YJL156C / SSY5

Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL156C / SSY5

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.88|P-value:1.74E-7 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.55|P-value:1.04E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.44|P-value:1.63E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.45|P-value:1.66E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.21|P-value:3.94E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.04|P-value:7.32E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:5.41|P-value:7.94E-9 ID:SGTC_186|Compound:3455-3465|FD-Score:3.00|P-value:8.61E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:-3.31|P-value:2.89E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.56|P-value:1.00E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:3.08|P-value:6.41E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.42|P-value:1.79E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.01|P-value:8.27E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.21|P-value:4.24E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.35|P-value:2.33E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.49|P-value:1.49E-6 ID:SGTC_906|Compound:1165-0455|FD-Score:3.29|P-value:2.98E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.72|P-value:4.21E-7 ID:SGTC_999|Compound:4022-0066|FD-Score:3.52|P-value:1.20E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.26|P-value:3.31E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.50|P-value:1.29E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:-4.26|P-value:4.82E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.27|P-value:3.40E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.24|P-value:3.73E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.04|P-value:7.38E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.29|P-value:2.90E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.23|P-value:3.74E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.56|P-value:1.01E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-3.02|P-value:8.61E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.26|P-value:3.23E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-3.10|P-value:6.30E-4 ID:SGTC_1896|Compound:st058441|FD-Score:5.26|P-value:1.98E-8 ID:SGTC_1901|Compound:st060216|FD-Score:-3.99|P-value:1.68E-5 ID:SGTC_2018|Compound:5133068|FD-Score:4.34|P-value:2.89E-6 ID:SGTC_2034|Compound:5197015|FD-Score:-3.38|P-value:2.26E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.36|P-value:2.20E-4 ID:SGTC_2138|Compound:5575593|FD-Score:4.77|P-value:3.18E-7 ID:SGTC_2178|Compound:5812956|FD-Score:3.24|P-value:3.59E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-4.25|P-value:4.95E-6 ID:SGTC_2299|Compound:7976368|FD-Score:3.11|P-value:5.83E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.81|P-value:3.38E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.29|P-value:2.95E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.11|P-value:5.86E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.03|P-value:8.33E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:11.70|P-value:2.31E-34 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.18|P-value:6.22E-6 ID:SGTC_2816|Compound:7982706|FD-Score:3.19|P-value:4.26E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.05|P-value:7.66E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.28|P-value:3.25E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-5.71|P-value:1.38E-9 ID:SGTC_2985|Compound:9022375|FD-Score:-3.51|P-value:1.33E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-7.06|P-value:1.03E-13 ID:SGTC_3135|Compound:9127742|FD-Score:-6.16|P-value:7.40E-11 ID:SGTC_3204|Compound:9114183|FD-Score:4.53|P-value:1.12E-6 ID:SGTC_3211|Compound:9128781|FD-Score:5.99|P-value:2.08E-10 ID:SGTC_8|Compound:0354-0001|FD-Score:4.88|P-value:1.74E-7 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.55|P-value:1.04E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.44|P-value:1.63E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.45|P-value:1.66E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.21|P-value:3.94E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.04|P-value:7.32E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:5.41|P-value:7.94E-9 ID:SGTC_186|Compound:3455-3465|FD-Score:3.00|P-value:8.61E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:-3.31|P-value:2.89E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.56|P-value:1.00E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:3.08|P-value:6.41E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.42|P-value:1.79E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.01|P-value:8.27E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.21|P-value:4.24E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.35|P-value:2.33E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.49|P-value:1.49E-6 ID:SGTC_906|Compound:1165-0455|FD-Score:3.29|P-value:2.98E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.72|P-value:4.21E-7 ID:SGTC_999|Compound:4022-0066|FD-Score:3.52|P-value:1.20E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.26|P-value:3.31E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.50|P-value:1.29E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:-4.26|P-value:4.82E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.27|P-value:3.40E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.24|P-value:3.73E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.04|P-value:7.38E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.29|P-value:2.90E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.23|P-value:3.74E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.56|P-value:1.01E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-3.02|P-value:8.61E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.26|P-value:3.23E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-3.10|P-value:6.30E-4 ID:SGTC_1896|Compound:st058441|FD-Score:5.26|P-value:1.98E-8 ID:SGTC_1901|Compound:st060216|FD-Score:-3.99|P-value:1.68E-5 ID:SGTC_2018|Compound:5133068|FD-Score:4.34|P-value:2.89E-6 ID:SGTC_2034|Compound:5197015|FD-Score:-3.38|P-value:2.26E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.36|P-value:2.20E-4 ID:SGTC_2138|Compound:5575593|FD-Score:4.77|P-value:3.18E-7 ID:SGTC_2178|Compound:5812956|FD-Score:3.24|P-value:3.59E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-4.25|P-value:4.95E-6 ID:SGTC_2299|Compound:7976368|FD-Score:3.11|P-value:5.83E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.81|P-value:3.38E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.29|P-value:2.95E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.11|P-value:5.86E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.03|P-value:8.33E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:11.70|P-value:2.31E-34 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.18|P-value:6.22E-6 ID:SGTC_2816|Compound:7982706|FD-Score:3.19|P-value:4.26E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.05|P-value:7.66E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.28|P-value:3.25E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-5.71|P-value:1.38E-9 ID:SGTC_2985|Compound:9022375|FD-Score:-3.51|P-value:1.33E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-7.06|P-value:1.03E-13 ID:SGTC_3135|Compound:9127742|FD-Score:-6.16|P-value:7.40E-11 ID:SGTC_3204|Compound:9114183|FD-Score:4.53|P-value:1.12E-6 ID:SGTC_3211|Compound:9128781|FD-Score:5.99|P-value:2.08E-10

Top fitness defect scores for YJL156C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2679 rapamycin 11.70 1.0 nM 2.31E-34 4 9.35E-32 0.02
2 SGTC_3211 9128781 5.99 49.5 µM 2.08E-10 3 1.07E-9 0.02
3 SGTC_178 4092-0806 5.41 87.5 µM 7.94E-9 ergosterol depletion effects on membrane 14 3.07E-8 0.06
4 SGTC_1896 st058441 5.26 89.0 µM 1.98E-8 2 7.13E-8 0.56
5 SGTC_8 0354-0001 4.88 70.0 µM 1.74E-7 5 5.27E-7 0.30
6 SGTC_2138 5575593 4.77 77.7 µM 3.18E-7 1 9.20E-7 1.03
7 SGTC_991 3996-0057 4.72 64.7 µM 4.21E-7 2 1.19E-6 0.19
8 SGTC_3204 9114183 4.53 49.5 µM 1.12E-6 3 2.95E-6 0.03
9 SGTC_2018 5133068 4.34 143.0 µM 2.89E-6 6 7.06E-6 0.13
10 SGTC_2724 maprotiline 4.18 69.6 µM 6.22E-6 ERG2 4 1.43E-5 0.07
11 SGTC_2417 cerulenin 3.81 830.0 nM 3.38E-5 16 6.82E-5 0.21
12 SGTC_208 k072-0098 3.56 12.4 µM 1.00E-4 heme biosynthesis & mitochondrial translocase 24 1.86E-4 0.16
13 SGTC_1423 4048-0112 3.56 5.6 µM 1.01E-4 3 1.87E-4 0.05
14 SGTC_46 0329-0187a 3.55 2.2 µM 1.04E-4 15 1.92E-4 0.23
15 SGTC_999 4022-0066 3.52 22.7 µM 1.20E-4 Golgi 20 2.19E-4 0.02
16 SGTC_1069 diphenylcyclopropenone 3.50 8.5 µM 1.29E-4 13 2.34E-4 0.15
17 SGTC_57 miconazole 3.44 162.5 nM 1.63E-4 ergosterol depletion effects on membrane 31 2.90E-4 0.05
18 SGTC_449 xestospongin c 3.42 11.2 µM 1.79E-4 NEO1-PIK1 5 3.17E-4 0.09
19 SGTC_2110 5483698 3.36 200.0 µM 2.20E-4 TSC3-RPN4 12 3.83E-4 0.17
20 SGTC_769 0302-0231 3.35 76.0 µM 2.33E-4 20 4.05E-4 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.210 9.79E-35 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.189 1.96E-28 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.174 2.73E-24 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.156 9.67E-20 YBR077C SLM4 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
0.155 2.00E-19 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.146 2.30E-17 YOR274W MOD5 hom Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis
0.146 2.31E-17 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.131 2.24E-14 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.131 2.50E-14 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.130 4.82E-14 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.128 1.21E-13 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.128 1.30E-13 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.124 5.53E-13 YKR095W MLP1 hom Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
0.122 1.40E-12 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.117 1.07E-11 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p