YJL170C / ASG7

Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL170C / ASG7

Click on Significant Values for Screen Details ID:SGTC_132|Compound:0417-1715|FD-Score:6.65|P-value:7.40E-11 ID:SGTC_137|Compound:0438-0332|FD-Score:3.83|P-value:1.14E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.76|P-value:1.49E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.31|P-value:7.27E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.46|P-value:4.35E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:4.04|P-value:5.00E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:4.12|P-value:3.57E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:-4.14|P-value:3.18E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.55|P-value:3.09E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:-3.32|P-value:6.62E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:4.26|P-value:2.01E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:-3.26|P-value:8.11E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.68|P-value:1.89E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:4.24|P-value:2.23E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:-5.64|P-value:2.59E-8 ID:SGTC_1082|Compound:camptothecin|FD-Score:-5.84|P-value:8.70E-9 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.74|P-value:1.61E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:-3.22|P-value:9.33E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.46|P-value:4.22E-4 ID:SGTC_1666|Compound:st014829|FD-Score:5.02|P-value:6.74E-7 ID:SGTC_1767|Compound:st044992|FD-Score:4.72|P-value:2.75E-6 ID:SGTC_1798|Compound:st045719|FD-Score:-4.00|P-value:5.69E-5 ID:SGTC_1847|Compound:st056231|FD-Score:3.24|P-value:9.19E-4 ID:SGTC_1902|Compound:st060212|FD-Score:3.31|P-value:7.29E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.78|P-value:1.34E-4 ID:SGTC_1913|Compound:st060213|FD-Score:4.30|P-value:1.74E-5 ID:SGTC_2105|Compound:5350118|FD-Score:4.52|P-value:6.62E-6 ID:SGTC_2123|Compound:5259487|FD-Score:3.82|P-value:1.16E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.30|P-value:7.39E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.39|P-value:5.43E-4 ID:SGTC_2168|Compound:5727979|FD-Score:4.24|P-value:2.26E-5 ID:SGTC_2177|Compound:5811945|FD-Score:-3.93|P-value:7.46E-5 ID:SGTC_2292|Compound:7671323|FD-Score:-4.33|P-value:1.46E-5 ID:SGTC_2295|Compound:7971645|FD-Score:-5.30|P-value:1.58E-7 ID:SGTC_2298|Compound:7976326|FD-Score:-3.38|P-value:5.55E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.62|P-value:2.48E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.30|P-value:7.42E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.38|P-value:5.45E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.28|P-value:1.84E-5 ID:SGTC_2810|Compound:7959871|FD-Score:3.80|P-value:1.28E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.37|P-value:5.93E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.64|P-value:2.30E-4 ID:SGTC_3001|Compound:9076041|FD-Score:5.43|P-value:8.24E-8 ID:SGTC_3007|Compound:9078383|FD-Score:3.56|P-value:3.03E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.57|P-value:2.94E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:6.65|P-value:7.40E-11 ID:SGTC_137|Compound:0438-0332|FD-Score:3.83|P-value:1.14E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.76|P-value:1.49E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.31|P-value:7.27E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.46|P-value:4.35E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:4.04|P-value:5.00E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:4.12|P-value:3.57E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:-4.14|P-value:3.18E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.55|P-value:3.09E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:-3.32|P-value:6.62E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:4.26|P-value:2.01E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:-3.26|P-value:8.11E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.68|P-value:1.89E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:4.24|P-value:2.23E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:-5.64|P-value:2.59E-8 ID:SGTC_1082|Compound:camptothecin|FD-Score:-5.84|P-value:8.70E-9 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.74|P-value:1.61E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:-3.22|P-value:9.33E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.46|P-value:4.22E-4 ID:SGTC_1666|Compound:st014829|FD-Score:5.02|P-value:6.74E-7 ID:SGTC_1767|Compound:st044992|FD-Score:4.72|P-value:2.75E-6 ID:SGTC_1798|Compound:st045719|FD-Score:-4.00|P-value:5.69E-5 ID:SGTC_1847|Compound:st056231|FD-Score:3.24|P-value:9.19E-4 ID:SGTC_1902|Compound:st060212|FD-Score:3.31|P-value:7.29E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.78|P-value:1.34E-4 ID:SGTC_1913|Compound:st060213|FD-Score:4.30|P-value:1.74E-5 ID:SGTC_2105|Compound:5350118|FD-Score:4.52|P-value:6.62E-6 ID:SGTC_2123|Compound:5259487|FD-Score:3.82|P-value:1.16E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.30|P-value:7.39E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.39|P-value:5.43E-4 ID:SGTC_2168|Compound:5727979|FD-Score:4.24|P-value:2.26E-5 ID:SGTC_2177|Compound:5811945|FD-Score:-3.93|P-value:7.46E-5 ID:SGTC_2292|Compound:7671323|FD-Score:-4.33|P-value:1.46E-5 ID:SGTC_2295|Compound:7971645|FD-Score:-5.30|P-value:1.58E-7 ID:SGTC_2298|Compound:7976326|FD-Score:-3.38|P-value:5.55E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.62|P-value:2.48E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.30|P-value:7.42E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.38|P-value:5.45E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.28|P-value:1.84E-5 ID:SGTC_2810|Compound:7959871|FD-Score:3.80|P-value:1.28E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.37|P-value:5.93E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.64|P-value:2.30E-4 ID:SGTC_3001|Compound:9076041|FD-Score:5.43|P-value:8.24E-8 ID:SGTC_3007|Compound:9078383|FD-Score:3.56|P-value:3.03E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.57|P-value:2.94E-4

Top fitness defect scores for YJL170C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_132 0417-1715 6.65 25.8 µM 7.40E-11 RPP1 & pyrimidine depletion 2 1.46E-11
2 SGTC_3001 9076041 5.43 71.4 µM 8.24E-8 4 2.75E-8
3 SGTC_1666 st014829 5.02 29.0 µM 6.74E-7 calcium & mitochondrial duress 14 2.62E-7
4 SGTC_1767 st044992 4.72 70.3 µM 2.75E-6 11 1.19E-6
5 SGTC_2105 5350118 4.52 200.0 µM 6.62E-6 16 3.05E-6
6 SGTC_1913 st060213 4.30 96.1 µM 1.74E-5 21 8.62E-6
7 SGTC_2633 5,7-dihydroxyisoflavone 4.28 100.0 µM 1.84E-5 25 9.16E-6
8 SGTC_870 0573-2213 4.26 57.6 µM 2.01E-5 ERG2 13 1.00E-5
9 SGTC_949 1165-0505 4.24 146.0 µM 2.23E-5 15 1.13E-5
10 SGTC_2168 5727979 4.24 200.0 µM 2.26E-5 14 1.14E-5
11 SGTC_538 2922-0838 4.12 53.3 µM 3.57E-5 Golgi 29 1.86E-5
12 SGTC_371 0195-0006 4.04 7.4 µM 5.00E-5 19 2.67E-5
13 SGTC_137 0438-0332 3.83 85.4 µM 1.14E-4 ubiquinone biosynthesis & proteasome 133 6.47E-5
14 SGTC_2123 5259487 3.82 200.0 µM 1.16E-4 21 6.58E-5
15 SGTC_2810 7959871 3.80 45.5 µM 1.28E-4 copper-dependent oxidative stress 43 7.35E-5
16 SGTC_1911 st060208 3.78 74.3 µM 1.34E-4 40 7.69E-5
17 SGTC_147 4466-0538 3.76 29.2 µM 1.49E-4 ergosterol biosynthesis 26 8.65E-5
18 SGTC_1339 1486-1321 3.74 22.7 µM 1.61E-4 ERG2 28 9.38E-5
19 SGTC_2868 9035608 3.64 32.5 µM 2.30E-4 23 1.37E-4
20 SGTC_2453 5731132 3.62 22.2 µM 2.48E-4 27 1.49E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.36E-9 YLR311C_d YLR311C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.080 3.11E-6 YOL038W PRE6 het Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
0.076 1.06E-5 YOR285W RDL1 hom Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress
0.076 1.19E-5 YIL009C-A EST3 hom Component of the telomerase holoenzyme, involved in telomere replication
0.074 1.69E-5 YER063W THO1 hom Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
0.073 2.57E-5 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.072 2.72E-5 YPR017C DSS4 hom Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol
0.071 3.95E-5 YBR010W HHT1 hom Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation
0.070 4.68E-5 YKR047W_d YKR047W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1
0.070 4.76E-5 YFR012W DCV1 hom Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication
0.070 5.55E-5 YML084W_d YML084W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.069 6.89E-5 YNL062C GCD10 het Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
0.067 9.56E-5 YJL142C_d IRC9_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci
0.066 1.30E-4 YMR310C_p YMR310C_p hom Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene
0.066 1.30E-4 YFR046C CNN1 hom Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T