YJL147C_p

Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL147C / YJL147C

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:2.90|P-value:9.24E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:4.15|P-value:4.31E-6 ID:SGTC_83|Compound:0170-0301|FD-Score:3.23|P-value:2.62E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.42|P-value:1.23E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.01|P-value:6.29E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.09|P-value:4.53E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.30|P-value:2.03E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.65|P-value:4.58E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.33|P-value:1.75E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.36|P-value:1.56E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:-3.34|P-value:1.70E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.06|P-value:5.23E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.39|P-value:1.39E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.21|P-value:2.91E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.08|P-value:5.94E-6 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.71|P-value:3.38E-5 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-2.97|P-value:7.15E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.69|P-value:3.85E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.09|P-value:4.61E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:4.91|P-value:7.08E-8 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.00|P-value:6.51E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:3.39|P-value:1.36E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:2.89|P-value:9.53E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.45|P-value:1.06E-4 ID:SGTC_1661|Compound:st013063|FD-Score:4.31|P-value:1.85E-6 ID:SGTC_1665|Compound:st014639|FD-Score:3.01|P-value:6.34E-4 ID:SGTC_1861|Compound:st057647|FD-Score:2.90|P-value:9.40E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.02|P-value:6.04E-4 ID:SGTC_1909|Compound:st060837|FD-Score:8.50|P-value:3.96E-20 ID:SGTC_1917|Compound:st066507|FD-Score:6.10|P-value:3.10E-11 ID:SGTC_1962|Compound:st076595|FD-Score:-4.38|P-value:1.32E-6 ID:SGTC_1976|Compound:st070609|FD-Score:3.02|P-value:5.89E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.51|P-value:8.14E-5 ID:SGTC_2158|Compound:5657123|FD-Score:3.07|P-value:5.06E-4 ID:SGTC_2288|Compound:7946289|FD-Score:4.49|P-value:7.23E-7 ID:SGTC_2382|Compound:9035899|FD-Score:5.29|P-value:7.17E-9 ID:SGTC_2391|Compound:6285546|FD-Score:4.21|P-value:3.13E-6 ID:SGTC_3166|Compound:9102297|FD-Score:3.17|P-value:3.43E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.06|P-value:5.21E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:2.90|P-value:9.24E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:4.15|P-value:4.31E-6 ID:SGTC_83|Compound:0170-0301|FD-Score:3.23|P-value:2.62E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.42|P-value:1.23E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.01|P-value:6.29E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.09|P-value:4.53E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.30|P-value:2.03E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.65|P-value:4.58E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.33|P-value:1.75E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.36|P-value:1.56E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:-3.34|P-value:1.70E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.06|P-value:5.23E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.39|P-value:1.39E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.21|P-value:2.91E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.08|P-value:5.94E-6 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.71|P-value:3.38E-5 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-2.97|P-value:7.15E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.69|P-value:3.85E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.09|P-value:4.61E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:4.91|P-value:7.08E-8 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.00|P-value:6.51E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:3.39|P-value:1.36E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:2.89|P-value:9.53E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.45|P-value:1.06E-4 ID:SGTC_1661|Compound:st013063|FD-Score:4.31|P-value:1.85E-6 ID:SGTC_1665|Compound:st014639|FD-Score:3.01|P-value:6.34E-4 ID:SGTC_1861|Compound:st057647|FD-Score:2.90|P-value:9.40E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.02|P-value:6.04E-4 ID:SGTC_1909|Compound:st060837|FD-Score:8.50|P-value:3.96E-20 ID:SGTC_1917|Compound:st066507|FD-Score:6.10|P-value:3.10E-11 ID:SGTC_1962|Compound:st076595|FD-Score:-4.38|P-value:1.32E-6 ID:SGTC_1976|Compound:st070609|FD-Score:3.02|P-value:5.89E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.51|P-value:8.14E-5 ID:SGTC_2158|Compound:5657123|FD-Score:3.07|P-value:5.06E-4 ID:SGTC_2288|Compound:7946289|FD-Score:4.49|P-value:7.23E-7 ID:SGTC_2382|Compound:9035899|FD-Score:5.29|P-value:7.17E-9 ID:SGTC_2391|Compound:6285546|FD-Score:4.21|P-value:3.13E-6 ID:SGTC_3166|Compound:9102297|FD-Score:3.17|P-value:3.43E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.06|P-value:5.21E-4

Top fitness defect scores for YJL147C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1909 st060837 8.50 51.5 µM 3.96E-20 8 9.71E-18
2 SGTC_1917 st066507 6.10 28.5 µM 3.10E-11 Golgi 11 5.43E-10
3 SGTC_2382 9035899 5.29 200.0 µM 7.17E-9 60S ribosome export 5 6.26E-8
4 SGTC_1386 3228-0095 4.91 33.8 µM 7.08E-8 5 4.62E-7
5 SGTC_2288 7946289 4.49 167.3 µM 7.23E-7 17 3.52E-6
6 SGTC_1661 st013063 4.31 9.7 µM 1.85E-6 21 8.00E-6
7 SGTC_2391 6285546 4.21 200.0 µM 3.13E-6 9 1.27E-5
8 SGTC_80 0159-0065 4.15 512.2 µM 4.31E-6 3 1.67E-5
9 SGTC_1078 idebenone 4.08 36.1 µM 5.94E-6 Golgi 38 2.22E-5
10 SGTC_1177 0983-0204 3.71 23.6 µM 3.38E-5 21 1.02E-4
11 SGTC_1317 1273-0028 3.69 910.0 nM 3.85E-5 azole & statin 61 1.14E-4
12 SGTC_789 1309-1135 3.65 70.6 µM 4.58E-5 ERG2 43 1.33E-4
13 SGTC_1551 6-bromo-3'-methylflavone 3.45 63.5 µM 1.06E-4 37 2.75E-4
14 SGTC_272 doxorubicin 3.42 8.1 µM 1.23E-4 anthracycline transcription coupled DNA repair 40 3.15E-4
15 SGTC_1481 3346-2004 3.39 36.0 µM 1.36E-4 19 3.44E-4
16 SGTC_996 3970-0799 3.39 1.8 µM 1.39E-4 124 3.50E-4
17 SGTC_863 0466-0191 3.36 129.0 µM 1.56E-4 cell wall 97 3.89E-4
18 SGTC_717 1532-0246 3.30 73.2 µM 2.03E-4 Golgi 61 4.88E-4
19 SGTC_83 0170-0301 3.23 39.0 µM 2.62E-4 endomembrane recycling 11 6.11E-4
20 SGTC_1058 3448-5425 3.21 97.3 µM 2.91E-4 55 6.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 6.61E-16 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.128 1.10E-13 YNL193W_p YNL193W_p hom Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis
0.116 1.64E-11 YPL230W USV1 hom Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication
0.110 1.46E-10 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.109 2.59E-10 YJR022W LSM8 het Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
0.105 1.04E-9 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.099 7.72E-9 YHR044C DOG1 hom 2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified
0.099 9.50E-9 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.096 2.47E-8 YBR016W YBR016W hom Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication
0.094 5.52E-8 YOL152W FRE7 hom Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
0.093 6.35E-8 YHR109W CTM1 hom Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth
0.093 6.36E-8 YMR273C ZDS1 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication
0.090 1.77E-7 YML048W GSF2 hom ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression
0.089 2.10E-7 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.089 2.49E-7 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus