YJL162C / JJJ2

Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL162C / JJJ2

Click on Significant Values for Screen Details ID:SGTC_131|Compound:0141-0277|FD-Score:-3.25|P-value:3.83E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:4.36|P-value:2.68E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.94|P-value:2.27E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.49|P-value:1.63E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.25|P-value:3.76E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:-3.64|P-value:8.08E-5 ID:SGTC_856|Compound:0433-0016|FD-Score:4.09|P-value:9.76E-6 ID:SGTC_864|Compound:0469-0573|FD-Score:4.72|P-value:4.31E-7 ID:SGTC_868|Compound:0527-0199|FD-Score:3.73|P-value:4.86E-5 ID:SGTC_883|Compound:0850-0245|FD-Score:3.33|P-value:2.49E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.12|P-value:6.17E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.43|P-value:1.89E-6 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.20|P-value:4.17E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-4.67|P-value:6.50E-7 ID:SGTC_1720|Compound:st037298|FD-Score:4.86|P-value:2.01E-7 ID:SGTC_1736|Compound:st036774|FD-Score:3.14|P-value:5.23E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:-3.92|P-value:2.49E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.14|P-value:7.92E-6 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.32|P-value:2.94E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.23|P-value:3.69E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.65|P-value:7.06E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.68|P-value:6.01E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:3.04|P-value:7.38E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.60|P-value:7.94E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.27|P-value:3.61E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.89|P-value:2.47E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.50|P-value:1.26E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-4.06|P-value:1.27E-5 ID:SGTC_2906|Compound:7926292|FD-Score:-3.05|P-value:7.89E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.12|P-value:6.22E-4 ID:SGTC_3322|Compound:9139058|FD-Score:4.52|P-value:1.23E-6 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.25|P-value:3.83E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:4.36|P-value:2.68E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.94|P-value:2.27E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.49|P-value:1.63E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.25|P-value:3.76E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:-3.64|P-value:8.08E-5 ID:SGTC_856|Compound:0433-0016|FD-Score:4.09|P-value:9.76E-6 ID:SGTC_864|Compound:0469-0573|FD-Score:4.72|P-value:4.31E-7 ID:SGTC_868|Compound:0527-0199|FD-Score:3.73|P-value:4.86E-5 ID:SGTC_883|Compound:0850-0245|FD-Score:3.33|P-value:2.49E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.12|P-value:6.17E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.43|P-value:1.89E-6 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.20|P-value:4.17E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-4.67|P-value:6.50E-7 ID:SGTC_1720|Compound:st037298|FD-Score:4.86|P-value:2.01E-7 ID:SGTC_1736|Compound:st036774|FD-Score:3.14|P-value:5.23E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:-3.92|P-value:2.49E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.14|P-value:7.92E-6 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.32|P-value:2.94E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.23|P-value:3.69E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.65|P-value:7.06E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.68|P-value:6.01E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:3.04|P-value:7.38E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.60|P-value:7.94E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.27|P-value:3.61E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.89|P-value:2.47E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.50|P-value:1.26E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-4.06|P-value:1.27E-5 ID:SGTC_2906|Compound:7926292|FD-Score:-3.05|P-value:7.89E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.12|P-value:6.22E-4 ID:SGTC_3322|Compound:9139058|FD-Score:4.52|P-value:1.23E-6

Top fitness defect scores for YJL162C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1720 st037298 4.86 9.5 µM 2.01E-7 25 5.90E-7
2 SGTC_864 0469-0573 4.72 172.0 µM 4.31E-7 7 1.20E-6
3 SGTC_2596 sinensetin 4.60 100.0 µM 7.94E-7 18 2.11E-6
4 SGTC_3322 9139058 4.52 2.1 µM 1.23E-6 cell wall 18 3.15E-6
5 SGTC_1083 didemethylchlorpromazine sulfoxide 4.43 707.4 nM 1.89E-6 redox potentiating 55 4.69E-6
6 SGTC_132 0417-1715 4.36 25.8 µM 2.68E-6 RPP1 & pyrimidine depletion 15 6.47E-6
7 SGTC_1877 wortmannin 4.14 25.0 µM 7.92E-6 89 1.77E-5
8 SGTC_856 0433-0016 4.09 11.3 µM 9.76E-6 14 2.14E-5
9 SGTC_2665 lovastatin 3.89 100.0 µM 2.47E-5 12 5.06E-5
10 SGTC_868 0527-0199 3.73 213.0 µM 4.86E-5 fatty acid desaturase (OLE1) 32 9.46E-5
11 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 3.68 100.0 µM 6.01E-5 30 1.15E-4
12 SGTC_2514 salinomycin 3.65 42.7 µM 7.06E-5 59 1.34E-4
13 SGTC_2762 leflunomide 3.50 42.1 µM 1.26E-4 49 2.29E-4
14 SGTC_883 0850-0245 3.33 24.6 µM 2.49E-4 cell wall 52 4.28E-4
15 SGTC_1897 st060201 3.23 15.0 µM 3.69E-4 mitochondrial processes 39 6.17E-4
16 SGTC_1356 1502-0781 3.20 85.8 µM 4.17E-4 fatty acid desaturase (OLE1) 42 6.91E-4
17 SGTC_1736 st036774 3.14 51.0 µM 5.23E-4 67 8.53E-4
18 SGTC_2544 sphondin 3.04 68.5 µM 7.38E-4 RNA pol III & RNase P/MRP 56 0.00117
19 SGTC_2621 lithochol-11-enic acid 2.95 100.0 µM 0.00102 82 0.00158
20 SGTC_2679 rapamycin 2.93 1.0 nM 0.00109 229 0.00168

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.183 1.01E-26 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.153 4.68E-19 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.114 3.95E-11 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.110 1.55E-10 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.102 3.21E-9 YFL042C_p YFL042C_p hom Putative protein of unknown function; YFL042C is not an essential gene
0.098 1.20E-8 YJR093C FIP1 het Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
0.098 1.42E-8 YPR093C ASR1 hom Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein
0.096 2.22E-8 YAL054C ACS1 hom Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
0.096 2.49E-8 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.095 3.10E-8 YOL061W PRS5 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress
0.093 6.12E-8 YFR039C_p YFR039C_p hom Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces
0.090 1.52E-7 YIL087C AIM19 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth
0.090 1.66E-7 YMR017W SPO20 hom Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
0.090 1.98E-7 YGR133W PEX4 hom Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis
0.090 2.02E-7 YLR311C_d YLR311C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data