YJL155C / FBP26

Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL155C / FBP26

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.58|P-value:1.72E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.32|P-value:4.49E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:4.39|P-value:5.74E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:6.37|P-value:9.95E-11 ID:SGTC_58|Compound:0957-0393|FD-Score:11.50|P-value:1.17E-30 ID:SGTC_64|Compound:000l-0018|FD-Score:13.00|P-value:1.64E-38 ID:SGTC_67|Compound:0335-0847|FD-Score:9.08|P-value:6.54E-20 ID:SGTC_71|Compound:0417-1750|FD-Score:4.12|P-value:1.86E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:13.20|P-value:7.08E-40 ID:SGTC_93|Compound:0109-0045|FD-Score:3.83|P-value:6.27E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:12.40|P-value:1.62E-35 ID:SGTC_107|Compound:0358-0022|FD-Score:9.29|P-value:9.65E-21 ID:SGTC_113|Compound:0099-0221|FD-Score:-3.27|P-value:6.03E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:16.80|P-value:1.96E-63 ID:SGTC_138|Compound:0850-0259|FD-Score:6.87|P-value:3.52E-12 ID:SGTC_142|Compound:0335-0849|FD-Score:18.30|P-value:2.14E-74 ID:SGTC_158|Compound:k038-0087|FD-Score:6.77|P-value:7.11E-12 ID:SGTC_225|Compound:nsc-122657|FD-Score:3.09|P-value:9.69E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.10|P-value:9.65E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.64|P-value:1.35E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:5.55|P-value:1.45E-8 ID:SGTC_367|Compound:0335-0881|FD-Score:3.41|P-value:3.26E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.67|P-value:1.22E-4 ID:SGTC_500|Compound:h-89|FD-Score:5.79|P-value:3.60E-9 ID:SGTC_543|Compound:3844-1095|FD-Score:3.38|P-value:3.60E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.62|P-value:1.44E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:5.25|P-value:7.92E-8 ID:SGTC_590|Compound:k048-0076|FD-Score:4.22|P-value:1.20E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:3.18|P-value:7.13E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.71|P-value:1.02E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:9.30|P-value:8.93E-21 ID:SGTC_809|Compound:3998-0021|FD-Score:-3.20|P-value:7.66E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.70|P-value:1.32E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:3.91|P-value:4.66E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:3.78|P-value:7.87E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.16|P-value:7.84E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.45|P-value:2.73E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.19|P-value:7.92E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.70|P-value:1.08E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:14.20|P-value:1.68E-45 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.37|P-value:6.32E-6 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.10|P-value:9.55E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.77|P-value:7.99E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.12|P-value:8.76E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.97|P-value:3.62E-5 ID:SGTC_1827|Compound:berberine|FD-Score:3.17|P-value:7.43E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-3.30|P-value:5.53E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.72|P-value:1.22E-6 ID:SGTC_1949|Compound:st076024|FD-Score:3.75|P-value:8.88E-5 ID:SGTC_1950|Compound:st077106|FD-Score:5.01|P-value:2.82E-7 ID:SGTC_1961|Compound:st076550|FD-Score:3.67|P-value:1.21E-4 ID:SGTC_1969|Compound:st069479|FD-Score:4.12|P-value:1.90E-5 ID:SGTC_1979|Compound:st071809|FD-Score:3.38|P-value:3.54E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.54|P-value:1.98E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.53|P-value:2.05E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.10|P-value:9.56E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.09|P-value:2.16E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.02|P-value:3.48E-5 ID:SGTC_2466|Compound:5983409|FD-Score:3.69|P-value:1.13E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:13.90|P-value:4.25E-44 ID:SGTC_2585|Compound:alliin|FD-Score:-3.87|P-value:6.36E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:4.33|P-value:7.53E-6 ID:SGTC_2694|Compound:st077685|FD-Score:4.23|P-value:1.18E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-3.89|P-value:5.97E-5 ID:SGTC_2808|Compound:7946468|FD-Score:5.92|P-value:1.71E-9 ID:SGTC_2897|Compound:9048598|FD-Score:-3.18|P-value:8.20E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:8.98|P-value:1.67E-19 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.38|P-value:5.92E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:6.33|P-value:1.29E-10 ID:SGTC_3318|Compound:9139014|FD-Score:3.16|P-value:7.74E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.58|P-value:1.72E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.32|P-value:4.49E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:4.39|P-value:5.74E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:6.37|P-value:9.95E-11 ID:SGTC_58|Compound:0957-0393|FD-Score:11.50|P-value:1.17E-30 ID:SGTC_64|Compound:000l-0018|FD-Score:13.00|P-value:1.64E-38 ID:SGTC_67|Compound:0335-0847|FD-Score:9.08|P-value:6.54E-20 ID:SGTC_71|Compound:0417-1750|FD-Score:4.12|P-value:1.86E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:13.20|P-value:7.08E-40 ID:SGTC_93|Compound:0109-0045|FD-Score:3.83|P-value:6.27E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:12.40|P-value:1.62E-35 ID:SGTC_107|Compound:0358-0022|FD-Score:9.29|P-value:9.65E-21 ID:SGTC_113|Compound:0099-0221|FD-Score:-3.27|P-value:6.03E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:16.80|P-value:1.96E-63 ID:SGTC_138|Compound:0850-0259|FD-Score:6.87|P-value:3.52E-12 ID:SGTC_142|Compound:0335-0849|FD-Score:18.30|P-value:2.14E-74 ID:SGTC_158|Compound:k038-0087|FD-Score:6.77|P-value:7.11E-12 ID:SGTC_225|Compound:nsc-122657|FD-Score:3.09|P-value:9.69E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.10|P-value:9.65E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.64|P-value:1.35E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:5.55|P-value:1.45E-8 ID:SGTC_367|Compound:0335-0881|FD-Score:3.41|P-value:3.26E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.67|P-value:1.22E-4 ID:SGTC_500|Compound:h-89|FD-Score:5.79|P-value:3.60E-9 ID:SGTC_543|Compound:3844-1095|FD-Score:3.38|P-value:3.60E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.62|P-value:1.44E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:5.25|P-value:7.92E-8 ID:SGTC_590|Compound:k048-0076|FD-Score:4.22|P-value:1.20E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:3.18|P-value:7.13E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.71|P-value:1.02E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:9.30|P-value:8.93E-21 ID:SGTC_809|Compound:3998-0021|FD-Score:-3.20|P-value:7.66E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.70|P-value:1.32E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:3.91|P-value:4.66E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:3.78|P-value:7.87E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.16|P-value:7.84E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.45|P-value:2.73E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.19|P-value:7.92E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.70|P-value:1.08E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:14.20|P-value:1.68E-45 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.37|P-value:6.32E-6 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.10|P-value:9.55E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.77|P-value:7.99E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.12|P-value:8.76E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.97|P-value:3.62E-5 ID:SGTC_1827|Compound:berberine|FD-Score:3.17|P-value:7.43E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-3.30|P-value:5.53E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.72|P-value:1.22E-6 ID:SGTC_1949|Compound:st076024|FD-Score:3.75|P-value:8.88E-5 ID:SGTC_1950|Compound:st077106|FD-Score:5.01|P-value:2.82E-7 ID:SGTC_1961|Compound:st076550|FD-Score:3.67|P-value:1.21E-4 ID:SGTC_1969|Compound:st069479|FD-Score:4.12|P-value:1.90E-5 ID:SGTC_1979|Compound:st071809|FD-Score:3.38|P-value:3.54E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.54|P-value:1.98E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.53|P-value:2.05E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.10|P-value:9.56E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.09|P-value:2.16E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.02|P-value:3.48E-5 ID:SGTC_2466|Compound:5983409|FD-Score:3.69|P-value:1.13E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:13.90|P-value:4.25E-44 ID:SGTC_2585|Compound:alliin|FD-Score:-3.87|P-value:6.36E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:4.33|P-value:7.53E-6 ID:SGTC_2694|Compound:st077685|FD-Score:4.23|P-value:1.18E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-3.89|P-value:5.97E-5 ID:SGTC_2808|Compound:7946468|FD-Score:5.92|P-value:1.71E-9 ID:SGTC_2897|Compound:9048598|FD-Score:-3.18|P-value:8.20E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:8.98|P-value:1.67E-19 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.38|P-value:5.92E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:6.33|P-value:1.29E-10 ID:SGTC_3318|Compound:9139014|FD-Score:3.16|P-value:7.74E-4

Top fitness defect scores for YJL155C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_142 0335-0849 18.30 62.7 µM 2.14E-74 ubiquinone biosynthesis & proteasome 9 6.09E-75
2 SGTC_137 0438-0332 16.80 85.4 µM 1.96E-63 ubiquinone biosynthesis & proteasome 9 6.93E-64
3 SGTC_1294 1000-1494 14.20 117.0 µM 1.68E-45 6 8.40E-46
4 SGTC_2582 agaric acid 13.90 100.0 µM 4.25E-44 redox potentiating 22 2.19E-44
5 SGTC_86 0417-1630 13.20 471.9 µM 7.08E-40 ubiquinone biosynthesis & proteasome 24 3.94E-40
6 SGTC_64 000l-0018 13.00 272.1 µM 1.64E-38 ubiquinone biosynthesis & proteasome 26 9.37E-39
7 SGTC_103 0844-0104 12.40 51.8 µM 1.62E-35 ERAD & cell cycle 14 9.81E-36
8 SGTC_58 0957-0393 11.50 9.0 µM 1.17E-30 cell wall 56 7.73E-31
9 SGTC_794 k038-0031 9.30 316.0 µM 8.93E-21 ubiquinone biosynthesis & proteasome 21 7.06E-21
10 SGTC_107 0358-0022 9.29 2.7 µM 9.65E-21 SWF1 & branched chain AA biosynthesis 7 7.63E-21
11 SGTC_67 0335-0847 9.08 266.0 µM 6.54E-20 ubiquinone biosynthesis & proteasome 29 5.25E-20
12 SGTC_3059 1327-0034 8.98 3.0 µM 1.67E-19 14 1.35E-19
13 SGTC_138 0850-0259 6.87 40.9 µM 3.52E-12 cell wall 78 3.21E-12
14 SGTC_158 k038-0087 6.77 26.4 µM 7.11E-12 ubiquinone biosynthesis & proteasome 57 6.51E-12
15 SGTC_36 0335-0881 6.37 14.2 µM 9.95E-11 ubiquinone biosynthesis & proteasome 55 9.27E-11
16 SGTC_3063 1327-0034 6.33 4.0 µM 1.29E-10 18 1.21E-10
17 SGTC_2808 7946468 5.92 45.5 µM 1.71E-9 6 1.62E-9
18 SGTC_500 h-89 5.79 112.0 µM 3.60E-9 cell wall signaling 11 3.43E-9
19 SGTC_352 k048-0007 5.55 5.1 µM 1.45E-8 ERAD & cell cycle 38 1.40E-8
20 SGTC_580 1123-0028 5.25 41.0 µM 7.92E-8 DNA damage response 7 7.69E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.717 0 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.710 0 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.688 0 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.685 0 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.662 0 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.659 0 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.628 0 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.622 0 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.475 1.40E-188 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.462 3.09E-177 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.451 1.15E-167 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.446 1.99E-163 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.443 6.96E-161 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.428 8.26E-150 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.426 4.56E-148 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication