YJL151C / SNA3

Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL151C / SNA3

Click on Significant Values for Screen Details ID:SGTC_75|Compound:0159-0059|FD-Score:-3.09|P-value:5.24E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.90|P-value:1.98E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:4.78|P-value:2.43E-7 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.21|P-value:3.39E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-3.69|P-value:4.63E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-4.28|P-value:2.91E-6 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:3.79|P-value:3.35E-5 ID:SGTC_489|Compound:paxilline|FD-Score:-3.21|P-value:3.33E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.23|P-value:3.39E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.12|P-value:5.09E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.19|P-value:3.96E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.07|P-value:6.25E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:2.97|P-value:9.09E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.30|P-value:2.56E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.07|P-value:6.18E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:5.36|P-value:8.11E-9 ID:SGTC_1453|Compound:4237-0541|FD-Score:5.31|P-value:1.10E-8 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.18|P-value:4.04E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:-3.48|P-value:1.13E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.47|P-value:1.17E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.03|P-value:7.08E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-3.96|P-value:1.36E-5 ID:SGTC_1747|Compound:st037496|FD-Score:-3.97|P-value:1.32E-5 ID:SGTC_1757|Compound:st041620|FD-Score:3.27|P-value:2.93E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.14|P-value:4.40E-4 ID:SGTC_1799|Compound:st045822|FD-Score:2.95|P-value:9.54E-4 ID:SGTC_1891|Compound:st059073|FD-Score:4.09|P-value:8.50E-6 ID:SGTC_1924|Compound:st058459|FD-Score:3.23|P-value:3.43E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-4.55|P-value:7.31E-7 ID:SGTC_2115|Compound:tiliquinol|FD-Score:2.95|P-value:9.75E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.67|P-value:5.59E-5 ID:SGTC_2319|Compound:6033012|FD-Score:3.82|P-value:2.91E-5 ID:SGTC_2800|Compound:7887935|FD-Score:4.39|P-value:1.86E-6 ID:SGTC_2934|Compound:9036370|FD-Score:4.53|P-value:9.10E-7 ID:SGTC_2935|Compound:9038016|FD-Score:4.04|P-value:1.04E-5 ID:SGTC_2967|Compound:9089538|FD-Score:2.95|P-value:9.65E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.22|P-value:3.59E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.09|P-value:4.11E-8 ID:SGTC_3318|Compound:9139014|FD-Score:-3.18|P-value:3.68E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.09|P-value:5.24E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.90|P-value:1.98E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:4.78|P-value:2.43E-7 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.21|P-value:3.39E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-3.69|P-value:4.63E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-4.28|P-value:2.91E-6 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:3.79|P-value:3.35E-5 ID:SGTC_489|Compound:paxilline|FD-Score:-3.21|P-value:3.33E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.23|P-value:3.39E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.12|P-value:5.09E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.19|P-value:3.96E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.07|P-value:6.25E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:2.97|P-value:9.09E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.30|P-value:2.56E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.07|P-value:6.18E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:5.36|P-value:8.11E-9 ID:SGTC_1453|Compound:4237-0541|FD-Score:5.31|P-value:1.10E-8 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.18|P-value:4.04E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:-3.48|P-value:1.13E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.47|P-value:1.17E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.03|P-value:7.08E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-3.96|P-value:1.36E-5 ID:SGTC_1747|Compound:st037496|FD-Score:-3.97|P-value:1.32E-5 ID:SGTC_1757|Compound:st041620|FD-Score:3.27|P-value:2.93E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.14|P-value:4.40E-4 ID:SGTC_1799|Compound:st045822|FD-Score:2.95|P-value:9.54E-4 ID:SGTC_1891|Compound:st059073|FD-Score:4.09|P-value:8.50E-6 ID:SGTC_1924|Compound:st058459|FD-Score:3.23|P-value:3.43E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-4.55|P-value:7.31E-7 ID:SGTC_2115|Compound:tiliquinol|FD-Score:2.95|P-value:9.75E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.67|P-value:5.59E-5 ID:SGTC_2319|Compound:6033012|FD-Score:3.82|P-value:2.91E-5 ID:SGTC_2800|Compound:7887935|FD-Score:4.39|P-value:1.86E-6 ID:SGTC_2934|Compound:9036370|FD-Score:4.53|P-value:9.10E-7 ID:SGTC_2935|Compound:9038016|FD-Score:4.04|P-value:1.04E-5 ID:SGTC_2967|Compound:9089538|FD-Score:2.95|P-value:9.65E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.22|P-value:3.59E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.09|P-value:4.11E-8 ID:SGTC_3318|Compound:9139014|FD-Score:-3.18|P-value:3.68E-4

Top fitness defect scores for YJL151C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1418 3966-3099 5.36 2.4 µM 8.11E-9 7 4.14E-8
2 SGTC_1453 4237-0541 5.31 195.0 µM 1.10E-8 heme biosynthesis & mitochondrial translocase 7 5.45E-8
3 SGTC_3211 9128781 5.09 49.5 µM 4.11E-8 36 1.79E-7
4 SGTC_156 3474-0145 4.78 5.6 µM 2.43E-7 endomembrane recycling 36 8.91E-7
5 SGTC_2934 9036370 4.53 36.9 µM 9.10E-7 18 2.93E-6
6 SGTC_2800 7887935 4.39 81.8 µM 1.86E-6 RPP1 & pyrimidine depletion 16 5.58E-6
7 SGTC_1891 st059073 4.09 26.2 µM 8.50E-6 TSC3-RPN4 20 2.20E-5
8 SGTC_2935 9038016 4.04 30.0 µM 1.04E-5 19 2.64E-5
9 SGTC_85 0868-0259 3.90 160.1 µM 1.98E-5 60S ribosome export 11 4.72E-5
10 SGTC_2319 6033012 3.82 152.6 µM 2.91E-5 tubulin folding & SWR complex 34 6.69E-5
11 SGTC_461 N-acetylfarnesylcysteine 3.79 136.0 µM 3.35E-5 4 7.61E-5
12 SGTC_2316 5844804 3.67 197.4 µM 5.59E-5 41 1.21E-4
13 SGTC_1292 0kpi-0043 3.30 232.0 µM 2.56E-4 30 4.80E-4
14 SGTC_1757 st041620 3.27 31.8 µM 2.93E-4 54 5.43E-4
15 SGTC_551 k048-0028 3.23 34.9 µM 3.39E-4 45 6.19E-4
16 SGTC_1924 st058459 3.23 75.1 µM 3.43E-4 29 6.25E-4
17 SGTC_3205 9113483 3.22 49.5 µM 3.59E-4 66 6.52E-4
18 SGTC_669 0108-0021 3.19 26.2 µM 3.96E-4 fatty acid desaturase (OLE1) 137 7.12E-4
19 SGTC_1470 k295-0292 3.18 231.0 µM 4.04E-4 43 7.25E-4
20 SGTC_639 0833-0042 3.12 114.0 µM 5.09E-4 87 8.93E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 5.67E-23 YGR122C-A_d YGR122C-A_d hom Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
0.135 4.37E-15 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.110 1.55E-10 YGR047C TFC4 het One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102
0.106 6.58E-10 YJR148W BAT2 hom Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase
0.100 6.24E-9 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.092 9.07E-8 YNL001W DOM34 hom Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
0.091 1.11E-7 YLR146C SPE4 hom Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid
0.091 1.25E-7 YGR257C MTM1 hom Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
0.090 2.05E-7 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.087 4.04E-7 YER183C FAU1 hom 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis
0.085 8.29E-7 YLR184W_d YLR184W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.084 9.53E-7 YBR130C SHE3 hom Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
0.082 2.15E-6 YLR147C SMD3 het Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3
0.081 2.40E-6 YLR196W PWP1 het Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
0.080 3.06E-6 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data