YJL163C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL163C / YJL163C

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:-5.63|P-value:6.38E-9 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.32|P-value:4.13E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.65|P-value:1.07E-6 ID:SGTC_88|Compound:0180-0332|FD-Score:3.17|P-value:5.84E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.34|P-value:3.19E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:-3.81|P-value:6.06E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:3.17|P-value:5.93E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:3.17|P-value:5.84E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:4.53|P-value:1.88E-6 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.20|P-value:9.22E-6 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.09|P-value:7.91E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.42|P-value:1.66E-8 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.08|P-value:9.55E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.05|P-value:9.01E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:5.56|P-value:7.20E-9 ID:SGTC_1664|Compound:st014217|FD-Score:3.14|P-value:6.59E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-3.73|P-value:8.37E-5 ID:SGTC_1885|Compound:st057546|FD-Score:3.47|P-value:1.96E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.15|P-value:6.45E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.57|P-value:1.57E-6 ID:SGTC_2076|Compound:5212012|FD-Score:3.10|P-value:7.62E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.43|P-value:2.72E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.57|P-value:1.34E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-3.58|P-value:1.57E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:-3.34|P-value:3.82E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:5.31|P-value:3.07E-8 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.55|P-value:1.75E-4 ID:SGTC_2920|Compound:7982904|FD-Score:5.28|P-value:3.75E-8 ID:SGTC_3196|Compound:9111891|FD-Score:-3.26|P-value:5.08E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.09|P-value:7.84E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-4.27|P-value:8.45E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:-5.63|P-value:6.38E-9 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.32|P-value:4.13E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.65|P-value:1.07E-6 ID:SGTC_88|Compound:0180-0332|FD-Score:3.17|P-value:5.84E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.34|P-value:3.19E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:-3.81|P-value:6.06E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:3.17|P-value:5.93E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:3.17|P-value:5.84E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:4.53|P-value:1.88E-6 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.20|P-value:9.22E-6 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.09|P-value:7.91E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.42|P-value:1.66E-8 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.08|P-value:9.55E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.05|P-value:9.01E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:5.56|P-value:7.20E-9 ID:SGTC_1664|Compound:st014217|FD-Score:3.14|P-value:6.59E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-3.73|P-value:8.37E-5 ID:SGTC_1885|Compound:st057546|FD-Score:3.47|P-value:1.96E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.15|P-value:6.45E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.57|P-value:1.57E-6 ID:SGTC_2076|Compound:5212012|FD-Score:3.10|P-value:7.62E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.43|P-value:2.72E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.57|P-value:1.34E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-3.58|P-value:1.57E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:-3.34|P-value:3.82E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:5.31|P-value:3.07E-8 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.55|P-value:1.75E-4 ID:SGTC_2920|Compound:7982904|FD-Score:5.28|P-value:3.75E-8 ID:SGTC_3196|Compound:9111891|FD-Score:-3.26|P-value:5.08E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.09|P-value:7.84E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-4.27|P-value:8.45E-6

Top fitness defect scores for YJL163C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1631 benzylvanillin 5.56 81.9 µM 7.20E-9 Golgi 7 1.34E-8
2 SGTC_1374 2889-5571 5.42 141.0 µM 1.66E-8 RSC complex & mRNA processing 15 2.99E-8
3 SGTC_2501 sodium tetradecyl sulfate 5.31 13.4 µM 3.07E-8 12 5.44E-8
4 SGTC_2920 7982904 5.28 15.8 µM 3.75E-8 3 6.60E-8
5 SGTC_58 0957-0393 4.65 9.0 µM 1.07E-6 cell wall 318 1.69E-6
6 SGTC_1948 st076329 4.57 66.6 µM 1.57E-6 15 2.44E-6
7 SGTC_814 3342-0569 4.53 96.0 µM 1.88E-6 13 2.92E-6
8 SGTC_1265 0819-1001 4.20 68.8 µM 9.22E-6 19 1.36E-5
9 SGTC_2263 7948595 3.57 193.3 µM 1.34E-4 13 1.81E-4
10 SGTC_1885 st057546 3.47 99.9 µM 1.96E-4 31 2.61E-4
11 SGTC_360 0957-0399 3.34 1.0 µM 3.19E-4 cell wall 72 4.18E-4
12 SGTC_88 0180-0332 3.17 8.7 µM 5.84E-4 50 7.50E-4
13 SGTC_772 k072-0172 3.17 35.3 µM 5.84E-4 49 7.51E-4
14 SGTC_718 1130-0073 3.17 349.0 µM 5.93E-4 49 7.61E-4
15 SGTC_1891 st059073 3.15 26.2 µM 6.45E-4 TSC3-RPN4 51 8.26E-4
16 SGTC_1664 st014217 3.14 9.0 µM 6.59E-4 60S ribosome export 32 8.43E-4
17 SGTC_2076 5212012 3.10 200.0 µM 7.62E-4 20 9.71E-4
18 SGTC_3210 9128157 3.09 49.5 µM 7.84E-4 96 9.98E-4
19 SGTC_1367 1812-0510 3.09 76.9 µM 7.91E-4 66 0.00101
20 SGTC_1511 0906-3109 3.05 28.5 µM 9.01E-4 excess fatty acid 102 0.00114

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 3.67E-24 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.143 6.81E-17 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.142 1.28E-16 YCR002C CDC10 hom Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress
0.140 4.29E-16 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.134 6.86E-15 YBR244W GPX2 hom Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress
0.126 2.17E-13 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.126 2.59E-13 YML021C UNG1 hom Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
0.124 6.24E-13 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.123 8.66E-13 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.123 8.82E-13 YCR043C_p YCR043C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene
0.121 1.88E-12 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.120 3.36E-12 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.116 1.61E-11 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.115 2.00E-11 YIL005W EPS1 hom ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family
0.114 3.78E-11 YNL211C_p YNL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene