Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor
Zygosity: Homozygous strain
fixedexpanded
![]() ![]() Click on Significant Values for Screen Details |
Top fitness defect scores for YJL170C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.104 | 1.36E-9 | YLR311C_d | YLR311C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
0.080 | 3.11E-6 | YOL038W | PRE6 | het | Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress |
0.076 | 1.06E-5 | YOR285W | RDL1 | hom | Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress |
0.076 | 1.19E-5 | YIL009C-A | EST3 | hom | Component of the telomerase holoenzyme, involved in telomere replication |
0.074 | 1.69E-5 | YER063W | THO1 | hom | Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation |
0.073 | 2.57E-5 | YER012W | PRE1 | het | Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle |
0.072 | 2.72E-5 | YPR017C | DSS4 | hom | Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol |
0.071 | 3.95E-5 | YBR010W | HHT1 | hom | Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation |
0.070 | 4.68E-5 | YKR047W_d | YKR047W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1 |
0.070 | 4.76E-5 | YFR012W | DCV1 | hom | Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication |
0.070 | 5.55E-5 | YML084W_d | YML084W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
0.069 | 6.89E-5 | YNL062C | GCD10 | het | Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression |
0.067 | 9.56E-5 | YJL142C_d | IRC9_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci |
0.066 | 1.30E-4 | YMR310C_p | YMR310C_p | hom | Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene |
0.066 | 1.30E-4 | YFR046C | CNN1 | hom | Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T |