HIPHOP chemogenomics database
YJL162C / JJJ2 
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YJL162C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.183 | 1.01E-26 | YPL251W_d | YPL251W_d | het | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C |
| 0.153 | 4.68E-19 | YPL252C | YAH1 | het | Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin |
| 0.114 | 3.95E-11 | YDR431W_d | YDR431W_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.110 | 1.55E-10 | YOR190W | SPR1 | hom | Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance |
| 0.102 | 3.21E-9 | YFL042C_p | YFL042C_p | hom | Putative protein of unknown function; YFL042C is not an essential gene |
| 0.098 | 1.20E-8 | YJR093C | FIP1 | het | Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p |
| 0.098 | 1.42E-8 | YPR093C | ASR1 | hom | Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein |
| 0.096 | 2.22E-8 | YAL054C | ACS1 | hom | Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions |
| 0.096 | 2.49E-8 | YDR376W | ARH1 | het | Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability |
| 0.095 | 3.10E-8 | YOL061W | PRS5 | hom | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress |
| 0.093 | 6.12E-8 | YFR039C_p | YFR039C_p | hom | Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces |
| 0.090 | 1.52E-7 | YIL087C | AIM19 | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth |
| 0.090 | 1.66E-7 | YMR017W | SPO20 | hom | Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog |
| 0.090 | 1.98E-7 | YGR133W | PEX4 | hom | Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis |
| 0.090 | 2.02E-7 | YLR311C_d | YLR311C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |