YJL139C / YUR1

Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL139C / YUR1

Click on Significant Values for Screen Details ID:SGTC_89|Compound:0302-0250|FD-Score:3.27|P-value:6.60E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:5.02|P-value:4.21E-7 ID:SGTC_324|Compound:1315-0088|FD-Score:3.60|P-value:2.05E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.55|P-value:2.41E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.57|P-value:2.25E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:5.83|P-value:5.06E-9 ID:SGTC_773|Compound:4358-1457|FD-Score:4.90|P-value:7.64E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:7.45|P-value:1.30E-13 ID:SGTC_830|Compound:4076-0286|FD-Score:3.75|P-value:1.15E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.32|P-value:5.61E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.23|P-value:7.59E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.46|P-value:5.84E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.36|P-value:4.85E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.74|P-value:1.21E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.42|P-value:7.19E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.15|P-value:2.33E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.10|P-value:2.80E-5 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.36|P-value:4.86E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.71|P-value:1.37E-4 ID:SGTC_1674|Compound:st016616|FD-Score:4.20|P-value:1.84E-5 ID:SGTC_1697|Compound:st025554|FD-Score:4.31|P-value:1.17E-5 ID:SGTC_1850|Compound:st056238|FD-Score:9.88|P-value:1.40E-22 ID:SGTC_1851|Compound:st056236|FD-Score:-3.92|P-value:5.84E-5 ID:SGTC_1854|Compound:st056233|FD-Score:-4.02|P-value:3.97E-5 ID:SGTC_1857|Compound:st056007|FD-Score:4.37|P-value:8.75E-6 ID:SGTC_1864|Compound:st057645|FD-Score:3.23|P-value:7.57E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.20|P-value:8.48E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.41|P-value:4.10E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.75|P-value:1.15E-4 ID:SGTC_2257|Compound:7960413|FD-Score:-3.51|P-value:2.81E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.57|P-value:2.31E-4 ID:SGTC_2271|Compound:7849410|FD-Score:3.15|P-value:9.86E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.84|P-value:8.14E-5 ID:SGTC_2289|Compound:7946404|FD-Score:8.61|P-value:1.36E-17 ID:SGTC_2295|Compound:7971645|FD-Score:5.42|P-value:5.16E-8 ID:SGTC_2296|Compound:7971656|FD-Score:-4.11|P-value:2.67E-5 ID:SGTC_2351|Compound:9026858|FD-Score:-3.30|P-value:6.03E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.93|P-value:5.59E-5 ID:SGTC_2459|Compound:5811157|FD-Score:3.16|P-value:9.50E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.67|P-value:1.56E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.38|P-value:4.58E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.83|P-value:9.76E-12 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.65|P-value:1.70E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.21|P-value:8.15E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.21|P-value:7.98E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.49|P-value:3.03E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.25|P-value:7.20E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-3.39|P-value:4.35E-4 ID:SGTC_2982|Compound:9019404|FD-Score:5.36|P-value:6.88E-8 ID:SGTC_3068|Compound:9116768|FD-Score:4.86|P-value:9.02E-7 ID:SGTC_3204|Compound:9114183|FD-Score:3.55|P-value:2.44E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.27|P-value:6.60E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:5.02|P-value:4.21E-7 ID:SGTC_324|Compound:1315-0088|FD-Score:3.60|P-value:2.05E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.55|P-value:2.41E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.57|P-value:2.25E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:5.83|P-value:5.06E-9 ID:SGTC_773|Compound:4358-1457|FD-Score:4.90|P-value:7.64E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:7.45|P-value:1.30E-13 ID:SGTC_830|Compound:4076-0286|FD-Score:3.75|P-value:1.15E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.32|P-value:5.61E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.23|P-value:7.59E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.46|P-value:5.84E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.36|P-value:4.85E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.74|P-value:1.21E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.42|P-value:7.19E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.15|P-value:2.33E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.10|P-value:2.80E-5 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.36|P-value:4.86E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.71|P-value:1.37E-4 ID:SGTC_1674|Compound:st016616|FD-Score:4.20|P-value:1.84E-5 ID:SGTC_1697|Compound:st025554|FD-Score:4.31|P-value:1.17E-5 ID:SGTC_1850|Compound:st056238|FD-Score:9.88|P-value:1.40E-22 ID:SGTC_1851|Compound:st056236|FD-Score:-3.92|P-value:5.84E-5 ID:SGTC_1854|Compound:st056233|FD-Score:-4.02|P-value:3.97E-5 ID:SGTC_1857|Compound:st056007|FD-Score:4.37|P-value:8.75E-6 ID:SGTC_1864|Compound:st057645|FD-Score:3.23|P-value:7.57E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.20|P-value:8.48E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.41|P-value:4.10E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.75|P-value:1.15E-4 ID:SGTC_2257|Compound:7960413|FD-Score:-3.51|P-value:2.81E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.57|P-value:2.31E-4 ID:SGTC_2271|Compound:7849410|FD-Score:3.15|P-value:9.86E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.84|P-value:8.14E-5 ID:SGTC_2289|Compound:7946404|FD-Score:8.61|P-value:1.36E-17 ID:SGTC_2295|Compound:7971645|FD-Score:5.42|P-value:5.16E-8 ID:SGTC_2296|Compound:7971656|FD-Score:-4.11|P-value:2.67E-5 ID:SGTC_2351|Compound:9026858|FD-Score:-3.30|P-value:6.03E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.93|P-value:5.59E-5 ID:SGTC_2459|Compound:5811157|FD-Score:3.16|P-value:9.50E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.67|P-value:1.56E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.38|P-value:4.58E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.83|P-value:9.76E-12 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.65|P-value:1.70E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.21|P-value:8.15E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.21|P-value:7.98E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.49|P-value:3.03E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.25|P-value:7.20E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-3.39|P-value:4.35E-4 ID:SGTC_2982|Compound:9019404|FD-Score:5.36|P-value:6.88E-8 ID:SGTC_3068|Compound:9116768|FD-Score:4.86|P-value:9.02E-7 ID:SGTC_3204|Compound:9114183|FD-Score:3.55|P-value:2.44E-4

Top fitness defect scores for YJL139C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1850 st056238 9.88 17.0 µM 1.40E-22 RPP1 & pyrimidine depletion 1 2.44E-23
2 SGTC_2289 7946404 8.61 165.1 µM 1.36E-17 11 3.59E-18
3 SGTC_800 3448-7362 7.45 155.0 µM 1.30E-13 translation 19 4.79E-14
4 SGTC_766 1391-0721 5.83 126.0 µM 5.06E-9 1 2.72E-9
5 SGTC_2295 7971645 5.42 200.0 µM 5.16E-8 8 3.01E-8
6 SGTC_2982 9019404 5.36 26.0 µM 6.88E-8 10 4.06E-8
7 SGTC_95 0471-0001 5.02 561.1 µM 4.21E-7 8 2.64E-7
8 SGTC_773 4358-1457 4.90 44.6 µM 7.64E-7 21 4.90E-7
9 SGTC_3068 9116768 4.86 49.5 µM 9.02E-7 9 5.82E-7
10 SGTC_999 4022-0066 4.46 22.7 µM 5.84E-6 Golgi 28 4.03E-6
11 SGTC_1041 0206-0046 4.42 107.0 µM 7.19E-6 25 5.00E-6
12 SGTC_1857 st056007 4.37 79.3 µM 8.75E-6 4 6.12E-6
13 SGTC_1697 st025554 4.31 27.7 µM 1.17E-5 19 8.30E-6
14 SGTC_1674 st016616 4.20 23.6 µM 1.84E-5 22 1.32E-5
15 SGTC_1055 3448-0672 4.15 86.0 µM 2.33E-5 27 1.69E-5
16 SGTC_1083 didemethylchlorpromazine sulfoxide 4.10 707.4 nM 2.80E-5 redox potentiating 71 2.04E-5
17 SGTC_2399 5884133 3.93 200.0 µM 5.59E-5 cell wall signaling 72 4.17E-5
18 SGTC_2286 7945697 3.84 125.0 µM 8.14E-5 58 6.16E-5
19 SGTC_830 4076-0286 3.75 57.8 µM 1.15E-4 translation 70 8.81E-5
20 SGTC_2254 7938975 3.75 95.2 µM 1.15E-4 60 8.81E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.294 4.53E-68 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.207 6.68E-34 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.206 2.05E-33 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.195 5.43E-30 YAL058W CNE1 hom Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.181 3.17E-26 YDL117W CYK3 hom SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants
0.176 7.60E-25 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.176 8.89E-25 YKL096C-B_p YKL096C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.158 3.84E-20 YAL056C-A_d YAL056C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.154 3.59E-19 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.152 8.96E-19 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.140 4.16E-16 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.134 7.10E-15 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.131 2.17E-14 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.126 2.91E-13 YDR516C EMI2 hom Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.126 3.00E-13 YDR398W UTP5 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit