:SGTC_2259|Compound:7964009|FD-Score:5.95|P-value:2.61E-8 ID:SGTC_2266|Compound:7929956|FD-Score:5.08|P-value:1.75E-6 ID:SGTC_2325|Compound:6158266|FD-Score:4.07|P-value:1.03E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.33|P-value:3.87E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.66|P-value:4.16E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:5.95|P-value:2.64E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:-5.66|P-value:8.99E-8 ID:SGTC_2681|Compound:menadione|FD-Score:12.40|P-value:3.87E-30 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.67|P-value:9.74E-6 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.50|P-value:1.94E-5 ID:SGTC_3120|Compound:9124077|FD-Score:4.67|P-value:9.81E-6 ID:SGTC_3147|Compound:9097027|FD-Score:3.51|P-value:6.92E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-3.66|P-value:3.61E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.68|P-value:3.35E-4 ID:SGTC_3334|Compound:9142812|FD-Score:4.22|P-value:5.74E-5 ID:SGTC_7|Compound:0192-1582|FD-Score:3.54|P-value:6.17E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:5.74|P-value:7.69E-8 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:6.37|P-value:2.80E-9 ID:SGTC_29|Compound:0299-0004|FD-Score:6.15|P-value:9.10E-9 ID:SGTC_37|Compound:0566-0070|FD-Score:5.12|P-value:1.40E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:10.60|P-value:2.01E-22 ID:SGTC_106|Compound:0092-0003|FD-Score:4.92|P-value:3.39E-6 ID:SGTC_177|Compound:1327-0068|FD-Score:9.69|P-value:3.34E-19 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.78|P-value:6.24E-6 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.81|P-value:2.51E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.52|P-value:1.52E-5 ID:SGTC_394|Compound:menadione|FD-Score:3.97|P-value:1.44E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.33|P-value:3.17E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:4.37|P-value:3.26E-5 ID:SGTC_470|Compound:aa-861|FD-Score:5.09|P-value:1.64E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.57|P-value:4.79E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.57|P-value:5.58E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:6.50|P-value:1.36E-9 ID:SGTC_785|Compound:1270-0111|FD-Score:3.72|P-value:3.43E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:6.43|P-value:2.05E-9 ID:SGTC_883|Compound:0850-0245|FD-Score:3.71|P-value:3.58E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.09|P-value:9.44E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:4.71|P-value:8.24E-6 ID:SGTC_1035|Compound:k081-0041|FD-Score:-3.76|P-value:2.58E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-4.15|P-value:6.31E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:3.57|P-value:5.63E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.15|P-value:7.60E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.07|P-value:1.02E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.66|P-value:1.03E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:-3.34|P-value:9.99E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:7.83|P-value:3.79E-13 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:4.12|P-value:8.54E-5 ID:SGTC_1608|Compound:st001473|FD-Score:5.60|P-value:1.51E-7 ID:SGTC_1633|Compound:st005664|FD-Score:5.46|P-value:2.98E-7 ID:SGTC_1766|Compound:st045414|FD-Score:3.64|P-value:4.54E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.28|P-value:7.08E-7 ID:SGTC_1853|Compound:st056710|FD-Score:3.46|P-value:7.89E-4 ID:SGTC_2085|Compound:5307070|FD-Score:6.07|P-value:1.44E-8 ID:SGTC_2139|Compound:5578692|FD-Score:3.63|P-value:4.65E-4 ID:SGTC_2198|Compound:6589944|FD-Score:4.16|P-value:7.27E-5 ID:SGTC_2223|Compound:6903751|FD-Score:6.33|P-value:3.49E-9 ID:SGTC_2233|Compound:sulbentine|FD-Score:6.35|P-value:3.08E-9 ID:SGTC_2243|Compound:6634756|FD-Score:4.44|P-value:2.46E-5 ID:SGTC_2259|Compound:7964009|FD-Score:5.95|P-value:2.61E-8 ID:SGTC_2266|Compound:7929956|FD-Score:5.08|P-value:1.75E-6 ID:SGTC_2325|Compound:6158266|FD-Score:4.07|P-value:1.03E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.33|P-value:3.87E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.66|P-value:4.16E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:5.95|P-value:2.64E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:-5.66|P-value:8.99E-8 ID:SGTC_2681|Compound:menadione|FD-Score:12.40|P-value:3.87E-30 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.67|P-value:9.74E-6 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.50|P-value:1.94E-5 ID:SGTC_3120|Compound:9124077|FD-Score:4.67|P-value:9.81E-6 ID:SGTC_3147|Compound:9097027|FD-Score:3.51|P-value:6.92E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-3.66|P-value:3.61E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.68|P-value:3.35E-4 ID:SGTC_3334|Compound:9142812|FD-Score:4.22|P-value:5.74E-5

Top fitness defect scores for YJL121C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2681 menadione 12.40 3.2 µM 3.87E-30 superoxide 6 1.68E-35
2 SGTC_46 0329-0187a 10.60 2.2 µM 2.01E-22 7 2.41E-26
3 SGTC_177 1327-0068 9.69 8.4 µM 3.34E-19 7 1.60E-22
4 SGTC_1556 plumbagin 7.83 1.5 µM 3.79E-13 superoxide 9 2.44E-15
5 SGTC_690 glyoxal 6.50 20.3 µM 1.36E-9 37 3.99E-11
6 SGTC_799 1310-0557 6.43 151.0 µM 2.05E-9 superoxide 4 6.52E-11
7 SGTC_28 pentachloropyridine N-oxide 6.37 1.6 µM 2.80E-9 TSC3-RPN4 12 9.41E-11
8 SGTC_2233 sulbentine 6.35 40.4 µM 3.08E-9 20 1.06E-10
9 SGTC_2223 6903751 6.33 107.6 µM 3.49E-9 superoxide 3 1.22E-10
10 SGTC_29 0299-0004 6.15 13.0 µM 9.10E-9 12 3.81E-10
11 SGTC_2085 5307070 6.07 144.1 µM 1.44E-8 superoxide 6 6.58E-10
12 SGTC_2259 7964009 5.95 200.0 µM 2.61E-8 superoxide 13 1.33E-9
13 SGTC_2575 plumbagin 5.95 510.0 nM 2.64E-8 superoxide 16 1.34E-9
14 SGTC_9 0092-0002 5.74 10.4 µM 7.69E-8 7 4.78E-9
15 SGTC_1608 st001473 5.60 40.5 µM 1.51E-7 18 1.07E-8
16 SGTC_1633 st005664 5.46 67.9 µM 2.98E-7 9 2.38E-8
17 SGTC_1803 st050068 5.28 52.4 µM 7.08E-7 NEO1-PIK1 107 6.63E-8
18 SGTC_37 0566-0070 5.12 1.6 µM 1.40E-6 10 1.49E-7
19 SGTC_470 aa-861 5.09 153.0 µM 1.64E-6 sphingolipid biosynthesis & PDR1 34 1.79E-7
20 SGTC_2266 7929956 5.08 200.0 µM 1.75E-6 12 1.93E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.448 1.03E-165 YPR074C TKL1 hom Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
0.367 9.94E-108 YJL120W_d YJL120W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
0.308 1.92E-74 YHR206W SKN7 hom Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; SKN7 has a paralog, HMS2, that arose from the whole genome duplication
0.266 2.94E-55 YML007W YAP1 hom Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.222 1.47E-38 YNL241C ZWF1 hom Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress
0.216 1.17E-36 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.206 1.64E-33 YJR049C UTR1 hom ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication
0.180 9.04E-26 YJR104C SOD1 hom Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
0.149 4.78E-18 YOR209C NPT1 hom Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus
0.143 7.63E-17 YML081W TDA9 hom DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication
0.143 9.45E-17 YMR038C CCS1 hom Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress
0.135 5.04E-15 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.129 6.85E-14 YHR193C EGD2 hom Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
0.128 1.06E-13 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.125 3.06E-13 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication