YJL161W_p / FMP33

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL161W / FMP33

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-4.07|P-value:3.19E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.10|P-value:2.94E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.85|P-value:9.70E-6 ID:SGTC_444|Compound:curcumin|FD-Score:3.56|P-value:4.04E-5 ID:SGTC_460|Compound:trequinsin|FD-Score:3.32|P-value:1.17E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:3.55|P-value:4.19E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:3.29|P-value:1.33E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.63|P-value:2.85E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:4.08|P-value:3.03E-6 ID:SGTC_998|Compound:3996-0085|FD-Score:2.81|P-value:9.10E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.90|P-value:7.57E-6 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.19|P-value:2.07E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-2.91|P-value:6.21E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:2.80|P-value:9.50E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.26|P-value:1.54E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.16|P-value:2.27E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.13|P-value:2.62E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:-3.27|P-value:1.47E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:-3.54|P-value:4.37E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.11|P-value:2.89E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.03|P-value:3.87E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:2.87|P-value:7.43E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.61|P-value:3.19E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:2.99|P-value:4.59E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.01|P-value:4.33E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.99|P-value:4.84E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.02|P-value:4.14E-6 ID:SGTC_1686|Compound:st019653|FD-Score:3.51|P-value:4.95E-5 ID:SGTC_1835|Compound:st008666|FD-Score:-3.57|P-value:3.83E-5 ID:SGTC_1861|Compound:st057647|FD-Score:3.54|P-value:4.41E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.80|P-value:5.13E-8 ID:SGTC_1887|Compound:st057648|FD-Score:3.15|P-value:2.40E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.60|P-value:3.31E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.95|P-value:6.03E-6 ID:SGTC_2267|Compound:7931562|FD-Score:3.46|P-value:6.40E-5 ID:SGTC_2287|Compound:7945887|FD-Score:3.25|P-value:1.62E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.16|P-value:2.36E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.66|P-value:2.53E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:-2.92|P-value:6.11E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:3.39|P-value:8.69E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-2.92|P-value:5.96E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.34|P-value:1.09E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.36|P-value:9.67E-5 ID:SGTC_2822|Compound:7994718|FD-Score:-2.85|P-value:8.00E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-3.01|P-value:4.23E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.90|P-value:7.59E-6 ID:SGTC_2923|Compound:7992654|FD-Score:-5.74|P-value:9.99E-11 ID:SGTC_2928|Compound:9011484|FD-Score:3.25|P-value:1.60E-4 ID:SGTC_2991|Compound:9074669|FD-Score:2.90|P-value:6.65E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.07|P-value:3.19E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.10|P-value:2.94E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.85|P-value:9.70E-6 ID:SGTC_444|Compound:curcumin|FD-Score:3.56|P-value:4.04E-5 ID:SGTC_460|Compound:trequinsin|FD-Score:3.32|P-value:1.17E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:3.55|P-value:4.19E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:3.29|P-value:1.33E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.63|P-value:2.85E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:4.08|P-value:3.03E-6 ID:SGTC_998|Compound:3996-0085|FD-Score:2.81|P-value:9.10E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.90|P-value:7.57E-6 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.19|P-value:2.07E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-2.91|P-value:6.21E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:2.80|P-value:9.50E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.26|P-value:1.54E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.16|P-value:2.27E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.13|P-value:2.62E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:-3.27|P-value:1.47E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:-3.54|P-value:4.37E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.11|P-value:2.89E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.03|P-value:3.87E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:2.87|P-value:7.43E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.61|P-value:3.19E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:2.99|P-value:4.59E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.01|P-value:4.33E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.99|P-value:4.84E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.02|P-value:4.14E-6 ID:SGTC_1686|Compound:st019653|FD-Score:3.51|P-value:4.95E-5 ID:SGTC_1835|Compound:st008666|FD-Score:-3.57|P-value:3.83E-5 ID:SGTC_1861|Compound:st057647|FD-Score:3.54|P-value:4.41E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.80|P-value:5.13E-8 ID:SGTC_1887|Compound:st057648|FD-Score:3.15|P-value:2.40E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.60|P-value:3.31E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.95|P-value:6.03E-6 ID:SGTC_2267|Compound:7931562|FD-Score:3.46|P-value:6.40E-5 ID:SGTC_2287|Compound:7945887|FD-Score:3.25|P-value:1.62E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.16|P-value:2.36E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.66|P-value:2.53E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:-2.92|P-value:6.11E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:3.39|P-value:8.69E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-2.92|P-value:5.96E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.34|P-value:1.09E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.36|P-value:9.67E-5 ID:SGTC_2822|Compound:7994718|FD-Score:-2.85|P-value:8.00E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-3.01|P-value:4.23E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.90|P-value:7.59E-6 ID:SGTC_2923|Compound:7992654|FD-Score:-5.74|P-value:9.99E-11 ID:SGTC_2928|Compound:9011484|FD-Score:3.25|P-value:1.60E-4 ID:SGTC_2991|Compound:9074669|FD-Score:2.90|P-value:6.65E-4

Top fitness defect scores for YJL161W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1875 nocodazole 4.80 6.0 µM 5.13E-8 tubulin folding & SWR complex 40 7.82E-7
2 SGTC_795 0685-0265 4.08 78.0 µM 3.03E-6 excess fatty acid 19 2.22E-5
3 SGTC_1525 8-methoxypsoralen 4.02 92.5 µM 4.14E-6 DNA damage response 30 2.87E-5
4 SGTC_1492 4158-0558 3.99 28.5 µM 4.84E-6 60S ribosome export 13 3.27E-5
5 SGTC_2014 4013930 3.95 200.0 µM 6.03E-6 30 3.91E-5
6 SGTC_1008 4106-0037 3.90 6.0 µM 7.57E-6 PDR1 21 4.71E-5
7 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 3.66 63.6 µM 2.53E-5 55 1.27E-4
8 SGTC_775 4577-0580 3.63 57.3 µM 2.85E-5 11 1.40E-4
9 SGTC_1372 2752-0194 3.61 270.0 µM 3.19E-5 26 1.54E-4
10 SGTC_444 curcumin 3.56 90.4 µM 4.04E-5 iron homeostasis 40 1.87E-4
11 SGTC_509 pifithrin 3.55 175.0 µM 4.19E-5 mitochondrial processes 9 1.93E-4
12 SGTC_1861 st057647 3.54 17.4 µM 4.41E-5 33 2.01E-4
13 SGTC_1686 st019653 3.51 115.5 µM 4.95E-5 mitochondrial processes 18 2.21E-4
14 SGTC_2267 7931562 3.46 200.0 µM 6.40E-5 36 2.73E-4
15 SGTC_2545 solidagenone 3.39 89.6 µM 8.69E-5 5 3.51E-4
16 SGTC_2816 7982706 3.36 58.4 µM 9.67E-5 azole & statin 81 3.84E-4
17 SGTC_2794 7785382 3.34 27.3 µM 1.09E-4 61 4.23E-4
18 SGTC_460 trequinsin 3.32 123.0 µM 1.17E-4 8 4.49E-4
19 SGTC_774 k060-0086 3.29 136.0 µM 1.33E-4 40 4.99E-4
20 SGTC_1149 3909-7961 3.26 23.3 µM 1.54E-4 55 5.64E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.185 3.56E-27 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.161 5.15E-21 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126 2.46E-13 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.122 1.22E-12 YGL181W GTS1 hom Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
0.118 7.24E-12 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.114 3.17E-11 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.111 1.23E-10 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.108 3.01E-10 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.103 2.06E-9 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.097 1.76E-8 YMR094W CTF13 het Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
0.097 1.98E-8 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.096 2.23E-8 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.096 2.78E-8 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.095 4.08E-8 YOR284W HUA2 hom Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
0.094 4.98E-8 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo