YJL124C / LSM1

Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL124C / LSM1

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:-4.87|P-value:1.38E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:-5.13|P-value:4.95E-6 ID:SGTC_18|Compound:0111-0177|FD-Score:5.14|P-value:4.35E-6 ID:SGTC_20|Compound:0481-0013|FD-Score:5.95|P-value:1.37E-7 ID:SGTC_21|Compound:0849-0113|FD-Score:4.28|P-value:1.06E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.73|P-value:6.25E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.93|P-value:3.61E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:-5.13|P-value:4.96E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.68|P-value:7.74E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:4.00|P-value:2.73E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:4.07|P-value:2.14E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.20|P-value:1.50E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.69|P-value:2.69E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:4.98|P-value:8.21E-6 ID:SGTC_88|Compound:0180-0332|FD-Score:3.72|P-value:6.50E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:-4.40|P-value:7.68E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.23|P-value:1.35E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.85|P-value:4.69E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:12.70|P-value:2.85E-28 ID:SGTC_148|Compound:3253-0744|FD-Score:3.98|P-value:2.84E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:6.94|P-value:9.96E-10 ID:SGTC_150|Compound:3970-0969|FD-Score:6.06|P-value:7.99E-8 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.65|P-value:3.17E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-7.24|P-value:2.26E-10 ID:SGTC_168|Compound:3970-0862|FD-Score:3.87|P-value:4.07E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:8.57|P-value:6.66E-14 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.89|P-value:4.06E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.52|P-value:4.57E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:8.35|P-value:2.70E-13 ID:SGTC_221|Compound:trifluoperazine|FD-Score:13.50|P-value:9.17E-32 ID:SGTC_232|Compound:clozapine|FD-Score:14.20|P-value:1.14E-34 ID:SGTC_268|Compound:camptothecin|FD-Score:18.60|P-value:2.29E-58 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.23|P-value:1.24E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.70|P-value:2.65E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:8.67|P-value:3.41E-14 ID:SGTC_310|Compound:1273-0058|FD-Score:-10.40|P-value:1.26E-19 ID:SGTC_313|Compound:3474-0040|FD-Score:8.61|P-value:5.00E-14 ID:SGTC_398|Compound:bronopol|FD-Score:4.31|P-value:9.76E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:4.37|P-value:7.74E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.65|P-value:8.58E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:12.40|P-value:7.25E-27 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.75|P-value:5.81E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.06|P-value:6.07E-10 ID:SGTC_505|Compound:gw-5074|FD-Score:4.37|P-value:7.75E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:5.36|P-value:1.82E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:12.30|P-value:9.29E-27 ID:SGTC_544|Compound:k015-0020|FD-Score:4.89|P-value:1.18E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:4.78|P-value:1.80E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:11.30|P-value:8.56E-23 ID:SGTC_576|Compound:1073-0113|FD-Score:3.97|P-value:2.95E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:8.88|P-value:8.21E-15 ID:SGTC_650|Compound:1328-0195|FD-Score:-3.77|P-value:5.89E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:4.36|P-value:8.03E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:5.94|P-value:1.39E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.74|P-value:6.39E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:4.94|P-value:9.60E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:5.58|P-value:7.01E-7 ID:SGTC_768|Compound:0384-0033|FD-Score:3.90|P-value:3.69E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:4.03|P-value:2.46E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:7.75|P-value:1.05E-11 ID:SGTC_919|Compound:tnp00227|FD-Score:5.92|P-value:1.57E-7 ID:SGTC_932|Compound:2857-0803|FD-Score:4.84|P-value:1.42E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:7.17|P-value:2.90E-10 ID:SGTC_955|Compound:1216-0110|FD-Score:11.00|P-value:1.27E-21 ID:SGTC_999|Compound:4022-0066|FD-Score:14.00|P-value:4.20E-34 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.46|P-value:6.17E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.47|P-value:5.50E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:4.49|P-value:5.07E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.99|P-value:2.79E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.50|P-value:5.01E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:5.92|P-value:1.54E-7 ID:SGTC_1287|Compound:0971-0001|FD-Score:4.48|P-value:5.26E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:6.12|P-value:6.03E-8 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.57|P-value:3.91E-5 ID:SGTC_1687|Compound:st020778|FD-Score:6.20|P-value:4.16E-8 ID:SGTC_1754|Compound:st042065|FD-Score:15.80|P-value:1.77E-42 ID:SGTC_1760|Compound:st045453|FD-Score:17.50|P-value:5.92E-52 ID:SGTC_1781|Compound:st038725|FD-Score:13.60|P-value:2.68E-32 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.66|P-value:5.04E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.69|P-value:2.66E-5 ID:SGTC_1801|Compound:st050089|FD-Score:7.52|P-value:4.13E-11 ID:SGTC_1803|Compound:st050068|FD-Score:7.07|P-value:4.97E-10 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.13|P-value:4.50E-6 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.46|P-value:1.17E-6 ID:SGTC_1917|Compound:st066507|FD-Score:3.76|P-value:5.61E-4 ID:SGTC_1930|Compound:st074634|FD-Score:10.90|P-value:2.14E-21 ID:SGTC_1941|Compound:st076221|FD-Score:4.26|P-value:1.14E-4 ID:SGTC_1950|Compound:st077106|FD-Score:4.03|P-value:2.45E-4 ID:SGTC_1991|Compound:st073000|FD-Score:4.30|P-value:9.87E-5 ID:SGTC_2006|Compound:4011487|FD-Score:6.84|P-value:1.70E-9 ID:SGTC_2007|Compound:4011539|FD-Score:4.18|P-value:1.51E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.78|P-value:2.92E-7 ID:SGTC_2036|Compound:5160441|FD-Score:4.46|P-value:5.75E-5 ID:SGTC_2082|Compound:5219693|FD-Score:3.78|P-value:5.31E-4 ID:SGTC_2139|Compound:5578692|FD-Score:-7.20|P-value:2.75E-10 ID:SGTC_2141|Compound:5621638|FD-Score:-4.02|P-value:2.71E-4 ID:SGTC_2149|Compound:5554786|FD-Score:-6.34|P-value:2.41E-8 ID:SGTC_2159|Compound:5658611|FD-Score:-6.63|P-value:5.77E-9 ID:SGTC_2160|Compound:5660466|FD-Score:-4.67|P-value:2.92E-5 ID:SGTC_2242|Compound:6630449|FD-Score:14.10|P-value:2.57E-34 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.79|P-value:1.71E-5 ID:SGTC_2257|Compound:7960413|FD-Score:6.38|P-value:1.75E-8 ID:SGTC_2300|Compound:7976697|FD-Score:4.16|P-value:1.60E-4 ID:SGTC_2322|Compound:7413319|FD-Score:8.78|P-value:1.65E-14 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.27|P-value:1.12E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:8.15|P-value:9.21E-13 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.51|P-value:9.49E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.77|P-value:1.86E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.53|P-value:4.40E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:14.50|P-value:1.94E-36 ID:SGTC_2699|Compound:st077704|FD-Score:4.56|P-value:4.06E-5 ID:SGTC_2706|Compound:st078239|FD-Score:3.69|P-value:7.09E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.67|P-value:7.43E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:6.80|P-value:2.06E-9 ID:SGTC_2790|Compound:5423970|FD-Score:4.97|P-value:8.64E-6 ID:SGTC_2805|Compound:7950783|FD-Score:-3.83|P-value:4.95E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.66|P-value:4.90E-7 ID:SGTC_2896|Compound:9052656|FD-Score:3.78|P-value:5.35E-4 ID:SGTC_2938|Compound:9059746|FD-Score:6.56|P-value:7.03E-9 ID:SGTC_3037|Compound:9091026|FD-Score:7.01|P-value:6.95E-10 ID:SGTC_3039|Compound:9090270|FD-Score:3.82|P-value:4.74E-4 ID:SGTC_3120|Compound:9124077|FD-Score:4.88|P-value:1.24E-5 ID:SGTC_3148|Compound:9097893|FD-Score:6.93|P-value:1.07E-9 ID:SGTC_3152|Compound:9099253|FD-Score:4.53|P-value:4.45E-5 ID:SGTC_3164|Compound:9100705|FD-Score:-3.80|P-value:5.34E-4 ID:SGTC_3220|Compound:9131269|FD-Score:5.07|P-value:5.75E-6 ID:SGTC_3337|Compound:9144342|FD-Score:11.60|P-value:6.81E-24 ID:SGTC_3|Compound:0833-0587|FD-Score:-4.87|P-value:1.38E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:-5.13|P-value:4.95E-6 ID:SGTC_18|Compound:0111-0177|FD-Score:5.14|P-value:4.35E-6 ID:SGTC_20|Compound:0481-0013|FD-Score:5.95|P-value:1.37E-7 ID:SGTC_21|Compound:0849-0113|FD-Score:4.28|P-value:1.06E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.73|P-value:6.25E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.93|P-value:3.61E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:-5.13|P-value:4.96E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.68|P-value:7.74E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:4.00|P-value:2.73E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:4.07|P-value:2.14E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.20|P-value:1.50E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.69|P-value:2.69E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:4.98|P-value:8.21E-6 ID:SGTC_88|Compound:0180-0332|FD-Score:3.72|P-value:6.50E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:-4.40|P-value:7.68E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.23|P-value:1.35E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.85|P-value:4.69E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:12.70|P-value:2.85E-28 ID:SGTC_148|Compound:3253-0744|FD-Score:3.98|P-value:2.84E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:6.94|P-value:9.96E-10 ID:SGTC_150|Compound:3970-0969|FD-Score:6.06|P-value:7.99E-8 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.65|P-value:3.17E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-7.24|P-value:2.26E-10 ID:SGTC_168|Compound:3970-0862|FD-Score:3.87|P-value:4.07E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:8.57|P-value:6.66E-14 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.89|P-value:4.06E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.52|P-value:4.57E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:8.35|P-value:2.70E-13 ID:SGTC_221|Compound:trifluoperazine|FD-Score:13.50|P-value:9.17E-32 ID:SGTC_232|Compound:clozapine|FD-Score:14.20|P-value:1.14E-34 ID:SGTC_268|Compound:camptothecin|FD-Score:18.60|P-value:2.29E-58 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.23|P-value:1.24E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.70|P-value:2.65E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:8.67|P-value:3.41E-14 ID:SGTC_310|Compound:1273-0058|FD-Score:-10.40|P-value:1.26E-19 ID:SGTC_313|Compound:3474-0040|FD-Score:8.61|P-value:5.00E-14 ID:SGTC_398|Compound:bronopol|FD-Score:4.31|P-value:9.76E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:4.37|P-value:7.74E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.65|P-value:8.58E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:12.40|P-value:7.25E-27 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.75|P-value:5.81E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.06|P-value:6.07E-10 ID:SGTC_505|Compound:gw-5074|FD-Score:4.37|P-value:7.75E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:5.36|P-value:1.82E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:12.30|P-value:9.29E-27 ID:SGTC_544|Compound:k015-0020|FD-Score:4.89|P-value:1.18E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:4.78|P-value:1.80E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:11.30|P-value:8.56E-23 ID:SGTC_576|Compound:1073-0113|FD-Score:3.97|P-value:2.95E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:8.88|P-value:8.21E-15 ID:SGTC_650|Compound:1328-0195|FD-Score:-3.77|P-value:5.89E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:4.36|P-value:8.03E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:5.94|P-value:1.39E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.74|P-value:6.39E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:4.94|P-value:9.60E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:5.58|P-value:7.01E-7 ID:SGTC_768|Compound:0384-0033|FD-Score:3.90|P-value:3.69E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:4.03|P-value:2.46E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:7.75|P-value:1.05E-11 ID:SGTC_919|Compound:tnp00227|FD-Score:5.92|P-value:1.57E-7 ID:SGTC_932|Compound:2857-0803|FD-Score:4.84|P-value:1.42E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:7.17|P-value:2.90E-10 ID:SGTC_955|Compound:1216-0110|FD-Score:11.00|P-value:1.27E-21 ID:SGTC_999|Compound:4022-0066|FD-Score:14.00|P-value:4.20E-34 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.46|P-value:6.17E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.47|P-value:5.50E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:4.49|P-value:5.07E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.99|P-value:2.79E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.50|P-value:5.01E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:5.92|P-value:1.54E-7 ID:SGTC_1287|Compound:0971-0001|FD-Score:4.48|P-value:5.26E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:6.12|P-value:6.03E-8 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.57|P-value:3.91E-5 ID:SGTC_1687|Compound:st020778|FD-Score:6.20|P-value:4.16E-8 ID:SGTC_1754|Compound:st042065|FD-Score:15.80|P-value:1.77E-42 ID:SGTC_1760|Compound:st045453|FD-Score:17.50|P-value:5.92E-52 ID:SGTC_1781|Compound:st038725|FD-Score:13.60|P-value:2.68E-32 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.66|P-value:5.04E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.69|P-value:2.66E-5 ID:SGTC_1801|Compound:st050089|FD-Score:7.52|P-value:4.13E-11 ID:SGTC_1803|Compound:st050068|FD-Score:7.07|P-value:4.97E-10 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.13|P-value:4.50E-6 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.46|P-value:1.17E-6 ID:SGTC_1917|Compound:st066507|FD-Score:3.76|P-value:5.61E-4 ID:SGTC_1930|Compound:st074634|FD-Score:10.90|P-value:2.14E-21 ID:SGTC_1941|Compound:st076221|FD-Score:4.26|P-value:1.14E-4 ID:SGTC_1950|Compound:st077106|FD-Score:4.03|P-value:2.45E-4 ID:SGTC_1991|Compound:st073000|FD-Score:4.30|P-value:9.87E-5 ID:SGTC_2006|Compound:4011487|FD-Score:6.84|P-value:1.70E-9 ID:SGTC_2007|Compound:4011539|FD-Score:4.18|P-value:1.51E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.78|P-value:2.92E-7 ID:SGTC_2036|Compound:5160441|FD-Score:4.46|P-value:5.75E-5 ID:SGTC_2082|Compound:5219693|FD-Score:3.78|P-value:5.31E-4 ID:SGTC_2139|Compound:5578692|FD-Score:-7.20|P-value:2.75E-10 ID:SGTC_2141|Compound:5621638|FD-Score:-4.02|P-value:2.71E-4 ID:SGTC_2149|Compound:5554786|FD-Score:-6.34|P-value:2.41E-8 ID:SGTC_2159|Compound:5658611|FD-Score:-6.63|P-value:5.77E-9 ID:SGTC_2160|Compound:5660466|FD-Score:-4.67|P-value:2.92E-5 ID:SGTC_2242|Compound:6630449|FD-Score:14.10|P-value:2.57E-34 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.79|P-value:1.71E-5 ID:SGTC_2257|Compound:7960413|FD-Score:6.38|P-value:1.75E-8 ID:SGTC_2300|Compound:7976697|FD-Score:4.16|P-value:1.60E-4 ID:SGTC_2322|Compound:7413319|FD-Score:8.78|P-value:1.65E-14 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.27|P-value:1.12E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:8.15|P-value:9.21E-13 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.51|P-value:9.49E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.77|P-value:1.86E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.53|P-value:4.40E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:14.50|P-value:1.94E-36 ID:SGTC_2699|Compound:st077704|FD-Score:4.56|P-value:4.06E-5 ID:SGTC_2706|Compound:st078239|FD-Score:3.69|P-value:7.09E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.67|P-value:7.43E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:6.80|P-value:2.06E-9 ID:SGTC_2790|Compound:5423970|FD-Score:4.97|P-value:8.64E-6 ID:SGTC_2805|Compound:7950783|FD-Score:-3.83|P-value:4.95E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.66|P-value:4.90E-7 ID:SGTC_2896|Compound:9052656|FD-Score:3.78|P-value:5.35E-4 ID:SGTC_2938|Compound:9059746|FD-Score:6.56|P-value:7.03E-9 ID:SGTC_3037|Compound:9091026|FD-Score:7.01|P-value:6.95E-10 ID:SGTC_3039|Compound:9090270|FD-Score:3.82|P-value:4.74E-4 ID:SGTC_3120|Compound:9124077|FD-Score:4.88|P-value:1.24E-5 ID:SGTC_3148|Compound:9097893|FD-Score:6.93|P-value:1.07E-9 ID:SGTC_3152|Compound:9099253|FD-Score:4.53|P-value:4.45E-5 ID:SGTC_3164|Compound:9100705|FD-Score:-3.80|P-value:5.34E-4 ID:SGTC_3220|Compound:9131269|FD-Score:5.07|P-value:5.75E-6 ID:SGTC_3337|Compound:9144342|FD-Score:11.60|P-value:6.81E-24

Top fitness defect scores for YJL124C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_268 camptothecin 18.60 39.6 µM 2.29E-58 DNA damage response 1 1.43E-77
2 SGTC_1760 st045453 17.50 10.4 µM 5.92E-52 NEO1-PIK1 9 5.70E-69
3 SGTC_1754 st042065 15.80 16.1 µM 1.77E-42 NEO1-PIK1 9 2.87E-56
4 SGTC_2697 mebhydrolin 14.50 72.4 µM 1.94E-36 NEO1 8 3.60E-48
5 SGTC_232 clozapine 14.20 119.0 µM 1.14E-34 NEO1 10 8.42E-46
6 SGTC_2242 6630449 14.10 61.3 µM 2.57E-34 Golgi 3 2.50E-45
7 SGTC_999 4022-0066 14.00 22.7 µM 4.20E-34 Golgi 2 4.83E-45
8 SGTC_1781 st038725 13.60 66.3 µM 2.68E-32 NEO1 8 1.27E-42
9 SGTC_221 trifluoperazine 13.50 10.3 µM 9.17E-32 NEO1-PIK1 30 6.58E-42
10 SGTC_146 3448-8650 12.70 53.1 µM 2.85E-28 NEO1-PIK1 10 3.13E-37
11 SGTC_439 amiodarone 12.40 34.4 µM 7.25E-27 NEO1-PIK1 10 2.39E-35
12 SGTC_535 2293-4129 12.30 48.2 µM 9.29E-27 NEO1 6 3.33E-35
13 SGTC_3337 9144342 11.60 33.5 µM 6.81E-24 1 2.28E-31
14 SGTC_568 1193-0097 11.30 7.5 µM 8.56E-23 ERAD & cell cycle 15 6.76E-30
15 SGTC_955 1216-0110 11.00 33.0 µM 1.27E-21 sphingolipid biosynthesis & PDR1 12 2.51E-28
16 SGTC_1930 st074634 10.90 34.3 µM 2.14E-21 RNA pol III & RNase P/MRP 1 5.02E-28
17 SGTC_649 1123-0311 8.88 367.0 µM 8.21E-15 endomembrane recycling 12 3.20E-19
18 SGTC_2322 7413319 8.78 38.2 µM 1.65E-14 ERAD & cell cycle 28 8.12E-19
19 SGTC_301 4119-0100 8.67 24.5 µM 3.41E-14 NEO1 17 2.14E-18
20 SGTC_313 3474-0040 8.61 5.0 µM 5.00E-14 NEO1-PIK1 6 3.58E-18

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.502 3.48E-213 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.470 1.44E-183 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.459 1.21E-173 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.456 1.02E-171 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.439 9.60E-158 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.428 2.31E-149 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.420 3.29E-142 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.412 5.78E-137 YDR378C LSM6 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.409 1.24E-134 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.404 3.01E-131 YCR077C PAT1 hom Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress
0.400 6.21E-129 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.399 3.64E-128 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.392 2.39E-123 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.357 3.74E-101 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.353 1.52E-98 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation