YJL129C / TRK1

Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL129C / TRK1

Click on Significant Values for Screen Details ID:SGTC_54|Compound:0159-0055|FD-Score:8.90|P-value:1.82E-14 ID:SGTC_60|Compound:0986-0278|FD-Score:-4.03|P-value:2.51E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.35|P-value:1.15E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:6.15|P-value:8.96E-8 ID:SGTC_121|Compound:0557-0495|FD-Score:6.45|P-value:2.10E-8 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.07|P-value:2.21E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:-4.90|P-value:1.20E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:11.60|P-value:2.98E-23 ID:SGTC_197|Compound:4544-0043|FD-Score:8.49|P-value:2.57E-13 ID:SGTC_227|Compound:fluconazole|FD-Score:5.32|P-value:3.19E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:3.78|P-value:6.94E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:6.74|P-value:5.16E-9 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.87|P-value:5.29E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.23|P-value:1.71E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:5.34|P-value:2.93E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.54|P-value:1.30E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.76|P-value:7.37E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:9.06|P-value:6.16E-15 ID:SGTC_500|Compound:h-89|FD-Score:4.01|P-value:3.44E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:12.20|P-value:1.56E-25 ID:SGTC_514|Compound:4466-0038|FD-Score:5.35|P-value:2.79E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:6.09|P-value:1.14E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:13.10|P-value:2.59E-29 ID:SGTC_582|Compound:0987-0078|FD-Score:10.50|P-value:1.78E-19 ID:SGTC_584|Compound:0986-0246|FD-Score:3.95|P-value:4.18E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.91|P-value:4.75E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.84|P-value:5.74E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.81|P-value:6.33E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:5.18|P-value:5.52E-6 ID:SGTC_924|Compound:2046-0044|FD-Score:4.34|P-value:1.18E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.40|P-value:9.68E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:-4.14|P-value:1.76E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.88|P-value:3.98E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.94|P-value:4.31E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.44|P-value:8.45E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.01|P-value:3.45E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.70|P-value:6.48E-7 ID:SGTC_1136|Compound:pergolide|FD-Score:4.50|P-value:6.98E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.93|P-value:3.47E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.02|P-value:3.36E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:6.36|P-value:3.27E-8 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.96|P-value:3.18E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:5.14|P-value:6.63E-6 ID:SGTC_1588|Compound:farnesol|FD-Score:3.69|P-value:9.05E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:4.10|P-value:2.60E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:20.00|P-value:1.92E-65 ID:SGTC_1622|Compound:st003707|FD-Score:5.94|P-value:2.31E-7 ID:SGTC_1623|Compound:st003709|FD-Score:6.14|P-value:9.33E-8 ID:SGTC_1624|Compound:st003710|FD-Score:5.35|P-value:2.77E-6 ID:SGTC_1627|Compound:st003713|FD-Score:8.85|P-value:2.55E-14 ID:SGTC_1666|Compound:st014829|FD-Score:3.84|P-value:5.89E-4 ID:SGTC_1672|Compound:st016598|FD-Score:8.94|P-value:1.36E-14 ID:SGTC_1690|Compound:st023502|FD-Score:3.92|P-value:4.49E-4 ID:SGTC_1712|Compound:st032288|FD-Score:14.70|P-value:1.64E-36 ID:SGTC_1750|Compound:st081859|FD-Score:6.77|P-value:4.31E-9 ID:SGTC_1754|Compound:st042065|FD-Score:4.51|P-value:6.74E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.83|P-value:2.12E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.40|P-value:9.54E-5 ID:SGTC_1800|Compound:st050079|FD-Score:7.58|P-value:5.68E-11 ID:SGTC_1801|Compound:st050089|FD-Score:4.57|P-value:5.37E-5 ID:SGTC_1803|Compound:st050068|FD-Score:8.10|P-value:2.78E-12 ID:SGTC_1806|Compound:st050005|FD-Score:3.80|P-value:6.47E-4 ID:SGTC_1812|Compound:st052057|FD-Score:10.60|P-value:8.86E-20 ID:SGTC_1818|Compound:st052136|FD-Score:3.96|P-value:4.03E-4 ID:SGTC_1851|Compound:st056236|FD-Score:5.26|P-value:4.08E-6 ID:SGTC_1872|Compound:amphotericin b|FD-Score:-4.31|P-value:1.02E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.62|P-value:4.54E-5 ID:SGTC_1898|Compound:st060199|FD-Score:3.73|P-value:8.06E-4 ID:SGTC_1922|Compound:5578187|FD-Score:4.08|P-value:2.76E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.69|P-value:8.98E-4 ID:SGTC_1998|Compound:st075797|FD-Score:-3.65|P-value:8.12E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.74|P-value:7.85E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.91|P-value:1.16E-5 ID:SGTC_2108|Compound:5365811|FD-Score:-3.98|P-value:2.95E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-3.81|P-value:5.01E-4 ID:SGTC_2186|Compound:6124449|FD-Score:5.39|P-value:2.45E-6 ID:SGTC_2323|Compound:6148992|FD-Score:4.99|P-value:1.15E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:5.14|P-value:6.42E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:9.54|P-value:2.34E-16 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.36|P-value:1.11E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.92|P-value:2.49E-7 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.12|P-value:1.88E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.98|P-value:3.78E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:4.27|P-value:1.51E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.82|P-value:1.44E-11 ID:SGTC_2737|Compound:bleomycin|FD-Score:10.50|P-value:1.34E-19 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.96|P-value:4.01E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:5.84|P-value:3.49E-7 ID:SGTC_2867|Compound:9039098|FD-Score:5.14|P-value:6.48E-6 ID:SGTC_2877|Compound:9040724|FD-Score:3.72|P-value:8.29E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.73|P-value:7.94E-4 ID:SGTC_2900|Compound:5328528|FD-Score:4.70|P-value:3.44E-5 ID:SGTC_2952|Compound:9073731|FD-Score:5.60|P-value:1.00E-6 ID:SGTC_2958|Compound:9077254|FD-Score:4.20|P-value:1.91E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.61|P-value:9.17E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.66|P-value:7.73E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-4.54|P-value:4.47E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:8.90|P-value:1.82E-14 ID:SGTC_60|Compound:0986-0278|FD-Score:-4.03|P-value:2.51E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.35|P-value:1.15E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:6.15|P-value:8.96E-8 ID:SGTC_121|Compound:0557-0495|FD-Score:6.45|P-value:2.10E-8 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.07|P-value:2.21E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:-4.90|P-value:1.20E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:11.60|P-value:2.98E-23 ID:SGTC_197|Compound:4544-0043|FD-Score:8.49|P-value:2.57E-13 ID:SGTC_227|Compound:fluconazole|FD-Score:5.32|P-value:3.19E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:3.78|P-value:6.94E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:6.74|P-value:5.16E-9 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.87|P-value:5.29E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.23|P-value:1.71E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:5.34|P-value:2.93E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.54|P-value:1.30E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.76|P-value:7.37E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:9.06|P-value:6.16E-15 ID:SGTC_500|Compound:h-89|FD-Score:4.01|P-value:3.44E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:12.20|P-value:1.56E-25 ID:SGTC_514|Compound:4466-0038|FD-Score:5.35|P-value:2.79E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:6.09|P-value:1.14E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:13.10|P-value:2.59E-29 ID:SGTC_582|Compound:0987-0078|FD-Score:10.50|P-value:1.78E-19 ID:SGTC_584|Compound:0986-0246|FD-Score:3.95|P-value:4.18E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.91|P-value:4.75E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.84|P-value:5.74E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.81|P-value:6.33E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:5.18|P-value:5.52E-6 ID:SGTC_924|Compound:2046-0044|FD-Score:4.34|P-value:1.18E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.40|P-value:9.68E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:-4.14|P-value:1.76E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.88|P-value:3.98E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.94|P-value:4.31E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.44|P-value:8.45E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.01|P-value:3.45E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.70|P-value:6.48E-7 ID:SGTC_1136|Compound:pergolide|FD-Score:4.50|P-value:6.98E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.93|P-value:3.47E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.02|P-value:3.36E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:6.36|P-value:3.27E-8 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.96|P-value:3.18E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:5.14|P-value:6.63E-6 ID:SGTC_1588|Compound:farnesol|FD-Score:3.69|P-value:9.05E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:4.10|P-value:2.60E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:20.00|P-value:1.92E-65 ID:SGTC_1622|Compound:st003707|FD-Score:5.94|P-value:2.31E-7 ID:SGTC_1623|Compound:st003709|FD-Score:6.14|P-value:9.33E-8 ID:SGTC_1624|Compound:st003710|FD-Score:5.35|P-value:2.77E-6 ID:SGTC_1627|Compound:st003713|FD-Score:8.85|P-value:2.55E-14 ID:SGTC_1666|Compound:st014829|FD-Score:3.84|P-value:5.89E-4 ID:SGTC_1672|Compound:st016598|FD-Score:8.94|P-value:1.36E-14 ID:SGTC_1690|Compound:st023502|FD-Score:3.92|P-value:4.49E-4 ID:SGTC_1712|Compound:st032288|FD-Score:14.70|P-value:1.64E-36 ID:SGTC_1750|Compound:st081859|FD-Score:6.77|P-value:4.31E-9 ID:SGTC_1754|Compound:st042065|FD-Score:4.51|P-value:6.74E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.83|P-value:2.12E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.40|P-value:9.54E-5 ID:SGTC_1800|Compound:st050079|FD-Score:7.58|P-value:5.68E-11 ID:SGTC_1801|Compound:st050089|FD-Score:4.57|P-value:5.37E-5 ID:SGTC_1803|Compound:st050068|FD-Score:8.10|P-value:2.78E-12 ID:SGTC_1806|Compound:st050005|FD-Score:3.80|P-value:6.47E-4 ID:SGTC_1812|Compound:st052057|FD-Score:10.60|P-value:8.86E-20 ID:SGTC_1818|Compound:st052136|FD-Score:3.96|P-value:4.03E-4 ID:SGTC_1851|Compound:st056236|FD-Score:5.26|P-value:4.08E-6 ID:SGTC_1872|Compound:amphotericin b|FD-Score:-4.31|P-value:1.02E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.62|P-value:4.54E-5 ID:SGTC_1898|Compound:st060199|FD-Score:3.73|P-value:8.06E-4 ID:SGTC_1922|Compound:5578187|FD-Score:4.08|P-value:2.76E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.69|P-value:8.98E-4 ID:SGTC_1998|Compound:st075797|FD-Score:-3.65|P-value:8.12E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.74|P-value:7.85E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.91|P-value:1.16E-5 ID:SGTC_2108|Compound:5365811|FD-Score:-3.98|P-value:2.95E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-3.81|P-value:5.01E-4 ID:SGTC_2186|Compound:6124449|FD-Score:5.39|P-value:2.45E-6 ID:SGTC_2323|Compound:6148992|FD-Score:4.99|P-value:1.15E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:5.14|P-value:6.42E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:9.54|P-value:2.34E-16 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.36|P-value:1.11E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.92|P-value:2.49E-7 