HIPHOP chemogenomics database
YJL144W 
Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YJL144W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.124 | 6.34E-13 | YNL272C | SEC2 | het | Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles |
| 0.114 | 3.90E-11 | YHR191C | CTF8 | hom | Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion |
| 0.095 | 3.24E-8 | YPL052W | OAZ1 | hom | Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p |
| 0.094 | 5.10E-8 | YER118C | SHO1 | hom | Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p |
| 0.093 | 6.36E-8 | YEL068C_p | YEL068C_p | hom | Protein of unknown function; expressed at both mRNA and protein levels |
| 0.093 | 7.47E-8 | YJL029C | VPS53 | hom | Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting |
| 0.092 | 1.01E-7 | YIL019W | FAF1 | het | Protein required for pre-rRNA processing and 40S ribosomal subunit assembly |
| 0.091 | 1.42E-7 | YPR138C | MEP3 | hom | Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease |
| 0.088 | 3.36E-7 | YPL074W | YTA6 | hom | Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress |
| 0.085 | 9.08E-7 | YER157W | COG3 | het | Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
| 0.085 | 9.40E-7 | YLR274W | MCM5 | het | Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase |
| 0.084 | 9.70E-7 | YJL013C | MAD3 | hom | Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover |
| 0.080 | 3.29E-6 | YGL031C | RPL24A | hom | Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication |
| 0.079 | 5.23E-6 | YLR079W | SIC1 | hom | Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1 |
| 0.078 | 6.91E-6 | YHR018C | ARG4 | hom | Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway |