YJL176C / SWI3

Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL176C / SWI3

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:-3.65|P-value:6.62E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.96|P-value:2.46E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.60|P-value:2.66E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.12|P-value:1.48E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.84|P-value:3.74E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:4.52|P-value:3.60E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:4.69|P-value:1.85E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:3.72|P-value:5.37E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:4.65|P-value:2.17E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.00|P-value:2.17E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.69|P-value:5.86E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.62|P-value:7.29E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.25|P-value:9.46E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-4.49|P-value:3.99E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.18|P-value:1.20E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.83|P-value:3.78E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.95|P-value:2.55E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.16|P-value:1.29E-4 ID:SGTC_2113|Compound:5491891|FD-Score:4.03|P-value:1.98E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.91|P-value:2.90E-4 ID:SGTC_2177|Compound:5811945|FD-Score:4.41|P-value:5.32E-5 ID:SGTC_2319|Compound:6033012|FD-Score:-3.97|P-value:2.42E-4 ID:SGTC_2358|Compound:9037157|FD-Score:4.47|P-value:4.26E-5 ID:SGTC_2460|Compound:5552655|FD-Score:4.35|P-value:6.67E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.65|P-value:3.47E-7 ID:SGTC_2787|Compound:5284540|FD-Score:4.41|P-value:5.28E-5 ID:SGTC_2796|Compound:7949634|FD-Score:3.54|P-value:9.21E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.71|P-value:5.53E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.52|P-value:3.52E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-3.96|P-value:2.47E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.18|P-value:1.18E-4 ID:SGTC_3143|Compound:9086658|FD-Score:5.41|P-value:9.98E-7 ID:SGTC_3155|Compound:9099265|FD-Score:5.59|P-value:4.43E-7 ID:SGTC_3313|Compound:9133968|FD-Score:-4.02|P-value:2.05E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.65|P-value:6.62E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.96|P-value:2.46E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.60|P-value:2.66E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.12|P-value:1.48E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.84|P-value:3.74E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:4.52|P-value:3.60E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:4.69|P-value:1.85E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:3.72|P-value:5.37E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:4.65|P-value:2.17E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.00|P-value:2.17E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.69|P-value:5.86E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.62|P-value:7.29E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.25|P-value:9.46E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-4.49|P-value:3.99E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.18|P-value:1.20E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.83|P-value:3.78E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.95|P-value:2.55E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.16|P-value:1.29E-4 ID:SGTC_2113|Compound:5491891|FD-Score:4.03|P-value:1.98E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.91|P-value:2.90E-4 ID:SGTC_2177|Compound:5811945|FD-Score:4.41|P-value:5.32E-5 ID:SGTC_2319|Compound:6033012|FD-Score:-3.97|P-value:2.42E-4 ID:SGTC_2358|Compound:9037157|FD-Score:4.47|P-value:4.26E-5 ID:SGTC_2460|Compound:5552655|FD-Score:4.35|P-value:6.67E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.65|P-value:3.47E-7 ID:SGTC_2787|Compound:5284540|FD-Score:4.41|P-value:5.28E-5 ID:SGTC_2796|Compound:7949634|FD-Score:3.54|P-value:9.21E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.71|P-value:5.53E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.52|P-value:3.52E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-3.96|P-value:2.47E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.18|P-value:1.18E-4 ID:SGTC_3143|Compound:9086658|FD-Score:5.41|P-value:9.98E-7 ID:SGTC_3155|Compound:9099265|FD-Score:5.59|P-value:4.43E-7 ID:SGTC_3313|Compound:9133968|FD-Score:-4.02|P-value:2.05E-4

Top fitness defect scores for YJL176C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3155 9099265 5.59 49.5 µM 4.43E-7 7 1.13E-8
2 SGTC_3143 9086658 5.41 49.5 µM 9.98E-7 12 3.19E-8
3 SGTC_577 r071-0003 4.69 38.6 µM 1.85E-5 fatty acid desaturase (OLE1) 33 1.35E-6
4 SGTC_700 3453-2283 4.65 142.0 µM 2.17E-5 amide catabolism 11 1.65E-6
5 SGTC_273 hydroxyurea 4.60 18.1 mM 2.66E-5 heme biosynthesis & mitochondrial translocase 20 2.15E-6
6 SGTC_2831 7999036 4.52 19.5 µM 3.52E-5 28 3.06E-6
7 SGTC_563 tetrahydrosecaminediol 4.52 614.0 µM 3.60E-5 amide catabolism 9 3.15E-6
8 SGTC_2358 9037157 4.47 4.0 µM 4.26E-5 18 3.92E-6
9 SGTC_2787 5284540 4.41 71.4 µM 5.28E-5 17 5.16E-6
10 SGTC_2177 5811945 4.41 192.0 µM 5.32E-5 20 5.21E-6
11 SGTC_2460 5552655 4.35 174.2 µM 6.67E-5 amide catabolism 22 6.95E-6
12 SGTC_1608 st001473 4.25 40.5 µM 9.46E-5 27 1.09E-5
13 SGTC_2997 9067075 4.18 71.4 µM 1.18E-4 unfolded protein response 50 1.43E-5
14 SGTC_2052 5265182 4.16 7.1 µM 1.29E-4 25 1.62E-5
15 SGTC_2113 5491891 4.03 107.0 µM 1.98E-4 TSC3-RPN4 18 2.78E-5
16 SGTC_70 0141-0289 3.96 43.3 µM 2.46E-4 mitochondrial stress 173 3.68E-5
17 SGTC_2011 4012611 3.95 177.0 µM 2.55E-4 mitochondrial processes 31 3.86E-5
18 SGTC_2130 NSC 7 3.91 2.5 µM 2.90E-4 copper-dependent oxidative stress 25 4.54E-5
19 SGTC_1853 st056710 3.83 91.2 µM 3.78E-4 amide catabolism 29 6.38E-5
20 SGTC_676 falcarinol 3.72 140.0 µM 5.37E-4 61 9.97E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 3.29E-15 YNL135C FPR1 hom Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
0.133 1.18E-14 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.130 4.59E-14 YDR074W TPS2 hom Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress
0.109 2.07E-10 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.109 2.17E-10 YCR068W ATG15 hom Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
0.105 1.19E-9 YPL139C UME1 hom Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p
0.102 3.72E-9 YJL029C VPS53 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting
0.100 6.43E-9 YIR023W DAL81 hom Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
0.100 7.52E-9 YJR083C ACF4 hom Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate
0.094 5.01E-8 YNL199C GCR2 hom Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p
0.093 6.15E-8 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.093 6.43E-8 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.093 8.02E-8 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.091 1.31E-7 YFL021W GAT1 hom Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
0.089 2.32E-7 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data