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.12|P-value:1.88E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.98|P-value:3.78E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:4.27|P-value:1.51E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.82|P-value:1.44E-11 ID:SGTC_2737|Compound:bleomycin|FD-Score:10.50|P-value:1.34E-19 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.96|P-value:4.01E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:5.84|P-value:3.49E-7 ID:SGTC_2867|Compound:9039098|FD-Score:5.14|P-value:6.48E-6 ID:SGTC_2877|Compound:9040724|FD-Score:3.72|P-value:8.29E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.73|P-value:7.94E-4 ID:SGTC_2900|Compound:5328528|FD-Score:4.70|P-value:3.44E-5 ID:SGTC_2952|Compound:9073731|FD-Score:5.60|P-value:1.00E-6 ID:SGTC_2958|Compound:9077254|FD-Score:4.20|P-value:1.91E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.61|P-value:9.17E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.66|P-value:7.73E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-4.54|P-value:4.47E-5

Top fitness defect scores for YJL129C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1597 7-benzyloxygramine 20.00 47.5 µM 1.92E-65 calcium & mitochondrial duress 3 4.08E-89
2 SGTC_1712 st032288 14.70 53.4 µM 1.64E-36 calcium & mitochondrial duress 3 1.79E-49
3 SGTC_528 3492-0019 13.10 172.0 µM 2.59E-29 calcium & mitochondrial duress 22 1.30E-39
4 SGTC_502 l-744,832 12.20 89.3 µM 1.56E-25 calcium & mitochondrial duress 1 1.95E-34
5 SGTC_187 1488-2104 11.60 32.7 µM 2.98E-23 calcium & mitochondrial duress 4 2.60E-31
6 SGTC_1812 st052057 10.60 4.3 µM 8.86E-20 calcium & mitochondrial duress 1 1.49E-26
7 SGTC_2737 bleomycin 10.50 30.5 nM 1.34E-19 Golgi 11 2.63E-26
8 SGTC_582 0987-0078 10.50 156.0 µM 1.78E-19 calcium & mitochondrial duress 8 3.89E-26
9 SGTC_2566 crystal violet carbinol 9.54 226.0 nM 2.34E-16 4 7.23E-22
10 SGTC_467 ro 31-8220 9.06 72.8 µM 6.16E-15 calcium & mitochondrial duress 11 6.34E-20
11 SGTC_1672 st016598 8.94 6.5 µM 1.36E-14 endomembrane recycling 12 1.88E-19
12 SGTC_54 0159-0055 8.90 9.0 µM 1.82E-14 ERG2 11 2.79E-19
13 SGTC_1627 st003713 8.85 25.6 µM 2.55E-14 calcium & mitochondrial duress 10 4.44E-19
14 SGTC_197 4544-0043 8.49 41.6 µM 2.57E-13 endomembrane recycling 9 1.05E-17
15 SGTC_1803 st050068 8.10 52.4 µM 2.78E-12 NEO1-PIK1 42 2.72E-16
16 SGTC_2688 kanamycin b 7.82 96.7 µM 1.44E-11 calcium & mitochondrial duress 71 2.58E-15
17 SGTC_1800 st050079 7.58 29.1 µM 5.68E-11 NEO1-PIK1 15 1.69E-14
18 SGTC_1750 st081859 6.77 2.4 µM 4.31E-9 endomembrane recycling 91 6.28E-12
19 SGTC_383 2324-0395 6.74 7.4 µM 5.16E-9 azole & statin 9 8.03E-12
20 SGTC_121 0557-0495 6.45 61.3 µM 2.10E-8 calcium & mitochondrial duress 13 5.46E-11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.503 4.90E-214 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.443 2.49E-161 YGR285C ZUO1 hom Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
0.431 6.87E-152 YHR064C SSZ1 hom Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
0.376 1.59E-112 YIL154C IMP2' hom Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
0.372 1.92E-110 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.370 2.15E-109 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.355 1.57E-100 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.342 1.33E-92 YBR109C CMD1 het Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
0.305 4.67E-73 YCR008W SAT4 hom Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
0.285 7.36E-64 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.280 2.75E-61 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.270 5.20E-57 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.268 2.13E-56 YLR404W FLD1 hom Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy
0.265 3.49E-55 YDL160C DHH1 hom Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress
0.264 1.70E-54 YER133W GLC7 het Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest