YJL158C / CIS3

Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL158C / CIS3

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.16|P-value:3.86E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.98|P-value:1.28E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:5.91|P-value:1.62E-10 ID:SGTC_90|Compound:0870-0863|FD-Score:-2.99|P-value:7.87E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-4.37|P-value:1.90E-6 ID:SGTC_507|Compound:nimesulide|FD-Score:2.92|P-value:9.27E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.22|P-value:2.98E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.38|P-value:1.76E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.49|P-value:1.02E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.38|P-value:1.61E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.36|P-value:1.99E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:3.43|P-value:1.31E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.38|P-value:1.59E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.22|P-value:3.03E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.95|P-value:8.29E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.19|P-value:3.31E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.26|P-value:2.59E-4 ID:SGTC_1649|Compound:st011737|FD-Score:-3.08|P-value:5.71E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.10|P-value:4.84E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.32|P-value:2.26E-4 ID:SGTC_1978|Compound:st071761|FD-Score:3.45|P-value:1.17E-4 ID:SGTC_2259|Compound:7964009|FD-Score:4.07|P-value:7.43E-6 ID:SGTC_2287|Compound:7945887|FD-Score:4.01|P-value:9.57E-6 ID:SGTC_2488|Compound:5268135|FD-Score:-3.24|P-value:3.04E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.37|P-value:1.68E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.10|P-value:4.71E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-2.93|P-value:9.98E-4 ID:SGTC_2856|Compound:9022925|FD-Score:4.12|P-value:5.86E-6 ID:SGTC_2960|Compound:9079389|FD-Score:3.57|P-value:7.17E-5 ID:SGTC_2996|Compound:9066192|FD-Score:-4.34|P-value:2.22E-6 ID:SGTC_2997|Compound:9067075|FD-Score:3.33|P-value:1.91E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.30|P-value:2.44E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.19|P-value:3.38E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.35|P-value:1.77E-4 ID:SGTC_3323|Compound:9138564|FD-Score:2.95|P-value:8.24E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.28|P-value:2.39E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.16|P-value:3.86E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.98|P-value:1.28E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:5.91|P-value:1.62E-10 ID:SGTC_90|Compound:0870-0863|FD-Score:-2.99|P-value:7.87E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-4.37|P-value:1.90E-6 ID:SGTC_507|Compound:nimesulide|FD-Score:2.92|P-value:9.27E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.22|P-value:2.98E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.38|P-value:1.76E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.49|P-value:1.02E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.38|P-value:1.61E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.36|P-value:1.99E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:3.43|P-value:1.31E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.38|P-value:1.59E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.22|P-value:3.03E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.95|P-value:8.29E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.19|P-value:3.31E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.26|P-value:2.59E-4 ID:SGTC_1649|Compound:st011737|FD-Score:-3.08|P-value:5.71E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.10|P-value:4.84E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.32|P-value:2.26E-4 ID:SGTC_1978|Compound:st071761|FD-Score:3.45|P-value:1.17E-4 ID:SGTC_2259|Compound:7964009|FD-Score:4.07|P-value:7.43E-6 ID:SGTC_2287|Compound:7945887|FD-Score:4.01|P-value:9.57E-6 ID:SGTC_2488|Compound:5268135|FD-Score:-3.24|P-value:3.04E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.37|P-value:1.68E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.10|P-value:4.71E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-2.93|P-value:9.98E-4 ID:SGTC_2856|Compound:9022925|FD-Score:4.12|P-value:5.86E-6 ID:SGTC_2960|Compound:9079389|FD-Score:3.57|P-value:7.17E-5 ID:SGTC_2996|Compound:9066192|FD-Score:-4.34|P-value:2.22E-6 ID:SGTC_2997|Compound:9067075|FD-Score:3.33|P-value:1.91E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.30|P-value:2.44E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.19|P-value:3.38E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.35|P-value:1.77E-4 ID:SGTC_3323|Compound:9138564|FD-Score:2.95|P-value:8.24E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.28|P-value:2.39E-4

Top fitness defect scores for YJL158C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_73 0327-0325 5.91 16.2 µM 1.62E-10 DNA damage response 16 1.70E-9
2 SGTC_2856 9022925 4.12 19.5 µM 5.86E-6 15 1.92E-5
3 SGTC_2259 7964009 4.07 200.0 µM 7.43E-6 superoxide 27 2.37E-5
4 SGTC_2287 7945887 4.01 168.8 µM 9.57E-6 7 2.97E-5
5 SGTC_2960 9079389 3.57 6.0 µM 7.17E-5 44 1.79E-4
6 SGTC_808 0711-0032 3.49 135.0 µM 1.02E-4 26 2.45E-4
7 SGTC_1978 st071761 3.45 42.0 µM 1.17E-4 TSC3-RPN4 24 2.76E-4
8 SGTC_1123 mangostin 3.43 811.3 nM 1.31E-4 mitochondrial response to ROS 55 3.06E-4
9 SGTC_1151 3909-8316 3.38 15.3 µM 1.59E-4 37 3.63E-4
10 SGTC_1083 didemethylchlorpromazine sulfoxide 3.38 707.4 nM 1.61E-4 redox potentiating 118 3.68E-4
11 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 3.37 63.6 µM 1.68E-4 68 3.82E-4
12 SGTC_3201 9113999 3.35 49.5 µM 1.77E-4 61 4.00E-4
13 SGTC_2997 9067075 3.33 71.4 µM 1.91E-4 unfolded protein response 80 4.28E-4
14 SGTC_3334 9142812 3.28 21.9 µM 2.39E-4 56 5.22E-4
15 SGTC_1520 flindersine 3.26 88.0 µM 2.59E-4 56 5.63E-4
16 SGTC_690 glyoxal 3.22 20.3 µM 2.98E-4 127 6.36E-4
17 SGTC_1269 0831-0796 3.22 3.0 µM 3.03E-4 60S ribosome export 35 6.45E-4
18 SGTC_1494 4358-1428 3.19 177.0 µM 3.31E-4 46 6.99E-4
19 SGTC_3182 9108849 3.19 49.5 µM 3.38E-4 RPP1 & pyrimidine depletion 34 7.12E-4
20 SGTC_45 0kpi-0036 3.16 14.9 µM 3.86E-4 excess fatty acid 56 8.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.172 1.46E-23 YMR047C NUP116 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p)
0.165 5.11E-22 YLR346C_p YLR346C_p hom Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
0.145 3.26E-17 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.141 2.30E-16 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.141 2.59E-16 YLR283W_p YLR283W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene
0.141 2.89E-16 YJR108W ABM1 hom Protein of unknown function, required for normal microtubule organization
0.135 3.31E-15 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.129 5.26E-14 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.129 7.66E-14 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.126 2.80E-13 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.125 3.44E-13 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.122 1.36E-12 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.120 2.74E-12 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.114 3.20E-11 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.112 8.59E-11 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane