YJL133W / MRS3

Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL133W / MRS3

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:-3.64|P-value:1.23E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.07|P-value:7.56E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.96|P-value:2.26E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:3.60|P-value:1.03E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.80|P-value:4.61E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:5.66|P-value:3.16E-9 ID:SGTC_644|Compound:1498-1197|FD-Score:-3.12|P-value:8.51E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.28|P-value:3.52E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.49|P-value:2.23E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.40|P-value:2.26E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:-3.56|P-value:1.68E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.25|P-value:5.37E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.78|P-value:4.95E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.51|P-value:1.49E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.33|P-value:3.01E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:4.26|P-value:5.95E-6 ID:SGTC_1443|Compound:4112-3303|FD-Score:-4.09|P-value:1.90E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.31|P-value:3.18E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.48|P-value:1.69E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.02|P-value:9.15E-4 ID:SGTC_1917|Compound:st066507|FD-Score:4.07|P-value:1.39E-5 ID:SGTC_1938|Compound:st074717|FD-Score:3.03|P-value:8.82E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.57|P-value:1.15E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.52|P-value:1.41E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.04|P-value:8.32E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.81|P-value:4.43E-5 ID:SGTC_2126|Compound:5251174|FD-Score:4.57|P-value:1.29E-6 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.36|P-value:5.60E-6 ID:SGTC_2135|Compound:5326629|FD-Score:-7.57|P-value:8.78E-15 ID:SGTC_2193|Compound:5925765|FD-Score:3.54|P-value:1.29E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.07|P-value:7.49E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.79|P-value:6.87E-5 ID:SGTC_2421|Compound:5690543|FD-Score:3.14|P-value:5.94E-4 ID:SGTC_2428|Compound:5615643|FD-Score:6.14|P-value:1.48E-10 ID:SGTC_2430|Compound:5571206|FD-Score:5.91|P-value:6.66E-10 ID:SGTC_2686|Compound:alizarin|FD-Score:3.22|P-value:4.51E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.54|P-value:1.87E-4 ID:SGTC_2692|Compound:st077426|FD-Score:5.20|P-value:4.77E-8 ID:SGTC_2693|Compound:st077581|FD-Score:3.67|P-value:7.65E-5 ID:SGTC_2696|Compound:st077691|FD-Score:5.60|P-value:4.61E-9 ID:SGTC_3018|Compound:9082602|FD-Score:3.00|P-value:9.69E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-3.54|P-value:1.81E-4 ID:SGTC_3261|Compound:9137475|FD-Score:3.44|P-value:1.92E-4 ID:SGTC_3262|Compound:9137218|FD-Score:5.56|P-value:5.92E-9 ID:SGTC_3265|Compound:9137266|FD-Score:4.66|P-value:8.51E-7 ID:SGTC_3270|Compound:9137563|FD-Score:4.55|P-value:1.45E-6 ID:SGTC_3323|Compound:9138564|FD-Score:-3.86|P-value:5.01E-5 ID:SGTC_3328|Compound:9140624|FD-Score:5.24|P-value:3.64E-8 ID:SGTC_3331|Compound:9141060|FD-Score:-3.51|P-value:2.10E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:-3.64|P-value:1.23E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.07|P-value:7.56E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.96|P-value:2.26E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:3.60|P-value:1.03E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.80|P-value:4.61E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:5.66|P-value:3.16E-9 ID:SGTC_644|Compound:1498-1197|FD-Score:-3.12|P-value:8.51E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.28|P-value:3.52E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.49|P-value:2.23E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.40|P-value:2.26E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:-3.56|P-value:1.68E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.25|P-value:5.37E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.78|P-value:4.95E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.51|P-value:1.49E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.33|P-value:3.01E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:4.26|P-value:5.95E-6 ID:SGTC_1443|Compound:4112-3303|FD-Score:-4.09|P-value:1.90E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.31|P-value:3.18E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.48|P-value:1.69E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.02|P-value:9.15E-4 ID:SGTC_1917|Compound:st066507|FD-Score:4.07|P-value:1.39E-5 ID:SGTC_1938|Compound:st074717|FD-Score:3.03|P-value:8.82E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.57|P-value:1.15E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.52|P-value:1.41E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.04|P-value:8.32E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.81|P-value:4.43E-5 ID:SGTC_2126|Compound:5251174|FD-Score:4.57|P-value:1.29E-6 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.36|P-value:5.60E-6 ID:SGTC_2135|Compound:5326629|FD-Score:-7.57|P-value:8.78E-15 ID:SGTC_2193|Compound:5925765|FD-Score:3.54|P-value:1.29E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.07|P-value:7.49E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.79|P-value:6.87E-5 ID:SGTC_2421|Compound:5690543|FD-Score:3.14|P-value:5.94E-4 ID:SGTC_2428|Compound:5615643|FD-Score:6.14|P-value:1.48E-10 ID:SGTC_2430|Compound:5571206|FD-Score:5.91|P-value:6.66E-10 ID:SGTC_2686|Compound:alizarin|FD-Score:3.22|P-value:4.51E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.54|P-value:1.87E-4 ID:SGTC_2692|Compound:st077426|FD-Score:5.20|P-value:4.77E-8 ID:SGTC_2693|Compound:st077581|FD-Score:3.67|P-value:7.65E-5 ID:SGTC_2696|Compound:st077691|FD-Score:5.60|P-value:4.61E-9 ID:SGTC_3018|Compound:9082602|FD-Score:3.00|P-value:9.69E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-3.54|P-value:1.81E-4 ID:SGTC_3261|Compound:9137475|FD-Score:3.44|P-value:1.92E-4 ID:SGTC_3262|Compound:9137218|FD-Score:5.56|P-value:5.92E-9 ID:SGTC_3265|Compound:9137266|FD-Score:4.66|P-value:8.51E-7 ID:SGTC_3270|Compound:9137563|FD-Score:4.55|P-value:1.45E-6 ID:SGTC_3323|Compound:9138564|FD-Score:-3.86|P-value:5.01E-5 ID:SGTC_3328|Compound:9140624|FD-Score:5.24|P-value:3.64E-8 ID:SGTC_3331|Compound:9141060|FD-Score:-3.51|P-value:2.10E-4

Top fitness defect scores for YJL133W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2428 5615643 6.14 7.8 µM 1.48E-10 9 4.02E-10
2 SGTC_2430 5571206 5.91 200.0 µM 6.66E-10 24 1.70E-9
3 SGTC_439 amiodarone 5.66 34.4 µM 3.16E-9 NEO1-PIK1 51 7.57E-9
4 SGTC_2696 st077691 5.60 74.3 µM 4.61E-9 8 1.09E-8
5 SGTC_3262 9137218 5.56 49.5 µM 5.92E-9 1 1.38E-8
6 SGTC_3328 9140624 5.24 29.0 µM 3.64E-8 7 7.88E-8
7 SGTC_2692 st077426 5.20 47.7 µM 4.77E-8 7 1.02E-7
8 SGTC_3265 9137266 4.66 49.5 µM 8.51E-7 3 1.61E-6
9 SGTC_2126 5251174 4.57 33.9 µM 1.29E-6 16 2.40E-6
10 SGTC_3270 9137563 4.55 49.5 µM 1.45E-6 RPP1 & pyrimidine depletion 3 2.69E-6
11 SGTC_1423 4048-0112 4.26 5.6 µM 5.95E-6 21 1.04E-5
12 SGTC_1917 st066507 4.07 28.5 µM 1.39E-5 Golgi 32 2.33E-5
13 SGTC_229 benomyl 3.96 22.9 µM 2.26E-5 tubulin folding & SWR complex 30 3.71E-5
14 SGTC_2053 5265679 3.81 138.0 µM 4.43E-5 28 7.07E-5
15 SGTC_416 estradiol valerate 3.80 100.0 µM 4.61E-5 16 7.34E-5
16 SGTC_1184 1269-1718 3.78 139.0 µM 4.95E-5 33 7.86E-5
17 SGTC_2693 st077581 3.67 40.7 µM 7.65E-5 47 1.19E-4
18 SGTC_279 1273-0055 3.60 2.9 µM 1.03E-4 azole & statin 49 1.58E-4
19 SGTC_1946 st076057 3.57 65.1 µM 1.15E-4 11 1.76E-4
20 SGTC_2193 5925765 3.54 200.0 µM 1.29E-4 10 1.96E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 4.85E-13 YGR123C PPT1 hom Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth
0.123 9.62E-13 YDR128W MTC5 hom Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress
0.106 7.71E-10 YMR235C RNA1 het GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport
0.097 1.87E-8 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.089 2.14E-7 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.089 2.32E-7 YOR339C UBC11 hom Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2
0.084 1.09E-6 YNL122C_p YNL122C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene
0.082 1.86E-6 YHR074W QNS1 het Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide
0.082 2.13E-6 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.081 2.41E-6 YPL233W NSL1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
0.079 4.15E-6 YGL244W RTF1 hom Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
0.079 4.36E-6 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.078 5.57E-6 YNR024W MPP6 hom Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes
0.078 6.22E-6 YDR246W TRS23 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4
0.077 7.34E-6 YLR094C GIS3 hom Protein of unknown function