YJL127C / SPT10

Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL127C / SPT10

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:3.14|P-value:7.27E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.35|P-value:2.94E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:-4.69|P-value:7.47E-7 ID:SGTC_315|Compound:k915-0449|FD-Score:-4.13|P-value:1.12E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:3.26|P-value:4.61E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.95|P-value:3.01E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.22|P-value:5.47E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.43|P-value:2.15E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.09|P-value:8.47E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.38|P-value:3.53E-6 ID:SGTC_923|Compound:1900-2434|FD-Score:4.12|P-value:1.40E-5 ID:SGTC_941|Compound:3237-0776|FD-Score:4.25|P-value:7.71E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:4.07|P-value:1.79E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:3.55|P-value:1.57E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.62|P-value:1.18E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.38|P-value:3.03E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.70|P-value:8.84E-7 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.61|P-value:1.41E-6 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.18|P-value:1.08E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.53|P-value:2.09E-6 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.24|P-value:5.01E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.99|P-value:2.54E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.13|P-value:6.50E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.61|P-value:1.07E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.07|P-value:9.24E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.77|P-value:6.39E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.15|P-value:7.01E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.19|P-value:6.10E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.14|P-value:7.21E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.34|P-value:3.02E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.18|P-value:6.35E-4 ID:SGTC_1720|Compound:st037298|FD-Score:5.03|P-value:1.56E-7 ID:SGTC_1833|Compound:st055984|FD-Score:4.72|P-value:7.93E-7 ID:SGTC_1834|Compound:st055981|FD-Score:4.18|P-value:1.08E-5 ID:SGTC_1939|Compound:st074455|FD-Score:-3.38|P-value:2.56E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.66|P-value:1.00E-4 ID:SGTC_2003|Compound:4023581|FD-Score:4.91|P-value:2.91E-7 ID:SGTC_2079|Compound:5212404|FD-Score:3.64|P-value:1.11E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.70|P-value:8.88E-7 ID:SGTC_2102|Compound:5377816|FD-Score:3.10|P-value:8.27E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.75|P-value:7.01E-5 ID:SGTC_2360|Compound:9040895|FD-Score:3.46|P-value:2.21E-4 ID:SGTC_2423|Compound:st077119|FD-Score:4.32|P-value:5.65E-6 ID:SGTC_2479|Compound:5617353|FD-Score:4.23|P-value:8.60E-6 ID:SGTC_2486|Compound:5283202|FD-Score:5.02|P-value:1.65E-7 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.11|P-value:1.47E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:4.82|P-value:4.89E-7 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.41|P-value:2.32E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.48|P-value:2.08E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.11|P-value:7.02E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.36|P-value:2.79E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.46|P-value:2.84E-6 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.72|P-value:8.04E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.23|P-value:8.72E-6 ID:SGTC_2712|Compound:st079126|FD-Score:4.07|P-value:1.81E-5 ID:SGTC_2788|Compound:5282734|FD-Score:3.86|P-value:4.33E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.72|P-value:7.78E-5 ID:SGTC_2796|Compound:7949634|FD-Score:3.51|P-value:1.87E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.31|P-value:3.84E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.99|P-value:2.48E-5 ID:SGTC_3052|Compound:9092717|FD-Score:3.60|P-value:1.29E-4 ID:SGTC_3100|Compound:9120536|FD-Score:3.73|P-value:7.59E-5 ID:SGTC_3135|Compound:9127742|FD-Score:-3.87|P-value:3.61E-5 ID:SGTC_3288|Compound:9119690|FD-Score:-3.10|P-value:7.30E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.23|P-value:5.17E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.34|P-value:3.56E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.32|P-value:3.78E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.14|P-value:7.27E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.35|P-value:2.94E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:-4.69|P-value:7.47E-7 ID:SGTC_315|Compound:k915-0449|FD-Score:-4.13|P-value:1.12E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:3.26|P-value:4.61E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.95|P-value:3.01E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.22|P-value:5.47E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.43|P-value:2.15E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.09|P-value:8.47E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.38|P-value:3.53E-6 ID:SGTC_923|Compound:1900-2434|FD-Score:4.12|P-value:1.40E-5 ID:SGTC_941|Compound:3237-0776|FD-Score:4.25|P-value:7.71E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:4.07|P-value:1.79E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:3.55|P-value:1.57E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.62|P-value:1.18E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.38|P-value:3.03E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.70|P-value:8.84E-7 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.61|P-value:1.41E-6 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.18|P-value:1.08E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.53|P-value:2.09E-6 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.24|P-value:5.01E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.99|P-value:2.54E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.13|P-value:6.50E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.61|P-value:1.07E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.07|P-value:9.24E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.77|P-value:6.39E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.15|P-value:7.01E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.19|P-value:6.10E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.14|P-value:7.21E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.34|P-value:3.02E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.18|P-value:6.35E-4 ID:SGTC_1720|Compound:st037298|FD-Score:5.03|P-value:1.56E-7 ID:SGTC_1833|Compound:st055984|FD-Score:4.72|P-value:7.93E-7 ID:SGTC_1834|Compound:st055981|FD-Score:4.18|P-value:1.08E-5 ID:SGTC_1939|Compound:st074455|FD-Score:-3.38|P-value:2.56E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.66|P-value:1.00E-4 ID:SGTC_2003|Compound:4023581|FD-Score:4.91|P-value:2.91E-7 ID:SGTC_2079|Compound:5212404|FD-Score:3.64|P-value:1.11E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.70|P-value:8.88E-7 ID:SGTC_2102|Compound:5377816|FD-Score:3.10|P-value:8.27E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.75|P-value:7.01E-5 ID:SGTC_2360|Compound:9040895|FD-Score:3.46|P-value:2.21E-4 ID:SGTC_2423|Compound:st077119|FD-Score:4.32|P-value:5.65E-6 ID:SGTC_2479|Compound:5617353|FD-Score:4.23|P-value:8.60E-6 ID:SGTC_2486|Compound:5283202|FD-Score:5.02|P-value:1.65E-7 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.11|P-value:1.47E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:4.82|P-value:4.89E-7 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.41|P-value:2.32E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.48|P-value:2.08E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.11|P-value:7.02E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.36|P-value:2.79E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.46|P-value:2.84E-6 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.72|P-value:8.04E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.23|P-value:8.72E-6 ID:SGTC_2712|Compound:st079126|FD-Score:4.07|P-value:1.81E-5 ID:SGTC_2788|Compound:5282734|FD-Score:3.86|P-value:4.33E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.72|P-value:7.78E-5 ID:SGTC_2796|Compound:7949634|FD-Score:3.51|P-value:1.87E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.31|P-value:3.84E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.99|P-value:2.48E-5 ID:SGTC_3052|Compound:9092717|FD-Score:3.60|P-value:1.29E-4 ID:SGTC_3100|Compound:9120536|FD-Score:3.73|P-value:7.59E-5 ID:SGTC_3135|Compound:9127742|FD-Score:-3.87|P-value:3.61E-5 ID:SGTC_3288|Compound:9119690|FD-Score:-3.10|P-value:7.30E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.23|P-value:5.17E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.34|P-value:3.56E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.32|P-value:3.78E-4

Top fitness defect scores for YJL127C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1720 st037298 5.03 9.5 µM 1.56E-7 23 2.44E-7
2 SGTC_2486 5283202 5.02 22.4 µM 1.65E-7 19 2.57E-7
3 SGTC_2003 4023581 4.91 200.0 µM 2.91E-7 cell wall signaling 23 4.45E-7
4 SGTC_2533 agelasine 4.82 13.7 µM 4.89E-7 ERG2 29 7.34E-7
5 SGTC_1833 st055984 4.72 71.0 µM 7.93E-7 7 1.17E-6
6 SGTC_1018 4259-0013 4.70 28.1 µM 8.84E-7 6 1.30E-6
7 SGTC_2092 5303694 4.70 80.7 µM 8.88E-7 TSC3-RPN4 19 1.31E-6
8 SGTC_1051 3253-3903 4.61 78.0 µM 1.41E-6 10 2.04E-6
9 SGTC_1252 0493-0875 4.53 34.8 µM 2.09E-6 15 2.99E-6
10 SGTC_2600 tangeritin 4.46 88.0 µM 2.84E-6 22 4.01E-6
11 SGTC_2423 st077119 4.32 87.2 µM 5.65E-6 9 7.79E-6
12 SGTC_941 3237-0776 4.25 460.0 µM 7.71E-6 9 1.05E-5
13 SGTC_2479 5617353 4.23 43.9 µM 8.60E-6 28 1.17E-5
14 SGTC_2634 4'-methoxyflavone 4.23 100.0 µM 8.72E-6 24 1.18E-5
15 SGTC_1834 st055981 4.18 52.8 µM 1.08E-5 RPP1 & pyrimidine depletion 31 1.45E-5
16 SGTC_1246 0422-0085 4.18 105.0 µM 1.08E-5 24 1.45E-5
17 SGTC_923 1900-2434 4.12 73.3 µM 1.40E-5 RNA processing & uracil transport 31 1.87E-5
18 SGTC_2497 7-hydroxyflavone 4.11 100.0 µM 1.47E-5 18 1.96E-5
19 SGTC_951 1171-0579 4.07 82.7 µM 1.79E-5 cell wall 74 2.38E-5
20 SGTC_2712 st079126 4.07 47.7 µM 1.81E-5 13 2.39E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 3.51E-25 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.173 4.37E-24 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.083 1.59E-6 YMR169C ALD3 hom Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose
0.078 5.53E-6 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.078 5.62E-6 YNL296W_d YNL296W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog
0.078 6.30E-6 YOR033C EXO1 hom 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress
0.075 1.50E-5 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.073 2.08E-5 YNL110C NOP15 het Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
0.072 3.13E-5 YCL063W VAC17 hom Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p
0.072 3.15E-5 YJR112W NNF1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
0.070 4.64E-5 YER038C KRE29 het Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
0.069 6.31E-5 YFR032C_p RRT5_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation
0.067 9.86E-5 YMR078C CTF18 hom Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint
0.066 1.30E-4 YHR161C YAP1801 hom Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication
0.065 1.61E-4 YGR035W-A_p YGR035W-A_p hom Putative protein of unknown function