Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YJL161W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.185 | 3.56E-27 | YGL094C | PAN2 | hom | Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes |
0.161 | 5.15E-21 | YGR025W_d | YGR025W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.126 | 2.46E-13 | YGR097W | ASK10 | hom | Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication |
0.122 | 1.22E-12 | YGL181W | GTS1 | hom | Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations |
0.118 | 7.24E-12 | YJR106W | ECM27 | hom | Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p |
0.114 | 3.17E-11 | YLR414C | PUN1 | hom | Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress |
0.111 | 1.23E-10 | YMR041C | ARA2 | hom | NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase |
0.108 | 3.01E-10 | YGR008C | STF2 | hom | Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress |
0.103 | 2.06E-9 | YNL097C-B_p | YNL097C-B_p | hom | Putative protein of unknown function |
0.097 | 1.76E-8 | YMR094W | CTF13 | het | Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis |
0.097 | 1.98E-8 | YKL025C | PAN3 | hom | Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes |
0.096 | 2.23E-8 | YKL131W_d | YKL131W_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.096 | 2.78E-8 | YLR117C | CLF1 | het | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins |
0.095 | 4.08E-8 | YOR284W | HUA2 | hom | Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly |
0.094 | 4.98E-8 | YJL008C | CCT8 | het | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |