YJL123C / MTC1

Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL123C / MTC1

Click on Significant Values for Screen Details ID:SGTC_93|Compound:0109-0045|FD-Score:4.57|P-value:4.23E-6 ID:SGTC_94|Compound:0334-0113|FD-Score:3.95|P-value:5.91E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:3.61|P-value:2.14E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.30|P-value:1.42E-5 ID:SGTC_228|Compound:caffeine|FD-Score:-3.51|P-value:3.58E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.26|P-value:7.47E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.84|P-value:8.99E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:4.62|P-value:3.41E-6 ID:SGTC_632|Compound:0781-2353|FD-Score:5.03|P-value:4.94E-7 ID:SGTC_730|Compound:1436-0052|FD-Score:3.28|P-value:6.80E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.59|P-value:2.33E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.28|P-value:6.94E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.35|P-value:5.48E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.33|P-value:5.83E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.51|P-value:3.07E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.61|P-value:3.62E-6 ID:SGTC_1939|Compound:st074455|FD-Score:3.24|P-value:7.76E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.42|P-value:4.84E-4 ID:SGTC_2148|Compound:5546263|FD-Score:4.43|P-value:8.16E-6 ID:SGTC_2176|Compound:5809774|FD-Score:3.85|P-value:8.61E-5 ID:SGTC_2177|Compound:5811945|FD-Score:3.26|P-value:7.46E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.84|P-value:9.02E-5 ID:SGTC_2184|Compound:6075246|FD-Score:4.60|P-value:3.70E-6 ID:SGTC_2369|Compound:9071472|FD-Score:4.38|P-value:9.96E-6 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.71|P-value:1.47E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.46|P-value:6.88E-6 ID:SGTC_2704|Compound:st078022|FD-Score:3.23|P-value:8.06E-4 ID:SGTC_2842|Compound:9000675|FD-Score:4.85|P-value:1.18E-6 ID:SGTC_2906|Compound:7926292|FD-Score:3.98|P-value:5.16E-5 ID:SGTC_2985|Compound:9022375|FD-Score:8.35|P-value:2.33E-16 ID:SGTC_3028|Compound:9087778|FD-Score:3.78|P-value:1.16E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.39|P-value:4.65E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.65|P-value:1.84E-4 ID:SGTC_3252|Compound:9135871|FD-Score:4.06|P-value:3.78E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:4.57|P-value:4.23E-6 ID:SGTC_94|Compound:0334-0113|FD-Score:3.95|P-value:5.91E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:3.61|P-value:2.14E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.30|P-value:1.42E-5 ID:SGTC_228|Compound:caffeine|FD-Score:-3.51|P-value:3.58E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.26|P-value:7.47E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.84|P-value:8.99E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:4.62|P-value:3.41E-6 ID:SGTC_632|Compound:0781-2353|FD-Score:5.03|P-value:4.94E-7 ID:SGTC_730|Compound:1436-0052|FD-Score:3.28|P-value:6.80E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.59|P-value:2.33E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.28|P-value:6.94E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.35|P-value:5.48E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.33|P-value:5.83E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.51|P-value:3.07E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.61|P-value:3.62E-6 ID:SGTC_1939|Compound:st074455|FD-Score:3.24|P-value:7.76E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.42|P-value:4.84E-4 ID:SGTC_2148|Compound:5546263|FD-Score:4.43|P-value:8.16E-6 ID:SGTC_2176|Compound:5809774|FD-Score:3.85|P-value:8.61E-5 ID:SGTC_2177|Compound:5811945|FD-Score:3.26|P-value:7.46E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.84|P-value:9.02E-5 ID:SGTC_2184|Compound:6075246|FD-Score:4.60|P-value:3.70E-6 ID:SGTC_2369|Compound:9071472|FD-Score:4.38|P-value:9.96E-6 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.71|P-value:1.47E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.46|P-value:6.88E-6 ID:SGTC_2704|Compound:st078022|FD-Score:3.23|P-value:8.06E-4 ID:SGTC_2842|Compound:9000675|FD-Score:4.85|P-value:1.18E-6 ID:SGTC_2906|Compound:7926292|FD-Score:3.98|P-value:5.16E-5 ID:SGTC_2985|Compound:9022375|FD-Score:8.35|P-value:2.33E-16 ID:SGTC_3028|Compound:9087778|FD-Score:3.78|P-value:1.16E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.39|P-value:4.65E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.65|P-value:1.84E-4 ID:SGTC_3252|Compound:9135871|FD-Score:4.06|P-value:3.78E-5

Top fitness defect scores for YJL123C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2985 9022375 8.35 71.4 µM 2.33E-16 RPP1 & pyrimidine depletion 2 3.30E-17
2 SGTC_632 0781-2353 5.03 4.7 µM 4.94E-7 Golgi 19 2.49E-7
3 SGTC_2842 9000675 4.85 19.5 µM 1.18E-6 8 6.24E-7
4 SGTC_577 r071-0003 4.62 38.6 µM 3.41E-6 fatty acid desaturase (OLE1) 35 1.92E-6
5 SGTC_1744 st037937 4.61 38.9 µM 3.62E-6 11 2.04E-6
6 SGTC_2184 6075246 4.60 200.0 µM 3.70E-6 13 2.09E-6
7 SGTC_93 0109-0045 4.57 59.2 µM 4.23E-6 DNA damage response 24 2.41E-6
8 SGTC_2617 dihydrotanshinone i 4.46 20.8 µM 6.88E-6 copper-dependent oxidative stress 21 4.02E-6
9 SGTC_2148 5546263 4.43 113.6 µM 8.16E-6 15 4.82E-6
10 SGTC_2369 9071472 4.38 200.0 µM 9.96E-6 10 5.95E-6
11 SGTC_137 0438-0332 4.30 85.4 µM 1.42E-5 ubiquinone biosynthesis & proteasome 104 8.64E-6
12 SGTC_3252 9135871 4.06 49.5 µM 3.78E-5 9 2.44E-5
13 SGTC_2906 7926292 3.98 26.4 µM 5.16E-5 24 3.38E-5
14 SGTC_94 0334-0113 3.95 514.8 µM 5.91E-5 24 3.90E-5
15 SGTC_2176 5809774 3.85 34.0 µM 8.61E-5 mitochondrial processes 12 5.80E-5
16 SGTC_410 α-linolenic acid 3.84 100.0 µM 8.99E-5 excess fatty acid 42 6.07E-5
17 SGTC_2182 6325192 3.84 200.0 µM 9.02E-5 Golgi 16 6.09E-5
18 SGTC_3028 9087778 3.78 49.5 µM 1.16E-4 19 7.92E-5
19 SGTC_2502 avocadyne acetate 3.71 18.6 µM 1.47E-4 33 1.02E-4
20 SGTC_3173 9105693 3.65 49.5 µM 1.84E-4 33 1.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.089 2.34E-7 YLR282C_d YLR282C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition
0.089 2.55E-7 YOR165W SEY1 hom Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.084 1.16E-6 YKR091W SRL3 hom Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate
0.083 1.53E-6 YDL092W SRP14 het Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14
0.080 3.85E-6 YLR043C TRX1 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.080 3.87E-6 YCL038C ATG22 hom Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
0.079 4.21E-6 YDL079C MRK1 hom Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
0.076 1.06E-5 YKR073C_d YKR073C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.076 1.09E-5 YMR081C ISF1 hom Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
0.076 1.16E-5 YJR149W_p YJR149W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.075 1.44E-5 YJL157C FAR1 hom Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.072 2.92E-5 YDR193W_d YDR193W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.072 3.17E-5 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.070 4.41E-5 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.069 6.25E-5 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress