YJL174W / KRE9

Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL174W / KRE9

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:-9.49|P-value:1.20E-22 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.57|P-value:1.32E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.92|P-value:3.09E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:4.31|P-value:5.24E-6 ID:SGTC_286|Compound:k060-0067|FD-Score:3.19|P-value:5.59E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:4.89|P-value:2.79E-7 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.94|P-value:2.74E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.39|P-value:2.59E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:7.66|P-value:2.26E-15 ID:SGTC_785|Compound:1270-0111|FD-Score:3.20|P-value:5.40E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:4.15|P-value:1.10E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.55|P-value:1.58E-6 ID:SGTC_847|Compound:0342-0274|FD-Score:3.79|P-value:5.27E-5 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.47|P-value:1.89E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.71|P-value:7.25E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:-4.42|P-value:3.01E-6 ID:SGTC_1016|Compound:4226-1401|FD-Score:6.11|P-value:2.08E-10 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.46|P-value:2.47E-6 ID:SGTC_1023|Compound:4482-3888|FD-Score:4.21|P-value:8.12E-6 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.82|P-value:4.46E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.53|P-value:1.52E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.84|P-value:4.33E-5 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.95|P-value:2.68E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.70|P-value:7.68E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.32|P-value:3.46E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.09|P-value:7.96E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.64|P-value:1.05E-6 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.92|P-value:3.02E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.44|P-value:2.19E-4 ID:SGTC_1725|Compound:st036284|FD-Score:-4.46|P-value:2.46E-6 ID:SGTC_1806|Compound:st050005|FD-Score:3.33|P-value:3.30E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.17|P-value:5.80E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.90|P-value:3.35E-5 ID:SGTC_1983|Compound:st071813|FD-Score:4.37|P-value:3.94E-6 ID:SGTC_2007|Compound:4011539|FD-Score:4.05|P-value:1.73E-5 ID:SGTC_2072|Compound:5231554|FD-Score:-3.37|P-value:2.70E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-5.29|P-value:3.00E-8 ID:SGTC_2286|Compound:7945697|FD-Score:4.62|P-value:1.15E-6 ID:SGTC_2439|Compound:5492030|FD-Score:3.05|P-value:9.09E-4 ID:SGTC_2486|Compound:5283202|FD-Score:5.16|P-value:6.55E-8 ID:SGTC_2703|Compound:st077852|FD-Score:-3.10|P-value:7.46E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-3.31|P-value:3.48E-4 ID:SGTC_2713|Compound:st079149|FD-Score:4.44|P-value:2.83E-6 ID:SGTC_2715|Compound:st079500|FD-Score:-3.36|P-value:2.91E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.06|P-value:8.70E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.15|P-value:1.10E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.72|P-value:6.93E-5 ID:SGTC_2955|Compound:9076254|FD-Score:3.06|P-value:8.63E-4 ID:SGTC_3189|Compound:9110682|FD-Score:-3.38|P-value:2.61E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-3.54|P-value:1.43E-4 ID:SGTC_3199|Compound:9111318|FD-Score:11.90|P-value:1.15E-34 ID:SGTC_3202|Compound:9113761|FD-Score:3.71|P-value:7.53E-5 ID:SGTC_3345|Compound:9148410|FD-Score:3.11|P-value:7.39E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-3.12|P-value:6.79E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-9.49|P-value:1.20E-22 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.57|P-value:1.32E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.92|P-value:3.09E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:4.31|P-value:5.24E-6 ID:SGTC_286|Compound:k060-0067|FD-Score:3.19|P-value:5.59E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:4.89|P-value:2.79E-7 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.94|P-value:2.74E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.39|P-value:2.59E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:7.66|P-value:2.26E-15 ID:SGTC_785|Compound:1270-0111|FD-Score:3.20|P-value:5.40E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:4.15|P-value:1.10E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.55|P-value:1.58E-6 ID:SGTC_847|Compound:0342-0274|FD-Score:3.79|P-value:5.27E-5 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.47|P-value:1.89E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.71|P-value:7.25E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:-4.42|P-value:3.01E-6 ID:SGTC_1016|Compound:4226-1401|FD-Score:6.11|P-value:2.08E-10 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.46|P-value:2.47E-6 ID:SGTC_1023|Compound:4482-3888|FD-Score:4.21|P-value:8.12E-6 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.82|P-value:4.46E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.53|P-value:1.52E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.84|P-value:4.33E-5 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.95|P-value:2.68E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.70|P-value:7.68E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.32|P-value:3.46E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.09|P-value:7.96E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.64|P-value:1.05E-6 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.92|P-value:3.02E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.44|P-value:2.19E-4 ID:SGTC_1725|Compound:st036284|FD-Score:-4.46|P-value:2.46E-6 ID:SGTC_1806|Compound:st050005|FD-Score:3.33|P-value:3.30E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.17|P-value:5.80E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.90|P-value:3.35E-5 ID:SGTC_1983|Compound:st071813|FD-Score:4.37|P-value:3.94E-6 ID:SGTC_2007|Compound:4011539|FD-Score:4.05|P-value:1.73E-5 ID:SGTC_2072|Compound:5231554|FD-Score:-3.37|P-value:2.70E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-5.29|P-value:3.00E-8 ID:SGTC_2286|Compound:7945697|FD-Score:4.62|P-value:1.15E-6 ID:SGTC_2439|Compound:5492030|FD-Score:3.05|P-value:9.09E-4 ID:SGTC_2486|Compound:5283202|FD-Score:5.16|P-value:6.55E-8 ID:SGTC_2703|Compound:st077852|FD-Score:-3.10|P-value:7.46E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-3.31|P-value:3.48E-4 ID:SGTC_2713|Compound:st079149|FD-Score:4.44|P-value:2.83E-6 ID:SGTC_2715|Compound:st079500|FD-Score:-3.36|P-value:2.91E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.06|P-value:8.70E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.15|P-value:1.10E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.72|P-value:6.93E-5 ID:SGTC_2955|Compound:9076254|FD-Score:3.06|P-value:8.63E-4 ID:SGTC_3189|Compound:9110682|FD-Score:-3.38|P-value:2.61E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-3.54|P-value:1.43E-4 ID:SGTC_3199|Compound:9111318|FD-Score:11.90|P-value:1.15E-34 ID:SGTC_3202|Compound:9113761|FD-Score:3.71|P-value:7.53E-5 ID:SGTC_3345|Compound:9148410|FD-Score:3.11|P-value:7.39E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-3.12|P-value:6.79E-4

Top fitness defect scores for YJL174W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3199 9111318 11.90 49.5 µM 1.15E-34 1 3.56E-33 3.71
2 SGTC_663 1486-0733 7.66 13.9 µM 2.26E-15 cell wall signaling 3 9.32E-15 3.05
3 SGTC_1016 4226-1401 6.11 38.0 µM 2.08E-10 RNA pol III & RNase P/MRP 7 5.12E-10 0.22
4 SGTC_2486 5283202 5.16 22.4 µM 6.55E-8 1 1.25E-7 1.41
5 SGTC_341 1486-1430 4.89 230.0 µM 2.79E-7 15 4.99E-7 0.09
6 SGTC_1482 3346-2049 4.64 8.5 µM 1.05E-6 3 1.76E-6 0.03
7 SGTC_2286 7945697 4.62 125.0 µM 1.15E-6 7 1.94E-6 0.41
8 SGTC_800 3448-7362 4.55 155.0 µM 1.58E-6 translation 38 2.62E-6 0.03
9 SGTC_1020 4335-0961 4.46 93.3 µM 2.47E-6 5 4.02E-6 0.44
10 SGTC_2713 st079149 4.44 53.4 µM 2.83E-6 2 4.57E-6 0.20
11 SGTC_1983 st071813 4.37 46.9 µM 3.94E-6 RPP1 & pyrimidine depletion 4 6.28E-6 0.18
12 SGTC_194 1486-1323 4.31 56.9 µM 5.24E-6 6 8.24E-6 0.39
13 SGTC_1023 4482-3888 4.21 16.0 µM 8.12E-6 TSC3-RPN4 8 1.25E-5 0.29
14 SGTC_2758 dehydroepiandrosterone 4.15 69.3 µM 1.10E-5 5 1.68E-5 0.09
15 SGTC_786 4544-0069 4.15 423.0 µM 1.10E-5 7 1.68E-5 0.21
16 SGTC_2007 4011539 4.05 71.8 µM 1.73E-5 cell wall signaling 9 2.59E-5 0.60
17 SGTC_1158 4092-0494 3.95 91.8 µM 2.68E-5 4 3.93E-5 0.09
18 SGTC_1500 4488-1866 3.92 171.0 µM 3.02E-5 RPP1 & pyrimidine depletion 2 4.40E-5 0.34
19 SGTC_150 3970-0969 3.92 77.2 µM 3.09E-5 15 4.50E-5 0.09
20 SGTC_1930 st074634 3.90 34.3 µM 3.35E-5 RNA pol III & RNase P/MRP 16 4.87E-5 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.180 9.27E-26 YOR063W RPL3 het Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus
0.172 1.38E-23 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.143 6.81E-17 YHR019C DED81 het Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.137 1.68E-15 YKL152C GPM1 het Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.134 7.11E-15 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.127 1.85E-13 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.125 4.01E-13 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.123 9.43E-13 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.122 1.13E-12 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.120 2.96E-12 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.119 3.99E-12 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.117 1.27E-11 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.112 7.11E-11 YKL035W UGP1 het UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication
0.110 1.99E-10 YAR002C-A ERP1 hom Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication
0.108 3.92E-10 YNR055C HOL1 hom Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake