YJL160C_p

Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL160C / YJL160C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.97|P-value:4.16E-6 ID:SGTC_235|Compound:0330-0087|FD-Score:3.60|P-value:6.40E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:4.73|P-value:1.13E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:6.12|P-value:1.98E-8 ID:SGTC_664|Compound:1222-0054|FD-Score:3.68|P-value:5.03E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:-3.47|P-value:7.61E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.98|P-value:1.86E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.62|P-value:6.00E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.28|P-value:6.27E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:4.24|P-value:7.37E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:-4.71|P-value:9.12E-6 ID:SGTC_1360|Compound:1598-0022|FD-Score:-4.23|P-value:5.84E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.07|P-value:1.34E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:-5.69|P-value:1.18E-7 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.74|P-value:4.16E-4 ID:SGTC_1678|Compound:st019265|FD-Score:4.81|P-value:8.16E-6 ID:SGTC_1691|Compound:st019933|FD-Score:-3.72|P-value:3.43E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.48|P-value:3.02E-5 ID:SGTC_1734|Compound:st037168|FD-Score:4.64|P-value:1.64E-5 ID:SGTC_1901|Compound:st060216|FD-Score:3.69|P-value:4.85E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.74|P-value:4.11E-4 ID:SGTC_1997|Compound:st073024|FD-Score:-3.52|P-value:6.47E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.65|P-value:5.50E-4 ID:SGTC_2332|Compound:7982454|FD-Score:4.18|P-value:9.09E-5 ID:SGTC_2349|Compound:9023730|FD-Score:3.53|P-value:7.95E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.24|P-value:7.43E-5 ID:SGTC_2860|Compound:9025725|FD-Score:-4.26|P-value:5.12E-5 ID:SGTC_2866|Compound:9034245|FD-Score:-3.72|P-value:3.41E-4 ID:SGTC_2879|Compound:9041815|FD-Score:-3.40|P-value:9.39E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.75|P-value:3.99E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.97|P-value:4.16E-6 ID:SGTC_235|Compound:0330-0087|FD-Score:3.60|P-value:6.40E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:4.73|P-value:1.13E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:6.12|P-value:1.98E-8 ID:SGTC_664|Compound:1222-0054|FD-Score:3.68|P-value:5.03E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:-3.47|P-value:7.61E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.98|P-value:1.86E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.62|P-value:6.00E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.28|P-value:6.27E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:4.24|P-value:7.37E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:-4.71|P-value:9.12E-6 ID:SGTC_1360|Compound:1598-0022|FD-Score:-4.23|P-value:5.84E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.07|P-value:1.34E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:-5.69|P-value:1.18E-7 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.74|P-value:4.16E-4 ID:SGTC_1678|Compound:st019265|FD-Score:4.81|P-value:8.16E-6 ID:SGTC_1691|Compound:st019933|FD-Score:-3.72|P-value:3.43E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.48|P-value:3.02E-5 ID:SGTC_1734|Compound:st037168|FD-Score:4.64|P-value:1.64E-5 ID:SGTC_1901|Compound:st060216|FD-Score:3.69|P-value:4.85E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.74|P-value:4.11E-4 ID:SGTC_1997|Compound:st073024|FD-Score:-3.52|P-value:6.47E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.65|P-value:5.50E-4 ID:SGTC_2332|Compound:7982454|FD-Score:4.18|P-value:9.09E-5 ID:SGTC_2349|Compound:9023730|FD-Score:3.53|P-value:7.95E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.24|P-value:7.43E-5 ID:SGTC_2860|Compound:9025725|FD-Score:-4.26|P-value:5.12E-5 ID:SGTC_2866|Compound:9034245|FD-Score:-3.72|P-value:3.41E-4 ID:SGTC_2879|Compound:9041815|FD-Score:-3.40|P-value:9.39E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.75|P-value:3.99E-4

Top fitness defect scores for YJL160C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_530 4358-1714 6.12 28.0 µM 1.98E-8 8 4.74E-10
2 SGTC_6 0844-0013 4.97 19.8 µM 4.16E-6 36 3.33E-7
3 SGTC_1678 st019265 4.81 80.2 µM 8.16E-6 60S ribosome export 10 7.60E-7
4 SGTC_437 s-farnesyl-l-cysteine methyl ester 4.73 6.7 µM 1.13E-5 4 1.13E-6
5 SGTC_1734 st037168 4.64 69.4 µM 1.64E-5 11 1.78E-6
6 SGTC_1712 st032288 4.48 53.4 µM 3.02E-5 calcium & mitochondrial duress 145 3.76E-6
7 SGTC_1203 3992-3522 4.28 103.0 µM 6.27E-5 23 9.22E-6
8 SGTC_1287 0971-0001 4.24 34.6 µM 7.37E-5 sphingolipid biosynthesis & PDR1 40 1.12E-5
9 SGTC_2635 hydroquinidine 4.24 100.0 µM 7.43E-5 19 1.13E-5
10 SGTC_2332 7982454 4.18 138.9 µM 9.09E-5 40 1.45E-5
11 SGTC_1364 1653-0028 4.07 37.6 µM 1.34E-4 18 2.34E-5
12 SGTC_1124 fisetin 3.98 1.2 µM 1.86E-4 34 3.49E-5
13 SGTC_3196 9111891 3.75 49.5 µM 3.99E-4 mitochondrial processes 22 8.87E-5
14 SGTC_1947 st076332 3.74 61.6 µM 4.11E-4 16 9.19E-5
15 SGTC_1575 cyproterone acetate 3.74 48.0 µM 4.16E-4 29 9.33E-5
16 SGTC_1901 st060216 3.69 58.6 µM 4.85E-4 27 1.12E-4
17 SGTC_664 1222-0054 3.68 14.9 µM 5.03E-4 sphingolipid biosynthesis & PDR1 41 1.17E-4
18 SGTC_2181 6316240 3.65 54.3 µM 5.50E-4 28 1.31E-4
19 SGTC_1190 1486-1332 3.62 13.0 µM 6.00E-4 22 1.46E-4
20 SGTC_235 0330-0087 3.60 5.0 mM 6.40E-4 TSC3-RPN4 38 1.58E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 6.85E-10 YHL002W HSE1 hom Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
0.105 1.03E-9 YLR101C_d YLR101C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
0.101 5.24E-9 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.087 4.58E-7 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.086 5.97E-7 YNL312W RFA2 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.083 1.33E-6 YMR241W YHM2 hom Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome
0.081 2.50E-6 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.080 3.36E-6 YEL023C_p YEL023C_p hom Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene
0.079 4.28E-6 YKR080W MTD1 hom NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
0.079 4.95E-6 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.078 5.34E-6 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
0.078 6.13E-6 YPL191C_p YPL191C_p hom Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.075 1.37E-5 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.075 1.44E-5 YDR520C_p URC2_p hom Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism
0.074 1.72E-5 YKL146W AVT3 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters