YJL178C / ATG27

Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL178C / ATG27

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:3.95|P-value:6.93E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:3.90|P-value:8.40E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:7.13|P-value:4.07E-12 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.43|P-value:6.54E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:5.25|P-value:2.23E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.32|P-value:1.11E-12 ID:SGTC_526|Compound:4469-0568|FD-Score:-4.39|P-value:1.82E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:-4.79|P-value:3.32E-6 ID:SGTC_532|Compound:1548-0774|FD-Score:5.57|P-value:4.33E-8 ID:SGTC_540|Compound:1187-0821|FD-Score:-4.56|P-value:8.79E-6 ID:SGTC_680|Compound:0417-1641|FD-Score:3.82|P-value:1.16E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:3.47|P-value:3.94E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.32|P-value:9.46E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.69|P-value:1.87E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:5.80|P-value:1.29E-8 ID:SGTC_1074|Compound:carmofur|FD-Score:-3.89|P-value:1.30E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.60|P-value:2.54E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.69|P-value:1.85E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.68|P-value:1.94E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:-4.04|P-value:7.43E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.49|P-value:5.35E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-4.84|P-value:2.61E-6 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.17|P-value:2.98E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:-4.36|P-value:2.07E-5 ID:SGTC_1814|Compound:st052110|FD-Score:5.68|P-value:2.47E-8 ID:SGTC_1817|Compound:st052116|FD-Score:4.81|P-value:1.82E-6 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-3.39|P-value:7.39E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.92|P-value:7.74E-5 ID:SGTC_2074|Compound:5212007|FD-Score:3.35|P-value:5.91E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.52|P-value:3.32E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.39|P-value:5.28E-4 ID:SGTC_2264|Compound:7948757|FD-Score:-4.00|P-value:8.72E-5 ID:SGTC_2267|Compound:7931562|FD-Score:3.99|P-value:5.90E-5 ID:SGTC_2350|Compound:9023895|FD-Score:-3.82|P-value:1.66E-4 ID:SGTC_2355|Compound:9061122|FD-Score:4.07|P-value:4.42E-5 ID:SGTC_2356|Compound:9061756|FD-Score:3.86|P-value:9.77E-5 ID:SGTC_2359|Compound:9039622|FD-Score:4.28|P-value:1.84E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.49|P-value:3.67E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.61|P-value:2.47E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-4.20|P-value:4.02E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.23|P-value:8.86E-4 ID:SGTC_2843|Compound:9000894|FD-Score:3.79|P-value:1.28E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.73|P-value:2.30E-4 ID:SGTC_2978|Compound:9011784|FD-Score:6.42|P-value:3.58E-10 ID:SGTC_2979|Compound:9012552|FD-Score:-4.31|P-value:2.52E-5 ID:SGTC_2987|Compound:9018338|FD-Score:-3.85|P-value:1.52E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.95|P-value:6.93E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:3.90|P-value:8.40E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:7.13|P-value:4.07E-12 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.43|P-value:6.54E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:5.25|P-value:2.23E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.32|P-value:1.11E-12 ID:SGTC_526|Compound:4469-0568|FD-Score:-4.39|P-value:1.82E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:-4.79|P-value:3.32E-6 ID:SGTC_532|Compound:1548-0774|FD-Score:5.57|P-value:4.33E-8 ID:SGTC_540|Compound:1187-0821|FD-Score:-4.56|P-value:8.79E-6 ID:SGTC_680|Compound:0417-1641|FD-Score:3.82|P-value:1.16E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:3.47|P-value:3.94E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.32|P-value:9.46E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.69|P-value:1.87E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:5.80|P-value:1.29E-8 ID:SGTC_1074|Compound:carmofur|FD-Score:-3.89|P-value:1.30E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.60|P-value:2.54E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.69|P-value:1.85E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.68|P-value:1.94E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:-4.04|P-value:7.43E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.49|P-value:5.35E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-4.84|P-value:2.61E-6 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.17|P-value:2.98E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:-4.36|P-value:2.07E-5 ID:SGTC_1814|Compound:st052110|FD-Score:5.68|P-value:2.47E-8 ID:SGTC_1817|Compound:st052116|FD-Score:4.81|P-value:1.82E-6 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-3.39|P-value:7.39E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.92|P-value:7.74E-5 ID:SGTC_2074|Compound:5212007|FD-Score:3.35|P-value:5.91E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.52|P-value:3.32E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.39|P-value:5.28E-4 ID:SGTC_2264|Compound:7948757|FD-Score:-4.00|P-value:8.72E-5 ID:SGTC_2267|Compound:7931562|FD-Score:3.99|P-value:5.90E-5 ID:SGTC_2350|Compound:9023895|FD-Score:-3.82|P-value:1.66E-4 ID:SGTC_2355|Compound:9061122|FD-Score:4.07|P-value:4.42E-5 ID:SGTC_2356|Compound:9061756|FD-Score:3.86|P-value:9.77E-5 ID:SGTC_2359|Compound:9039622|FD-Score:4.28|P-value:1.84E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.49|P-value:3.67E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.61|P-value:2.47E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-4.20|P-value:4.02E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.23|P-value:8.86E-4 ID:SGTC_2843|Compound:9000894|FD-Score:3.79|P-value:1.28E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.73|P-value:2.30E-4 ID:SGTC_2978|Compound:9011784|FD-Score:6.42|P-value:3.58E-10 ID:SGTC_2979|Compound:9012552|FD-Score:-4.31|P-value:2.52E-5 ID:SGTC_2987|Compound:9018338|FD-Score:-3.85|P-value:1.52E-4

Top fitness defect scores for YJL178C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_453 enantio-paf c16 7.32 10.0 µM 1.11E-12 22 1.21E-13
2 SGTC_58 0957-0393 7.13 9.0 µM 4.07E-12 cell wall 159 5.04E-13
3 SGTC_2978 9011784 6.42 43.0 µM 3.58E-10 3 6.73E-11
4 SGTC_873 0591-4978 5.80 488.0 µM 1.29E-8 3 3.38E-9
5 SGTC_1814 st052110 5.68 31.5 µM 2.47E-8 RNA processing & uracil transport 4 6.88E-9
6 SGTC_532 1548-0774 5.57 215.0 µM 4.33E-8 3 1.27E-8
7 SGTC_358 0075-0058 5.25 9.4 µM 2.23E-7 27 7.57E-8
8 SGTC_1817 st052116 4.81 64.4 µM 1.82E-6 RNA processing & uracil transport 5 7.43E-7
9 SGTC_2359 9039622 4.28 200.0 µM 1.84E-5 endomembrane recycling 17 9.25E-6
10 SGTC_1391 3442-0225 4.17 151.0 µM 2.98E-5 10 1.55E-5
11 SGTC_2355 9061122 4.07 103.1 µM 4.42E-5 12 2.39E-5
12 SGTC_2267 7931562 3.99 200.0 µM 5.90E-5 18 3.27E-5
13 SGTC_18 0111-0177 3.95 500.0 nM 6.93E-5 73 3.89E-5
14 SGTC_2054 5233173 3.92 129.0 µM 7.74E-5 mitochondrial response to ROS 54 4.39E-5
15 SGTC_21 0849-0113 3.90 23.0 µM 8.40E-5 34 4.80E-5
16 SGTC_2356 9061756 3.86 189.0 µM 9.77E-5 11 5.65E-5
17 SGTC_680 0417-1641 3.82 114.0 µM 1.16E-4 RPP1 & pyrimidine depletion 19 6.81E-5
18 SGTC_2843 9000894 3.79 45.5 µM 1.28E-4 14 7.60E-5
19 SGTC_1126 isoteolin 3.69 1.0 µM 1.85E-4 38 1.13E-4
20 SGTC_863 0466-0191 3.69 129.0 µM 1.87E-4 cell wall 81 1.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.222 9.39E-39 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.154 3.89E-19 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.143 7.25E-17 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.142 1.22E-16 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.133 1.31E-14 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.132 1.62E-14 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.131 2.67E-14 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.130 4.19E-14 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.127 1.45E-13 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.126 2.18E-13 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.125 4.02E-13 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.124 4.92E-13 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.123 8.38E-13 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.123 9.59E-13 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.123 9.95E-13 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins