YJL126W / NIT2

Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL126W / NIT2

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:3.71|P-value:9.22E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.20|P-value:5.74E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.77|P-value:7.27E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.67|P-value:9.70E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:3.16|P-value:7.34E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-4.15|P-value:1.26E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:3.33|P-value:3.99E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.20|P-value:1.17E-5 ID:SGTC_507|Compound:nimesulide|FD-Score:3.51|P-value:2.01E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.48|P-value:2.24E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.29|P-value:4.67E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:3.57|P-value:1.62E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:4.89|P-value:4.11E-7 ID:SGTC_785|Compound:1270-0111|FD-Score:4.29|P-value:7.47E-6 ID:SGTC_972|Compound:1319-0219|FD-Score:3.78|P-value:6.91E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.48|P-value:2.32E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.72|P-value:9.63E-7 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.12|P-value:8.55E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.69|P-value:1.01E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.14|P-value:7.96E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.41|P-value:2.98E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.16|P-value:7.45E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.13|P-value:8.20E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.17|P-value:6.96E-4 ID:SGTC_1810|Compound:st050138|FD-Score:3.59|P-value:1.50E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.10|P-value:7.99E-4 ID:SGTC_1836|Compound:st055642|FD-Score:4.26|P-value:8.75E-6 ID:SGTC_1854|Compound:st056233|FD-Score:3.31|P-value:4.36E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-3.07|P-value:8.86E-4 ID:SGTC_1902|Compound:st060212|FD-Score:3.10|P-value:8.94E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.19|P-value:5.93E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.59|P-value:1.49E-4 ID:SGTC_2015|Compound:5119600|FD-Score:4.87|P-value:4.60E-7 ID:SGTC_2035|Compound:5154463|FD-Score:-3.18|P-value:6.05E-4 ID:SGTC_2041|Compound:5107442|FD-Score:-3.94|P-value:3.18E-5 ID:SGTC_2047|Compound:4141938|FD-Score:3.19|P-value:6.53E-4 ID:SGTC_2288|Compound:7946289|FD-Score:4.63|P-value:1.50E-6 ID:SGTC_2448|Compound:5185112|FD-Score:4.32|P-value:6.76E-6 ID:SGTC_2702|Compound:st077768|FD-Score:5.99|P-value:7.47E-10 ID:SGTC_2764|Compound:methyldopa|FD-Score:4.30|P-value:7.12E-6 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.54|P-value:1.82E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.37|P-value:3.40E-4 ID:SGTC_2905|Compound:7799065|FD-Score:4.10|P-value:1.83E-5 ID:SGTC_2923|Compound:7992654|FD-Score:-3.81|P-value:5.39E-5 ID:SGTC_2975|Compound:9084847|FD-Score:3.75|P-value:7.84E-5 ID:SGTC_3035|Compound:9091303|FD-Score:3.35|P-value:3.64E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.09|P-value:9.30E-4 ID:SGTC_3204|Compound:9114183|FD-Score:5.22|P-value:7.04E-8 ID:SGTC_3270|Compound:9137563|FD-Score:4.93|P-value:3.27E-7 ID:SGTC_3271|Compound:9137798|FD-Score:3.29|P-value:4.63E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.45|P-value:2.54E-4 ID:SGTC_3280|Compound:9140961|FD-Score:3.56|P-value:1.67E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.71|P-value:9.22E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.20|P-value:5.74E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.77|P-value:7.27E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.67|P-value:9.70E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:3.16|P-value:7.34E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-4.15|P-value:1.26E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:3.33|P-value:3.99E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.20|P-value:1.17E-5 ID:SGTC_507|Compound:nimesulide|FD-Score:3.51|P-value:2.01E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.48|P-value:2.24E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.29|P-value:4.67E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:3.57|P-value:1.62E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:4.89|P-value:4.11E-7 ID:SGTC_785|Compound:1270-0111|FD-Score:4.29|P-value:7.47E-6 ID:SGTC_972|Compound:1319-0219|FD-Score:3.78|P-value:6.91E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.48|P-value:2.32E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.72|P-value:9.63E-7 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.12|P-value:8.55E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.69|P-value:1.01E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.14|P-value:7.96E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.41|P-value:2.98E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.16|P-value:7.45E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.13|P-value:8.20E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.17|P-value:6.96E-4 ID:SGTC_1810|Compound:st050138|FD-Score:3.59|P-value:1.50E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.10|P-value:7.99E-4 ID:SGTC_1836|Compound:st055642|FD-Score:4.26|P-value:8.75E-6 ID:SGTC_1854|Compound:st056233|FD-Score:3.31|P-value:4.36E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-3.07|P-value:8.86E-4 ID:SGTC_1902|Compound:st060212|FD-Score:3.10|P-value:8.94E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.19|P-value:5.93E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.59|P-value:1.49E-4 ID:SGTC_2015|Compound:5119600|FD-Score:4.87|P-value:4.60E-7 ID:SGTC_2035|Compound:5154463|FD-Score:-3.18|P-value:6.05E-4 ID:SGTC_2041|Compound:5107442|FD-Score:-3.94|P-value:3.18E-5 ID:SGTC_2047|Compound:4141938|FD-Score:3.19|P-value:6.53E-4 ID:SGTC_2288|Compound:7946289|FD-Score:4.63|P-value:1.50E-6 ID:SGTC_2448|Compound:5185112|FD-Score:4.32|P-value:6.76E-6 ID:SGTC_2702|Compound:st077768|FD-Score:5.99|P-value:7.47E-10 ID:SGTC_2764|Compound:methyldopa|FD-Score:4.30|P-value:7.12E-6 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.54|P-value:1.82E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.37|P-value:3.40E-4 ID:SGTC_2905|Compound:7799065|FD-Score:4.10|P-value:1.83E-5 ID:SGTC_2923|Compound:7992654|FD-Score:-3.81|P-value:5.39E-5 ID:SGTC_2975|Compound:9084847|FD-Score:3.75|P-value:7.84E-5 ID:SGTC_3035|Compound:9091303|FD-Score:3.35|P-value:3.64E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.09|P-value:9.30E-4 ID:SGTC_3204|Compound:9114183|FD-Score:5.22|P-value:7.04E-8 ID:SGTC_3270|Compound:9137563|FD-Score:4.93|P-value:3.27E-7 ID:SGTC_3271|Compound:9137798|FD-Score:3.29|P-value:4.63E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.45|P-value:2.54E-4 ID:SGTC_3280|Compound:9140961|FD-Score:3.56|P-value:1.67E-4

Top fitness defect scores for YJL126W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2702 st077768 5.99 96.8 µM 7.47E-10 2 1.05E-9
2 SGTC_3204 9114183 5.22 49.5 µM 7.04E-8 10 9.04E-8
3 SGTC_3270 9137563 4.93 49.5 µM 3.27E-7 RPP1 & pyrimidine depletion 2 4.08E-7
4 SGTC_773 4358-1457 4.89 44.6 µM 4.11E-7 22 5.10E-7
5 SGTC_2015 5119600 4.87 184.0 µM 4.60E-7 15 5.70E-7
6 SGTC_1049 3226-0134 4.72 66.0 µM 9.63E-7 14 1.17E-6
7 SGTC_2288 7946289 4.63 167.3 µM 1.50E-6 13 1.81E-6
8 SGTC_2448 5185112 4.32 27.2 µM 6.76E-6 10 7.94E-6
9 SGTC_2764 methyldopa 4.30 94.7 µM 7.12E-6 13 8.35E-6
10 SGTC_785 1270-0111 4.29 65.3 µM 7.47E-6 18 8.76E-6
11 SGTC_1836 st055642 4.26 81.0 µM 8.75E-6 14 1.02E-5
12 SGTC_436 n,n-dimethylsphingosine 4.20 3.3 µM 1.17E-5 21 1.36E-5
13 SGTC_2905 7799065 4.10 20.1 µM 1.83E-5 11 2.11E-5
14 SGTC_972 1319-0219 3.78 195.0 µM 6.91E-5 36 7.77E-5
15 SGTC_47 0149-0135 3.77 24.2 µM 7.27E-5 TSC3-RPN4 23 8.17E-5
16 SGTC_2975 9084847 3.75 53.7 µM 7.84E-5 27 8.79E-5
17 SGTC_42 0133-0086 3.71 60.6 µM 9.22E-5 36 1.03E-4
18 SGTC_1094 duloxetine 3.69 25.4 µM 1.01E-4 RPP1 & pyrimidine depletion 22 1.13E-4
19 SGTC_1922 5578187 3.59 25.0 µM 1.49E-4 TRP & mitochondrial translation 44 1.65E-4
20 SGTC_1810 st050138 3.59 53.0 µM 1.50E-4 PDR1 19 1.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.099 1.00E-8 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.094 5.19E-8 YLR013W GAT3 hom Protein containing GATA family zinc finger motifs
0.088 3.60E-7 YPL149W ATG5 hom Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation
0.086 6.21E-7 YLR165C PUS5 hom Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability
0.084 1.12E-6 YOL100W PKH2 hom Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
0.079 4.26E-6 YER079W_p YER079W_p hom Putative protein of unknown function
0.079 5.27E-6 YGL115W SNF4 hom Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress
0.078 6.16E-6 YLR341W SPO77 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
0.077 8.97E-6 YML125C PGA3 het Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication
0.076 9.31E-6 YPL210C SRP72 het Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
0.075 1.53E-5 YCL024W KCC4 hom Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication
0.071 3.65E-5 YOR318C_d YOR318C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo
0.071 3.76E-5 YAL065C_p YAL065C_p hom Putative protein of unknown function; has homology to FLO1; possible pseudogene
0.071 3.80E-5 YCR015C_p YCR015C_p hom Putative protein of unknown function; YCR015C is not an essential gene
0.070 5.29E-5 YMR156C TPP1 hom DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3′-phosphatase