HIPHOP chemogenomics database

YJL161W_p / FMP33

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain

fixedexpanded
Profile for YJL161W / FMP33

Click on Significant Values for Screen Details

Top fitness defect scores for YJL161W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1875	nocodazole	4.80	6.0 µM	5.13E-8	tubulin folding & SWR complex	40	7.82E-7
2	SGTC_795	0685-0265	4.08	78.0 µM	3.03E-6	excess fatty acid	19	2.22E-5
3	SGTC_1525	8-methoxypsoralen	4.02	92.5 µM	4.14E-6	DNA damage response	30	2.87E-5
4	SGTC_1492	4158-0558	3.99	28.5 µM	4.84E-6	60S ribosome export	13	3.27E-5
5	SGTC_2014	4013930	3.95	200.0 µM	6.03E-6		30	3.91E-5
6	SGTC_1008	4106-0037	3.90	6.0 µM	7.57E-6	PDR1	21	4.71E-5
7	SGTC_2527	2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone	3.66	63.6 µM	2.53E-5		55	1.27E-4
8	SGTC_775	4577-0580	3.63	57.3 µM	2.85E-5		11	1.40E-4
9	SGTC_1372	2752-0194	3.61	270.0 µM	3.19E-5		26	1.54E-4
10	SGTC_444	curcumin	3.56	90.4 µM	4.04E-5	iron homeostasis	40	1.87E-4
11	SGTC_509	pifithrin	3.55	175.0 µM	4.19E-5	mitochondrial processes	9	1.93E-4
12	SGTC_1861	st057647	3.54	17.4 µM	4.41E-5		33	2.01E-4
13	SGTC_1686	st019653	3.51	115.5 µM	4.95E-5	mitochondrial processes	18	2.21E-4
14	SGTC_2267	7931562	3.46	200.0 µM	6.40E-5		36	2.73E-4
15	SGTC_2545	solidagenone	3.39	89.6 µM	8.69E-5		5	3.51E-4
16	SGTC_2816	7982706	3.36	58.4 µM	9.67E-5	azole & statin	81	3.84E-4
17	SGTC_2794	7785382	3.34	27.3 µM	1.09E-4		61	4.23E-4
18	SGTC_460	trequinsin	3.32	123.0 µM	1.17E-4		8	4.49E-4
19	SGTC_774	k060-0086	3.29	136.0 µM	1.33E-4		40	4.99E-4
20	SGTC_1149	3909-7961	3.26	23.3 µM	1.54E-4		55	5.64E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.185	3.56E-27	YGL094C	PAN2	hom	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.161	5.15E-21	YGR025W_d	YGR025W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126	2.46E-13	YGR097W	ASK10	hom	Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.122	1.22E-12	YGL181W	GTS1	hom	Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
0.118	7.24E-12	YJR106W	ECM27	hom	Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.114	3.17E-11	YLR414C	PUN1	hom	Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.111	1.23E-10	YMR041C	ARA2	hom	NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.108	3.01E-10	YGR008C	STF2	hom	Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.103	2.06E-9	YNL097C-B_p	YNL097C-B_p	hom	Putative protein of unknown function
0.097	1.76E-8	YMR094W	CTF13	het	Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
0.097	1.98E-8	YKL025C	PAN3	hom	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.096	2.23E-8	YKL131W_d	YKL131W_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.096	2.78E-8	YLR117C	CLF1	het	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.095	4.08E-8	YOR284W	HUA2	hom	Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
0.094	4.98E-8	YJL008C	CCT8	het	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo