YJL145W / SFH5

Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL145W / SFH5

Click on Significant Values for Screen Details ID:SGTC_249|Compound:wiskostatin|FD-Score:2.79|P-value:7.45E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.02|P-value:2.98E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:2.74|P-value:9.04E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.02|P-value:2.88E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:2.72|P-value:9.85E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:2.86|P-value:5.70E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.06|P-value:2.51E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:2.93|P-value:4.28E-4 ID:SGTC_1697|Compound:st025554|FD-Score:2.89|P-value:5.14E-4 ID:SGTC_1704|Compound:st028805|FD-Score:2.85|P-value:6.07E-4 ID:SGTC_1945|Compound:st075991|FD-Score:4.88|P-value:1.39E-8 ID:SGTC_1949|Compound:st076024|FD-Score:-3.48|P-value:3.70E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-2.80|P-value:7.13E-4 ID:SGTC_2092|Compound:5303694|FD-Score:-2.75|P-value:8.81E-4 ID:SGTC_2116|Compound:5511452|FD-Score:2.76|P-value:8.44E-4 ID:SGTC_2379|Compound:9035213|FD-Score:4.01|P-value:2.55E-6 ID:SGTC_2399|Compound:5884133|FD-Score:3.07|P-value:2.41E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-2.78|P-value:7.63E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.60|P-value:2.08E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:2.89|P-value:4.98E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.49|P-value:1.61E-7 ID:SGTC_2796|Compound:7949634|FD-Score:4.03|P-value:2.24E-6 ID:SGTC_2852|Compound:9023854|FD-Score:3.88|P-value:5.05E-6 ID:SGTC_2869|Compound:9037858|FD-Score:-2.72|P-value:9.63E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-3.64|P-value:1.73E-5 ID:SGTC_2913|Compound:7966556|FD-Score:2.97|P-value:3.64E-4 ID:SGTC_2923|Compound:7992654|FD-Score:2.93|P-value:4.24E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.37|P-value:6.45E-5 ID:SGTC_3136|Compound:9095672|FD-Score:2.77|P-value:8.03E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.32|P-value:8.10E-5 ID:SGTC_3286|Compound:9117135|FD-Score:-2.93|P-value:4.31E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.55|P-value:2.67E-5 ID:SGTC_3302|Compound:9125395|FD-Score:-3.58|P-value:2.30E-5 ID:SGTC_3306|Compound:9127676|FD-Score:-3.25|P-value:1.07E-4 ID:SGTC_3338|Compound:9144300|FD-Score:3.96|P-value:3.37E-6 ID:SGTC_3340|Compound:9146634|FD-Score:3.24|P-value:1.16E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-4.15|P-value:1.17E-6 ID:SGTC_249|Compound:wiskostatin|FD-Score:2.79|P-value:7.45E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.02|P-value:2.98E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:2.74|P-value:9.04E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.02|P-value:2.88E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:2.72|P-value:9.85E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:2.86|P-value:5.70E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.06|P-value:2.51E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:2.93|P-value:4.28E-4 ID:SGTC_1697|Compound:st025554|FD-Score:2.89|P-value:5.14E-4 ID:SGTC_1704|Compound:st028805|FD-Score:2.85|P-value:6.07E-4 ID:SGTC_1945|Compound:st075991|FD-Score:4.88|P-value:1.39E-8 ID:SGTC_1949|Compound:st076024|FD-Score:-3.48|P-value:3.70E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-2.80|P-value:7.13E-4 ID:SGTC_2092|Compound:5303694|FD-Score:-2.75|P-value:8.81E-4 ID:SGTC_2116|Compound:5511452|FD-Score:2.76|P-value:8.44E-4 ID:SGTC_2379|Compound:9035213|FD-Score:4.01|P-value:2.55E-6 ID:SGTC_2399|Compound:5884133|FD-Score:3.07|P-value:2.41E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-2.78|P-value:7.63E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.60|P-value:2.08E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:2.89|P-value:4.98E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.49|P-value:1.61E-7 ID:SGTC_2796|Compound:7949634|FD-Score:4.03|P-value:2.24E-6 ID:SGTC_2852|Compound:9023854|FD-Score:3.88|P-value:5.05E-6 ID:SGTC_2869|Compound:9037858|FD-Score:-2.72|P-value:9.63E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-3.64|P-value:1.73E-5 ID:SGTC_2913|Compound:7966556|FD-Score:2.97|P-value:3.64E-4 ID:SGTC_2923|Compound:7992654|FD-Score:2.93|P-value:4.24E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.37|P-value:6.45E-5 ID:SGTC_3136|Compound:9095672|FD-Score:2.77|P-value:8.03E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.32|P-value:8.10E-5 ID:SGTC_3286|Compound:9117135|FD-Score:-2.93|P-value:4.31E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.55|P-value:2.67E-5 ID:SGTC_3302|Compound:9125395|FD-Score:-3.58|P-value:2.30E-5 ID:SGTC_3306|Compound:9127676|FD-Score:-3.25|P-value:1.07E-4 ID:SGTC_3338|Compound:9144300|FD-Score:3.96|P-value:3.37E-6 ID:SGTC_3340|Compound:9146634|FD-Score:3.24|P-value:1.16E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-4.15|P-value:1.17E-6

Top fitness defect scores for YJL145W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1945 st075991 4.88 56.6 µM 1.39E-8 60S ribosome export 5 5.22E-7
2 SGTC_2766 oltipraz 4.49 83.9 µM 1.61E-7 heme requiring 16 3.53E-6
3 SGTC_2796 7949634 4.03 45.5 µM 2.24E-6 18 2.75E-5
4 SGTC_2379 9035213 4.01 200.0 µM 2.55E-6 19 3.04E-5
5 SGTC_3338 9144300 3.96 39.6 µM 3.37E-6 Golgi 27 3.78E-5
6 SGTC_2852 9023854 3.88 52.0 µM 5.05E-6 35 5.19E-5
7 SGTC_2936 9038235 3.37 15.6 µM 6.45E-5 45 3.81E-4
8 SGTC_3205 9113483 3.32 49.5 µM 8.10E-5 60 4.56E-4
9 SGTC_3340 9146634 3.24 11.1 µM 1.16E-4 36 6.02E-4
10 SGTC_2399 5884133 3.07 200.0 µM 2.41E-4 cell wall signaling 123 0.00107
11 SGTC_1210 3013-0140 3.06 750.0 nM 2.51E-4 33 0.00111
12 SGTC_251 melphalan 3.02 456.5 µM 2.98E-4 DNA damage response 73 0.00127
13 SGTC_2913 7966556 2.97 36.6 µM 3.64E-4 60S ribosome export 49 0.00148
14 SGTC_2923 7992654 2.93 58.1 µM 4.24E-4 Golgi 74 0.00167
15 SGTC_1378 2093-0007 2.93 380.0 nM 4.28E-4 71 0.00169
16 SGTC_2757 clomiphene 2.89 4.2 µM 4.98E-4 fatty acid desaturase (OLE1) 107 0.00190
17 SGTC_1697 st025554 2.89 27.7 µM 5.14E-4 58 0.00195
18 SGTC_1069 diphenylcyclopropenone 2.86 8.5 µM 5.70E-4 88 0.00211
19 SGTC_1704 st028805 2.85 70.8 µM 6.07E-4 48 0.00222
20 SGTC_249 wiskostatin 2.79 11.2 µM 7.45E-4 64 0.00261

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.12E-13 YGR127W_p YGR127W_p hom Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
0.115 2.98E-11 YDR082W STN1 het Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping
0.108 3.75E-10 YLR323C CWC24 het Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p
0.107 4.61E-10 YER183C FAU1 hom 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis
0.094 5.11E-8 YDL236W PHO13 hom Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
0.087 5.08E-7 YOR057W SGT1 het Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress
0.085 7.63E-7 YLR251W SYM1 hom Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17
0.085 8.07E-7 YDR124W_p YDR124W_p hom Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
0.084 1.05E-6 YGL091C NBP35 het Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases
0.083 1.39E-6 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.082 1.76E-6 YOR233W KIN4 hom Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.081 2.96E-6 YOL126C MDH2 hom Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1
0.079 4.15E-6 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.077 8.17E-6 YKL039W PTM1 hom Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication
0.074 1.63E-5 YER085C_p YER085C_p hom Putative protein of unknown function